Altered Sensorimotor Cortical Activities During Forearm Movement in Humans With Spinal Cord Injury.

Aims: Decoding the motor intention by electroencephalography to control external devices is an effective method of helping spinal cord injury (SCI) patients to regain motor function. Still, SCI patients have much lower accuracy in the decoding of motor intentions compared to healthy individuals, which severely hampers the clinical application. However, the underlying neural mechanisms are still unknown.

A Benzothiazole Derived Fluorescent Sensor for Real-time Detection of Aluminums Ion and Application in Real Samples and Living Cells.

Excessive aluminum ions (Al) contaminate environmental water bodies, and once they remain in the human body, they will pose a threat to human health. In this paper, a benzothiazole-based fluorescent sensor named BHMH for detecting Al was successfully synthesized and comprehensively characterized. It exhibited remarkable selectivity and sensitivity, manifested by a substantial fluorescence augmentation and a discernible color alteration in the presence of Al.

[Application of 3D-printed navigation for genital nerve regulation in male with lower urinary tract symptoms].

Objective: To investigate the efficacy of 3D-printed navigation guided pudendal lead implantation on nervous regulation of lower urinary tract symptoms（LUTS） in male patients.

Methods: Twenty-eight male patients who underwent perineal nervous regulation treatment for LUTS in Gongli Hospital of Pudong New Area from October 2021 to October 2023 were randomly divided into observation group and control group. The technology assisted with 3D-printed navigation to regulate the genital nerves was used in observation group.

Hollow Cu/Pt Interspersed GO Nanosheets Cascade Triggering Catalytic Signal Amplification for Colorimetric/SERS Sensing of in Clinical Samples.

Rapid and precise detection of () is crucial for early diagnosis, treatment of infectious ailments, and controlling outbreaks. Herein, we present a rapid, streamlined, and sensitive method for screening based on a hollow copper/platinum interspersed graphene oxide nanosheets (Cu/Pt-GO)-mediated cascade responsiveness strategy. The Cu/Pt-GO nanozymes were proposed to catalyze the colorless 3,3',5,5'-tetramethylbenzidine (TMB) to colored oxidized TMB (oxTMB) with enhanced SERS signals, achieving colorimetric/SERS dual-model detection.

Current advancements in the investigation of mitochondria-targeting organic sensitizers in cancer immunotherapy.

Cancer immunotherapy has transformed oncological treatment paradigms, yet tumor resistance and immune evasion continue to limit therapeutic efficacy. Mitochondria-targeting organic sensitizers (MTOSs) represent an emerging class of therapeutic agents that exploit mitochondrial dysfunction as a convergent node for tumor elimination and immune activation. As central regulators of cellular metabolism, apoptotic signaling, and immune cell function, mitochondria serve as critical determinants of tumor progression and the immunological landscape within the tumor microenvironment (TME).

Epigenetic‑ncRNA crosstalk in atherosclerosis: Mechanisms, disease progression and therapeutic potential (Review).

Atherosclerosis is a chronic and progressive vascular disease involving the gradual accumulation of lipids, cholesterol, cellular debris, and fibrous elements within the arterial wall. This process leads to the thickening and hardening of arteries, resulting in restricted blood flow and reduced oxygen delivery to tissues. Over time, these pathological changes significantly elevate the risk of life‑threatening cardiovascular events, including myocardial infarction and ischemic stroke.

Tumour necrosis factor alpha-inducing protein 3 (TNFAIP3) can independently predict coronary heart disease (CHD).

Background: Multiple indicators of inflammation are significantly associated with coronary heart disease (CHD). Tumour necrosis factor alpha-inducible protein 3 (TNFAIP3) is an anti-inflammatory protein that inhibits inflammatory responses. However, the relationship between TNFAIP3 and CHD is currently unknown.

Stage-Resolved Phosphoproteomic Landscape of Mouse Spermiogenesis Reveals Key Kinase Signaling in Sperm Morphogenesis.

Spermiogenesis is the committed step of sperm production, during which spermatid cells undergo dramatic morphological transformations and transcriptional silencing. Post-translational modifications (PTMs), including phosphorylation, provide a level of protein function flexibility and play important roles in spermiogenesis. Dynamic protein phosphorylation profiles of spermatids are characterized across four different developing steps, and identified phosphorylation regulation of key proteins in spermiogenesis.

In silico comparison of two non-invasive pre-procedural virtual coronary revascularisation techniques for personalised cardiovascular medicine.

Background And Objectives: Non-invasive pre-procedural prediction of post-PCI vessel morphology and CT angiography-derived fractional flow reserve (CT-FFR) can inform coronary revascularisation planning. However, the capabilities of different CT-based virtual coronary revascularisation (VCR) techniques need further investigation.

Methods: This study compared two CT-based VCR techniques: a virtual coronary intervention (VCI) method and a radius correction (RC) method.

Substituting Superhalogens for the Fluorine Atom of 5-Fluorouracil: A New Approach to Modulate its Structure, Electronic Properties, and Chemical Reactivity.

The development of 5-fluorouracil (5-FU) analogs contributes to overcome its side effects and drug resistance. To explore more 5-FU analogs, the substituent effect of BO, NO, and PO on the geometric structure, electronic properties, and reactivity of 5-FU has been systematically studied by density functional theory calculations and molecular docking in this article. It is revealed that the introduced superhalogens can not only form stable covalent bonds with the pyrimidine ring, like the original F atom in 5-FU, but also pose significant effect on the geometric and electronic structures of 5-FU.

The impact of aberrant lipid metabolism on the immune microenvironment of gastric cancer: a mini review.

Gastric cancer (GC) remains one of the leading causes of cancer-related mortality worldwide, with limited responses to immune checkpoint blockade (ICB) therapies in most patients. Increasing evidence indicates that the tumor immune microenvironment (TIME) plays a crucial role in immunotherapy outcomes. Among various metabolic abnormalities in the TIME, dysregulated lipid metabolism has emerged as a critical determinant of immune cell fate, differentiation, and function.

From basics to clinics: New opportunities for metformin in tumor metabolic intervention and treatment.

Metformin, a cornerstone therapy for type 2 diabetes, has recently garnered attention for its multifaceted antitumor potential in cancer prevention and treatment. Emerging preclinical studies reveal that metformin suppresses tumor growth and metastasis through integrated mechanisms beyond singular metabolic pathways, while enhancing sensitivity to immunotherapy. Clinical evidence preliminarily supports its survival benefits and risk reduction in breast, colorectal, and hepatocellular carcinomas, particularly when combined with conventional or novel anticancer agents, demonstrating synergistic efficacy.

Prognostic value of baseline plasma D-dimer levels in sepsis: a prospective cohort study.

Background: Plasma D-dimer, a fibrin degradation product, reflects coagulation activation and is often elevated in critically ill patients. Its prognostic significance in sepsis, particularly for short-term outcomes, remains unclear.

Methods: In this prospective cohort study, we enrolled 175 adult ICU patients with sepsis (Sepsis-3 criteria) from March 2024 to February 2025.

Exploration of prognostic genes associated with lymphangiogenesis in breast cancer based on transcriptomics and experimental verification.

Background: Breast cancer (BC), a malignant neoplasm resulting from the uncontrolled proliferation of mammary epithelial cells, is predominantly driven by pathogenic breast cancer gene (BRCA) 1/2 mutations in hereditary cases. Previous studies have implicated lymphangiogenesis in the progression of BC. This research aimed to identify prognostic genes associated with lymphangiogenesis in BC and explore their underlying biological mechanisms.

Houttuynia cordata Thunb-derived extracellular vesicle-like particles alleviate ischemic brain injury by miR159a targeting ACSL4 to suppress ferroptosis.

Introduction: Neuroprotective agents for acute ischemic stroke often fall short in efficacy due to the blood-brain barrier challenges, lack of target specificity, and limited effectiveness. Recently, plant-derived extracellular vesicle-like particles (EVLP) have shown promise in their multifaceted functions.

Objectives: The neuroprotective advantages that EVLP produced from Houttuynia cordata Thunb against cerebral ischemia/reperfusion injury are investigated.

Bacterial Extracellular Vesicles: Emerging Regulators in the Gut-Organ Axis and Prospective Biomedical Applications.

The critical role of gut microbiota and their metabolites in host health has been extensively studied. In recent years, bacterial extracellular vesicles (BEVs) released by gut bacteria have gained increasing attention as carriers of bioactive substances and signaling molecules. This review systematically summarizes the biogenesis of BEVs and their potential regulatory roles in gut-organ axis diseases, including disorders of the central nervous system, kidneys, liver, bones, lungs, cardiovascular system, and metabolism.

CircRERE promotes myocardial ischemia/reperfusion injury by increasing UHRF1 mRNA decay through targeting PUM2 to reduce Drp1 promoter methylation.

Background: Myocardial ischemia/reperfusion (I/R) injury contributes significantly to cardiac dysfunction following myocardial infarction, mainly due to excessive oxidative stress and mitochondrial injury. Despite advances in reperfusion therapies, secondary injuries remain a challenge, necessitating deeper insight into the molecular mechanisms underlying I/R injury. In the present study, we aim to investigate the roles of circular ribonucleic acid (circRNA) RERE (circRERE) in myocardial I/R injury.

Tetrastigma hemsleyanum Diels et Gilg polysaccharide mitigates macrophage pyroptosis and prevents acute lung injury by regulating NLRP3/Caspase-1/GSDMD signaling pathways.

Acute lung injury (ALI) manifests as an intense inflammatory disorder marked by heightened macrophage pyroptotic death and uncontrolled cytokine release. Tetrastigma hemsleyanum Diels et Gilg polysaccharide (THP), derived from a traditional Chinese medicinal herb, was evaluated for its therapeutic effects against ALI. Network pharmacology analysis suggested that THP targets macrophage-related inflammatory pathways.

Predictive computational framework to provide a digital twin for personalized cardiovascular medicine.

Background: In percutaneous coronary intervention (PCI), the ability to predict post-PCI fractional flow reserve (FFR) and stented vessel informs procedural planning. However, highly precise and effective methods to quantitatively simulate coronary intervention are lacking. This study developed and validated a virtual coronary intervention (VCI) technique for non-invasive physiological and anatomical assessment of PCI.

FOXQ1 Regulates Brain Endothelial Mitochondrial Function by Orchestrating Calcium Signaling and Cristae Morphology.

The blood-brain barrier (BBB) maintains brain homeostasis through specialized functions including tight junction formation and selective transport of brain endothelial cells (ECs). While ECs are generally thought to rely primarily on glycolysis for energy production, the transcriptional mechanisms underlying their metabolic specialization in the brain endothelium remain poorly understood, especially considering the brain's extraordinary energy demands. Through comparative transcriptomic analysis, it is demonstrated that brain endothelial cells are enriched for mitochondrial function genes, with forkhead box protein 1 (FOXQ1) being selectively expressed in cerebral vasculature.

Adverse Childhood Experiences, Genetic Susceptibility, and the Risk of Osteoporosis: A Cohort Study.

Emerging evidence indicates that individuals exposed to adverse childhood experiences (ACEs) face elevated risks for various chronic illnesses. However, the association between ACEs and osteoporosis risk remains underexplored, particularly regarding potential modifications by genetic susceptibility. This prospective cohort study aims to examine the relationship of ACEs with incident osteoporosis and investigate interactions with polygenic risk score (PRS).

Urinary Metabolites Variation After High-Intensity Rowing Training and Potential Biomarker Screening for Exercise-Induced Muscle Damage.

Exercise-induced muscle damage (EIMD) is the most common health risk in physical exercise. However, instant and non-invasive methods for EIMD prediction have not been reported. Urine is a promising tool for EIMD prediction.

Exercise mediates the sex differences in adult visuospatial cognitive ability.

Background: Sex differences in visuospatial cognitive performance have been consistently documented, with males typically demonstrating superior performance in tasks requiring spatial processing. While multiple biological, psychological, and sociocultural factors have been proposed to explain these differences, the role of physical exercise as a potential mediator remains understudied. Given that females typically engage in less physical exercise than males globally, this study aimed to investigate whether exercise intensity serves as a mediating factor in the observed sex/gender differences in visuospatial cognitive ability.