The impact of aberrant lipid metabolism on the immune microenvironment of gastric cancer: a mini review.

Gastric cancer (GC) remains one of the leading causes of cancer-related mortality worldwide, with limited responses to immune checkpoint blockade (ICB) therapies in most patients. Increasing evidence indicates that the tumor immune microenvironment (TIME) plays a crucial role in immunotherapy outcomes. Among various metabolic abnormalities in the TIME, dysregulated lipid metabolism has emerged as a critical determinant of immune cell fate, differentiation, and function.

Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition.

Immunotherapy with Immune Checkpoint Inhibitors (ICIs) has shown promising therapeutic effects in the treatment of lung cancer, the overall efficacy of PD-1/PD-L1 inhibitors is only 20%-30%. Thus, more effective combination therapies are needed. This study finds that cystine and cysteine levels in tumor tissues of lung cancer patients are significantly higher than adjacent non-tumor tissues.

Visible-light-driven oxidative coupling of arylhydrazines with sulfinates catalyzed by polyoxometalates for aryl sulfone synthesis.

This study reports a polyoxometalate-catalyzed visible-light-driven synthesis of aryl sulfones from arylhydrazines and sodium sulfinates using O as an oxidant. The method provides excellent stability, broad functional-group compatibility, and notably enhanced reactivity for electron-rich arylhydrazines, offering a sustainable alternative to traditional halogenated aromatic precursors.

Development of a portable multi-step microfluidic device for point-of-care nucleic acid diagnostics.

Background: The COVID-19 pandemic has significantly affected global health, economies, and societies, and highlighted the urgent need for rapid, sensitive, affordable, and portable diagnostic devices for respiratory diseases, especially in areas with limited resources. In recent years, there has been rapid development in integrated equipments using microfluidic chips and biochemical detection technologies. However, these devices are expensive and complex to operate, showing limited feasibility for in point of care tests (PoCTs).

Land-Use Planning Serves as a Critical Tool for Improving Resources and Environmental Carrying Capacity: A Review of Evaluation Methods and Application.

Research on resources and environmental carrying capacity (RECC) has been expanding since the early 20th century, and RECC has become a global concern and criterion for measuring regional sustainable development. Land-use planning (LUP) serves as a key tool of socioeconomic-ecological coordinated development and is deeply associated with RECC. In China, the newly established spatial planning system of 2019 identifies RECC assessment as the basis for spatial planning.

Circular RNA circ-AGFG1 contributes to esophageal squamous cell carcinoma progression and glutamine catabolism by targeting microRNA-497-5p/solute carrier family 1 member 5 axis.

Circular RNAs (circRNAs) have been shown to play important regulatory roles in human malignancies. However, the role of circRNA ArfGAP with FG repeats 1 (circ-AGFG1) in esophageal squamous cell carcinoma (ESCC) progression and its associated mechanism are still largely undefined. Cell proliferation was analyzed by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and 5-ethynyl-2'-deoxyuridine assay.

An energy metabolism-based eight-gene signature correlates with the clinical outcome of esophagus carcinoma.

Background: The essence of energy metabolism has spread to the field of esophageal cancer (ESC) cells. Herein, we tried to develop a prognostic prediction model for patients with ESC based on the expression profiles of energy metabolism associated genes.

Materials And Methods: The overall survival (OS) predictive gene signature was developed, internally and externally validated based on ESC datasets including The Cancer Genome Atlas (TCGA), GSE54993 and GSE19417 datasets.

Multistage-responsive clustered nanosystem to improve tumor accumulation and penetration for photothermal/enhanced radiation synergistic therapy.

Developing new strategies to overcome biological barriers and achieve efficient delivery of therapeutic nanoparticles (NPs) is the key to achieve positive therapeutic outcomes in nanomedicine. Herein, a multistage-responsive clustered nanosystem is designed to systematically resolve the multiple tumor biological barriers conflict between the enhanced permeability retention (EPR) effect and spatially uniform penetration of the nanoparticles. The nanosystem with desirable diameter (initial size of ~50 nm), which is favorable for long blood circulation and high propensity of extravasation through tumor vascular interstices, can accumulate effectively around the tumor tissue through the EPR effect.

miRNA-425-5p enhances lung cancer growth via the PTEN/PI3K/AKT signaling axis.

Background: miRNAs regulate a multitude of cellular processes and their aberrant regulation is linked to human cancer. However, the role of miR-425-5p in lung cancer (LCa) is still largely unclear. Here, we explored the role of miR-425-5p during LCa tumorigenesis.

Emergence of Maximal Symmetry.

An emergent global symmetry of the composite sector (called maximal symmetry) can soften the ultraviolet behavior of the Higgs potential and also significantly modify its structure. We explain the conditions for the emergence of maximal symmetry as well as its main consequences and present two simple implementations. In both cases the emergence of maximal symmetry is enforced by the structure of the gauge symmetries.

Measuring top-quark polarization in top-pair + missing-energy events.

The polarization of a top quark can be sensitive to new physics beyond the standard model. Since the charged lepton from top-quark decay is maximally correlated with the top-quark spin, it is common to measure the polarization from the distribution in the angle between the charged lepton and the top-quark directions. We propose a novel method based on the charged lepton energy fraction and illustrate the method with a detailed simulation of top-quark pairs produced in supersymmetric top squark pair production.

Top quark production asymmetries A(FB)t and A(FB)ℓ.

A large forward-backward asymmetry is seen in both the top quark rapidity distribution A(FB)(t) and in the rapidity distribution of charged leptons A(FB)(ℓ) from top quarks produced at the Tevatron. We study the kinematic and dynamic aspects of the relationship of the two observables arising from the spin correlation between the charged lepton and the top quark with different polarization states. We emphasize the value of both measurements, and we conclude that a new physics model which produces more right-handed than left-handed top quarks is favored by the present data.