A thermochromic tissue-mimicking phantom for catheter-based radiofrequency ablation of heterogenous lesions.

Background: In catheter-based radiofrequency ablation (RFA), energy is delivered to heterogeneous thin-walled tissues to induce therapeutic heating. Variations in electrical and mechanical properties of tissue contents have a great effect on outcomes.

Purpose: The objective of this study is to develop models that replicate tissue heterogeneity and visualize ablation zones for effective evaluation and optimization.

Photoacoustic-imaging nanomotors enhance tumor penetration and alleviate hypoxia for photodynamic therapy of breast cancer.

Breast cancer is the most prevalent malignancy worldwide, yet conventional therapies are invasive and prone to resistance, recurrence, and metastasis. Photodynamic therapy (PDT) is a promising noninvasive modality, but its efficacy is limited by tumor hypoxia and poor photosensitizer delivery. Here, we report a photoacoustic-imaging nanomotor, PPIC, which addresses these challenges through integrated functions of oxygen production, deep tissue penetration and photoacoustic imaging.

Research status of small molecule inhibitors, probes, and degraders of NSDs: a comprehensive review.

The nuclear receptor binding SET domain (NSD) family of histone methyltransferases, which comprised NSD1, NSD2, and NSD3. They play a pivotal role in catalyzing mono- and dimethylation of histone H3 at lysine 36 (H3K36me1/2), a modification critical for maintaining chromatin structure and transcriptional fidelity. Dysregulation of NSD enzymes, often through overexpression, mutation, or chromosomal translocation, has been implicated in a broad spectrum of malignancies and various diseases.

Harnessing the potential of phytochemicals to design anti-filarial molecules targeting the MurE enzyme of : a hierarchical virtual screening and molecular dynamics simulation study.

, a causative agent of lymphatic filariasis, relies on its endosymbiont for survival. MurE ligase, a key enzyme in peptidoglycan biosynthesis, serves as a promising drug target for anti-filarial therapy. In this study, we employed a hierarchical virtual screening pipeline to identify phytochemical inhibitors targeting the MurE enzyme of the endosymbiont of (MurE).

A directional self-priming continuous-driven compartmentalized microfluidic chip for multiplexed pathogen detection.

Rapid and efficient screening of foodborne pathogens is crucial for preventing bacterial spread and food poisoning. However, developing a multi-detection method that is easy to operate, offers good stability, and achieves high efficiency remains an enormous challenge. Existing multiplexed nucleic acid detection methods suffer from complex designs, leading to complicated operations, and non-robust sample introduction, causing primer/probe crosstalk and false-positive results.

Synthesis and Reactivity of a Crystalline Zinc-cAAC Radical.

Reaction of LZnI [L = BuC(N-DIPP), DIPP = 2,6-Pr-CH] with KC in the presence of cyclic (alkyl)(amino)carbene (cAAC) affords a stable radical complex [LZn(cAAC)] (3). Single-crystal structural analysis of 3 shows a short Zn─C bond and concomitant elongation of C─N bond within the cAAC ligand, indicating a significant π-backbonding from the metal to the cAAC ligand. EPR spectroscopy and DFT calculations reveal that the spin density is mainly localized on the carbenic carbon atom, with a small portion on the zinc center.

Single-Molecule Dual-Anchor Design Enables Extreme-Condition Lithium Metal Batteries Through Solvation Reconstruction and Cathode Polymerization.

Lithium metal batteries (LMBs) have emerged as the most promising candidate for next-generation high-energy-density energy storage systems. However, their practical implementation is hindered by the inability of conventional carbonate electrolytes to simultaneously stabilize the lithium metal anode and LiNiCoMnO (NCM811) cathode interfaces, particularly under extreme operating conditions. Herein, we present a transformative molecular design using 3,5-difluorophenylboronic acid neopentyl glycol ester (DNE), which uniquely integrates dual interfacial stabilization mechanisms in a single molecule.

Inverting the Rhodamine Paradigm: Closed-Form Fluorescence with 280 nm Stokes Shift Drives Plastic Circularity.

Rhodamine derivatives exhibiting inverted open-closed form fluorescence behavior redefines conventional photochemical paradigms while illuminating new structure-property relationships and fascinating application potentials. Herein, we report a donor-acceptor engineering strategy that activates closed form emission in rhodamines, achieving unprecedented Stokes shifts (>280 nm) while overcoming aggregation-caused quenching. The new class of rhodamines with inverted open-close form emission behavior are created through simultaneous substitution of N,N-diethyl groups with indole (donor) and conversion of spiro-lactam to benzene sulfonamide (acceptor).

A single-component white-light-emitting hybrid copper(I) halide constructed using a supramolecular cation for WLEDs.

Single-component white-light-emitters ensure color stability while reducing device complexity, and are ideal candidates for white light-emitting diodes (WLEDs). However, the realization of single-component white-light emission with high efficiency and stability is still a challenge. Herein, a supramolecular cation strategy was used to synthesize the organic-inorganic hybrid copper(I) halide [(AMTA)(18C6)]CuI (1), with AMTA = 1-adamantanamine and 18C6 = 18-crown-6.

A Novel Lipid Microbubble Targeting E-Selectin for Ultrasound Molecular Imaging of Acute Kidney Injury in Rats.

Acute kidney injury (AKI) is a common clinical syndrome characterized by abnormal renal function and structure. Microcirculatory perfusion disorders and inflammatory responses are critical pathophysiologies of AKI. Recently, ultrasound molecular imaging has been considered a valuable tool for preclinical and clinical diagnostics that can sensitively target histological structures of interest, particularly in evaluating renal microcirculation.

Protonation Enables Durable and Efficient Water Oxidation on Commercial TiO/IrO.

The oxygen evolution reaction (OER) performance of commercial TiO-supported IrO (IrO/TiO) suffers from the high electron transfer barriers at the IrO/TiO interface. Herein, we develop a cathodic polarization strategy to protonate TiO (p-TiO) in a commercial IrO/TiO catalyst. The high-density Ti-OH polaronic states on the surface of protonated TiO greatly contribute to the decrease in the electron transfer barriers at the IrO/TiO interface.

Thermal CO Adsorption and Activation on Copper Oxide Cluster Anions CuO ( = 3-9).

Understanding the active sites of copper (Cu)-based catalysts toward CO is a prerequisite for improving their rational design. The reactivity of copper oxide cluster anions CuO ( = 3-9) and bare copper cluster anions Cu toward CO has been investigated at room temperature by employing mass spectrometry combined with density functional theory (DFT) calculations. Only adsorption products are observed for the reaction of CuO with CO.

Hydroxylation of HPPD facilitates its PUB11-mediated ubiquitination and degradation in response to oxidative stress in Arabidopsis.

4-Hydroxyphenylpyruvate dioxygenase (HPPD) plays a critical role in plant photosynthesis, and is essential for enhancing tolerance to oxidative stress. However, the precise mechanisms through which plants regulate HPPD in response to oxidative stress remain largely unknown. Here, we report that the Arabidopsis thaliana HPPD (AtHPPD) undergoes an uncharacterized post-translational modification, namely phenylalanine hydroxylation, in response to excessive hydroxyl radicals (·OH), thereby mediating oxidative stress tolerance.

Interstitial Cobalt in Pt Shell of Pd@Pt Mesoporous Core-Shell Nanospheres with Strong d-d Orbital Hybridization for Enhanced Electrocatalytic Ammonia Oxidation.

Ammonia oxidation reaction (AOR) is critical for efficient ammonia utilization as a hydrogen carrier, yet state-of-the-art Pt-based catalysts suffer significant activity loss due to strong NO species (NO, NO) adsorption. Herein, Pd@Pt mesoporous core-shell nanospheres with interstitial Co in Pt shell (Pd@Pt-Co MCSN) are demonstrated as an excellent AOR electrocatalyst, which achieves a mass activity of 293.6 A g at 0.

Lewis Acid-Driven Weak Electrostatic Interaction of Polybenzimidazole-Based Membrane for Alkaline Zinc-Iron Redox Flow Batteries.

Alkaline zinc-iron flow batteries (AZIFBs) are one of the promising aqueous redox chemistries for large-scale energy storage due to their intrinsic safety and low cost. However, the energy efficiency (EE) and power density of batteries with low-cost polybenzimidazole (PBI) membranes are still limited due to the relatively poor ionic conductivity of PBI in an alkaline medium. Here, this study proposes a novel chemical approach for regulating the chemical environment of the PBI membrane.

Synthesis of Allylic Sulfones via Generation of Metal Π-Allyl Complexes in Metal-Catalyzed Sulfonylation.

Allyl sulfones are common motifs in many drugs and natural products, exhibiting a wide range of biological activities such as anticancer and antibacterial properties, etc. An overview is provided on the synthesis of allylic sulfones via generation of metal π-allyl complexes in metal-catalyzed sulfonylation over the period from 2020 to the present. The generation process of metal π-allyl complexes is introduced from the perspective of reaction mechanism and the reaction processes such as nucleophilic substitution, insertion of SO, and reductive elimination involving metal π-allyl complexes is discussed.

Inhibiting Graphite Co-Intercalation through Weak Solvating Ether Electrolytes for Stable Cycling in Potassium-Ion Batteries.

Ether-based electrolytes are widely acknowledged for their potential to form stable solid electrolyte interfaces (SEIs) for stable anode performance. However, conventional ether-based electrolytes have shown a tendency for cation-solvent co-intercalation phenomena on graphite electrodes, resulting in lower capacity and higher voltage platforms compared to those of neat cation insertion in ester-based electrolytes. In response, we propose the development of weakly solvating ether solvents to weaken the interaction between cations and solvents, thereby suppressing co-intercalation behavior.

Enantioselective Construction of Fused N-Heterocycles Sequential Annulation and Catalytic Transfer Hydrogenation.

Herein, we report the first regio- and enantioselective synthesis of tetrahydropyrido[2,3-]pyrazines using a chiral iridacycle catalyst. Pyridyl diamines and diketones undergo sequential annulation and asymmetric transfer hydrogenation of the generated pyrido[2,3-]pyrazine intermediates. This method provides diverse fused N-heterocycles in high yields (up to 95%) and enantioselectivity (98.

Spatial Distortion-Engineered Cationic Ru-Covalent Organic Framework Overcoming Aggregation-Caused Quenching for Synergistic Photodynamic/Photothermal Anti-Infective Therapy.

Decades of antibiotic misuse have spurred an antimicrobial resistance crisis, creating an urgent demand for alternative treatment options. Although phototherapy has therapeutic potential, the efficacy of the most advanced photosensitizers (PS) is essentially limited by aggregation-induced quenching, which significantly reduces their therapeutic effect. To address these challenges, we developed a cationic metallocovalent organic framework (CRuP-COF) via a solvent-mediated dual-reaction synthesis strategy.

Laboratory-Simulated UV-Triggered Transformation of Ambroxol in Aquatic Environments: Photoproduct Characterization and Ecological Risk to Model Aquatic Species.

Ambroxol (AMB), a common expectorant, enters aquatic environments via wastewater, yet its ecological risks remain unclear. Under UV exposure (15 mJ·cm, λ = 185-400 nm), AMB undergoes photolysis, among the photoproducts, 4-((2-amino-3-bromobenzyl)amino) cyclohexanol (P1) and 2-amino-3,5-dibromobenzaldehyde (DBA) are major species, comprising over 50% of the total photoproduct peak area at the photolytic plateau. Acute toxicity tests with AMB, P1, and DBA in four aquatic species at different trophic levels revealed: the highest sensitivity in (LC = 0.

Dynamic surface-based distributed practical predefined-time cooperative control for flight formation of a novel small tandem-rotor wheeled UAV.

A novel practical predefined-time sliding mode control strategy is proposed for the flight formation of a small tandem-rotor wheeled UAV (TRW-UAV) with unknown upper bound external disturbances and uncertainties in this paper. Firstly, a new predefined-time sliding mode surface is proposed to guide all errors of the position and velocity loops to converge to the origin in a predefined-time. Furthermore, a dynamic surface control approach is utilized to circumvent the higher-order differentiation when controlling the actuator loop.

High sensitivity C-reactive protein may be a significant predictor of non-alcoholic fatty liver disease in non-obese adults: A four-year retrospective study.

Background And Aims: Obesity-related non-alcoholic fatty liver disease (NAFLD) and serum high-sensitivity C-reactive protein (hs-CRP) are known to be associated to some extent. Nevertheless, this relationship remains unclear in non-obese individuals.

Methods And Results: A prospective cohort study was conducted using data from the health check ups of employees at Zhenhai Refining and Chemical Hospital in Ningbo City.

Integrated transcriptome and metabolome analyses reveal effects of carboxylated single-walled carbon nanotubes on Suaeda salsa under saline-alkali stress.

Suaeda salsa(S.salsa) is a promising halophytic species for vegetation restoration in highly saline-alkali soils. Carboxylated single-walled carbon nanotubes (COOH-SWCNTs) have emerged as potential agents for modulating plant responses to abiotic stress.

Selenification/Cyclization Reactions of Nonactivated Allyl 1,7-Diene: Access to Seleno-Benzo[]oxepine Derivatives.

A convenient protocol for the synthesis of selenated benzoxepine derivatives via iron(III)-catalyzed 7-endo-trig cyclization has been first established via reaction of 1,7-diene containing nonactivated allyl and dialkyl diselenides under room temperature and air conditions. Research has shown that different dialkyl diselenides could react with a wide range of 1,7-diene to achieve seven-membered products in good to excellent yields. Furthermore, this synthesis was directed to obtain the desired target products, indicating that this approach has an excellent chemical selectivity.