Assessment of the Anti-Inflammatory Efficacy and Symptom Resolution Time of Kangfuxin Liquid Combined with Metronidazole in Recurrent Oral Ulcers.

Objective: To evaluate the clinical efficacy and inflammatory modulation potential of Kangfuxin Liquid (KFXY; a traditional Chinese medicine recovery solution) in combination with metronidazole (MTZ) for the treatment of recurrent oral ulcers (ROU).

Methods: A retrospective cohort study was conducted using clinical data from 117 ROU patients admitted between January 2021 and January 2023. Patients were categorized into two groups: a control group (n=58) treated with MTZ oral adhesive patches alone, and an observation group (n=59) receiving KFXY plus MTZ.

New perspectives on molecular mechanisms underlying exercise-induced benefits in Parkinson's disease.

Exercise offers neuroprotective benefits in Parkinson's disease (PD) by enhancing neurotrophic factors (e.g., BDNF, GDNF), improving mitochondrial function, reducing inflammation, and promoting autophagy.

Electrochemical Cyanomethylation/Halocyclization Reaction of -QMs: Synthesis of Spiro[cyclohexane-1,2'-indene]-2,5-dien-4-one Derivatives.

An efficient synthesis of spiro[cyclohexane-1,2'-indene]-2,5-dien-4-one derivatives has been accomplished by the reactions of -quinone methides with haloacetonitrile under electrochemical conditions. In this synthesis, tandem radical additions resulted in a spiro skeleton by establishing a five-numbered ring, which features advantages such as a wide range of substrates, simple operation, good group tolerance, and only ()-configuration product. This work achieved the cyanomethylation and halogenation of -quinone methides under electrochemical conditions to assemble multiple different functional groups.

A novel multi-functional PVA- alginate hydrogel with dynamic bond crosslinking for infected wound repair.

The development of multifunctional antibacterial hydrogel dressings with enhanced mechanical properties and biological activity is essential for advancing wound healing strategies. In this study, we report the design and synthesis of a novel multifunctional hydrogel (PVA-Alg/FP), developed by integrating Fe, protocatechualdehyde (PA), polyvinyl alcohol (PVA), and sodium alginate (Alg). The hydrogel was crosslinked via multiple dynamic bonds and hydrogen bonds, avoiding the use of toxic crosslinking agents and eliminating the need for additional modification or purification steps.

A fine-tuned large language model based molecular dynamics agent for code generation to obtain material thermodynamic parameters.

In the field of materials science, addressing the complex relationship between the material structure and properties has increasingly involved leveraging the text generation capabilities of AI-generated content (AIGC) models for tasks that include literature mining and data analysis. However, theoretical calculations and code development remain labor-intensive challenges. This paper proposes a novel approach based on text-to-code generation, utilizing large language models to automate the implementation of simulation programs in materials science.

A Label-Free Aptasensor for the Detection of Sulfaquinoxaline Using AuNPs and Aptamer in Water Environment.

Sulfaquinoxaline (SQX) is widely utilized in aquaculture and animal husbandry due to its broad antimicrobial spectrum and low cost. However, it is difficult to degrade, and there are relevant residues in the aquatic environment, which could be harmful to both the ecological environment and human health. As a new recognition molecule, the aptamer can be recognized with SQX with high affinity and specificity, and the aptamer is no longer adsorbed to AuNPs after binding to SQX, which weakens the catalytic effect of AuNPs.

Research hotspots and future trends in sepsis-associated acute kidney injury: a bibliometric and visualization analysis.

Objectives: Sepsis-associated acute kidney injury (SA-AKI) commonly occurs in critically ill patients and is closely associated with adverse outcomes. A comprehensive analysis of the current research landscape in SA-AKI can help uncover trends and key issues in this field. This study aims to provide a scientific basis for research directions and critical issues through bibliometric analysis.

A study on the academic innovation ability and influencing factors of public health graduate students based on nomograms: a cross-sectional survey from Shandong, China.

Background: In recent years, the impact of the COVID-19 pandemic and various public crises has highlighted the importance of cultivating high-quality public health talents, especially those with innovative capabilities. This study focuses on the academic innovation ability of public health postgraduate students, which can provide important theoretical support for the cultivation of more public health workers with high innovative capabilities.

Methods: From May to October 2022, a cluster sampling method was used to select 1,076 public health postgraduate students from five universities in Shandong Province.

Pathophysiological role of ion channels and transporters in hepatocellular carcinoma.

The incidence of hepatocellular carcinoma (HCC) has continued to increase annually worldwide, and HCC has become a common cause of cancer-related death. Despite great progress in understanding the molecular mechanisms underlying HCC development, the treatment of HCC remains a considerable challenge. Thus, the survival and prognosis of HCC patients remain extremely poor.

Anti-synthase syndrome associated with SARS-Cov-2 infection.

Background: Anti-synthetase syndrome (AS) is a rare autoimmune idiopathic inflammatory myopathy (IIM) with diverse manifestations, including arthritis, interstitial lung disease (ILD), Raynaud's phenomenon, unexplained persistent fever, and mechanic's hands.

Case Presentation: We present the case of a 72-year-old woman, previously healthy, who was admitted to our hospital for treatment of cough and rapid breathing. The patient had elevated white blood cells and C-reactive protein, and tested negative for severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2).

Differential cytotoxicity to human cells in vitro of tire wear particles emitted from typical road friction patterns: The dominant role of environmental persistent free radicals.

Tire wear particles (TWPs) have been recognized as one of the major sources of microplastics (MPs), however, effects of initial properties and photochemical behavior of TWPs on cytotoxicity to human cells in vitro have not been reported. Therefore, here, three TWPs generated from typical wear of tires and pavements (i.e.

Intracellular chloride channel 1 and tumor.

As the major intracellular anion, chloride plays an important role in maintaining intracellular and extracellular ion homeostasis, osmotic pressure, and cell volume. Intracellular chloride channel 1, which has the physiological role of forming membrane proteins in the lipid bilayer and playing ion channels, is a hot research topic in recent years. It has been found that CLIC1 does not only act as an ion channel but also participates in cell cycle regulation, apoptosis, and intracellular oxidation; thus, it participates in the proliferation, invasion, and migration of various tumor cells in various systems throughout the body.

Potassium channels as novel molecular targets in hepatocellular carcinoma (Review).

Hepatocellular carcinoma (HCC) poses a serious health burden worldwide. It is often not diagnosed until the patient is at an advanced stage of the disease, when treatment options are limited and the prognosis is poor. Therefore, novel treatment strategies are urgently required.

Realizing of ZSM-5 microspheres with enhanced catalytic properties prepared from iron ore tailings via solid-phase conversion method.

The comprehensive utilization of iron ore tailings (IOTs) not only resolved environmental problems but also brought huge economic benefits. In this study, the synthetic route presented herein provides a novel method for the synthesis of ZSM-5 microspheres from IOTs. The effects of Si/Al molar ratios and the pH of the precursor solution on the formation of zeolite was evaluated by various analytical methods.

Novel roles of karyopherin subunit alpha 2 in hepatocellular carcinoma.

Hepatocellular carcinoma is the most common type of liver cancer and associated with a high fatality rate. This disease poses a major threat to human health worldwide. A considerable number of genetic and epigenetic factors are involved in the development of hepatocellular carcinoma.

Reshaping the Diversity of Oxidized Polyquinane Sesquiterpenoids by Cytochrome P450s.

Polyquinane sesquiterpenoids (PQSTs) are complex compounds with two or three fused cabocyclopentane ring systems, and the biocatalysts for direct C-H bond oxidation on these scaffolds have rarely been discovered. In this study, we discovered two versatile fungal CYP450s capable of performing diverse oxidations on seven PQST scaffolds, resulting in the generation of 20 unique products. Our findings significantly expand the diversity of oxidized PQST scaffolds and provide important biocatalysts for the selective oxidation of inert carbons of terpenoids in future research.

Selection and truncation of aptamers as fluorescence sensing platforms for selective and sensitive detection of nitrofurazone.

Nitrofurazone (NFZ) is an antibiotic banned in many countries, as its residue seriously harms the human body. Herein, anti-NFZ aptamers were selected and identified based on the magnetic bead SELEX technique using a ssDNA library with a full length of 90 nucleotides (nt). Five full sequence candidate aptamers (NFZ8, NFZ24, NFZ28, NFZ34, and NFZ70) were obtained by secondary structure analysis.

Clinical significance and changes to the immune microenvironment of colorectal cancer patients with liver metastasis.

Background: Liver metastasis is common in colorectal cancer patients. Immunotherapy covers a wide range of tumor types and is safer than traditional radiotherapy and chemotherapy. However, its overall effective rate is only 20-40%.

APOBEC3B: Future direction of liver cancer research.

Liver cancer is one of the most common cancers in the world, and the rate of liver cancer is high due to the of its illness. The main risk factor for liver cancer is infection with the hepatitis B virus (HBV), but a considerable number of genetic and epigenetic factors are also directly or indirectly involved in the underlying pathogenesis of liver cancer. In particular, the apolipoprotein B mRNA editing enzyme, catalytic peptide-like protein (APOBEC) family (DNA or mRNA editor family), which has been the focus of virology research for more than a decade, has been found to play a significant role in the occurrence and development of various cancers, providing a new direction for the research of liver cancer.

High-Sensitive FAM Labeled Aptasensor Based on FeO/Au/g-CN for the Detection of Sulfamethazine in Food Matrix.

In this study, we developed a fluorescent aptasensor based on FeO/Au/g-CN and a FAM-labeled aptamer (FAM-SMZ1S) against sulfamethazine (SMZ) for the specific and sensitive detection of SMZ in food matrix. The FAM-SMZ1S was adsorbed by the FeO/Au/g-CN via π-π stacking and electrostatic adsorption, serving as a basis for the ultrasensitive detection of SMZ. Molecular dynamics was used to explain the reasons why SMZ1S and SMZ were combined.

Effects of tire wear particles with and without photoaging on anaerobic biofilm sulfide production in sewers and related mechanisms.

Tire wear particles (TWPs) are considered to be one of the major sources of microplastics (MPs) in sewers; however, little has been reported on the surface properties and photochemical behavior of TWPs, especially in terms of their environmental persistent radicals, leachate type, and response after photoaging. It is also unknown how TWPs influence the production of common pollutants (e.g.

A label-free dual-modal aptasensor for colorimetric and fluorescent detection of sulfadiazine.

Sulfadiazine (SDZ) residues in food products and the environment pose a serious threat to human health and ecological balance, thereby warranting the development of new methods for simple, rapid and accurate detection of these compounds. To this end, we developed a novel label-free dual-modal aptasensor for SDZ detection based on distance-dependent color change of gold nanoparticles (AuNPs) and fluorescence resonance energy transfer between AuNPs and rhodamine B (RhoB). In this aptasensor, the binding of the aptamer to SDZ causes unprotected AuNPs to aggregate in NaCl solution, which alters the color of the solution and restores the fluorescence of RhoB.