Supplementation of plant fermentation carbon sources significantly enhances the abundance of ammonia-oxidizing genes and increases nitrogen removal in a municipal wastewater treatment plant.

This paper deals with the effects of a cost-effective plant fermentation carbon source (PFCS) on nitrogen removal in a municipal wastewater treatment plant (WWTP). Carbon source and electron donor shortage remained one of the limiting factors for denitrification and nitrogen removal in the WWTPs of China. The PFCS was supplemented to increase the influent carbon/nitrogen (C/N) ratio from the original 9:1 to 82:1.

The impact of sulfonylureas on diverse ion channels: an alternative explanation for the antidiabetic actions.

The oral hypoglycemic drug sulfonylureas exhibit substantial therapeutic benefits for millions of patients with type 2 diabetes mellitus (T2DM), although with common adverse effects, such as hypoglycemia. It is generally believed that inhibition of K channels by sulfonylureas in pancreatic β-cells enables the insulin release to reduce glycemic levels, a primary mechanism underlying pharmacological effectiveness. Accumulated evidence reveals that multiple ion channels, such as Kv and TRP, are also expressed in β-cells in the pancreatic islets of Langerhans, and these channels, particularly Kv2.

Genome‑wide identification of the cotton FAR gene family reveals GhFAR3 as a positive regulator of Verticillium dahliae resistance.

Although fatty acyl-CoA reductase (FAR) proteins are known to play essential roles in plant growth and development, their involvement in biotic and abiotic stress responses remains insufficiently characterized. In this study, we performed a comprehensive genome-wide analysis of 31 FAR genes across four cotton species (Gossypium arboreum, G. raimondii, G.

Reaction dynamics for the NH3+ + H2 → NH4+ + H reaction on a full-dimensional accurate potential energy surface.

The NH3+ + H2 reaction is one of the crucial steps for understanding the chemical network of nitrogen in the interstellar medium. The dynamics and kinetics of this reaction are studied using the quasi-classical trajectory method and microcanonical optimized multidimensional tunneling corrected-canonical variational transition state theory on a newly developed potential energy surface (PES). The PES is fitted by the fundamental invariant-neural network approach, giving a total root mean square error of 0.

Tumor-infiltrating nerves: unraveling the role of cancer neuroscience in tumorigenesis, disease progression, and emerging therapies.

Cancer neuroscience has evolved as a novel discipline that elucidates the intricate relationships between the neurological system and neoplasms. Research indicates that the ablation of particular nerve types, including parasympathetic, sympathetic, or sensory nerves, can suppress tumour growth in a tissue-specific manner. Moreover, numerous tumours exhibit greater innervation density than their normal tissue equivalents, prompting essential enquiries on the processes of tumour innervation and its molecular contribution to disease progression.

Multipath subflow transmission scheduling optimization algorithm based on cost-performance balance.

This article proposes a cost-performance balance algorithm for multipath data transmission within an Software Defined Network (SDN)-5G-Multipath Transmission Control Protocol (MPTCP) network framework. A unified communication interface is designed to schedule transmission paths, optimizing data flow allocation dynamically. To achieve a balance between network throughput and transmission costs, traffic volume and associated expenses are mapped into physical and virtual buffer queues for real-time substream updates.

Establishment and evaluation of a novel rat model of the fourth ventricle hemorrhage.

Background: Hemorrhagic expansion into the fourth ventricle is an independent risk factor for poor outcomes in intraventricular hemorrhage (IVH) patients. However, to date, available animal models of IVH are limited to models of supratentorial ventricular hemorrhage, and there are no specific models of fourth ventricle hemorrhage. This limitation hinders comprehensive basic research and the understanding of the pathophysiological changes that occur following fourth ventricle hemorrhage.

Fucosterol exerts an anti-atherosclerotic action via NF-κB and p38/Erk MAPK signaling pathways.

Background: Fucosterol is a sterol isolated from brown algae and has various biological properties, such anti-inflammatory and antidiabetic effects. In this study, we investigated the anti-atherosclerosis effects of fucosterol and .

Methods: ApoE mice were fed a high fat diet for 12 weeks with or without fucosterol treatment.

Longitudinal study of peer bullying victimization and its psychological effects on adolescents.

Background: Peer bullying victimization (PBV) is a significant public health issue that adolescents often face, with approximately one-third having experienced PBV. Understanding its interrelationships with mental health problems is crucial for effective intervention. This study aims to examine the longitudinal relationships between internalizing problems (depression and anxiety), externalizing problems (aggression), and PBV among middle school students using cross-lagged panel network analysis.

Single-cell chromatin accessibility profiling reveals regulatory mechanisms and evolution in pig brains.

Background: Pig brains serve as a valuable biomedical model for studying brain-related diseases due to their significant structural similarities to the human brain. Furthermore, the long-term domestication and artificial selection of domestic pigs have profoundly shaped their brains, making them an interesting subject for research. However, a comprehensive understanding of the regulatory mechanisms governing pig brain function and their impact on various phenotypes remains elusive due to the high degree of cellular heterogeneity present in the brain.

Bronchoalveolar lavage cytokine profile and clinical features as risk predictors of plastic bronchitis in children with Mycoplasma pneumoniae pneumonia.

Background: Plastic bronchitis (PB), a condition in which mucus plugs block the bronchial tree, is a serious complication of Mycoplasma pneumoniae pneumonia (MPP). This study investigated whether clinical features and cytokine levels in bronchoalveolar lavage fluid (BALF) distinguish MPP from MPP complicated by PB and sought to identify risk factors for PB in children with MPP.

Methods: A total of 128 children 3-14 years of age with MPP who underwent bronchoscopy at Jingmen Central Hospital, China, between 1 April 2023 and 31 March 2024 were enrolled.

3D-printed polymeric biomaterials in bone tissue engineering.

Polymers are large molecules composed of repeating subunits called monomers, which can be de-rived from both natural sources and synthetic processes. Due to their exceptional physicochemical properties and functional characteristics, polymers have garnered significant attention in the bio-medical field, particularly in tissue engineering. 3D printing technology, a process that manufactures three-dimensional objects by sequentially adding material based on digital models, has been widely recognized for its integration with polymers in bone tissue engineering (BTE).

Structural Variations Associated with Adaptation and Coat Color in Qinghai-Tibetan Plateau Cattle.

Structural variations (SVs) play crucial roles in the evolutionary adaptation of domesticated animals to natural and human-controlled environments, but SVs have not been explored in Tibetan cattle, which recently migrated and rapidly adapted to the high altitudes of the Qinghai-Tibetan Plateau (QTP). In this study, a de novo chromosome-level genome assembly for Tibetan cattle is constructed. It is found that using a lineage-specific reference genome significantly increased variant detection accuracy and completeness.

Remaining useful life prediction method of centrifugal pump rolling bearings based on digital twins.

To address challenges in extracting health indicator (HI) curves and making accurate predictions with limited datasets in mechanical system prognostics, this study proposes a digital twin (DT)-driven framework for estimating remaining useful life (RUL). To minimize the deviation between simulated and measured data, we introduce a finite element model correction method using a stacked autoencoder-long short-term memory (SAE-LSTM) network. To reduce reliance on manual expertise and prior knowledge, the LSTM network is used to directly extract features from the frequency-domain vibration data and construct initial HI curves representing equipment performance degradation.

Transcriptomic analysis reveals molecular mechanism by which Chinese olive fruit prolongs lifespan of Caenorhabditis elegans.

Chinese olive (Canarium album L.) contains various phytochemical compositions, exhibiting multiple health-promoting bioactivities. In this study, we used Caenorhabditis elegans (C.

Mapping trait justice sensitivity in the Brain: Whole-brain resting-state functional connectivity as a predictor of other-oriented not self-oriented justice sensitivity.

Justice sensitivity (JS) reflects personal concern and commitment to the principle of justice, showing considerable heterogeneity among the general population. Despite a growing interest in the behavioral characteristics of JS over the past decades, the neurobiological substrates underlying trait JS are not well comprehended. We addressed this issue by employing a machine learning approach to decode the trait JS, encompassing its various orientations, from whole-brain resting-state functional connectivity.

Association of serum uric acid-to-high-density lipoprotein cholesterol ratio with obstructive sleep apnea: a cross-sectional study.

Background: Characterized by intermittent hypoxia (IH), sleep fragmentation, and enhanced sympathetic nervous system activity, obstructive sleep apnea (OSA) precipitates oxidative stress, systemic inflammation, and metabolic perturbations. These disturbances manifest as alterations in serum uric acid (SUA) and high-density lipoprotein cholesterol (HDL-C) levels. Recently, the ratio of SUA to HDL-C (UHR) has emerged as a potential biomarker reflecting both inflammatory and metabolic status.

A method based on clustering fast search for bearing performance degradation assessment.

To address the problem of relying on manual experience to determine the number of cluster centers, this paper introduces an approach for evaluating the performance degradation of rolling bearings using the clustering by fast search (CFS) algorithm. Few studies have explored the application of CFS for bearing performance degradation assessment (PDA). Unlike traditional cluster models, such as Fuzzy C-Means, Gustafson-Kessel, Gath-Geva, K-means, and K-medoids, CFS automatically selects the cluster centers according to local density and distance.

The uORF-HsfA1a-WOX11 module controls crown root development in rice.

OsWOX11 is a key essential determinant of crown root development in rice. However, either overexpression or downregulation of OsWOX11 results in pleiotropic developmental defects, including dwarfism and reduced yield. Therefore, it is necessary to ensure an optimal level of OsWOX11 expression for balancing the subterranean root system and aerial organ development.

The Expression Characteristics of the RBFOX1 Gene in Colorectal Cancer.

IntroductionCopy number variation is a significant characteristic of colorectal cancer progression. RBFOX1 (A2BP1) is the gene with the highest frequency of copy number loss in colorectal cancer, but current research related to it and colorectal cancer is relatively scarce.MethodsData from TCGA and other sources were used to analyze the copy number variation and mRNA expression levels of RBFOX1, as well as their correlation with clinical pathological data.

Progress in the study of the effects of selective serotonin reuptake inhibitors (SSRIs) on the reproductive system.

In recent years, the increasing number of infertility cases has led to a greater research focus on the reproductive toxicity of drugs due to the fact that some classes of pharmacotherapeutic agents have been found to exert deleterious effects on the reproductive system. Depressive disorders are a class of common mental illnesses that seriously damage human health. The variety of antidepressant drugs is large and the incidence of adverse effects is high.

Research Progress of Autonomic Nerve Regulation in the Treatment of Myocardial Infarction.

The autonomic nervous system imbalance caused by the overactivation of the sympathetic nerve and the weakened activity of the parasympathetic nerve is closely related to the occurrence and development of myocardial infarction.Autonomic nerve regulation is a new therapeutic approach aiming at inhibiting sympathetic activity and increasing parasympathetic activity.It encompasses magnetic nerve stimulation,optogenetic neuromodulation,and microinjection of botulinum toxin,which could promote the rebalance of the autonomic nervous system,thereby curbing the deterioration of the cardiac function and reducing the occurrence of ventricular arrhythmias after myocardial infarction.

A construction of heterogeneous transfer learning model based on associative fusion of image feature data.

Source images and predicted target images differ in image features. When heterogeneous transfer learning is applied some difficulties and further issues appear. For example, noise in image recognition appears and is required to be reduced.

Lattice Flow Diverter for the Treatment of Unruptured Intracranial Aneurysms: A Retrospective Study.

Purpose: Flow diverters (FDs) represent an innovative approach distinct from traditional intra-aneurysm embolization for endovascular treatment. Recently, various types of FDs have been developed and extensively applied in managing intracranial aneurysms. This study evaluates the safety and efficacy of a new FD (Lattice) for treating unruptured intracranial aneurysms.