A near-infrared light responsive nanoheterojunction for antibacterial and anti-inflammatory applications through programmed ROS regulation.

Reactive oxygen species (ROS) play a fundamental role in antibacterial therapeutic strategies. However, excessive ROS generation can disrupt redox homeostasis and induce a severe inflammatory response, causing immense stress on surrounding cells and tissues. Herein, an intelligent nanoheterojunction established with Prussian blue (PB) and manganese polyphthalocyanine (MnPPc), PB@MnPPc (PM), was established to achieve sequential antibacterial and anti-inflammatory functions via controllable ROS regulation.

A geophysical investigation of the fairy circles in Nebraska for geologic hydrogen exploration.

Fairy circles are subcircular surface depression features that are widely distributed all over the world and they are commonly considered as a potential indicator to the presence of subsurface geologic hydrogen. Understanding the relationship between fairy circles and geological structures could assist in understanding potential hydrogen migration pathways and accumulations. We have carried out an integrated geophysical investigation over a group of such circles in the central U.

Unraveling the Role of the Microbiota in Cancer Immunotherapy: A New Frontier.

Cancer immunotherapy has greatly changed the therapeutic landscape for metastatic malignancies. Nevertheless, due to immune-related adverse events, drug resistance, and other factors, cancer immunotherapy remains largely untapped. Recent research has shown that the microbiota is crucial in shaping immune function and that its modulation can influence antitumor immunity.

Fucosterol exerts an anti-atherosclerotic action via NF-κB and p38/Erk MAPK signaling pathways.

Background: Fucosterol is a sterol isolated from brown algae and has various biological properties, such anti-inflammatory and antidiabetic effects. In this study, we investigated the anti-atherosclerosis effects of fucosterol and .

Methods: ApoE mice were fed a high fat diet for 12 weeks with or without fucosterol treatment.

Risk Factors and Predictive Model for Stress Hyperglycemia After Cardiac Surgery in Non-Diabetic Patients.

Objective: To create and verify a model that predicts the risk of stress hyperglycemia (SHG) in patients without diabetes after cardiac surgery.

Design: Retrospective analysis.

Methods: This retrospective analysis analyzed patients without diabetes post cardiac surgery at our hospital between June 2020 and December 2023.

Combination therapy with alisertib enhances the anti-tumor immunity induced by a liver cancer vaccine.

Alisertib is a potent aurora A kinase inhibitor in clinical trials for cancer treatment, but its efficacy on cancer vaccines remains unclear. Here, we developed a DNA vaccine targeting glypican-3 (pGPC3) and evaluated its efficacy with alisertib in hepatocellular carcinoma (HCC) models. The combination therapy of pGPC3 vaccine and alisertib significantly inhibited subcutaneous tumor growth, enhanced the induction and maturation of CD11c and CD8CD11c dendritic cells (DCs), and expanded tumor-specific CD8 T cell responses.

Metabolomics Analysis of the Mechanism of Yuquan Capsules in the Treatment of T2DM Rats Using UPLC/MS.

Purpose: Yuquan capsule (YQC) is a well-known proprietary Chinese medicine used for the treatment of type 2 diabetes mellitus. The aim of this study was to investigate the potential mechanism and efficacy of YQC in the treatment of T2DM by means of metabolomics.

Methods: Thirty-two male SD rats were randomly divided into four groups of control, type 2 diabetic mellitus (T2DM), metformin (Met), and YQC.

Midline frontal erythema responding favorably to pulsed dye laser: a persistant salmon patch or midline port wine stain?

To characterize midfrontal erythema and evaluate the clinical efficacy of 595 nm pulsed dye laser treatment for this condition. A total of 85 patients presenting with vascular lesions in the midfrontal area were analyzed who received the pulsed dye laser treatment between 2018 and 2023. The efficacy and safety of the treatment was assessed.

CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis.

Background: CTCF is considered as the most essential transcription factor regulating chromatin architecture and gene expression. However, genome-wide impact of CTCF on erythropoiesis has not been extensively investigated.

Results: Using a state-of-the-art human erythroid progenitor cell model (HUDEP-2 and HEL cell lines), we systematically investigate the effects of acute CTCF loss by an auxin-inducible degron system on transcriptional programs, chromatin accessibility, CTCF genome occupancy, and genome architecture.

Exploration of antioxidant peptides from crocodile (Crocodylus siamensis) meat using modern information technology: Virtual-screening and antioxidant mechanisms.

To develop a safe, stable and easily absorbed new antioxidant peptide. The myofibrillar protein hydrolysates of Siamese crocodile meat were prepared and purified, their free radical scavenging and Fe chelating ability were determined. The results showed that isolated component 3 of neutral protease hydrolysate (N) had the highest antioxidant activity.

Systematic Review and Meta-Analysis of Risk Factors Associated with Postoperative Stress Hyperglycemia in Patients without Diabetes Following Cardiac Surgery.

Background: To systematically evaluate risk factors for stress-induced hyperglycemia in patients without diabetes after cardiac surgery.

Methods: Databases including CNKI, WanFang data, VIP, SinoMed, PubMed, Web of Science, Embase, and the Cochrane Library were searched using computer retrieval. The data were subjected to an in-depth meta-analysis using RevMan 5.

Transketolase attenuates the chemotherapy sensitivity of glioma cells by modulating R-loop formation.

Glioblastoma (GBM) is a highly lethal malignant brain tumor with poor survival rates, and chemoresistance poses a significant challenge to the treatment of patients with GBM. Here, we show that transketolase (TKT), a metabolic enzyme in the pentose phosphate pathway (PPP), attenuates the chemotherapy sensitivity of glioma cells in a manner independent of catalytic activity. Mechanistically, chemotherapeutic drugs can facilitate the translocation of TKT protein from the cytosol into the nucleus, where TKT physically interacts with XRN2 to regulate the resolution and removal of R-loops.

Successful Treatment of Freckles Using a 730-nm Picosecond Laser: A Prospective Study.

Objective: Freckles are common hyperpigmented diseases that commonly occur in Caucasians and Asians. Freckles often cause cosmetic and even psychosocial concerns. Various lasers with different wavelengths have been used to treat pigmented spots.

Efficacy of a 1064-nm Picosecond Laser for Treating Early-Stage Traumatic and Surgical Scars.

Background: The role of fractional picosecond-domain lasers in scar remodeling is being increasingly recognized. In this study, we aimed to evaluate the efficacy of a fractional 1064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) picosecond laser for treating early-stage traumatic and surgical scars in an Asian population.

Methods: Thirty-seven patients with 49 early-stage traumatic and surgical scar lesions were enrolled.

LncRNA CCAT2 Knockdown Alleviates Pressure Overload or Ang II-Induced Cardiac Hypertrophy Via Disruption of the Wnt/β-Catenin Signaling.

Background: Sustained pathological cardiac hypertrophy (CH) is an independent risk factor for increased incidence and mortality of cardiovascular events.

Objectives: This research was designed to unravel the role of long non-coding RNA (LncRNA) CCAT2 in CH progression.

Methods: Transverse aortic constriction (TAC) procedures were conducted to construct a pressure overload-induced in vivo CH model.

The RIP3 activator C8 regulates the autophagy flux mediated by p62 and promotes the immunogenic form of cell death in human gastric cancer cells.

There has been growing interest in investigating anti-tumor drugs that not only kill cancer cells but also stimulate the immune system, among them, necroptosis is a classical immunogenic form of cell death. In our study, we discovered that by targeting RIP3, Jaspine B derivative C8 induces necroptosis and initiates cell death, and this effect can be reversed by knockout of RIP3. Furthermore, RIP3 initiates autophagy and binds to p62 to inhibit autophagic flux.

Structure, Function and Engineering of the Nonribosomal Peptide Synthetase Condensation Domain.

The nonribosomal peptide synthetase (NRPS) is a highly precise molecular assembly machinery for synthesizing structurally diverse peptides, which have broad medicinal applications. Withinthe NRPS, the condensation (C) domain is a core catalytic domain responsible for the formation of amide bonds between individual monomer residues during peptide elongation. This review summarizes various aspects of the C domain, including its structural characteristics, catalytic mechanisms, substrate specificity, substrate gating function, and auxiliary functions.

Insights into the mechanisms of serplulimab: a distinctive anti-PD-1 monoclonal antibody, in combination with a TIGIT or LAG3 inhibitor in preclinical tumor immunotherapy studies.

With more than 20 anti-PD-1/PD-L1 antibodies currently marketed, anti-PD-1 therapy has become a cornerstone of tumor immunotherapy. These agents, however, exhibit notable disparities in their characteristics and clinical performance. For instance, in the field of small cell lung cancer (SCLC) where the majority of anti-PD-1 antibodies have yielded limited success, serplulimab produced impressive survival improvements and was approved for this indication by China's National Medical Products Administration.

Ultra-High-Performance Liquid Chromatography-High-Definition Mass Spectrometry-Based Metabolomics to Reveal the Potential Anti-Arthritic Effects of in Cultured Fibroblast-like Synoviocytes Derived from Rheumatoid Arthritis.

Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. The fruits of , which is a medicinal and edible resource, have been shown to have anti-inflammatory properties.

Methods: In this study, we investigated the effects of extracts (IVEs) on human RA fibroblasts-like synoviocytes (RA-FLS) by using a sensitive and selective ultra-high-performance liquid chromatography with high-definition mass spectrometry (UPLC-HDMS) method.

Frozen dough steamed products: Deterioration mechanism, processing technology, and improvement strategies.

Fresh dough products lead to instability in product quality, high production costs, and more production time, which seriously affects the industrial production of the food industry. The frozen dough technology mitigates the problems of short shelf-life and easy deterioration of quality during storage and transportation. It has shown a series of advantages in large-scale industrialization, high-quality standardization, and chain operation.

The role of circRNAs and miRNAs in drug resistance and targeted therapy responses in breast cancer.

MicroRNAs (miRNAs) are small non-coding RNAs comprising 19-24 nucleotides that indirectly control gene expression. In contrast to other non-coding RNAs (ncRNAs), circular RNAs (circRNAs) are defined by their covalently closed loops, forming covalent bonds between the 3' and 5' ends. circRNAs regulate gene expression by interacting with miRNAs at transcriptional or post-transcriptional levels.

Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases.

Nonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases (NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs and their analogs are biologically active and serve as therapeutic agents. The adenylation (A) domain is a key catalytic domain that primarily controls the sequence of a product during the assembling of NRPs and thus plays a predominant role in the structural diversity of NRPs.

Mechanism simulation of polar and nonpolar organic solvent vapor adsorption on a multiwall carbon nanotubes paper gas sensor.

We investigate the adsorption behavior of polar and nonpolar molecules on carbon nanotube interfaces through computational simulations. Gaussian 16 was utilized to calculate the total energy of each possible molecular structure and analyze the adsorption mechanisms in stacked and inline configurations. The study reveals that nonpolar molecules favor stacked adsorption on two graphene interfaces, while polar molecules prefer inline adsorption.