Application and prospects of polysaccharide-based hydrogels in the treatment of intervertebral disc degeneration.

Intervertebral disc degeneration (IVDD) is a primary contributor to chronic low back pain (LBP) and neurological dysfunction. It significantly impairs patients' quality of life. With an aging population and changing lifestyles, the incidence of IVDD has been rising steadily.

Predicting future tropical theileriosis risk in China using tick distribution and climate models.

Tropical theileriosis, caused by Theileria annulata, is a tick-borne protozoan disease with high morbidity and mortality rates. While climate change and expanding livestock trade may increase transmission risks, the spatial distribution dynamics of tropical theileriosis in China under future climate scenarios remain poorly understood. This study aimed to predict the future distribution dynamics of tropical theileriosis in China by integrating climate variables and tick vector distribution data.

Electrothermal Manipulation of Current-Induced Phase Transitions in Ferrimagnetic Mn_{3}Si_{2}Te_{6}.

Phase transitions driven by external parameters are fundamental to condensed matter physics, providing critical insights into symmetry breaking and emergent phenomena. Recently, ferrimagnetic Mn_{3}Si_{2}Te_{6} has attracted considerable attention for its magnetic-field-induced insulator-metal transitions and current-driven phase transitions, but the role of applied currents in the magnetic phase remains poorly understood. Here, we employ local magnetization probes and time-resolved transport measurements to investigate the current-induced phase transitions.

Optimally Aligned Nerve Scaffolds with Sustained Astaxanthin Release Improve the Inflammatory Microenvironment through Mitophagy Activation.

Effective repair of peripheral nerve injury (PNI) depends on the scaffold orientation and immunomodulatory capabilities of functionalized scaffolds, both of which substantially influence nerve regeneration. In this study, composite nerve scaffolds incorporating astaxanthin (AXT) and polycaprolactone (PCL) are developed to investigate the influence of scaffold orientation and blend concentration on cellular behavior, including adhesion, migration, and proliferation. In vitro analysis identifies 0.

Advanced development of conductive biomaterials for enhanced peripheral nerve regeneration: a review.

Peripheral nerve injury (PNI), as a major cause of disability worldwide, makes it difficult to achieve effective repair and regeneration. Including autologous nerve transplantation, traditional therapies are restricted by surgical intricacy, donor scarcity, and inconsistent recovery effects. As to nerve guidance conduits (NGCs), conductive materials have brought novel pathways for PNI repair.

Upconversion imaging through scattering media in noisy environments.

Imaging through strongly scattering media in noisy environments is full of challenges. To address this issue, we present an imager based on an upconversion single-photon detector. This upconversion detector shows superior noise tolerance due to sharp optical time gating, quantum mode selectivity, and parametric frequency upconversion.

Preparation of amino-functionalized yeast/yam starch composite adsorption gel and its mechanism for the adsorption of Congo red and copper ions.

Water resource pollution is a major global challenge that poses a serious threat to human health and the environment. In this study, glutaraldehyde was used to cross-link polyethyleneimine (PEI) with yeast and starch. The PEI-modified yeast was attached to the yam starch adsorption gel using the gel properties of starch to prepare a novel starch-based composite adsorbent material (NH(Gl)-YSA@SZ4).

Photosynthetic performance and carbon metabolism in the ear organs of oats under drought stress.

Sufficiently exploiting the potential of crop photosynthesis is one of the critical ways for improving cultivation production to face global climate change. In this study, oat plants were potted with three watering treatments. The glumes, lemmas, and flag leaves were sampled on days 0, 7, and 14 after the first floret blossomed under the control (denoted as CK-0, CK-7, and CK-14), drought stress (denoted as DS-7, and DS-14) and rewatering treatments (RW-14).

Real-World Treatment Patterns and Clinical Outcomes in Patients With Multiple Myeloma Previously Treated With Lenalidomide and an Anti-CD38 Monoclonal Antibody.

Background: This analysis explored real-world characteristics, treatment patterns and clinical outcomes in patients with relapsed or refractory multiple myeloma (RRMM) previously treated with lenalidomide and an anti-CD38 monoclonal antibody (mAb) and requiring subsequent treatment.

Materials And Methods: The PREAMBLE and Connect MM prospective registries of patients with multiple myeloma (MM), and the US nationwide Flatiron Health electronic health record-derived de-identified database were analysed. MM-specific treatment patterns (prior/index therapies) and outcomes (progression-free survival [PFS]/overall survival [OS]) were assessed.

Identification of mitophagy-related gene signatures for predicting delayed graft function and renal allograft loss post-kidney transplantation.

Background: Ischemia-reperfusion injury (IRI) is an unavoidable consequence post-kidney transplantation, which inevitably leads to kidney damage. Numerous studies have demonstrated that mitophagy is implicated in human cancers. However, the function of mitophagy in kidney transplantation remains poorly understood.

EZH2 Activates HTLV-1 bZIP Factor-Mediated TGF-β Signaling in Adult T-Cell Leukemia.

Adult T-cell leukemia (ATL) is an aggressive malignancy caused by human T-cell leukemia virus type 1 (HTLV-1) infection. Enhancer of zeste homolog 2 (EZH2) has been implicated in the development and progression of multiple cancers, including virus-induced malignancies. However, the potential function of EZH2 in HTLV-1-induced oncogenesis has not been clearly elucidated.

Embryonal rhabdomyosarcoma of prostate combined with prostatic abscess in an adult patient: a case report and literature review.

Background: Embryonal rhabdomyosarcoma (ERMS) of the prostate is a rare and aggressive malignant tumor in adults with a poor prognosis in general. The main presenting symptoms are dysuria and acute urinary retention. Prostate ERMS is easily misdiagnosed, which leads to delays in treatment.

Nerve guide conduits promote nerve regeneration under a combination of electrical stimulation and RSCs combined with stem cell differentiation.

Nerve guide conduits (NGCs) offer a promising alternative to traditional tools for regenerating peripheral nerves. The efficacy of nerve regeneration and functional recovery is heavily dependent on the electrical, chemical, and physical properties of NGCs. A bionic melt electrowriting (MEW) NGC loaded with placental derived mesenchymal stem cells (PDMSCs) has been developed.

Yam protein ameliorates cyclophosphamide-induced intestinal immunosuppression by regulating gut microbiota and its metabolites.

Yam is a dual-purpose crop used in both medicine and food that is commonly used as a dietary supplement in food processing. Since yam proteins are often lost during the production of yam starch, elucidating the functionally active value of yam proteins is an important guideline for fully utilizing yam in industrial production processes. This study aimed to explore the potential protective effect of yam protein (YP) on cyclophosphamide (CTX)-induced immunosuppression in mice.

Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases.

Nonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases (NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs and their analogs are biologically active and serve as therapeutic agents. The adenylation (A) domain is a key catalytic domain that primarily controls the sequence of a product during the assembling of NRPs and thus plays a predominant role in the structural diversity of NRPs.

The incidence of urinary incontinence in Chinese hypertensive women and the relationship between hypertension and urinary incontinence.

Objectives: To determine the incidence of UI (urinary incontinence) and its subtypes in hypertensive women and examine the association between hypertension and new-onset UI.

Study Design: We conducted a cohort study on women aged ≥20 years in six regions of China. This cohort study was carried out from 2014 to 2016 at baseline, with follow-up completed in 2018.

Zearalenone removal using inactivated yeast embedded in porous modified yam starch aerogels and its application in corn silk tea.

Zearalenone contaminates food and poses a threat to human health. It is vital to develop cost-effective and environmentally-friendly adsorbents for its removal. By screening Sporobolomyces pararoseus (SZ4) and modified yam starch (adsorption capacity (q) of 1.

YTHDF2 Regulates Advanced Glycation End Products-Induced Melanogenesis through Inhibiting A20 Expression in Human Dermal Fibroblasts.

Fibroblast A20 suppresses advanced glycation end products (AGEs)-induced melanogenesis by inhibiting NLRP3 inflammasome activation. AGEs repress A20 expression and significantly m6A-methylate A20 mRNA in fibroblasts. YTHDF2 is the most studied m6A reader protein and can accelerate degradation of m6A-modified mRNA.

Integrating EEG and Ensemble Learning for Accurate Grading and Quantification of Generalized Anxiety Disorder: A Novel Diagnostic Approach.

Current assessments for generalized anxiety disorder (GAD) are often subjective and do not rely on a standardized measure to evaluate the GAD across its severity levels. The lack of objective and multi-level quantitative diagnostic criteria poses as a significant challenge for individualized treatment strategies. To address this need, this study aims to establish a GAD grading and quantification diagnostic model by integrating an electroencephalogram (EEG) and ensemble learning.

Population structure of sp. (Gobiiformes, Gobiidae) reveals their invasion history to inland waters of China based on mitochondrial DNA control region.

sp. is a small temperate fish originally known to inhabit muddy bottoms of brackish waters in coastal areas of China. However, it began to invade multiple inland freshwaters and caused severe damage to Chinese aquatic ecosystems in recent years.

Depression heightened the association of the systemic immune-inflammation index with all-cause mortality among osteoarthritis patient.

Background: Systemic immune-inflammatory index (SII) has been recognized as a novel inflammatory indicator in numerous diseases. It remains unknown how SII affects all-cause mortality among patients with osteoarthritis (OA). In this prospective cohort study, we intended to examine the relationship of SII with all-cause mortality among OA populations and assess the interaction between depression and SII.

Exploring Abnormal Brain Functional Connectivity in Healthy Adults, Depressive Disorder, and Generalized Anxiety Disorder through EEG Signals: A Machine Learning Approach for Triple Classification.

Depressive disorder (DD) and generalized anxiety disorder (GAD), two prominent mental health conditions, are commonly diagnosed using subjective methods such as scales and interviews. Previous research indicated that machine learning (ML) can enhance our understanding of their underlying mechanisms. This study seeks to investigate the mechanisms of DD, GAD, and healthy controls (HC) while constructing a diagnostic framework for triple classifications.

Computer gaming alters resting-state brain networks, enhancing cognitive and fluid intelligence in players: evidence from brain imaging-derived phenotypes-wide Mendelian randomization.

The debate on whether computer gaming enhances players' cognitive function is an ongoing and contentious issue. Aiming to delve into the potential impacts of computer gaming on the players' cognitive function, we embarked on a brain imaging-derived phenotypes (IDPs)-wide Mendelian randomization (MR) study, utilizing publicly available data from a European population. Our findings indicate that computer gaming has a positive impact on fluid intelligence (odds ratio [OR] = 6.

Preparation and characterization of carvacrol/ε-polylysine loaded antimicrobial nanobilayer emulsion and its application in mango preservation.

Carvacrol is well-known natural antimicrobial compounds. However, its usage in fruit preservation is restricted owing to poor water solubility. Our study aims to address this limitation by combining carvacrol with whey protein isolate (WPI) to form nanoemulsion and enhancing antimicrobial properties and stability of nanoemulsion through ε-polylysine addition, thereby improving their application in fruit preservation.

Nerve Guide Conduits Integrated with Fisetin-Loaded Chitosan Hydrogels for Reducing Oxidative Stress, Inflammation, and Nerve Regeneration.

Peripheral nerve injuries (PNI) represent a prevalent and severe category of damage resulting from traumatic incidents. Predominantly, the deficiency in nerve regeneration can be ascribed to enduring inflammatory reactions, hence imposing substantial clinical implications for patients. Fisetin, a flavonoid derived from plants, is naturally present in an array of vegetables and fruits, including strawberries, apples, onions, and cucumbers.