Publications by authors named "Baowen Zhao"

Sufficiently exploiting the potential of crop photosynthesis is one of the critical ways for improving cultivation production to face global climate change. In this study, oat plants were potted with three watering treatments. The glumes, lemmas, and flag leaves were sampled on days 0, 7, and 14 after the first floret blossomed under the control (denoted as CK-0, CK-7, and CK-14), drought stress (denoted as DS-7, and DS-14) and rewatering treatments (RW-14).

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Dexterous locomotion, such as immediate direction change during fast movement or shape reconfiguration to perform diverse tasks, are essential animal survival strategies which have not been achieved in existing soft robots. Here, we present a kind of small-scale dexterous soft robot, consisting of an active dielectric elastomer artificial muscle and reconfigurable chiral-lattice foot, that enables immediate and reversible forward, backward and circular direction changes during fast movement under single voltage input. Our electric-driven soft robot with the structural design can be combined with smart materials to realize multimodal functions via shape reconfigurations under the external stimulus.

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Article Synopsis
  • Abnormal growth and transformation of lens epithelial cells (LECs) lead to vision loss from posterior capsular opacification (PCO) following cataract surgery.
  • Overexpression of insulin-like growth factor-1 (IGF-1) promotes LEC proliferation, migration, and epithelial-mesenchymal transition (EMT), while reducing IGF-1 inhibits these processes.
  • The microRNA miR-3666 was identified as a potential regulator of IGF-1, showing that it can suppress LEC malignant behaviors and offers new therapeutic strategies for PCO prevention.
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Article Synopsis
  • Thiel-Behnke corneal dystrophy (TBCD) is linked to mutations in a specific gene, causing various corneal issues which have been explored using advanced microscopy techniques.
  • A novel gene mutation was identified in a TBCD family, and TBCD mouse models were created using CRISPR technology to study these effects further.
  • Findings suggest that lysosomal dysfunction contributes to TBCD pathology, and enhancing lysosomal function may offer a potential treatment by restoring proper autophagy and reducing problematic protein accumulation.
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Background: Age-related cataract (ARC) is a serious visual impairment disease, and its pathogenesis is unclear. This article aims to investigate the role of ROCK1 in the apoptosis of lens epithelial cells (LECs) in age-related cataracts.

Methods: We collect anterior capsule samples from normal people, patients with age-related cataracts, young mice and naturally aging cataract mice.

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Macular corneal dystrophy (MCD) is ascribed to mutations in the carbohydrate sulfotransferase () gene affecting keratan sulfate (KS) hydrophilicity and causing non-sulfated KS to precipitate in keratocytes and the corneal stroma. We investigated roles for inflammatory responses in MCD pathogenesis by examining the lysosomal-autophagy pathway and activation of pyroptosis in MCD keratocytes. Normal and lesioned keratocytes were obtained from MCD patients undergoing corneal transplantation.

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