Multi-omics joint analysis reveals the mechanism of flower color and fragrance variation in .

Introduction: , a fragrant purple-red wild lily endemic to Northeast Asia, represents both ecological significance (as a key protected species) and horticultural value. While its white variant ( var. ) exhibits distinct flower color and fragrance traits, the molecular mechanisms underlying these variations remain poorly understood.

Optimization of triterpene extraction method and its hypoglycemic activity.

To optimize the continuous reflux extraction process of triterpenes from using an orthogonal test and to lay a foundation for its industrial application, an orthogonal experiment was carried out for optimization. The optimal conditions were obtained and verified. The continuous reflux extraction technology for triterpenes from was optimized.

Nano-selenium alleviates tetrabromobisphenol A induced PANoptosis in carp gill tissue by inhibiting TLR4/MyD88/NF-κB pathway.

Tetrabromobisphenol A (TBBPA) is a common environmental pollutant with a molar mass of 543.91 g/mol. Nano-selenium (Nano-Se) has strong antioxidant capacity.

Hsa_circ_0008085 acts as a miR-146a-5p sponge to suppress influenza a virus replication via modulating of TRAF6.

Influenza A virus (IAV) has attracted considerable attention in recent years due to its increase in incidence and threat to human health. Circular RNA (circRNA) is a non-coding RNA with a closed structural pattern, which often acts as a sponge for microRNAs (miRNAs) in the cell. A growing body of evidence supports several crucial roles for circRNAs in viral infection, including regulation of viral replication, evasion of the host immune response and disease pathogenesis.

Panaxynol from dietary sources modulates ferroptosis through ceRNA networks in synovium: a novel strategy for alleviating rheumatoid arthritis through functional food intervention.

Panaxynol (PAL), a bioactive polyacetylene abundant in dietary plants such as carrots and ginseng, has shown potential in mitigating immune-related diseases, including rheumatoid arthritis (RA). This study investigates the anti-RA effects of PAL through ferroptosis induction and anti-inflammatory mechanisms. experiments revealed that PAL significantly reduced the viability of collagen-induced arthritis fibroblast-like synoviocytes (CIA-FLS) by triggering ferroptosis, as evidenced by decreased glutathione (GSH) levels, increased lipid peroxidation (LPO) and iron accumulation, and downregulation of key ferroptosis regulators (SLC7A11, GPX4).

GWAS Procedures for Gene Mapping in Diverse Populations With Complex Structures.

With reduced genotyping costs, genome-wide association studies (GWAS) face more challenges in diverse populations with complex structures to map genes of interest. The complex structure demands sophisticated statistical models, and increased marker density and population size require efficient computing tools. Many statistical models and computing tools have been developed with varied properties in statistical power, computing efficiency, and user-friendly accessibility.

Research Advances and Perspectives on Early Flowering Traits in Cucumber.

Early flowering refers to the phenomenon in which the first flower appears in fewer days than normal, regardless of the sex of the flower. It is a significant feature impacting the early maturity and economic yield of cucumbers. The early flowering trait of cucumber is influenced by several factors.

Reproductive Success of over in Multi-Generational Rearing on Corn Borer Eggs.

In China, the Asian corn borer (ACB), (Guenee) (Lepidoptera: Pyralidae), is the most significant economic insect pest of corn, causing losses ranging from six to nine million tons annually by feeding on all parts of maize, including damaging ears and leaves and making tunnels in stems. In China, since the 1970s, the species have extensively mass-reared from factitious hosts to control ACB and support integrated pest management programs. The Matsumura and Pang and Chen are the most efficient biocontrol agents for controlling ACB among the available species.

Advances and Future Prospects of Pigment Deposition in Pigmented Rice.

Pigmented rice, particularly the black and red varieties, is popular due to its better nutritional value. Anthocyanins and proanthocyanidins are two major flavonoid subcategories with broad physiological functions and therapeutic significance. However, pigment deposition is a complex process, and the molecular mechanism involved remains unknown.

New Insights into Melatonin's Function on Thiacloprid-Induced Pyroptosis and Inflammatory Response in Head Kidney Lymphocytes of : Implicating Mitochondrial Metabolic Imbalance and mtROS/cGAS-STING/NF-κB Axis.

Thiacloprid (THI) is a synthetic insecticide, the misuse is targeted chiefly to control aphid pest species in orchards and vegetables. Melatonin (MET) is a hormone that plays crucial physiological roles in anti-inflammatory capacities of fish. We explored the function of MET (100 μM) to mitigate the toxicity induced by THI (20 μM) in lymphocytes.

Transcriptomic analysis revealed that short-day treatment of seedlings promotes flowering in maize (Zea mays L.).

Background: In this study, blockage of transition from vegetative to reproductive growth was observed in short-day maize (Zea mays L.) varieties under long-day conditions.

Methods: Two short-day varieties, namely, CML116 and CML493, were cultivated under long-day conditions at various time points of short-day treatments of seedlings.

weIMPUTE: a user-friendly web-based genotype imputation platform.

Background: Genotype imputation is a critical preprocessing step in genome-wide association studies (GWAS), enhancing statistical power for detecting associated single nucleotide polymorphisms (SNPs) by increasing marker size.

Results: In response to the needs of researchers seeking user-friendly graphical tools for imputation without requiring informatics or computer expertise, we have developed weIMPUTE, a web-based imputation graphical user interface (GUI). Unlike existing genotype imputation software, weIMPUTE supports multiple imputation software, including SHAPEIT, Eagle, Minimac4, Beagle, and IMPUTE2, while encompassing the entire workflow, from quality control to data format conversion.

Ginsenoside Rg6 Improves Cisplatin Resistance in Epithelial Ovarian Cancer Cells via Suppressing Fucosylation and Inducing Autophagy.

Platinum-based chemotherapy remains a mainstay of clinical practice in the standard treatment of epithelial ovarian cancer (EOC). Most patients who receive this treatment, however, develop relapse and drug resistance. Ginsenoside Rg6 (G-Rg6), one of the anticarcinogenic active components in the American ginseng berry, may hold promise in the adjuvant chemotherapy of EOC.

Enhancing Underwater Images of a Bionic Horseshoe Crab Robot Using an Artificial Lateral Inhibition Network.

This paper proposes an underwater image enhancement technology based on an artificial lateral inhibition network (ALIN) generated in the compound eye of a bionic horseshoe crab robot (BHCR). The concept of a horizontal suppression network is applied to underwater image processing with the aim of achieving low energy consumption, high efficiency processing, and adaptability to limited computing resources. The lateral inhibition network has the effect of "enhancing the center and suppressing the surroundings".

Genome-Wide Identification, Characterization, and Expression Analysis of Orphan Genes Within Coriander.

Orphan genes () are genes that have no significant sequence similarity with known genes from other species or lineages. Identifying and characterizing have become more feasible with the increasing availability of plant transcriptomes and genome sequences. play important roles in response to both biotic and abiotic stresses, contributing to biological functions and lineage-specific traits.

Metabolomics and Transcriptomics Reveal the Function of Trigonelline and Its Synthesis Gene BrNANMT in Clubroot Susceptibility of Brassica rapa.

Clubroot caused by Plasmodiophora brassicae, a soil-borne pathogen, threatens cruciferous plants, resulting in severe yield reductions. To identify genes and metabolites associated with clubroot resistance and susceptibility, we performed metabolome and transcriptome analyses of Brassica rapa inbred line CRBJN3-2 inoculated with resistant and susceptible P. brassicae strains.

The Gut Microbiota of the Greater Horseshoe Bat Confers Rapidly Corresponding Immune Cells in Mice.

Background: Emerging infectious diseases threaten human and animal health, with most pathogens originating from wildlife. Bats are natural hosts for many infectious agents. Previous studies have demonstrated that changes in some specific genes in bats may contribute to resistance to viral infections, but they have mostly overlooked the immune function of the bat gut microbiota.

Establishment and validation of a simple and accurate qPCR detection method for Haemophilus parasuis.

As an infectious disease that poses a significant threat to the rapidly growing pig breeding industry, the detection of Haemophilus parasuis (HPS) is often compromised by various interfering substances present in the test sample during quantitative real-time PCR (qPCR). The rapid detection of HPS is important for the isolation of infectious pigs and their treatment. We designed and optimized a rapid qPCR test to detect the INFB gene of HPS in clinical and environmental samples on pig farms.

Resveratrol derivative modified Ru(II) complexes: Synthesis, characterization, in vitro and in vivo anticancer study.

The diversification of ligands provides more opportunities to adjust the photophysical performance as well as the bio-function of Ru(II) complexes as novel photosensitizers. Herein, a kind of Ru(II) complexes carrying resveratrol derivative, amino-Res, as ligand was designed and synthesized. The representative complex (named Ru4) showed potent anticancer activity under the trigger of 520 nm-light.

Research Progress on Laser-Assisted Precision Machining Technology.

As a revolutionary advanced manufacturing technology, the core of laser-assisted machining technology lies in the innovation of traditional machining technology. It uses a laser to precisely modify the surface of the workpiece material through clever integration. This process can lead to significant changes in the microstructure, thermodynamic properties, and physical properties of the workpiece's cutting layer, greatly facilitating the removal of material by the cutting tool.

Genome-wide identification and expression analysis of soybean bHLH transcription factor and its molecular mechanism on grain protein synthesis.

Introduction: Soybean seeds have a protein content of about 40% and are widely used due to their unique nutritional value. Research has found that drought and nitrogen fertilizer environments are conducive to the formation and accumulation of grain protein. Nitrogen is an essential element for soybean growth and development, and is converted into grain protein through a series of pathways such as the soybean root nodule system.

Ureases in nature: Multifaceted roles and implications for plant and human health - A review.

Urease, a multifunctional enzyme that catalyzes the hydrolysis of urea into ammonia, plays a pivotal role in nitrogen metabolism across diverse organisms. While essential for survival, its unregulated activity is implicated in numerous pathologies, including peptic ulcers, nephropathy, and gastric cancer, as well as agricultural challenges such as soil ammonium depletion and reduced nitrogen-use efficiency. Beyond its canonical enzymatic function, urease engages in protein-protein interactions with bioactive counterparts like jaburetox, canatoxin, and soyuretox plant-derived proteins with insecticidal, antifungal, and membranolytic properties.

Co-exposure to ammonia and lipopolysaccharide-induced impaired energy metabolism via the miR-1599/HK2 axis and triggered autophagy, ER stress, and apoptosis in chicken cardiomyocytes.

Ammonia (NH) and lipopolysaccharide (LPS), common pollutants in poultry farming environments, pose significant health risks by disrupting cellular processes. Although previous studies have demonstrated the individual effect of NH or LPS on human and animal health, the mechanisms underlying their combined impact on chicken heart tissue remain poorly understood. In this study, we established a chicken cardiotoxicity model to investigate the effects of NH and/or LPS exposure on energy metabolism, autophagy, endoplasmic reticulum (ER) stress, and apoptosis in cardiomyocytes.

Peptides from Dalian Stichopus japonicus: Antioxidant Activity and Melanogenesis Inhibition In Vitro Cell Models and In Vivo Zebrafish Models Guided by Molecular Docking Screening.

This article aims to reveal the optimal peptide segment with antioxidant activity from Dalian Stichopus japonicus, investigate its anti-melanogenesis effect, and elucidate its mechanisms of action both in vitro and in vivo. The best antioxidant alcalase hydrolysates, identified by the previous screening of proteases, was isolated by ultrafiltration; it was found that the components with a molecular weight of ≤ 3 kDa exhibited the best activity. The chemical components were characterized using LC-MS/MS.