Nonmuscle-Mediated Effects of Botulinum Toxin A on Fat Graft Survival in Nude Mice: Timing-Dependent Graft Outcomes.

Background: Enhancing fat graft survival is a key goal in adipose regenerative medicine. Although botulinum toxin type A (BoNTA) has shown potential benefits, its effects beyond muscle paralysis remain incompletely understood.

Objectives: The authors of this study aim to investigate the nonmuscle-mediated effects of BoNTA on fat graft survival and quality.

Engineering vacancy-rich van der Waals heterostructures in high-conductivity carbon networks for ultrastable sodium storage.

Rational design and application of high performance anodes are crucial for advancing sodium-ion batteries (SIBs). In this work, the 3D Mo-ZIF-L is subjected to a directional cross-linking process, followed by g-CN incorporation to modify the self-assembled precursor, ultimately yielding a high-conductivity carbon material. Subsequently, bimetallic selenide (ZnSe/MoSe) is successfully loaded onto the carbon surface via chemical vapor deposition.

NK cell-based immunotherapy strategies for myeloid leukemia.

Myeloid leukemia (ML) is a clonal malignant disease with abnormal hematopoietic stem cells. With the emergence of novel immunotherapies, such as CAR-T, therapeutic outcomes in ML patients have improved, while significant challenges persist, including severe adverse events and disease recurrence. Natural killer cells (NK cells) are "natural killers" of the immune system that do not require antigen presentation and responsible for recognizing and destroying tumor cells.

Nanocomposite Indicator-Based High-Resolution Naked-Eye Hue Sensor for Catecholamine Detection.

Naked-eye sensing in monochromatic systems is inherently limited in accuracy due to the subjective interpretation of subtle color changes, particularly in catecholamine detection. To address this challenge, we developed a high-resolution multicolor visualization platform utilizing nanocomposite indicators to amplify chromatic signals via dual synergistic colorimetric pathways: (1) catecholamine-concentration-dependent chemisorption protects silver triangular nanoplates (Ag NPLs) from HO etching, producing structural color shifts; and (2) Ag competitively inhibits urease-mediated urea hydrolysis, inducing pH-modulated phenol red chromogenic transitions. The strategic integration of these orthogonal systems created a nanocomposite indicator that expanded the hue range 4.

Influence of anions on black carbon generation and formation mechanism of magnetic black carbon during coal combustion.

Coal used in thermal power plants frequently contains various anions, and to investigate whether these anions influence the formation of black carbon (BC) from incomplete coal combustion, we conducted simulated combustion experiments by adding iron salts containing common coal-derived anions to purified coal. Comparative analysis of combustion products revealed that acidic anions, particularly sulfate ions, released from iron salts during combustion tend to form acidic gases that corrode BC surfaces, thereby generating more porous and morphologically complex BC structures while simultaneously suppressing BC yield. In contrast, basic anions such as hydroxide ions exhibited a modest promoting effect on BC production.

Ultrafast J-resolved magnetic resonance spectroscopic imaging for high-resolution metabolic brain imaging.

Magnetic resonance spectroscopic imaging has potential for non-invasive metabolic imaging of the human brain. Here we report a method that overcomes several long-standing technical barriers associated with clinical magnetic resonance spectroscopic imaging, including long data acquisition times, limited spatial coverage and poor spatial resolution. Our method achieves ultrafast data acquisition using an efficient approach to encode spatial, spectral and J-coupling information of multiple molecules.

Associations between Aβ deposition and neurometabolic alterations in Alzheimer's disease: Insights from hybrid 3D MRSI-PET imaging.

Introduction: Understanding the neurometabolic changes associated with amyloid-β (Aβ) deposition is important for early Alzheimer's disease (AD) diagnosis, but their spatial relationships remained unexplored due to technical limitations.

Methods: We investigated the relationship between Aβ deposition and neuronal and glial metabolites using high-resolution 3D magnetic resonance spectroscopic imaging (MRSI) (8-min scan, 2 × 3 × 3 mm resolution) and Aβ-positron emission tomography (Aβ-PET) imaging. N-acetylaspartate, myo-inositol, and creatine maps were obtained from 174 participants: 39 controls, 65 mild cognitive impairment (MCI), and 70 AD patients.

Phase Correction of MR Spectroscopic Imaging Data Using Model-Based Signal Estimation and Extrapolation.

Objective: To develop an effective method for phase correction of magnetic resonance spectroscopic imaging (MRSI) data.

Methods: In many MRSI applications, it is desirable to generate absorption-mode spectra, which requires correction of phase errors in the measured MRSI data. Conventional phase correction methods are sensitive to measurement noise and baseline distortion, often resulting in distorted absorption-mode spectra from MRSI data with low-SNR and long acquisition dead time.

Detecting and suppressing dolphin clicks in whistle signals using adaptive matched filtering and interpolation algorithm.

This paper describes a method for removing click disturbances from dolphin whistle signals. The algorithm is based on click end point detection, disturbance removal, and missing whistle segment interpolation, and enables both click suppression and whistle recovery from within mixed signals. Considering the impact of dolphin whistles on click detection, a Gabor filter is used to preprocess the spectrogram of the mixed signals.

High-Resolution Brain Metabolic Imaging at Ultrahigh Field Using Extended Spatiospectral Encoding and Subspace Modeling.

Objective: To develop a high-resolution magnetic resonance (MR) metabolic imaging method for mapping human brain metabolite distributions at ultrahigh field (7T).

Methods: In data acquisition, a free-induction-decay (FID) based MR spectroscopic imaging (MRSI) sequence was implemented. To achieve high spatial resolution, the sequence used fast echo-planar spectroscopic imaging (EPSI) trajectories with echo-spacings larger than the Nyquist sampling interval.

Topographic differences in EEG microstates: distinguishing juvenile myoclonic epilepsy from frontal lobe epilepsy.

Unlabelled: This study aims to develop an exploratory classification model for Juvenile Myoclonic Epilepsy (JME) based on electroencephalogram (EEG) microstate features to assist clinical diagnosis and reduce misdiagnosis rates. A total of 123 participants were included in this study, consisting of 74 patients diagnosed with JME and 49 patients with Frontal Lobe Epilepsy (FLE). Resting-state EEG data were retrospectively collected from all participants.

Divergent effects of straw and biochar single additions on soil water-heat-salt transport and corn productivity in arid salinized irrigation area.

Straw return and straw-derived biochar are promising practices for improving soil physicochemical properties and crop production. However, the integrated effects of a single application on soil moisture, heat, salinity transport, and their regulation mechanism on crop water use efficiency (WUE) in salt-affected soils are still understood deeply. Four amendments were used: control without any additives (CK), direct return of 10 t ha straw (BJ), and biochar treatments of 15 t ha (B15), and 30 t ha (B30).

Supercapacitor Performance of Activated Carbon from Oliver Wood Optimized by the Activation Method.

Amid the growing demand for sustainable energy storage, biomass-derived porous carbons have emerged as eco-friendly alternatives to conventional electrode materials. This study shows that activated carbon prepared by one-step activation exhibits an enhanced specific surface area and pore volume. The optimum parameter for ameliorating the structural and electrochemical properties is 60 min of microwave heating.

A diagnosis and prediction algorithm for juvenile myoclonic epilepsy based on clinical and quantitative EEG features.

Objective: To develop an objective ensemble machine learning model combining clinical features and quantitative EEG metrics (phase locking value [PLV] and multiscale sample entropy [MSE]) to support accurate diagnosis of juvenile myoclonic epilepsy (JME).

Methods: A total of 75 JME patients, 51 frontal lobe epilepsy (FLE) patients, and 30 normal controls were included. Eight clinical features, along with 684 PLV and 152 MSE features derived from EEG data, were extracted.

A general method to improve imprinting efficiency in surface protein imprinting by enhanced pre-assembly.

Surface protein-imprinted nanoparticles may replace the expensive and unstable antibodies in biomedical applications but still suffers from a low imprinting efficiency. A main reason may be the insufficient pre-assembly between monomers and template protein in surface imprinting using the conventional surface graft polymerization method. Increasing monomer concentrations enhances pre-assembly, but leads to agglomeration of the particles.

Morphlight theory inspired by raptors: musculoskeletal modeling and muscle control in Falco peregrinus wing flapping.

Falco peregrinus can achieve highly maneuverable flight through their morphing wing structure, which has significant research value. However, there has been limited research on the F. peregrinus wing musculoskeletal system.

The Role of Endothelial Cell Glycolysis in Schwann Cells and Peripheral Nerve Injury Repair: A Novel and Important Research Area.

Endothelial cell glycolysis plays a novel and significant role in Schwann cells and peripheral nerve injury repair, which represents an emerging and important area of research. Glycolysis in endothelial cells is a conserved and tightly regulated biological process that provides essential energy (ATP) and intermediates by ultimately converting glucose into lactate. This metabolic pathway is crucial for maintaining the normal function of endothelial cells.

Magnetite Nanoparticles with High Affinity Toward Target Protein for Efficient and Facile Bio-Separation.

Magnetite nanoparticles (FeO NPs) with molecular recognition capabilities offer significant potential for biomedical applications, yet existing surface protein imprinting methods often suffer from low efficiency. Herein, a surface enzyme-mediated polymerization strategy is exploited for surface imprinting of bovine serum albumin (BSA) onto FeO NPs. This method, compatible with all vinyl monomers and operable under mild conditions, enables imprinting at high monomer concentrations while preventing nanoparticle agglomeration.

High-Resolution Stretchable Soft Liquid Metal Circuits Based on Cu-Ga Alloying and Femtosecond Laser Ablation.

Flexible electronic circuits are critical in biomedical devices, human-machine interfaces, and wearable sensing systems, which further require flexible conductive materials with high conductivity, stretchability, and electrical stability. Liquid metal (LM) has attracted much attention due to its unique metallic conductivity and room-temperature fluidic properties. However, LM's high surface tension properties increase the difficulty of patterning processing.

Two-Dimensional Covalent Organic Frameworks in Organic Electronics.

Two-dimensional covalent organic frameworks (2DCOFs) are a unique class of crystalline porous materials interconnected by covalent bonds, which have attracted significant attention in recent years due to their chemical and structural diversity, as well as their applications in adsorption, separation, catalysis, and drug delivery. However, research on the electrical properties of 2DCOFs remains limited, despite their potential in organic electronics. Early studies recognized the poor electrical conductivity of 2DCOFs as a significant obstacle to their application in this field.

Multiple Information Prompt Learning for Cloth-Changing Person Re-Identification.

Cloth-changing person re-identification is a subject closer to the real world, which focuses on solving the problem of person re-identification after pedestrians change clothes. The primary challenge in this field is to overcome the complex interplay between intra-class and inter-class variations and to identify features that remain unaffected by changes in appearance. Sufficient data collection for model training would significantly aid in addressing this problem.

Iridium(III) complex functionalized ZIF-8 as a novel POD-like nanozyme for visual assay of triazine pesticides.

Due to the unique advantages of mimicking natural enzymes, nanozymes have received ever-growing interest in a wide range of fields including analytical chemistry in the past two decades. Exploring novel kinds of nanozymes with efficient active sites has always been one of the most important and hot topics in nanozyme-related research so far, especially in portable monitors. Herein, zeolitic imidazolate framework-8 (ZIF-8) incorporated with an organometallic iridium(III) complex as a new active site denoted as Irppy-ZIF-8 obtained a one-pot coordination reaction between the iridium solvent complex and 2-methylimidazole is reported as an efficient peroxidase (POD)-like nanozyme.

Comparison of the Outcomes of Endoscopic Posterolateral Interbody Fusion and Lateral Interbody Fusion in the Treatment of Lumbar Degenerative Disease: A Systematic Review and Network Meta-Analysis.

Objective: Although endoscopic technologies have been increasingly applied in lumbar fusion surgery in recent years, the advantages and disadvantages of endoscopic posterolateral fusion compared with lateral fusion remain unclear. Six different single-level lumbar interbody fusion procedures were compared to determine whether indirect decompression fusion could achieve levels of efficacy and safety comparable to those of minimally invasive direct decompression fusion in the treatment of lumbar degenerative disease (LDD).

Method: A literature search was conducted in the PubMed, Embase, and Cochrane Library databases, and studies on the treatment of LDD published from 2004 to March 2024 were retrieved.

Dynamic proteomic and phosphoproteomic analysis reveals key pathways and targets in the early stages of high-altitude traumatic brain injury.

Traumatic brain injury (TBI), particularly at high altitudes (HA-TBI), is a leading cause of mortality and disability, yet clear diagnostic and treatment protocols are lacking. This study explores the early pathophysiological changes occurring within 24 h following HA-TBI, with a focus on differentially expressed proteins (DEPs) and phosphorylated proteins (DEPPs). Using a low-pressure hypoxic chamber to simulate high-altitude conditions combined with a controllable cortical impact (CCI) model, we established a rat model of HA-TBI.