In Situ Construction of Optical Resonators from MXene Inks for Highly Modifiable and Scalable Structural Colors.

Structural colors offer distinct advantages over traditional chemical colors (such as pigments and dyes), including high saturation, resistance to fading, and environmental friendliness. However, unlike traditional dyes or pigments that allow for Structural colors offer distinct advantages over traditional chemical colors (such as pigments and dyes), including high saturation, resistance to fading, and environmental friendliness. However, unlike traditional dyes or pigments that allow for arbitrary color adjustments during the coloring process, current structural color surfaces lack flexibility in control, as their colors are difficult to reprocess or adjust once formed.

Single-Cell Transcriptomic Profiling Reveals Diet-Dependent Dynamics of Glucosinolate Sulfatases Expression and Cellular Origin in the Midgut of Plutella xylostella.

The diamondback moth (Plutella xylostella), a globally destructive pest, has Brassicaceae as its long-term co-evolved host and can also utilize Fabaceae as an alternative field host. The primary differential factor between these plant families is glucosinolates (GLs). Conventional transcriptome data revealed high midgut expression of glucosinolate sulfatases (GSSs) in response to glucosinolates.

Isobavachalcone ameliorates TNBS-induced Crohn's disease-like colitis via GPR84-PI3K-AKT axis.

Ethnopharmacological Relevance: The traditional Chinese medicine Psoralea corylifolia L. (PCL) has been clinically used to treat diarrhea and gastrointestinal inflammatory disorders. G protein-coupled receptor 84 (GPR84) is emerging as a potential target for inflammatory bowel disease (IBD).

ALAD as a prognostic biomarker regulates metabolism and immune responses in renal cell carcinoma through multi-omics analysis.

Background: Renal cell carcinoma (RCC) is a common malignant tumor with metabolic reprogramming and immune evasion features. δ-Aminolevulinic acid dehydratase (ALAD), a key enzyme in heme biosynthesis, has been implicated in cancer progression and treatment outcomes, but its role in RCC remains unclear.

Methods: This study integrated multi-omics datasets from TCGA, CPTAC, and GEO to analyze ALAD's expression, prognostic value, and functional implications in RCC.

Utility and performance of cerebrospinal fluid cytology in discriminating central nervous system infections and brain tumors.

Background And Objective: Differentiating central nervous system infections (CNSIs) from brain tumors (BTs) is difficult due to overlapping features and the limited individual indicators, and cerebrospinal fluid (CSF) cytology remains underutilized. To improve differential diagnosis, we developed a model based on 9 early, cost-effective cerebrospinal fluid parameters, including CSF cytology.

Methods: Patients diagnosed with CNSIs or BTs at Xiangya Hospital of Central South University between October 1st, 2017 and March 31st, 2024 were enrolled and divided into the training set and the test set.

The Age-Associated Long Noncoding RNA lnc81 Regulates Ovarian Granulosa Cell Proliferation and Apoptosis Through TEAD2-CCN1/2 Pathway in Mice.

Ovarian granulosa cells (GCs) are pivotal for follicular homeostasis, and their dysregulated apoptosis drives age-related ovarian aging. The Hippo signaling pathway, modulated by long noncoding RNAs (lncRNAs), is implicated in regulating GCs proliferation and ovarian aging. TEAD2 (Transcriptional Enhanced Associate Domain 2), a key downstream transcription factor of the Hippo signaling pathway, plays a critical role in regulating cell proliferation, apoptosis, and embryonic stem cell self-renewal.

Improved cyclability of high-voltage LiCoO by the coating of medium-entropy nanomaterials.

Although improving the charging cutoff voltage is an effective strategy to increase its capacity, LiCoO ("LCO") undergoes rapid capacity decay due to severe structural and interface degradations at high voltages. Herein, we proposed a multifunctional surface modification by coating nano-sized entropy materials (Li-La-Ti-Zr-Co-O, Nano-MEO). Nano-MEO rivets were constructed on the surface of LCO, which stabilized the fragile surface.

The X-Age Project to construct a Chinese aging clock.

The global surge in the population of people 60 years and older, including that in China, challenges healthcare systems with rising age-related diseases. To address this demographic change, the Aging Biomarker Consortium (ABC) has launched the X-Age Project to develop a comprehensive aging evaluation system tailored to the Chinese population. Our goal is to identify robust biomarkers and construct composite aging clocks that capture biological age, defined as an individual's physiological and molecular state, across diverse Chinese cohorts.

Construction of chitosan/wurtzite multiple sites on mesoporous halloysite and selective removal of Al(III) from rare earth ions solution: Microcalorimetry investigation.

Herein, organic/inorganic multiple adsorption sites were constructed on halloysite to intensify the selective adsorption performance of the adsorbent for Al(III) in rare earth solutions. The adsorption heat behavior and thermodynamics of the composite for different ion systems were investigated using microcalorimetry. The results showed that chitosan formed a mesoporous membrane on the acid-treated calcined halloysite (HalH) substrate through a strong electron interaction between the nitrogen atom of the amino group and the oxygen atom of SiO structure on HalH.

Rational design of Pt-integrated SnNbO/BiMoO monolayer S-scheme heterojunction for efficient ethylene removal toward fresh produce preservation.

Effective removal of ethylene (CH) during fruit and vegetables storage and transport remains a critical challenge for post-harvest preservation. Although S-scheme heterojunctions can improve charge separation and redox capacity for ethylene degradation, their efficiency is still restricted by limited carrier transfer and sluggish oxygen activation. Here, we rationally designed a novel 2D/2D SnNbO/BiMoO monolayer S-scheme heterojunction integrated with Pt co-catalyst to address these limitations.

In-situ extrusion 3D printing with tea polyphenol crosslinking for Hyaluronic acid sodium salt -based composite hydrogel scaffolds.

High-performance hydrogel biomaterials hold considerable promise for advanced wound care. However, the suboptimal mechanical properties of conventional hydrogel materials limit their practical application. In this study, Hyaluronic acid sodium salt (HA), xanthan gum (XG), and N-acryloyl-glycinamide (NAGA) hydrogels with porous structures were successfully fabricated using in-situ extrusion 3D printing technology, and a functionalization strategy involving tea polyphenol (TP) immersion was proposed to enhance material properties through additional hydrogen bonding.

Synthesis of Quaternary Ammonium Derivatives of Eugenol and Their Antifungal Mechanism against Wood-Decaying Fungi.

To discover novel preservatives for treating wood-decaying fungi, 48 novel eugenol quaternary ammonium salt derivatives were designed and synthesized. Among them, compounds , , , , , , and showed remarkable antifungal activity against (), affording EC values ranging from 2.11-7.

Astrocyte-Neuron Metabolic Synergies in Neurological Homeostasis and Disease.

Metabolic synergy between astrocytes and neurons is key to maintaining normal brain function. As the main supporting cells in the brain, astrocytes work closely with neurons through intercellular metabolic synergy networks to jointly regulate energy metabolism, lipid metabolism, synaptic transmission, and cerebral blood flow. This important synergy is often disrupted in neurological diseases such as Alzheimer's disease, Parkinson's disease, and stroke.

Boosted photocatalytic water splitting over a direct Z-scheme CdTe/CN van der Waals heterojunction: a first-principles insight into photocatalytic activity.

The quest for sustainable and clean energy sources has led to significant research into photocatalytic water splitting, a process that converts solar energy into hydrogen fuel. This study demonstrates constructing a high-performance CdTe/CN van der Waals heterojunction for solar-driven water splitting hydrogen evolution. The proposed CdTe/CN heterojunction, investigated using first-principles calculations, integrates favorable structural stability and features a direct bandgap of 1.

Bile Acid-based Microcapsule-Like Cocrystals of Phytosterols with Enhanced Solubility, Bioavailability, and Bioactivity.

Phytosterols are a class of natural steroids found in various plants. Commercially available phytosterols (PS) are primarily extracted from the deodorized distillate of soybean oil and consist predominantly of β-sitosterol with smaller amounts of stigmasterol and campesterol. Numerous studies have consistently demonstrated the significant lipid-lowering activity of PS.

Functionalization of Defective Covalent Organic Frameworks for High-Performance Solid-State Electrolytes.

Covalent organic frameworks (COFs) exhibit outstanding structural tunability, clearly defined ion pathways, and remarkable thermal/chemical stabilities, rendering them highly promising candidates for applications in solid-state electrolytes. However, it remains a challenge to develop a versatile method to incorporate both ionic groups and electron-withdrawing units into a single framework for effectively improving the lithium-ion conductivity. Herein, a series of novel [3+3] defective COFs is successfully synthesized featuring active amine/aldehyde anchoring sites for subsequent post-modification, and regulates the ion conductivity through elaborately tuning the anionic/cationic groups and weak/strong electron-withdrawing units.

Glycosyl Radical-Based, 1,2-trans-Selective Synthesis of C-Aryl Glycosides from Glycals Enabled by Photoredox PCET/Nickel-Dual Catalysis.

We report a glycosyl radical-based, 1,2-trans-selective synthesis of C-aryl glycosides of 2-deoxy-2-amino-sugars from glycals via photoredox PCET/Ni dual catalysis. Mechanistic studies indicate that glycosyl radical formation involves the generation of an N-radical through a proton-coupled electron transfer (PCET) process, followed by its addition to the glycal. This protocol features: a) the use of an inexpensive organic photosensitizer and readily available glycals and aryl bromides; b) good functional group tolerance for both aryl bromides and glycal substrates; c) excellent diastereoselectivity, with exclusive formation of the 1,2-trans C-glycosides in all cases.

Molecular mechanisms of the Suting Pill in the treatment of asthma: A study based on network pharmacology and molecular docking.

Background: Asthma is a chronic respiratory disease characterized by complex etiology and marked heterogeneity. It is one of the most prevalent chronic airway conditions in children, with increasing prevalence in recent years. The Suting Pill (STP), a traditional Chinese medicine for childhood asthma, has an unclear mechanism.

Exploring research advances and future trends in drug resistance in multiple myeloma: A comprehensive bibliometric analysis.

Introduction: This bibliometric analysis aims to explore global trends, research hotspots, and future directions in multidrug resistance of multiple myeloma (MM), providing insights for overcoming resistance mechanisms and optimizing therapeutic strategies.

Methods: We analyzed 3300 publications indexed in the Web of Science Core Collection (2015-2024) using CiteSpace and VOSviewer. Multidimensional evaluations of countries/regions, institutions, authors, journals, and keywords were conducted, supplemented by visual network mapping to elucidate research dynamics and collaborative patterns.

Efficacy of Fu's subcutaneous needling in the treatment of neck-type cervical spondylosis: A systematic review and meta-analysis.

Background: As a minimally invasive technique, Fu's subcutaneous needling (FSN) has been widely adopted in Chinese clinical practice for managing neck-type cervical spondylosis (CS). However, current evidence regarding its therapeutic efficacy remains inconclusive due to methodological limitations in existing studies. This systematic review and meta-analysis therefore sought to quantitatively synthesize available randomized controlled trials to evaluate the clinical effectiveness and safety of FSN for this prevalent musculoskeletal disorder.

Effects of orange variety on the physiochemical properties of self-secretory extracellular vesicle and its application potential as nutrient-rich beverage.

Plant-derived extracellular vesicles have presented great potential in drug and/or nutrition delivery, but it is still unclear whether the variety affects the physicochemical properties of plant derived extracellular vesicles. In this work, the extracellular vesicles from various oranges were first characterized, including navel orange juice (NOJ), green orange juice (GOJ), bingtang orange juice (BTOJ) and blood orange juice (BOJ). The results exhibited obvious distinctions of extracellular vesicles among different oranges, such as vesicle concentration, surface potential, lipid composition, protein content and so on.

Optimization and application of pretreatment for the analysis of typical per- and polyfluoroalkyl substances (PFAAs) in drinking water: a systematic evaluation of filter membranes and SPE Sorbents.

The accurate detection of trace perfluoroalkyl acids (PFAAs) in drinking water remains challenging due to nonspecific adsorption losses during pretreatment. This study systematically evaluated the adsorption behaviors of 11 PFAAs across five filtration membranes and four solid-phase extraction (SPE) sorbents to establish an optimized analytical protocol. Results demonstrated that glass fiber (GL) filters minimized PFAAs retention (94.

Robinin decreases myocardial ischemia/reperfusion injury via Nrf2 anti-oxidative effects mediated by Akt/GSK3β/Fyn in hypercholesterolemic rats.

Robinin (RB) is an accepted antioxidant herbal product with known cardio-protective activity. To explore the anti-oxidative potential of RB in treating myocardial ischemia or reperfusion (MI/RI) damage in rats after inducing hypercholesterolemia (HC). HC was induced by administering cholesterol (2%) to rats for eight weeks.

Ultrasonic-assisted three-phase partitioning with deep eutectic solvents for extraction of Nostoc commune Vauch polysaccharides and their anti-ulcerative colitis activity.

This study explores the extraction of polysaccharides from Nostoc commune Vauch. using ultrasonic-assisted three-phase partitioning with deep eutectic solvents (UA-TPP-DES). Response surface methodology was used to determine the optimized UA-TPP-DES conditions as follows: a 1: 2 M ratio of lauric acid to terpineol, 30 min of ultrasonication at 60 °C with 100 W power, 20 % moisture content, 20 % w/w (NH)SO concentration, and a 2: 1 top-to-bottom phase volume ratio.

Inter-modality feature prediction through multimodal fusion for 3D shape defect detection.

3D shape defect detection plays an important role in autonomous industrial inspection. However, accurate detection of anomalies remains challenging due to the complexity of multimodal sensor data, especially when both color and structural information are required. In this work, we propose a lightweight inter-modality feature prediction framework that effectively utilizes multimodal fused features from the inputs of RGB, depth and point clouds for efficient 3D shape defect detection.