The fate, impacts and potential risks of photoaging process of the microplastics in the aqueous environment.

Microplastics are ubiquitous in various environments with a wide distribution. When exposed to the natural environment, microplastics undergo photoaging under ultraviolet irradiation, accompanied by a series of physicochemical property changes such as bond breakage and oxygen addition. It is of great significance to understand the physical and chemical properties of photoaged microplastics and their potential environmental risks, but information is limited and lacking in summary to date.

Lattice-QCD Computable Quark Correlation Functions at Three-Loop Order and Extraction of Splitting Functions.

We present the first complete next-to-next-to-next-to-leading-order calculation of the matching coefficients that link unpolarized flavor nonsinglet parton distribution functions with lattice QCD computable correlation functions. By using this high-order result, we notice a reduction in theoretical uncertainties compared to relying solely on previously known lower-order matching coefficients. Furthermore, based on this result we have extracted the three-loop unpolarized flavor nonsinglet splitting function, which is in agreement with the state-of-the-art result.

Mitophagy related gene signature for prognosis and therapeutic evaluation in KIRC.

This study conducted a comprehensive investigation of the prognostic significance and immunological features associated with mitophagy-related gene signatures in clear cell renal cell carcinoma (KIRC). Our primary aim was to establish an optimized predictive model for precise prognosis stratification and treatment response prediction in KIRC patients. Through LASSO Cox regression analysis, we systematically identified mitophagy-related genes (MRGs) and implemented them to develop a prognostic risk stratification model.

Programmed cell death regulates hematopoietic cell homeostasis under radiation conditions.

Background: It is well-known that hematopoietic cells are sensitive to irradiation exposure. Apoptosis, necroptosis, pyroptosis and ferroptosis might contribute to irradiation-induced hematopoietic injury. However, it is uncertain whether different hematopoietic cells apply specific cell death pathways under irradiation exposure.

GIGYF2: A Multifunctional Regulator at the Crossroads of Gene Expression, mRNA Surveillance, and Human Disease.

GIGYF2 (Grb10-interacting GYF protein 2) functions as a versatile adaptor protein that regulates gene expression at various levels. At the transcriptional level, GIGYF2 facilitates VCP/p97-mediated extraction of ubiquitylated Rpb1 from stalled RNA polymerase II complexes during DNA damage response. In mRNA surveillance, GIGYF2 participates in ribosome collision-induced quality control, nonsense-mediated decay, no-go decay, and non-stop decay pathways.

Ultrasound-activated piezoelectric biomaterials for cartilage regeneration.

Due to the low density of chondrocytes and limited ability to repair damaged extracellular matrix (ECM) in cartilage, many patients with congenital or acquired craniofacial trauma require filler graft materials to support facial structure, restore function, improve self-confidence, and regain socialization. Ultrasound has the capacity to stimulate piezoelectric materials, converting mechanical energy into electrical signals that can regulate the metabolism, proliferation, and differentiation of chondrocytes. This unique property has sparked growing interest in using piezoelectric biomaterials in regenerative medicine.

SVF Cell Sheets as a New Multicellular Material-Based Strategy for Promoting Angiogenesis and Regeneration in Diced Cartilage Grafts.

Autologous diced cartilage, while biocompatible and easy to shape, is limited in clinical application due to its high adsorption rate and challenges in establishing timely and effective neovascularization postsurgery. In this study, the authors produced SVF cell sheets from adipose-derived stromal vascular fraction (SVF) through enzymatic digestion, employing a temperature-sensitive culture system. Our in vivo and in vitro experiments validated that SVF cell sheets, when wrapped around granular cartilage, exhibited a notable promotion of cartilage regeneration and mitigated granular cartilage adsorption in a rabbit diced cartilage graft model.

Contrast-Enhanced CT-Based Radiomics Nomogram for Prediction of Pathologic T3a Upstaging in Clinical T1 RCC.

: To develop a nomogram for the preoperative prediction of pathologic T3a (pT3a) upstaging in patients with clinical T1(cT1) renal cell carcinoma (RCC). : A total of 169 cT1 patients with RCC with preoperative contrast-enhanced CT (CECT) and clinical data were enrolled in this study. Afterwards, the sample was split randomly into training and testing sets in a 7:3 ratio.

Orally Administrated Inulin-Modified Nanozymes for CT-Guided IBD Theranostics.

Background: Inflammatory bowel disease (IBD) is a chronic inflammatory bowel disease with no clinical cure. Excessive production of reactive oxygen species (ROS) at the inflammatory sites leads to the onset and progression of IBD. And the current non-invasive imaging methods are not ideal for the diagnosis and monitoring of IBD.

Survival analysis and risk factors of indirect pulp capping in children with severe early childhood caries: a retrospective study.

Background Indirect pulp capping (IDPC) is a preferred treatment for pulp preservation in primary teeth. However, the survival rate of IDPC in primary teeth and impact factors is still equivocal.Aims To evaluate the survival rate of IDPC in primary teeth with a deep carious lesion approximating the pulp but without irreversible pulpitis or periapical disease.

Hematopoietic stem cell microtransplantation: current situation and challenges.

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) stands as a cornerstone in the treatment of hematological malignancies, recognized for its remarkable efficacy. However, the persistent challenge of graft-versus-host disease (GVHD) continues to represent a significant barrier, often being the leading cause of nonrelapse mortality after allo-HSCT. To address this limitation, hematopoietic stem cell microtransplantation (MST) has emerged as a novel therapeutic strategy that synergistically combines chemotherapy, allo-HSCT, and cellular immunotherapy.

Genome-wide identification of the WOX gene family in Populus davidiana×P.bolleana and functional analysis of PdbWOX4 in salt resistance.

WOX transcription factors (TFs) are plant specific transcription regulatory factors that have a momentous role in maintaining plant growth and development and responding to abiotic stress. In this study, a total of 13 PdbWOX genes were identified. qRT-PCR analyses showed that 13 PdbWOX genes were responsive to salt stress.

YOLO-Dynamic: A Detection Algorithm for Spaceborne Dynamic Objects.

Ground-based detection of spaceborne dynamic objects, such as near-Earth asteroids and space debris, is essential for ensuring the safety of space operations. This paper presents YOLO-Dynamic, a novel detection algorithm aimed at addressing the limitations of existing models, particularly in complex environments and small-object detection. The proposed algorithm introduces two newly designed modules: the SC_Block_C2f and the LASF_Neck.

Nonlinear optics of graphitic carbon allotropes: from 0D to 3D.

The dimensionality of materials fundamentally influences their electronic and optical properties, presenting a complex interplay with nonlinear optical (NLO) characteristics that remains largely unexplored. In this review, we focus on the influence of dimensionality on the NLO properties of graphitic allotropes, ranging from 0D fullerenes, 1D carbon nanotubes, and 2D graphene, to 3D graphite, all of which share a consistent sp hybridized chemical bonding structure. We examine the distinct physical and NLO properties across these dimensions, underscoring the profound impact of dimensionality.

HIV-1 viral decay in blood and semen in antiretroviral-naïve adults initiating dolutegravir/lamivudine vs. bictegravir/emtricitabine/tenofovir alafenamide.

Background: Co-formulated dolutegravir and lamivudine (DTG/3TC) is recommended as the first-line antiretroviral therapy (ART); however, the data on the viral decay in seminal plasma (SP) and blood plasma (BP), as well as changes in inflammatory biomarkers in BP, remain limited among antiretroviral-naïve people with HIV (PWH) receiving DTG/3TC. A prospective observational cohort study was conducted to compare the impact of DTG/3TC vs. bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) on viral decay kinetics and changes in inflammatory biomarkers in antiretroviral-naïve PWH.

Multi-Section Magnetic Soft Robot with Multirobot Navigation System for Vasculature Intervention.

Magnetic soft robots have recently become a promising technology that has been applied to minimally invasive cardiovascular surgery. This paper presents the analytical modeling of a novel multi-section magnetic soft robot (MS-MSR) with multi-curvature bending, which is maneuvered by an associated collaborative multirobot navigation system (CMNS) with magnetic actuation and ultrasound guidance targeted for intravascular intervention. The kinematic and dynamic analysis of the MS-MSR's telescopic motion is performed using the optimized Cosserat rod model by considering the effect of an external heterogeneous magnetic field, which is generated by a mobile magnetic actuation manipulator to adapt to complex steering scenarios.

[Effectiveness of robot-assisted minimally invasive and open freehand transforaminal lumbar interbody fusion in treatment of single-level degenerative lumbar spondylolisthesis and the influence on adjacent segment degeneration].

Objective: To compare the effectiveness of robot-assisted minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and open freehand TLIF for the treatment of single-level degenerative lumbar spondylolisthesis (DSL) and analyse the influence on postoperative adjacent segmental degeneration (ASD).

Methods: The clinical data of 116 patients with L DLS who were admitted between November 2019 and October 2021 and met the selection criteria were retrospectively analyzed. According to the surgical methods, they were divided into the robotic group (45 cases, who underwent robot-assisted MIS-TLIF) and the open group (71 cases, who underwent open freehand TLIF).

Characterizing transcripts of HIV-1 different substrains using direct RNA sequencing.

Post-transcriptional processing and modification of viral RNA, including alternative splicing, polyadenylation, and methylation, play crucial roles in regulating viral gene expression, enhancing genomic stability, and increasing replication efficiency. These processes have significant implications for viral biology and antiviral therapies. In this study, using Oxford Nanopore Technology (ONT) direct RNA sequencing (DRS), we provided a comprehensive analysis of the transcriptome and epitranscriptome features of the HIV-1 B (NL4-3) subtype strain and, for the first time, characterized these features in the CRF01_AE (GX2005002) subtype strain.

Associations of human blood metabolome with optic neurodegenerative diseases: a bi-directionally systematic mendelian randomization study.

Background: Metabolic disruptions were observed in patients with optic neurodegenerative diseases (OND). However, evidence for the causal association between metabolites and OND is limited.

Methods: Two-sample Mendelian randomization (MR).

PdbCRF5 Overexpression Negatively Regulates Salt Tolerance by Downregulating PdbbZIP61 to Mediate Reactive Oxygen Species Scavenging and ABA Synthesis in Populus davidiana × P. bolleana.

Salt stress is the main factor limiting the large-scale cultivation of Shanxin poplar; therefore, improving its salt tolerance is crucial. In this study, we identified and characterized a CRF gene (PdbCRF5) in Shanxin poplar. Compared with the wild-type poplar, the Shanxin poplar overexpressing PdbCRF5 were more sensitive to salt stress.

Research Status and Trends in Periodontal Ligament Stem Cells: A Bibliometric Analysis over the Past Two Decades.

Objective: Currently, the summaries of research on periodontal ligament stem cells (PDLSCs) are mainly reviews, and the systematic evaluation of all relevant studies is lacking. The aim of our study was to reveal the research status and developmental trends of PDLSCs using bibliometric analyses.

Methods: Publications on PDLSC from 2004 to 2023 in the PubMed database were searched and then screened according to certain inclusion and exclusion criteria.

Inorganic-Enriched Solid Electrolyte Interphases: A Key to Enhance Sodium-Ion Battery Cycle Stability?

The characteristics of solid electrolyte interphase (SEI) at both the cathode and anode interfaces are crucial for the performance of sodium-ion batteries (SIBs). The research demonstrates the merits of a balanced organic component, specifically the organic sodium alkyl sulfonate (ROSONa) featured in this work, in conjunction with the inorganic sodium fluoride (NaF), to enhance the interfacial stability. Using a customized electrolyte, it has optimized the interphase, curbing excess NaF production, and created a thin and uniform NaF/ROSONa-rich SEI layer.

Targeting SHCBP1 Inhibits Tumor Progression by Restoring Ciliogenesis in Ductal Carcinoma.

Primary cilia detect and transmit environmental signals into cells. Primary cilia are absent in a subset of ductal carcinomas characterized by distinctive biological activities, and recovery of cilia with normal functionality has been shown to have therapeutic potential in some cancer types. Therefore, elucidation of the underlying mechanism and clinical significance of ciliary loss in ductal carcinomas could help develop effective treatment strategies.