Exploring research advances and future trends in drug resistance in multiple myeloma: A comprehensive bibliometric analysis.

Introduction: This bibliometric analysis aims to explore global trends, research hotspots, and future directions in multidrug resistance of multiple myeloma (MM), providing insights for overcoming resistance mechanisms and optimizing therapeutic strategies.

Methods: We analyzed 3300 publications indexed in the Web of Science Core Collection (2015-2024) using CiteSpace and VOSviewer. Multidimensional evaluations of countries/regions, institutions, authors, journals, and keywords were conducted, supplemented by visual network mapping to elucidate research dynamics and collaborative patterns.

Global trends in shoulder dislocation research: A bibliometric review with hotspot visualization.

Background: Shoulder dislocation (SD) is a hot topic in sports medicine and has received increasing attention in related research areas. Although many studies have been conducted, few bibliometric analyses have been performed in this area. This study aims to analyze the characteristics of sustainable development over the past 2 decades from the bibliometric perspective and to explore the current status and key issues in sustainable development.

Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders: Present trends and future directions.

Background: Bipolar disorder (BD) is a severe mental illness characterized by significant mood swings. Effective drug treatment modalities are crucial for managing BD.

Aim: To analyze the current status and future trends of global research on BD drug treatment over the last decade.

A Novel CD3/BCMA Bispecific T-cell Redirecting Antibody for the Treatment of Multiple Myeloma.

Multiple myeloma (MM) is a B-cell malignancy for which new treatments are urgently needed. Redirecting the activity of T cells by bispecific antibodies against tumor cells is a potent approach. The B-cell maturation antigen (BCMA) is a highly plasma cell-selective protein and therefore is an ideal therapeutic target for T-cell redirecting therapies.

A Novel Blockade CD47 Antibody With Therapeutic Potential for Cancer.

Macrophages as components of the innate immune system play a critical role in antitumor responses. Strategies for targeting CD47 are becoming a hot spot for cancer therapy. The expression of CD47 is exercised by macrophages to make a distinction between "self" or "nonself.

Bispecific CD3-HAC carried by E1A-engineered mesenchymal stromal cells against metastatic breast cancer by blocking PD-L1 and activating T cells.

Background: PD-1/PD-L1 blockade can confer durable benefits in the treatment of metastatic cancers, but the response rate remains modest and potential adverse effects occur sometimes. Concentrating immunotherapeutic agents at the site of disease was believed to break local immune tolerance and reduce systemic toxicity. E1A-engineered mesenchymal stromal cell (MSC.

Paeoniflorin inhibits macrophage-mediated lung cancer metastasis.

Alternatively activated macrophages are more frequently involved in tumor growth, angiogenesis, and immunosuppression. A previous study showed that paeoniflorin, the major active constituent of Paeonia lactiflora Pallas, can inhibit tumor growth and lung metastases of Lewis lung tumor-bearing mice. This study tried to investigate whether paeoniflorin inhibited lung cancer metastasis by inhibiting the alternative activation of macrophages (M2 macrophage).