Facile synthesis of CoFeO@SiO nanoparticles anchored on reduced graphene oxide for highly efficient electromagnetic wave absorption.

In this study, a ternary composite material composed of CoFeO@SiO nanospheres and reduced graphene oxide (RGO) was successfully synthesized through a facile route. The composites exhibited a layered "sandwich" structure, where CoFeO@SiO nanospheres were anchored onto the surface of RGO nanosheets. The microstructure and electromagnetic wave absorption properties of the synthesized CoFeO@SiO/RGO were systematically investigated.

Discovery of Novel c‑MET Inhibitors for Hepatocellular Carcinoma Using an Integrated Virtual Screening Approach.

Hepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality worldwide, with the efficacy of current targeted therapies limited by drug resistance and adverse effects. The receptor tyrosine kinase c-MET has been identified as a promising target for HCC therapy due to its involvement in tumor progression, metastasis, and poor prognosis. However, no c-MET inhibitors have been approved for HCC treatment.

The implementation of the "Three-Year Action Plan for Winning the Blue Sky Defense Battle" has significantly reduced surface ozone pollution and its impacts on crop yields in China.

China has experienced a substantial reduction in PM concentrations since the enforcement of the "Air Pollution Prevention and Control Action Plan (APPCAP)". However, surafce ozone (O) levels and the resulting threats to agriculture have intensified. To further mitigate PM pollution, the government promulgated the "Three-Year (2018-2020) Action Plan for Winning the Blue Sky Defense Battle" (the Blue Sky Defense Battle).

Microstructure Engineered Nanoporous Copper for Enhanced Catalytic Degradation of Organic Pollutants in Wastewater.

Advanced oxidation processes offer bright potential for eliminating organic pollutants from wastewater, where the development of efficient catalysts revolves around deep understanding of the microstructure-property-performance relationship. In this study, we explore how microstructural engineering influences the catalytic performance of nanoporous copper (NPC) in degrading organic contaminants. By systematically tailoring the NPC microstructure, we achieve tunable three-dimensional porous architectures with nanoscale pores and macroscopic grains.

A Novel Synthesis of Highly Efficient Antimicrobial Quaternary Ammonium Pyridine Resin and Its Application in Drinking Water Treatment.

Multifunctional water-treatment materials urgently need to be developed to avoid normal organic matter, inorganic anions, resistant bacteria, and hazardous disinfection by-products in conventional drinking water treatment strategies. While quaternary ammonium pyridine resins (QAPRs) possess porous adsorption structures and incorporate antibacterial groups, enabling simultaneous water disinfection and purification, their limited bactericidal efficacy hinders broader utilization. Therefore, a deeper understanding of the structure-dependent antimicrobial mechanism in QAPRs is crucial for improving their antibacterial performance.

Fusing Domain Knowledge with a Fine-Tuned Large Language Model for Enhanced Molecular Property Prediction.

Although large language models (LLMs) have flourished in various scientific applications, their applications in the specific task of molecular property prediction have not reached a satisfactory level, even for the specific chemistry LLMs. This work addresses a highly crucial and significant challenge existing in the field of drug discovery: accurately predicting the molecular properties by effectively leveraging LLMs enhanced with profound domain knowledge. We propose a Knowledge-Fused Large Language Model for dual-Modality (KFLM2) learning for molecular property prediction.

Soft label collaborative view consistency enhancement with application to incomplete multi-view clustering.

Incomplete multi-view clustering (IMVC) is an unsupervised technique for clustering multi-view data when some view information is absent. However, most existing IMVC methods usually suffer from several significant challenges: (1) Inaccurate imputation or padding of missing data degrades clustering performance; (2) The ability to extract view features may decrease due to low-quality views, especially those that are inaccurately imputed. To overcome these challenges, in this paper, we introduce a novel IMVC framework, called soft label collaborative view consistency enhancement (SLC_CE).

Access to 1-Aryl-pyrazolin-5-ones via Photocatalytic Chemoselective Tri/Difluoromethylation and Cyclization of -Methacryloyl Aldehyde Hydrazones.

A photocatalytic trifluoromethylation and 5 cyclization of ()-'-arylidene--phenylmethacrylohydrazides was developed for the construction of trifluoromethylated pyrazolin-5-one derivatives using easily available trifluoromethyl thianthrenium triflate (TT-CFOTf) as the trifluoromethyl source. This protocol exhibits a broad substrate scope and excellent chemoselectivity. The utility of the current strategy is further highlighted by its application in the late-stage modification of drug molecules.

Column-free purification of functional HIV-1 capsid protein and its application in assembly and inhibitor assays.

The HIV-1 capsid protein (CA) is essential for viral replication and serves as a validated antiviral drug target. Traditional purification of CA relies on multi-step chromatographic protocols, which are time-consuming and labor-intensive. In this study, we established a rapid, column-free purification strategy using a cleavable self-aggregating tag (cSAT) to produce functional wild-type CA protein from E.

Trends and Techniques in 3D Reconstruction and Rendering: A Survey with Emphasis on Gaussian Splatting.

Three-Dimensional Gaussian Splatting (3DGS), an important advancement in the field of computer graphics and 3D vision, has emerged to greatly accelerate the rendering process in novel views' synthesis. Due to its ability to directly realize the real-time estimation of 3D shapes without neural networks, 3DGS has received a lot of attention in the fields of robotics, urban mapping, autonomous navigation, and virtual reality/augmented reality. In view of the growing popularity of 3DGS, we conduct a systematic review of the relevant literature.

N,P-Coordinated Breaking Local Charge Symmetry of Fe Single Atoms for Highly Efficient Electrocatalytic Oxygen Reduction.

Efficient and durable electrocatalysts for the oxygen reduction reaction (ORR) are pivotal in energy conversion and storage systems, particularly in alkaline fuel cells and metal-air batteries. Atomically dispersed Fe-NC electrocatalysts are a promising alternative to platinum group metal (PGM) catalysts. However, their catalytic activity and stability must be significantly improved.

Optimization of high-intensity resistance exercise protocols for improving bone mineral density in the elderly without chronic diseases: a systematic review and network meta-analysis.

Objective: This study aims to explore the effects of high-intensity resistance exercise (HIRE) protocols on improving bone mineral density (BMD) in the elderly without chronic diseases by using a forest plot and network meta-analysis.

Methods: A systematic search was performed across seven databases including PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure, Wan Fang and VIP, to investigate the effects of HIRE on BMD in the elderly by December 9, 2024. The search strategy incorporated Boolean operators (AND, OR, NOT) to refine the selection of relevant studies.

Photocatalytic difluoroalkylation/cyclization of -cinnamyl--cyanobenzamides with difluoroalkyl bromides toward C2-difluoroalkylated pyrroloquinazolinones.

A photoinduced cascade difluoroalkylation/cyclization of -cinnamyl--cyanobenzamides with difluoromethyl bromides was developed. In this transformation, the construction of C2-difluoroalkylated pyrroloquinazolinones was achieved through consecutive intramolecular dual cyclization. It features mild reaction conditions, a broad substrate scope and viable late-stage modification of natural products and pharmaceutical molecules.

Ternary composite material based on copper-metal organic frameworks, Mxene and carbon nanotubes as a sensitive electrochemical platform for determination of dopamine in aquatic environments.

Dopamine (DA) is a crucial neurotransmitter, however, its excessive use can lead to its accumulation as a micropollutant in aquatic ecosystems, thereby presenting various health risks to humans. Consequently, the accurate determination of dopamine levels is of paramount importance and has attracted considerable attention within scientific and regulatory communities. In this work, a ternary composite material (Cu-MOF/MXene/CNTs, MMC) based on copper-metal organic framework (Cu-MOF), the MXene and carbon nanotubes (CNTs) was developed using the hydrothermal method for sensitive electrochemical detection of DA.

Oxalic acid induced synthesis of renewable Ce-MnFeO nanocatalysts with hybrid crystallinity for enhanced ozone decomposition.

Developing ozone-decomposition catalysts with economic and exceptional moisture resistance is a significant challenge, as ozone is the second-largest air pollutant. Herein, the renewable Ce-MFO catalysts rich in oxygen vacancies were synthesized by the oxalic acid complexation method. The optimal 3 %Ce-MFO nanocatalyst with hybrid crystallinity exhibited an excellent ozone conversion rate of 100 % for high concentration O (50 ppm) with a weight hourly space velocity (WHSV) of 400 L g·h in dry air and 96 % for 50 ppm O with a WHSV of 400 L g·h under a relative humidity (RH) of 60 %.

Design of S-O "highway" at Z-scheme heterojunction interface for efficient degradation treatment of lomefloxacin and actual pharmaceutical wastewater.

The charge transfer path and the resistance generated at the interface were crucial factors affecting the carrier separation efficiency in heterojunction photocatalysts. Herein, a novel Z-scheme BiSnO/MoS heterojunction with covalent S-O interface was successfully synthesized by calcination and hydrothermal methods. Experimental evidence demonstrated that the prepared BiSnO/MoS composite exhibited high photocatalytic efficiency for the degradation of lomefloxacin, and the antibacterial effects of lomefloxacin and its degradation products decreased during the process.

Applications and Prospects of Artificial Intelligence in Proteomics Via Mass Spectrometry: A Review.

Proteomics holds immense significance in fundamental and applied research in various fields, including life sciences, medicinal sciences, and pharmaceutical sciences. The rapid development of mass spectrometry (MS) technologies has facilitated MS-based proteomics research, which has emerged as one of the primary methods for determining the composition, structures, and functions of proteins. The necessity of processing these complex datasets has increased significantly owing to the growing volume and diversity of MS data pertaining to proteins.

Manipulating high Curie temperature of Sm/Ag doped ZnO monolayers by first-principles GGA+U study.

This work studies the electronic structure, and magnetic properties of Sm/Ag doped ZnO monolayer by first-principles GGA + U calculations. The results show Sm-doped ZnO monolayer exhibits stable room temperature ferromagnetism with a high magnetic moment of 5.91 μB per unit.

High-Performance NiMn-LDO Catalysts for Efficient CO Methanation.

In response to the issue of Ni-based catalysts, they exhibit easy sintering at high temperatures and low catalytic activity at low temperatures in the CO methanation reaction. In this study, NiMn-LDO composite catalysts were synthesized using hydrotalcite as a precursor to investigate the effects of hydrogen reduction pretreatment conditions and the Ni/Mn ratios on the catalytic performance for CO methanation. It was observed that the NiMn(3:1)-LDO catalyst exhibited exceptional performance, characterized by maintaining over 90% CO conversion and CH selectivity after prolonged testing at a low temperature of 230 °C.

High-Performance Selection of Small-Molecule Nucleic Acid Aptamers and Their Applications.

Traditional screening of aptamers for small-molecule targets is often inefficient, typically requiring more than 13 rounds of selection. To address this inefficiency, we optimized the Capture-SELEX process by refining key factors that impact selection efficacy. By extending the length of the capture sequence and reducing the self-dissociation rate to minimize background noise, we significantly enhanced the screening efficiency.

Chemical analysis of mulberry (Morus alba L.) leaves treated with jasmonates on nutrition composition and biological activity.

To sustainably obtain bioactive substances in functional foods, immune plant hormones can enhance the nutrient content in edible mulberry leaves. Different concentrations of methyl jasmonate and coronatine influenced the bioactive compounds of mulberry leaf powder. Metabolomics analysis identified differences that affected the differential metabolites and related pathways, while molecular docking revealed the key metabolites regulating antidiabetic activity.

Unraveling the Efficacy of AR Antagonists Bearing -(4-(Benzyloxy)phenyl)piperidine-1-sulfonamide Scaffold in Prostate Cancer Therapy by Targeting LBP Mutations.

Point mutations in the androgen receptor (AR) are significant drivers of resistance in prostate cancer (PCa), posing a great challenge to the development of effective treatment strategies. Building on our previous discovery of the suboptimal AR antagonist , we developed , which contains an -(4-(benzyloxy)phenyl)piperidine-1-sulfonamide scaffold through structural optimization and comprehensive screening against T878A-mutated AR. outperformed existing antiandrogens by fully antagonizing clinical AR mutations and effectively suppressing castration- and enzalutamide-resistant LNCaP cells proliferation .

Deciphering early molecular responses to benzotriazole ultraviolet stabilizers-induced toxicity using a dose-dependent yeast functional genomics approach.

Benzotriazole ultraviolet stabilizers (BUVSs), widely used as anti-photoaging additives in industrial products, are increasingly detected in diverse environmental matrices and organisms. However, their toxicological profiles and mechanistic differences among structural analogues remain poorly characterized. In this study, we employed a dose-dependent yeast functional genomics approach to systematically map the biological pathways perturbed by 11 environmentally prevalent BUVSs at environmentally relevant concentrations.

Comparing copper and tin-based medium-entropy alloy oxide for producing hydrogen linking to waste polyethylene terephthalate (PET) upcycling.

Electrocatalytic water splitting for hydrogen production presents a promising solution to the global energy crisis. The high-value recycling and utilization of waste polyethylene terephthalate (PET) presents an environmental-friendly solution to address the "white pollution" caused by plastics. How to link the two reactions? Significantly, in a PET hydrolysate solution, the hydrogen evolution reaction (HER) occurs at the cathode, while the ethylene glycol oxidative reaction (EGOR) occurs at the anode, producing hydrogen and formic acid (FA), respectively.

Exploring the role of the ferric source in the structural regulation of ZIF-8 derived nitrogen-doped porous carbon for enhanced photothermal CO cycloaddition.

ZIF-8 derived nitrogen-doped porous carbons were fabricated using an incorporation-pyrolysis process. Due to the atomically dispersed metal species, enhanced surface area, and improved photothermal conversion ability, Fc-NPC shows distinct catalytic activity for CO cycloaddition compared with other analogues.