Hierarchical Structures of Protein-Fiber-Infused Aminoglycan Hydrogels to Promote Myocardial Repair.

Myocardial infarction (MI) is followed by irreversible damage to the myocardium, which eventually evolves into ventricular remodeling and heart failure. An imbalanced inflammatory response after MI can exacerbate myocardial injury. Current strategies to modulate inflammation and thereby improve myocardial tissue repair are limited.

Exploring optimal serum selenium range for heart failure prevention: A U-shaped association and mediation by hepatic steatosis in US adults.

ObjectiveThe relationship between serum selenium levels and heart failure risk remains unclear. This study aimed to investigate the potential nonlinear association between serum selenium level and heart failure risk and explore whether hepatic steatosis and dyslipidemia mediate this relationship.MethodsData from 6969 adults in the National Health and Nutrition Examination Survey 2017-2020 cohort were analyzed.

Machine learning-driven method for in-situ high-frequency CH measurement in paddy fields based on water-soil-air factors: A case study of the Yangtze River Basin.

Accurate and high-frequency monitoring of methane (CH) from rice paddies is crucial for effective carbon emission control but remains challenging due to fluctuant emissions and complex field environments. This study proposed a new in-situ high-frequency CH4 measurement method based on machine learning and sensor-measurable water-soil-air environment factors. The results show that: (1) soil and paddy water serve as critical media influencing CH production and transportation, with paddy water depth (H), soil electrical conductivity (EC), and soil temperature (T) being significantly positively correlated with CH emission flux, while soil redox potential (Eh) had a negative effect (p < 0.

A disproportionality analysis of adverse events caused by pexidartinib from the FDA adverse event reporting system.

Tenosynovial giant cell tumor (TGCT) is a rare neoplasm closely associated with dysregulation of the colony-stimulating factor 1(CSF1)/CSF1R signaling pathway, faces high recurrence rates despite surgical intervention, prompting exploration of CSF1R inhibitors like pexidartinib. This retrospective pharmacovigilance study analyzed pexidartinib-associated adverse events (AEs) from FDA Adverse Event Reporting System (FAERS) data (Q4 2019-Q3 2024), employing disproportionality analyses (ROR, PRR, BCPNN, EBGM) and sensitivity assessments to evaluate 844 reports. Hepatic events (46.

Microwave-Enhanced Catalytic Performance of Benzene Oxidation on MOF-Derived Mn/Ce-Co Oxides.

Microwave-assisted processing has shown tremendous promise in accelerating chemical reactions and reducing energy consumption through targeted dielectric heating. This study develops MOF-derived Mn-Co and Ce-Co oxide catalysts for energy-efficient benzene oxidation via microwave catalysis. The MnCo spinel oxides (particularly MnCo11-400) exhibit superior microwave absorption and catalytic activity due to enhanced oxygen mobility and tailored dielectric properties.

Efficient activation of peracetic acid by Fe-doped g-CN for selective degradation of emerging contaminants: Unraveling the role of reactive complex.

Peracetic acid (PAA)-driven advanced oxidation processes (AOPs) are increasing favored for water treatment due to their environmentally benignity and ease of activation. However, the development of low-cost and high-performance activators is still a primary challenge. In this study, Fe-doped g-CN (Fe-N-C) was fabricated as an efficient peracetic acid (PAA) activator for sustainable degradation of emerging contaminants (ECs) like bisphenol A (BPA) with a removal efficiency of 97.

Anesthetic Management in Combined Off-Pump CABG and EC-IC Bypass for CAD and Moyamoya Disease.

Background: Surgical treatment of moyamoya disease combined with coronary heart disease presents unique anesthetic challenges.

Case Summary: A 56-year-old woman underwent combined off-pump coronary artery bypass grafting and extracranial-intracranial arterial bypass surgery. The challenges in this surgery included maintaining cerebral oxygenation (regional cerebral oxygen saturation: >75% of baseline), controlled heart rate (60-70 beats/min), lung-protective ventilation (partial arterial pressure of carbon dioxide: 40-45 mm Hg), and mean arterial pressure >70 mm Hg.

Smartphone-integrated colorimetric nanosensor for azodicarbonamide detection in flour using BSA/MnOâ‚‚ nanoprobes.

A smartphone-integrated colorimetric sensing platform based on bovine serum albumin (BSA)-templated manganese dioxide (BSA/MnO) nanoprobe was successfully constructed to achieve high sensitivity and high selectivity for the detection of azodicarbonamide (ADA) in flour. The BSA/MnOnanoprobe was synthesized by a simple one-pot reduction method of BSA using KMnO, without the need for complex post-processing, and had excellent water dispersibility. It undergoes redox reactions with glutathione (GSH) causing self-degradation.

Activated Protein C Suppresses Cardiomyocyte Senescence in Diabetic Cardiomyopathy via PAR1/PAR3-P85-CaMKIIδ Axis.

Diabetes exacerbates cardiomyocyte senescence, leading to an accelerated decline in cardiac function. The systemic levels of activated protein C (aPC) were reduced, which correlated with deterioration of cardiac diastolic function in diabetic cardiomyopathy (DbCM), while the underlying mechanisms remained unclear. We aim to identify the role of aPC in ameliorating cardiomyocyte senescence in DbCM.

Serum uric acid, renal status, cardiovascular-kidney-metabolic syndrome and drug therapy, a wide-angled Mendelian randomization analysis.

Background: Serum uric acid (SUA) and renal status are associated with the Cardiovascular-Kidney-Metabolic (CKM) syndrome. However, the causal association among them along with drug therapy need to be explored.

Methods: We employed univariable, multivariate, mediation and drug-target mendelian randomization.

NIR light-driven transformable liquid metal-based nanovaccines restrain postoperative colorectal cancer recurrence.

Cancer vaccines mount specific immune memory responses and hold great potential in suppressing postoperative colorectal cancer (CRC) recurrence. However, undesired lymph node trafficking and antigen cross-presentation hamper clinical translation of nanovaccines. Here, we propose a controllable transformable nanovaccine grounded on thermal fusion feature of liquid metal (LM) nanoparticles against postoperative CRC recurrence.

Molecular analysis of three DNA mismatch repair protein variants in Chinese families with suspected Lynch syndrome.

Purpose: This study aimed to examine pathogenic variations in three families clinically diagnosed with suspected Lynch syndrome (LS).

Methods: Three probands clinically diagnosed suspected LS were subjected to immunohistochemical analysis of DNA mismatch repair (MMR) protein. Whole-exome sequencing and Sanger sequencing were performed to screen pathogenic variations.

Stretchable, Adhesive, Anti-Freezing Hydrogel Electrolytes with Dual-Functional Water Regulation Enabled by Amide Group-Salt-Water Interactions for All-Climate Zinc-Ion Batteries.

Aqueous zinc-ion batteries (AZIBs) are promising candidates for next-generation energy storage due to their intrinsic safety and environmental compatibility. However, parasitic reactions induced by active water molecules in conventional aqueous electrolytes severely degrade electrochemical performance and cycling stability. Herein, a stretchable, adhesive, anti-freezing hydrogel electrolyte with dual-functional water regulation is synthesized via a one-pot radical polymerization strategy, where acetate (Ac) anions and hydrophilic amide (─CONH) groups on polyacrylamide (PAM) chains synergistically regulate water activity.

Association Between Digital Isolation and Sleep Disorders in Older Adults: Cross-Sectional and Longitudinal Study Using National Health and Aging Trends Study (NHATS) Data.

Background: As digital technology becomes increasingly embedded in daily life, digital isolation among older adults has become more pronounced. This isolation may restrict access to health information and social support, potentially leading to poorer sleep quality. However, most existing studies on digital isolation and sleep disorders were cross-sectional, lacking longitudinal evidence to establish causality.

Optical and electrochemical probes-assisted dual-mode nanosensor for ultrasensitive monitoring of serotonin in single cells.

5-Hydroxytryptamine (5-HT), a vital neurotransmitter, plays a critical role in the development of various neurodegenerative diseases. Thus, in situ tracking and monitoring of 5-HT levels in single living cells and their fluctuations under nonylphenol (NP)-induced stimulation are of great significance. Herein, we constructed a novel aptamer and methylene blue (MB)-assisted nanosensor (AM-NS) for in situ monitoring of 5-HT by combining electrochemical with fluorescence sensing.

Glutathione-programmed in situ catalyst self-assembly activates tumor-specific NO storm for gasodynamic therapy.

Nitric oxide (NO) demonstrates promising prospects in tumor therapy, nevertheless, critical challenges remain in precisely modulating its concentration-dependent duality, minimizing off-target toxicity, and overcoming technical barriers in clinical translation. Herein, a glutathione (GSH)-responsive metal-organic framework, CuSNP, is constructed to realize the tumor-specific and burst generation of NO by on-site synthesizing catalysts within tumors. Triggered by the elevated GSH in cancer cells which could confer cellular resistance to NO-induced oxidative stress, CuSNP first undergoes structural disassembly, resulting in the release of free ligand nitroprusside and cuprous ions.

Lung-Derived Small Extracellular Vesicles Containing miR-15a-5p/miR-96-5p Promote Myocardial Fibrosis in Hypertrophic Cardiomyopathy via Targeting SMAD7.

Small extracellular vesicles (sEVs) are membrane-bound nanoparticles released by cells for intercellular or inter-tissue communication and play key roles in multiple cardiovascular disorders. However, the mechanisms underlying sEV-mediated myocardial fibrosis in hypertrophic cardiomyopathy (HCM) are not well understood. In this study, it is discovered that the levels of miR-15a-5p and miR-96-5p in circulating sEVs (miR-15a-5p/96-5p) are elevated in HCM patients with myocardial fibrosis.

MFG-E8 Accelerates Abdominal Aortic Aneurysm Formation by Enhancing ERK MAPK/NOX4 Axis-Associated Oxidative Stress.

MFG-E8 promotes oxidative stress by upregulating NOX4 and activating the MAPK pathway, which increases ROS production and affects vascular smooth muscle cell (VSMC) apoptosis, thereby driving the progression of abdominal aortic aneurysm (AAA). Resveratrol can inhibit the expression and function of MFG-E8, reduce ROS generation, and lower the incidence and severity of AAA, making it a potential therapeutic agent for AAA.

Unveiling Lipid Droplet Dynamics in Parkinson's Disease via a Polarity-Responsive Alkenyl Indole-Based Fluorophore.

Lipid droplets (LDs) are dynamic organelles implicated in Parkinson's disease (PD) pathology, yet their polarity dynamics and therapeutic relevance remain poorly understood. Herein, we rationally designed a polarity-responsive alkenyl indole-based fluorophore, , through systematic molecular engineering to enable real-time tracking of LD polarity in PD models. By modulating intramolecular charge transfer (ICT) effects via electron-donating/withdrawing substitutions, exhibited exceptional polarity sensitivity, with a dramatic fluorescence enhancement in low-polarity environments and negligible viscosity interference.

A superstrong, decarbonizing structural material enabled by microbe-assisted cell wall engineering via a biomechanochemical process.

Lightweight and high-strength structural materials promise exceptional applications in advanced engineering fields. As a productive and sustainable material, wood exhibits exceptional potential to be converted into high-performance structural materials. Inspired by ancient buried wood-a naturally formed material after wood endures in microbial-rich and high-pressure environments for thousands of years-here, we demonstrate a biomechanochemical process to rapidly transform natural wood into artificial ancient buried wood (named Bio-Strong-Wood).

Zero-dimensional organic-inorganic hybrid antimony bromide with efficient broadband orange emission and nonlinear optical response.

The development of lead-free hybrid metal halides with multiple optical properties is essential for advancing perovskite-based optical materials, though it remains challenging. Herein, we synthesized a zero-dimensional (0D) hybrid antimony-based halide, [DMPZ]SbBr Br·3HO (DP-SbBr, DMPZ = ,'-Dimethylpiperazine), precise molecular-level design, which exhibits both efficient photoluminescence (PL) and nonlinear optical (NLO) properties. Notably, DP-SbBr crystallizes in the 222 chiral space group, despite lacking chiral units, with isolated [SbBr] octahedral units separated by organic molecules, forming a typical 0D hybrid structure.

Phosphorylation-assisted cell wall engineering enables ultra-strong, highly ion-conductive bio-membranes for high-power salinity gradient energy harvesting.

Nanofluidic membranes derived from cellulose-based biomaterials have garnered increasing attention for ion transport and regulation due to their modifiable nature, ordered structures, sustainability, and excellent compatibility. However, their practical applications in ionic circuits, energy conversion, and sensing have been limited by insufficient mechanical strength and suboptimal ion transport properties. In this study, we report ultra-strong, highly ion-conductive bio-membranes fabricated through phosphorylation-assisted cell wall engineering.

AIEgen-Based Photoactivatable Polymeric Prodrug Nanoplatform for Combined Photodynamic-Chemotherapy.

The combination of photodynamic therapy (PDT) and chemotherapy is an innovative cancer treatment strategy, but its clinical application faces challenges: (1) conventional photosensitizers exhibit fluorescence quenching and reduced ROS generation due to aggregation in aqueous environments, and (2) existing nanocarriers suffer from low drug loading efficiency, premature leakage, and systemic toxicity. To overcome these issues, we developed a photoactivatable codelivery system integrating a red-emissive AIEgen photosensitizer (BTPTT-NTPE, BC) with a ROS-responsive polymeric paclitaxel (PTX) prodrug. Harnessing the AIE effect, the AIEgen photosensitizer in its aggregated state within the codelivery system not only resolves the fluorescence quenching issue common to conventional photosensitizers but also demonstrates exceptional photostability and efficient ROS generation.

A Bioinspired Gradient Hydrogel Electrolyte Network with Optimized Interfacial Chemistry toward Robust Aqueous Zinc-Ion Batteries.

Hydrogel electrolytes are regarded as a promising option for high-performance aqueous zinc-ion batteries (ZIBs), but they frequently fail to balance the reaction kinetics and Zn deposition stability. Inspired by articular cartilage, here we develop a gradient-networked hydrogel electrolyte comprising poly(vinyl alcohol) (PVA), cellulose nanofiber (CNF), and graphene oxide (GO) for ZIBs. The low-network-density PVA/CNF (PC) hydrogel layer (cathode side) with extensive channels and a higher water content ensures the rapid transport of ions, while the interfacial hydrogel layer in contact with the Zn anode exhibits a high-density PVA/CNF/GO (PCG) network with enriched carboxyl and hydroxyl groups, which facilitates the desolvation of Zn, decreases the activity of water, and homogenizes the Zn flux.