Insights Into the Separate and Joint Effects of Cadmium and Cesium on the Risk of Circadian Syndrome and the Underlying Mechanism: An Integrated Epidemiological and Network Toxicological Study.

The uncharted effects of cadmium and cesium on circadian syndrome (CircS), an emerging circadian rhythm disorder drawing considerable attention, and underlying mechanisms warrant exigent elaboration. Data of 11141 subjects from National Health and Nutrition Examination Survey 2005-2018 were incorporated to investigate separate-, joint-/interaction-, and mixture-effects of urinary cadmium and cesium on prevalent CircS risk exploiting survey weight regression and quantile g-computation. The underlying mechanisms were probed by network toxicological analysis.

Initiation of tocilizumab within 24 hours in acute necrotizing encephalopathy is related to a good outcome: a systematic review.

Objective: To evaluate the clinical efficacy of tocilizumab, a interleukin-6 (IL-6) receptor blocker, for the treatment of acute necrotizing encephalopathy (ANE).

Methods: PubMed, Cochrane Library, Embase, and Web of Science were searched for systematic review based on PRISMA guidelines. ANE patients treated with and without tocilizumab were included.

Investigating the early-stage emissions of formaldehyde/VOCs from building materials and their influencing factors.

As urbanization accelerates, the issue of pollutant discharge from building materials has become the focus of public attention. Conducted in a ventilated environmental chamber, the experiments investigated the emission characteristics of VOCs from dry and wet building materials, focusing on the influencing factors, such as temperature, relative humidity (RH), ventilation, and seasonality. The impact of influencing factors was quantified using a one-factor-at-a-time control method.

Poricoic Acid A attenuated TGF-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells through SPRY2/ERK signaling pathway.

The progression of renal fibrosis is difficult to reverse, and Poria cocos, one of the main components of Wenyang Zhenshuai Granules, has been shown to be crucial to the development of the epithelial-mesenchymal transition (EMT). This study aimed to examine the molecular mechanism by which Poricoic Acid A (PAA) inhibited the advancement of EMT in renal tubular epithelial (RTE) cells. The protein levels of sprouty RTK signaling antagonist 2 (SPRY2) extracellular regulated protein kinases (ERK), and p-ERK were measured.

Multidimensional Research on Hair Loss in Young Chinese Females With Oily Scalps.

Background: In recent years, the problem of female alopecia has been increasing and has shown a trend toward youthfulness. However, there are fewer studies on young female alopecia in the existing literature.

Aim: We aimed to study the possible causes of hair loss in young Chinese females aged 18-35 with oily scalps.

Role of Pulmonary Neuroendocrine Cells in COPD.

Background: Pulmonary neuroendocrine cells (PNECs) are specialized airway epithelial cells with dual sensory and secretory functions. They release bioactive mediators --including neuropeptides such as calcitonin gene-related peptide (CGRP) and gastrin-releasing peptide (GRP), and neurotransmitters such as 5-hydroxytryptamine (5-HT) and γ-aminobutyric acid (GABA) --that regulate airway smooth-muscle tone, mucus production, and immune responses. In chronic obstructive pulmonary disease (COPD), these PNEC-derived mediators contribute to airway inflammation, remodeling, and smooth-muscle dysfunction.

The GPR120 agonist TUG-891 mitigates ischemic brain injury by attenuating endoplasmic reticulum stress and apoptosis via the PI3K/AKT signaling pathway.

Extensive research has confirmed that omega-3 fatty acids provide cardiovascular protection primarily by activating the G protein-coupled receptor 120 (GPR120) signaling pathway. However, natural activators of this receptor often lack sufficient strength and precision. TUG-891, a recently synthesized selective GPR120 activator, has displayed significant therapeutic potential in multiple disease.

Mendelian Randomization Study: The Impact of Gut Microbiota on Survival in HR+ Breast Cancer Patients Under Different Treatment Regimens Through the Modulation of Immune Cell Phenotypes.

Background: Emerging evidence suggests that the gut microbiota (GM) may influence the progression of breast cancer by modulating immune responses. Given the vast diversity of GM and immune cell phenotypes, this study aimed to utilize the most advanced and comprehensive data to explore the causal relationships among the GM, immune cell phenotypes, and survival rates in hormone receptor-positive (HR+) breast cancer patients under different treatment regimens.

Methods: We investigated the causal relationships between the GM, immune cell phenotypes, and survival rates in HR+ breast cancer patients treated with 11 distinct therapeutic strategies using Mendelian randomization.

Targeting Tregs in T1DM: bridging heterogeneity, mechanisms, and clinical progress.

Regulatory T cells (Tregs) play a pivotal role in maintaining immune tolerance and sustaining immunological homeostasis. Emerging evidence indicates that Treg characteristics and functional alterations can significantly contribute to the pathogenesis of autoimmune diseases including type 1 diabetes mellitus (T1DM). Notably, recent studies have established a positive correlation between diminished numbers of Tregs and the onset of T1DM.

Design of a modified model predictive control and composite control strategy for hydraulic turbine regulation system.

As a critical component in hydropower systems, the Hydraulic Turbine Regulation System (HTRS) exhibits strong coupling characteristics that impose substantial challenges on control system design, necessitating the development of high-performance control strategies. To address the complex control requirements, this paper proposes an improved T-S fuzzy modeling method based on the Luenberger observer theory. It constructs a system model that combines high accuracy and simplicity.

Effects of structured orofacial muscle rehabilitation training on the recovery of facial expression muscles in patients with skeletal class II malocclusion after orthognathic surgery.

Objective: This study aimed to investigate the effects of structured orofacial muscle rehabilitation training (OMRT) on the recovery of facial expression muscles in patients with skeletal Class II malocclusion after orthognathic surgery.

Study Design: This randomized controlled trial enrolled 56 skeletal Class II malocclusion patients who underwent orthognathic surgery. The intervention group received structured OMRT, while the control group received standard postoperative care.

Contrast and Gain-Aware Attention: A Plug-and-Play Feature Fusion Attention Module for Torso Region Fetal Plane Identification.

Accurate identification of fetal torso ultrasound planes is essential in pre-natal examinations, as it plays a critical role in the early detection of severe fetal malformations and this process is heavily dependent on the clinical expertise of health care providers. However, the limited number of medical professionals skilled at identification and the complexity of fetal plane screening underscore the need for efficient diagnostic support tools. Clinicians often encounter challenges such as image artifacts and the intricate nature of fetal planes, which require adjustments to image gain and contrast to obtain clearer diagnostic information.

The relationship among inflammatory biomarkers, hyperuricemia and chronic kidney disease: analysis of the NHANES 2015-2020.

Background: Inflammation and hyperuricemia are closely associated with chronic kidney disease (CKD). The systemic inflammation response index (SIRI), systemic immune-inflammation index (SII), monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are emerging as novel biomarkers. While, the synergistic effects of these biomarkers with hyperuricemia on CKD remain unclear.

RNA interference targeting cytochrome P450 cyp303a1 on the performance of Henosepilachna vigintioctopunctata.

CYP303A1 is vital for metamorphosis in Locusta migratoria and Drosophila melanogaster. Here we uncovered that RNA interference (RNAi) against Hvcyp303a1 in the third instar larvae in a Coleopteran Henosepilachna vigintioctopunctata caused severe phenotypic defects. The Hvcyp303a1 RNAi larvae grew slowly, had thin head capsule and soft scoli, and ate less potato foliage.

Fenoxaprop-P-ethyl resistance in Alopecurus aequalis: Involvement of GSTF13 in addition to Ile-1781-Leu mutation.

Shortawn foxtail (Alopecurus aequalis Sobol.) is a challenging weed species to manage in wheat production systems globally. In prior research, we identified a field population of A.

Degradation and ecological risk of a novel neonicotinoid insecticide imidaclothiz in aquatic environments: Kinetics, photodegradation and hydrolysis pathways, mechanism and metabolites toxicity evaluation.

Neonicotinoid insecticides residuals pose a threat to aquatic ecosystems and human health. Imidaclothiz, as a novel neonicotinoid pesticide, the metabolic mechanisms in aquatic environments was unclear. This study investigated the degradation characteristics of imidaclothiz in both pure and actual water, and analyzed the photodegradation and hydrolysis metabolites of imidaclothiz in aquatic environments and assessed their toxicity.

Effects of microbial infection on key gene expression in the Toll signaling pathway and immune response in Myzus persicae.

The Toll signaling pathway serves as a crucial regulatory mechanism in the insect innate immune system, playing a pivotal role in defending against pathogenic microorganisms. However, the specific functions of aphids' unique immune system and Toll signaling pathway remain poorly understood. In this study, we systematically analyzed 12 key genes associated with the Toll signaling pathway in Myzus persicae.