Effects of artesunate-loaded nanoparticles on Plasmodium berghei treatment in a mouse model.

Malaria is still one of the most important parasitic diseases with millions of cases reported globally every year. Combination therapies of artemisinin or its derivatives, with a partner drug, are the first-and second-line treatments for malaria. However, recently, artemisinin partial resistance or tolerance has emerged and emphasizes the need for new therapeutic approaches to malaria.

Density-dependent network structuring within and across wild animal systems.

Theory predicts that high population density leads to more strongly connected spatial and social networks, but how local density drives individuals' positions within their networks is unclear. This gap reduces our ability to understand and predict density-dependent processes. Here we show that density drives greater network connectedness at the scale of individuals within wild animal populations.

Understanding the association between pressure ulcers and sitting in adults: What does it mean for all of us?

This third version of the seating guidelines aims to deliver a practical guide, using the most up to date research and evidence on pressure ulcer prevention and management. This guide can be applied to adults who remain seated for extended periods of time across health and social care settings. In the UK, over 700,000 patients are affected by pressure ulcers each year; 180,000 of those are newly acquired and their treatment is estimated to cost the NHS £3.

Lenvatinib Plus Pembrolizumab Versus Chemotherapy in Advanced Endometrial Cancer: Efficacy and Safety Insights.

Advanced endometrial cancer (aEC) presents a formidable therapeutic challenge, particularly in patients with recurrent or metastatic disease. Historically, platinum-based chemotherapy is the mainstay treatment for aEC. However, the treatment paradigm has shifted with the emergence of immune checkpoint inhibitors (ICIs) and targeted therapies.

An expert panel review of endoscopic vein harvesting devices: benefits, limitations, and clinical insights.

Objectives: Endoscopic Vessel Harvesting (EVH) devices are technically complex and the learning curve for novice practitioners can be steep, due to the need for refined hand-eye coordination and device familiarity. Training and mentoring approaches vary widely, as does the experience level of practitioners entering EVH practice.

Methods: This expert review was conducted by 10 international EVH specialists from the UK, USA, and Serbia, each with 18 to 28 years of experience.

The effects of different focus cues and motor learning strategies on landing mechanics in male handball players.

Anterior Cruciate Ligament (ACL) injuries are a major concern in sports, especially among athletes with limited ankle dorsiflexion, impacting performance and career longevity. Targeting kinetic and kinematic risk factors of high-risk sports actions through effective strategies is crucial for injury mitigation. This study aimed to assess the impact of internal focus (IF), and external focus (EF) within linear (LP) and differential learning (DL) methods on movement quality of a single leg drop jump (SL-DJ) task training in male handball players with restricted ankle dorsiflexion.

TIGIT in cancer: from mechanism of action to promising immunotherapeutic strategies.

TIGIT immune checkpoint (IC) has attracted great interest in recent years. It belongs to the PVR-like protein family, and it inhibits T and NK cell cytotoxic activities. TIGIT mediates its inhibitory effect by direct signaling through the cytoplasmic tail, CD155-mediated inhibition, or competition with the immune-activating receptor CD226.

Using Wearable Sensors to Identify Home and Community-Based Movement Using Continuous and Straight Line Stepping Time.

Objective measurement of community participation is essential for evaluating functional recovery and intervention outcomes in clinical populations, yet current methods rely heavily on subjective self-report measures. This study developed and validated a classification model to distinguish between home- and community-based activities using stepping and lying data from activPAL devices. Twenty-four healthy participants wore activPAL 4+ monitors continuously while completing activity diaries over 7 days.

The Digital Future of Nursing: Implications for Practice.

Commissioned by Health Education England, the country's organization for education and workforce development, the Phillips Ives Review on the Digital Future of Nursing highlighted the requisite priorities of person-centered care in digital health innovations and the required changes in nursing education to ensure competent practice in the digital age. Findings from this unpublished review, shared in the Health Service Journal and Nursing Times, bring attention to emerging care models such as virtual nursing and the critical importance of embedding person-centered nursing into the design and implementation of technology. Additionally, the importance of equipping nurses with skills in genomics, artificial intelligence, and data science was essential to delivering the benefits of these advancements.

How to undertake venepuncture in adults.

Venepuncture in adults is one of the most common procedures performed in nursing care. It enables a blood sample to be obtained for laboratory analysis, thereby facilitating crucial diagnostic and treatment processes. It is essential that venepuncture is undertaken correctly to prevent any misleading blood test results and support the provision of high-quality patient care.

An Enhanced Slime Mould Algorithm Based on Best-Worst Management for Numerical Optimization Problems.

The Slime Mould Algorithm (SMA) is a widely used swarm intelligence algorithm. Encouraged by the theory of no free lunch and the inherent shortcomings of the SMA, this work proposes a new variant of the SMA, called the BWSMA, in which three improvement mechanisms are integrated. The adaptive greedy mechanism is used to accelerate the convergence of the algorithm and avoid ineffective updates.

Normative Single Joint Isometric Hamstring Strength Scores From Professional Soccer Players During Preseason.

Ripley, NJ, Fahey, JT, Comfort, P, McMahon, JJ, Jones, PA, and Bramah, C. Normative single joint isometric hamstring strength scores from professional soccer players during pre-season. J Strength Cond Res XX(X): 000-000, 2025-Monitoring changes in isometric force production from the hamstrings has become increasingly common in team sports.

First Assembly of a Draft Genome of the Critically Endangered Northern Muriqui (, Primates, Atelidae) Including Non-Invasive Genotyping Strategies for the Species.

Genomic resources, such as draft genomes, are vital for biodiversity monitoring and conservation. For endangered species, they enable the development of tools like organellar genomes and molecular markers, which are crucial for population genetics. Advances in sequencing technologies now allow high-throughput genotyping with detailed amplicon sequences, enhancing genetic variation studies.

Detecting inter-adjustment coupling changes for transtibial adjustable prosthetic sockets: A novel motion capture model feasibility study.

Prosthetic sockets provide a connection between the residual limb and prosthesis. However, this connection is non-rigid, leading to unintended prosthesis movement during functional activities. These movements can diminish socket function, cause discomfort, and damage soft tissue.

Joint contributions to lower limb range of motion: A simple means of exploring joint function.

Background: This paper proposes a novel means of quantifying lower limb function by exploring relative contributions to lower limb range of motion (RoM).

Research Question: Are joint contributions to RoM sensitive, and associated with gait velocity and joint kinetics and energetics?

Methods: Sagittal plane hip, knee and ankle joint kinematics and kinetics, recorded using 3D motion capture, during walking and the propulsive phase of a drop vertical jump were used to calculate and explore relative joint contribution to RoM (RoM = sum hip, knee and ankle RoM). Sensitivity was assessed by comparing joint contributions to RoM between healthy controls and patients pre and 3-months post total knee replacement during walking.

Population dynamics and evolutionary history of the genus Sakesphorus (Aves: Thamnophilidae) in the Amazonian floodplains.

The genus Sakesphorus (Aves: Thamnophilidae) includes two species that are floodplain specialists within Amazonia. While S. luctuosus occupies floodplains of southeastern Amazonia and extends south along riparian habitats in central Brazil, S.

Evolution of Patient and Public Involvement and Engagement in Health-Related Research: A Concept Analysis.

Aims: To clarify the definition and evolution of Patient and Public Involvement and Engagement (PPIE) and identify its attributes, antecedents, and consequences in health-related research.

Design: This study follows Rodgers' evolutionary concept analysis with a seven-step framework.

Methods: Datasets were searched using terms related to PPIE and key categories (i.

Proposing a subgenus Borreliella.

In 2014, it was proposed (validly published in 2015) that the genus Borrelia be divided into two genera, with a new genus Borreliella holding species of the Lyme borreliosis group of spirochetes and the genus Borrelia retaining all other species. As borrelias are medically important bacteria and as concerns about this taxonomic proposal were raised, this genus split was controversial. In particular, the accuracy of the genetic signatures used to support the division of the genus has been questioned, particularly as new taxa have markedly increased the diversity of the genus in recent years.

OrthoticS for TReatment of symptomatic flat feet In CHildren (OSTRICH): a randomised controlled trial.

Background: Children and young people with symptomatic pes planus (flat feet) often seek treatment from healthcare professionals. There are various treatment options, but there is a lack of high-quality evidence about which is most effective.

Objectives: To assess the clinical and cost-effectiveness of prefabricated orthoses, plus exercise and advice, compared with exercise and advice alone on physical function, measured using the physical domain of the Oxford Ankle Foot Questionnaire for Children, among children with symptomatic pes planus.

Measuring diaphragmatic excursion using 4-dimensional ultrasound: a feasibility study.

Four-dimensional ultrasound (4DUS) could provide more accurate characterisation of diaphragm function than existing M-mode ultrasound approaches. Therefore, the aim of this study was to investigate the feasibility of a novel method for tracking diaphragm excursion from 4DUS data. 4DUS was acquired from 12 participants who exhibited a range of breathing patterns.

Wear and use of prostheses in sport by adolescents with upper limb absence: A preliminary mixed-methods study.

Background: There is minimal research on sports participation in adolescents with upper limb absence (ULA) and specifically on the impact of prosthesis provision.

Objectives: This study explored using activity monitoring sensors and interviews to gain insight into levels of sport participation and associated prosthesis use in active adolescents with ULA.

Study Design: A mixed methods study using a convergent parallel design.

A scoping review of digital fabrication techniques applied to prosthetics & orthotics: Part 2 of 2-orthotics.

Introduction: Traditionally, orthosis manufacturing is time and labor-intensive. Digitalization of some of the fabrication process is already ubiquitous, yet extension across device types could reduce the burden of manual labor and advance automation to help unblock access to assistive technologies globally. It seems, however, that appropriately strong evidence is holding this back.