Galectin-10 Silencing Reduces Eosinophilic Inflammation in Chronic Rhinosinusitis with Nasal Polyps by Inhibiting the p38/MAPK/NF-κB Pathway.

Galectin-10(Gal-10)/CLC(Charcot-Leyden crystal) has been discovered to be related to ECRSwNP characterized by high eosinophilic infiltration. We aimed to investigate the effects of Gal-10 on ECRSwNP. A total of 36 tissue samples were collected, including 11 ECRSwNP samples, 15 non-ECRSwNP samples, and 10 Control samples.

Shenling Baizhu Powder Inhibits Lung Metastasis of Breast Cancer via Regulation of Epithelial-Mesenchymal Transition and Ferroptosis.

Objective: This study aimed to probe the role of Shenling Baizhu powder (SLBZP) in inhibiting breast cancer (BC) lung metastasis, focusing on epithelial-to-mesenchymal transition (EMT) and ferroptosis.

Methods: BC 4T1 cells were treated with low (3.13 µg/mL) and high (12.

Immunomodulatory Roles of Tonsil-Derived Mesenchymal Stem Cells.

Stemming from human immune organs, tonsil-derived mesenchymal stem cells (TMSCs) hold unique strengths in differentiation potential and immune regulatory functions. These characteristics make them valuable for therapeutic applications, particularly in regenerative medicine and autoimmune disease treatment, as they can modulate immune responses and promote tissue repair. Their ability to interact with various cell types and secrete a range of bioactive molecules further enhances their role in orchestrating healing processes, making them a promising avenue for innovative therapies aimed at restoring balance in the immune system and facilitating recovery from injury or disease.

Downregulation of miR-605-5p Facilitates Breast Cancer Progression and Predicts Unfavorable Prognosis.

Breast cancer (BC) is one of the main causes of cancer-related death in women. The purpose of this study was to evaluate the expression of miR-605-5p in BC and its diagnostic and prognostic value. BC patients and healthy individuals who met the study criteria were included.

lncRNA-miRNA/RBP-mRNA Network Involved in Human Triple-Negative Breast Cancer: An Integrated Approach.

Noncoding RNA regulatory networks play crucial roles in human breast cancer. The aim of this study was to establish a network containing multi-type RNAs and RBPs in triple-negative breast cancer (TNBC). Differential expression analyses of lncRNAs, miRNAs, and genes were performed using the GEO2R tool.

Histone Methyltransferase EHMT2 Promotes the Progression of Breast Ductal Carcinoma by Regulating the Hippo Pathway.

Invasive ductal carcinoma (IDC) is a major type of breast cancer. The utilization of inhibitors targeting histone methyltransferases introduces novel therapeutic avenues for the treatment of cancer. Immunohistochemistry, Western blot, and reverse transcription quantitative polymerase chain reaction experiments were applied to assess the levels of EHMT2 in IDC and adjacent tissues.

Inhibition of Interleukin-1 Receptor-Associated Kinase-1 by Pacritinib Is a Therapeutic Strategy to Overcome Melanoma Resistance.

Despite advancements in systemic therapy, the mortality rate for patients with metastatic melanoma remains around 70%, underscoring the imperative for alternative treatment strategies. Through the establishment of a chemoresistant melanoma model and a subsequent drug investigation, we have identified pacritinib, a medication designed for treating myelofibrosis and severe thrombocytopenia, as a potential candidate to overcome resistance to melanoma therapy. Our research reveals that pacritinib, administered at clinically achievable concentrations, effectively targets dacarbazine-resistant melanoma cells by suppressing IRAK1 rather than JAK2.

Ethyl Acetate Extract of Oratosquilla Inhibits the Growth of Nasopharyngeal Carcinoma through the Hippo Pathway.

The Hippo pathway and its transcription co-activator YAP play a critical role in the regulation of cell proliferation, apoptosis and the control of organ size. In the past several years, YAP has been found to be expressed in various human cancers, however, its expression in Nasopharyngeal Carcinoma (NPC) remains unstudied. In this report, we found that YAP was overexpressed in human NPC tissues, and its expression was also significantly higher in five NPC cell lines when compared with the nasopharyngeal epithelial cell line NP69 (P < 0.

Molecular Mechanism of Long Non-Coding RNAs in Ovarian Cancer: CASC19 Regulates the Malignant Progression of Ovarian Cancer through miR-761/CBX2 Axis.

Long non-coding RNAs (lncRNAs) are involved in the numerous types of tumors. The aim of this study is to comprehend the pathological mechanism of lncRNA CASC19 in ovarian cancer. CASC19, miR-761 and CBX2 expression in the samples was quantitatively detected by real-time quantitative polymerase chain reaction (RT-qPCR) reaction.

Isolated lumbar vertebral infection caused by Coxiella burnetii: A case report and literature review.

This study describes the clinical characteristics and treatment of vertebral infection caused by Coxiella burnetii through a case report and literature review. We present a 60-year-old male with isolated lumbar vertebral infection. A comprehensive literature review identified 17 cases, with 82.

Stabilization of delayed stochastic reaction-diffusion Cohen-Grossberg neural networks via variable gain intermittent boundary control.

This study presents a novel variable gain intermittent boundary control (VGIBC) approach for stabilizing delayed stochastic reaction-diffusion Cohen-Grossberg neural networks (SRDCGNN). In contrast to traditional constant gain intermittent boundary control (CGIBC) methods, the proposed VGIBC framework dynamically adjusts the control gain based on the operational duration within each control cycle, thereby improving adaptability to variations in work interval lengths. The time-varying control gain is designed using a piecewise interpolation method across work intervals, defined by a finite set of static gain matrices.

Region-guided attack on the segment anything model.

The Segment Anything Model (SAM) is a cornerstone of image segmentation, demonstrating exceptional performance across various applications, particularly in autonomous driving and medical imaging, where precise segmentation is crucial. However, SAM is vulnerable to adversarial attacks that can significantly impair its functionality through minor input perturbations. Traditional techniques, such as FGSM and PGD, are often ineffective in segmentation tasks due to their reliance on global perturbations that overlook spatial nuances.

A spatial-frequency hybrid restoration network for JPEG compressed image deblurring.

Image deblurring and compression-artifact removal are both ill-posed inverse problems in low-level vision tasks. So far, although numerous image deblurring and compression-artifact removal methods have been proposed respectively, the research for explicit handling blur and compression-artifact coexisting degradation image (BCDI) is rare. In the BCDI, image contents will be damaged more seriously, especially for edges and texture details.

Multimodal self-supervised retinal vessel segmentation.

Automatic segmentation of retinal vessels from retinography images is crucial for timely clinical diagnosis. However, the high cost and specialized expertise required for annotating medical images often result in limited labeled datasets, which constrains the full potential of deep learning methods. Recent advances in self-supervised pretraining using unlabeled data have shown significant benefits for downstream tasks.

Inter-modality feature prediction through multimodal fusion for 3D shape defect detection.

3D shape defect detection plays an important role in autonomous industrial inspection. However, accurate detection of anomalies remains challenging due to the complexity of multimodal sensor data, especially when both color and structural information are required. In this work, we propose a lightweight inter-modality feature prediction framework that effectively utilizes multimodal fused features from the inputs of RGB, depth and point clouds for efficient 3D shape defect detection.

Dual aggregation based joint-modal similarity hashing for cross-modal retrieval.

Cross-modal hashing aims to leverage hashing functions to map multimodal data into a unified low-dimensional space, realizing efficient cross-modal retrieval. In particular, unsupervised cross-modal hashing methods attract significant attention for not needing external label information. However, in the field of unsupervised cross-modal hashing, there are several pressing issues to address: (1) how to facilitate semantic alignment between modalities, and (2) how to effectively capture the intrinsic relationships between data, thereby constructing a more reliable affinity matrix to assist in the learning of hash codes.

Recent progress of rapid detection technologies for mycotoxins.

Mycotoxins, due to their high carcinogenic and genotoxic properties, pose a significant threat to global food safety. Traditional detection methods often fall short in meeting the demands for large-scale, real-time, simple, and rapid monitoring. As a result, innovative rapid detection approaches, leveraging advanced materials and sensor technologies, are emerging as key solutions for preventing food contamination.

Starch crystalline types modulate myofibrillar protein aggregation and its functional properties in gelling and emulsifying systems.

Different starch crystal structures significantly influence meat product quality, though their specific impacts on myofibrillar protein (MP) functionality remain unclear despite industry demand for optimized ingredients. This study compared how potato, corn, mung bean, and pea starches affect MP properties in minced pork. Our findings reveal that starch-protein interactions fundamentally regulate MP gel and emulsion properties through the following mechanisms: First, starch promotes protein aggregation by enhancing hydrophobic interactions and disulfide bond formation, affecting gel network crosslinking.

TRIM39 reinforces E2-ESR1 signaling through SUMOylation of ESR1 to hinder the progression of aortic dissection.

Background And Aims: Aortic dissection (AD) is one of the most dangerous and tricky diseases in the field of cardiovascular surgery, severely affecting public health. Recent studies have found that SUMOylation is linked to the pathogenesis of cardiovascular diseases. However, we know very little about the molecular mechanisms of SUMOylation in AD.

Targeted degradation of Werner syndrome helicase (WRN) via ligand-directed covalent hydrophobic tagging.

The Werner syndrome RecQ helicase (WRN) has recently emerged as a novel synthetic lethality target for microsatellite instability-high (MSI-H) cancers. However, available WRN inhibitors or degraders is still lacking so far. Particularly, chemically designed probes capable of degrading WRN irrespective of microsatellite status remain unexplored.

Integration of multi-omics resources reveals genetic features associated with environmental adaptation in the Wuzhishan pig genome.

In light of the challenges posed by global climate change, the environmental adaptability of organisms is becoming increasingly important. The Wuzhishan (WZS) pig, tolerant to high heat and humidity, is an ideal model for genomic study. By characterizing its genome and assessing its genetic diversity and runs of homozygosity (ROH), we can gain insights into its current conservation status and genomic architecture.

The distribution characteristics of marine litter in the intertidal zone of Lvhua Island and its impact on the macrobenthic community structure.

Marine litter typically originates from human discards at sea or enters the ocean through land-based pathways such as surface runoff and natural disasters. The extensive accumulation of plastic litter poses severe threats to marine life. In August 2024, a specialized survey was conducted to investigate the distribution characteristics of marine litter and macrobenthic communities across four intertidal zones on Lvhua Island (XIAO'AO, DA'AO, FANGANG, and SHIZIKENG).

Ultrasensitive multifunctional biosensor integrating ECL quenching and DPV enhancement for early classification of thyroid cancer via BRAF V600E and microRNA-221 detection.

Papillary thyroid carcinoma (PTC) is the most prevalent form of thyroid cancer with a high incidence among endocrine malignancies. It tends to metastasize early in lymph nodes and differs markedly from other subtypes in biological behavior, clinical management, and prognosis. Therefore, accurately distinguishing PTC from other pathological subtypes is crucial for guiding diagnosis and treatment decisions.

An ultrasensitive biosensor for H1N1 virus coupled with 3D spherical DNA nanostructure and CRISPR-Cas12a.

To achieve ultrasensitive and real-time detection of the H1N1 influenza virus, this study designed a nucleic acid-free fluorescent biosensor based on 3D spherical DNA nanostructure and CRISPR/Cas12a (3D-SDNC). The biosensor constructs a rigid 3D nano-framework via self-assembly of six oligonucleotide chains, with H1N1-specific nucleic acid aptamers and Cas12a activator strands strategically positioned at multi-spined vertices for precise spatial coupling between viral recognition and signal transduction. Upon aptamer-virus binding, the induced conformational change liberates the activator strand, thereby activating the trans-cleavage activity of the Cas12a/crRNA complex to efficiently cleave the HEX/BHQ1 double-labeled fluorescent probe and initiate cascade signal amplification.

Microbial regulation of organic solid waste composting: Lignocellulose degradation (fertilization), process gas emissions, and containment of typical pollutants.

Microbial agents represent a valuable class of additives that can enhance the value and effectiveness of compost products. This paper provides a comprehensive review of the mechanisms and applications of microorganisms in regulating lignocellulose degradation, controlling gas emissions, and managing typical pollutants during the composting of organic solid wastes. Inoculation with microbial agents can significantly improve the degradation efficiency, quality, and environmental friendliness of compost.