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Mycotoxins, due to their high carcinogenic and genotoxic properties, pose a significant threat to global food safety. Traditional detection methods often fall short in meeting the demands for large-scale, real-time, simple, and rapid monitoring. As a result, innovative rapid detection approaches, leveraging advanced materials and sensor technologies, are emerging as key solutions for preventing food contamination. This review covers the classification and detection needs of mycotoxins, the development of recognition elements, sample preparation techniques, and types of detection signals. It also highlights recent progress in the field, particularly focusing on the advantages and limitations of three major rapid detection technologies: immunoassays, aptamer-based methods, and biosensors. The aim is to provide valuable insights for the future development of efficient and rapid mycotoxin detection technologies.
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http://dx.doi.org/10.1016/j.foodchem.2025.146212 | DOI Listing |
PLoS One
September 2025
Nutrition Innovation Center, Standard Process Inc., Kannapolis, North Carolina, United States of America.
Polyamines (PAs), including spermidine, spermine and their precursor, putrescine, are ubiquitous molecules that are vital for a variety of physiological processes. Recently, PAs gained research attention because of their roles in promoting longevity and preventing age-related diseases. Circulating and tissue levels of PAs appear to decline with age, while higher intake of PAs in humans is correlated with better health during aging.
View Article and Find Full Text PDFAnal Methods
September 2025
Jilin Province Product Quality Supervision and Inspection Institute, Changchun 130103, China.
A method for determination of ten kinds of sweeteners in soybean products by multi-plug filtration cleanup (-PFC) combined with ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was established. The sample was extracted with acetonitrile (containing 1% formic acid), degreased by using -hexane liquid-liquid extraction and purified by solid phase extraction using an -PFC column (Oasis PRiME HLB). The analytes were separated by using a Waters ACQUITY UPLC® BEH C (2.
View Article and Find Full Text PDFAnal Bioanal Chem
September 2025
Hebei Key Laboratory of Public Health Safety, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Public Health, College of Chemistry and Materials Science, Hebei University, Baoding, 071002, China.
This work presents the development of a highly sensitive, selective, and efficient aptamer-based fluorescent sensor for detecting cortisol in human urine. Carbon quantum dots-nucleic acid aptamer (CQDs-Apt) synthesized with excellent photoluminescent properties and stability, were selected as the fluorescent probe. In the presence of MoS-NSs, CQDs-Apt adsorbed onto the surface of MoS-NSs via electrostatic and π-π interactions, leading to strong and rapid fluorescence quenching due to static quenching mechanism between them.
View Article and Find Full Text PDFJ Glaucoma
September 2025
Department of Ophthalmology, Kurashiki Medical Center, Kurashiki, Okayama, Japan.
Prcis: Protocol 30-2 of Melbourne Rapid Fields, online computer perimetry, provides a portable, reliable, and patient-friendly alternative to Humphrey Field Analyzer 30-2 SITA fast protocol for Japanese all severity stages of glaucoma patients.
Purpose: Melbourne Rapid Fields (MRF) online computer perimetry is a web-browser-based software that offers white-on-white threshold perimetry using any computer. This study evaluates the perimetric results of 30-2 protocol from MRF performed using a laptop computer in comparison to Humphrey Field Analyzer (HFA).
Small Methods
September 2025
Institute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Natural polyreactive antibodies achieve enhanced avidity through heterogeneous ligand binding. However, engineering synthetic heteroligation systems with precise control over recognition motif orientation and distance remains challenging. Here, a DNA framework-based strategy is presented to program heterotypic binding by spatially organizing bivalent aptamers targeting platelet-derived growth factor-BB (PDGF-BB).
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