Primary endobronchial epithelial-myoepithelial carcinoma: A case report and literature review.

Pulmonary epithelial-myoepithelial carcinoma (P-EMC) is a rare type of salivary gland tumour of the lung. Due to its rarity and lack of long-term follow-up data, there is no established standard for optimal treatment or duration of follow-up. The present study reports the case of a 58-year-old female patient with P-EMC originating from the middle part of the bronchus and presenting as an endobronchial mass in the left superior lobe.

From gut to proteomics: the impact of on post-translational modifications in colorectal cancer.

Background: Colorectal cancer (CRC) represents a significant global health challenge. Gut microbiota imbalance and abnormal chromatin modifications play critical roles in the progression of CRC. However, the mechanisms by which they exert their influences, particularly the involvement of ()-mediated post-translational modifications (PTMs), remain inadequately understood.

Genetic predisposition to immune dysregulation and extracellular matrix remodeling in cardiac arrhythmia reveals potential mediation by + macrophages.

Introduction: Cardiac arrhythmia frequently co-presents with structural abnormalities such as cardiomyopathy and myocardial fibrosis, creating a bidirectional relationship where electrical disturbances and structural remodeling exacerbate each other. Current genetic studies focus on ion channel variants, which explain part of the etiology. Molecular mechanisms underlying arrhythmias pathogenesis and its progression warrant further investigation.

Morphology of the larval midgut of the longhorn beetle Rhytidodera bowringii White, 1853 (Coleoptera: Cerambycidae: Cerambycinae).

The midgut of insects originates from the endoderm. It is located in the central part of the digestive tract and serves as the primary site for chemical digestion and nutrient absorption. The larvae of Cerambycidae are the most destructive life stage.

QTL mapping and candidate genes prediction for plant height and brix content in sorghum [Sorghum bicolor (L.) Moench].

By constructing a high-density genetic linkage map using a recombinant inbred line (RIL) population from two sorghum lines with distinct variations in plant height and brix content, eight genetic loci were identified, and candidate genes associated with these traits were predicted. Sorghum, recognized as a crucial forage and energy crop, exhibits yield and quality influenced by plant height and sugar content traits. Considering the complex genetic architecture of plant height and sugar content, this study utilized a sorghum recombinant inbred line population comprising 250 lines to elucidate the phenotypic variation and genetic foundations of these traits.

How Do Patient Outcomes in Mechanical Thrombectomy for Large-Core Stroke Vary Based on Neuroimaging Modalities Used for Patient Selection? A Multicenter Multinational Study.

The role of different imaging modalities-non-contrast CT (NCCT), CT perfusion (CTP), and diffusion-weighted imaging (DWI)-in selecting patients with large-core stroke for endovascular thrombectomy (EVT) is a subject of ongoing debate. This study aims to determine whether patients with large-core acute ischemic stroke (AIS) undergoing EVT triaged with CTP or DWI in addition to NCCT had different clinical outcomes compared to those only triaged with NCCT. We queried the Stroke Thrombectomy and Aneurysm Registry (STAR) for patients enrolled between 2014 and 2023 who presented with anterior-circulation AIS and large ischemic core (ASPECTS < 6) who underwent EVT in 41 stroke centers in the USA, Europe, Asia, and South America.

The impact of autoimmune comorbidities on multiple sclerosis progression: insights from a longitudinal single-center study.

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system. The presence of other conditions alongside MS imposes a substantial personal and socioeconomic burden. In particular, the impact of comorbid autoimmune diseases (AID) on MS outcomes remains uncertain.

Prevalence of radiographic knee osteoarthritis in China: a national survey of thirty thousand, four hundred and fifty five individuals cross-sectional study.

Background: Knee osteoarthritis (KOA) is a major health burden for adults and the elderly globally; however, national radiological and epidemiological data and predictive models for KOA are lacking in China. Most of the existing studies are limited to regional samples, which cannot accurately reflect disease burden and risk factors.

Objectives: This study aimed to systematically analyze the prevalence and risk factors of adult radiology KOA in China for the first time using a national representative sample and to develop a prediction model to provide a basis for public health strategies.

The Prevalence of Myopia in Finnish Conscripts Has not Increased in Recent Decades and Is Lower Than in Many East and Southeast Asian Countries.

Purpose: This study aimed to determine the prevalence of myopia among Finnish conscripts and to identify the factors associated with its occurrence in Finland.

Methods: A total of 1694 conscripts (mean age: 19.3 ± 1.

Functional Anatomy of Ocular Counter-Rolling in Superior Oblique Palsy.

Purpose: Simulations suggest that displacement of rectus extraocular muscle pulleys in superior oblique (SO) palsy accounts for incomitant strabismus patterns even without postulating SO contractile weakness. We asked how rectus extraocular muscle pulleys reorient during head tilt in SO palsy.

Methods: In 13 subjects with unilateral SO palsy, supine magnetic resonance imaging (MRI) in 2-mm-thick quasi-coronal planes in target-controlled central gaze was repeated in both lateral decubitus positions equivalent to 90° head tilts.

Prevalence and distribution patterns of drug resistance in to first-line antituberculosis drugs in Urumqi, China.

Unlabelled: This study aimed to investigate the epidemic status and distribution characteristics of drug-resistant in Urumqi. From January 2019 to July 2024, all sputum culture-positive strains were collected in Urumqi. Using the traditional solid-state proportion method for drug-sensitivity testing, we determined the resistance of to first-line antituberculosis (TB) drugs.

Dual-Layer Flexible Liquid Metal Fiber for Plantar Pressure Monitoring and Synchronous Wound Electrotherapy.

Plantar wounds, particularly diabetic foot ulcers (DFUs), impose significant burdens on patients' quality of life and healthcare systems. Personalized wound management demands real-time monitoring of biomechanical parameters and effective therapeutic interventions to prevent exacerbations. Here, a dual-layer flexible liquid metal fiber (LMF) capable of simultaneous plantar pressure sensing and electrical stimulation for accelerated wound healing is presented.

Highly Ordered DNA Framework Interface Enables Efficient Enzymatic Oligonucleotide Synthesis.

De novo DNA synthesis plays crucial roles in life science. Enzymatic oligonucleotide synthesis (EOS) has attracted interest due to longer synthesized chains, simple procedure, cost-effectiveness, and environmental friendliness. However, unlike chemical synthesis dominated by small molecule, the EOS relies on enzyme reacting with primers.

Moisture Microenvironment-Regulating Electro spun Membranes for Extending Litchi Shelf Life.

To address post-harvest issues of litchi, including browning, water loss, and nutrient degradation, a moisture microenvironment-regulating electro spun membrane was prepared by incorporating hydrophobic carnauba wax (CW)@nano silica (SiO) composite powder into a polyethylene terephthalate (PET) matrix via electro spinning. The dynamic water penetration equilibrium was evaluated by monitoring the water vapor absorption of the electrospun membrane within 12 h, while the effects of CW@SiO on the micro-structure, mechanical properties, hydrophobicity, and thermal stability were investigated. Results showed that the tensile strength of the PET-2.

Intermolecular Electron Transfer: Toward a General Photochemical Engine for Type I Photodynamic Therapy.

Hypoxia is an intrinsic characteristic within tumors or infected tissues, which poses a significant barrier to effective photodynamic therapy (PDT). Type I PDT is a promising complement or alternative to conventional Type II PDT owing to its reduced or absent reliance on molecular oxygen. Type I photosensitizers (PSs) are essential to Type I PDT, which undergoes photoinduced electron transfer with biological substrates to produce cytotoxic radical species (O •, •OH) for the targeted destruction of pathological tissues.

The LsBAHD3-LsAAE3 Module Catalyses Biosynthesis of β-N-Oxalyl-L-α,β-Diaminopropionic Acid in Lathyrus sativus and Pisum sativum.

The neuroactive β-N-oxalyl-L-α,β-diaminopropionic acid (β-ODAP) was first identified in Lathyrus sativus and present also in several Chinese traditional herbs including Panax notoginseng. It exhibit toxicological effects as the causative agent of neurolathyrism when L. sativus was over-consumed under drought-triggered famines or pharmacological effects including neuroprotection and wound healing.

[Functional remodeling of the mandibular condylar process after bimaxillary orthognathic surgery in patients with skeletal class III malocclusion].

Objective: To evaluate morphological changes in the mandibular condyle (MC) during its remodeling following bimaxillary orthognathic surgery in patients with skeletal class III malocclusion.

Material And Methods: İn this study 32 three-dimensional virtual models of the condylar process of the mandible from 16 patients with skeletal class III malocclusion have been analyzed. The models were generated from computed tomography scans performed one week before (T) and 12 months after (T) bimaxillary orthognathic surgery.

[Analysis of the associations between maxillary anterior teeth and facial measurements in Han Chinese individuals with the most attractive smiles].

Objectives: This study aimed to analyze the correlations and proportional relationships between maxillary anterior teeth (MAT) and facial measurements in Han Chinese individuals with the most attractive smiles, as evaluated by dental professionals.

Methods: Ten dentists with more than 5 years of clinical experience from different professional directions in a tertiary stomatological hospital were selected to evaluate the smile attractiveness of volunteers by visual analogue scale (VAS). Eighty-eight Han volunteers with the most attractive smile were selected.

Promoting Li Transfer and Storage in Si Anode Through Dynamically Precise Modulation of Constructed Carbon Coating.

Silicon is considered as a promising anode material for lithium-ion batteries due to its high capacity. However, its huge volume expansion during lithium de-embedding and low Li/electron diffusion pose a great challenge for practical applications, while carbon coatings are important strategies to enhance the cycling performance of Si anode. Herein, three kinds of carbon coatings are designed with different microstructures and evaluated the relationship between microstructure and electrochemical behaviors.

Impact of structured multiprofessional rounds on clinical outcomes in a resource-limited intensive care unit: A retrospective study.

Effective communication among intensive care professionals is essential for patient safety and outcome optimization. Multiprofessional rounds supported by checklists have demonstrated the potential to improve the quality of care, particularly in high-income settings. However, evidence remains limited for low- and middle-income countries (LMICs).

Association of balance, anthropometric measurements, fall risk, and awareness with quality of life in older females according to hypertensive status.

Falls and their consequences are perhaps the greatest moderators of quality of life (QoL) among older adults with hypertension. However, limited studies have been conducted to identify associations between fall risk and awareness, anthropometric, balance, and QoL among older women with different blood pressure patterns within the Pakistani population. This cross-sectional study examined the relationship between anthropometric measurements, postural balance (PB), fear of falling, fall risk awareness, and QoL in older females with hypersensitive status in Lahore, Pakistan.

Application of tissue engineering in wound healing: A 20-year bibliometric and visualized study.

Background: Tissue engineering has recently been shown to have a considerable advantage in promoting wound healing in clinical studies and animal models, with an increasing number of documents in designing and mechanism investigations. The lack of bibliometric analysis and knowledge mapping in this field would hinder comprehensive understanding of this field and the development of future research.

Methods: Our investigation into the application of tissue engineering in wound healing involved a search of the Web of Science Core Collection (WoSCC).

Predictive value of the STOP-Bang Questionnaire for respiratory depression risk in patients undergoing painless gastrointestinal endoscopy.

Background: Obstructive sleep apnea (OSA) is an independent risk factor for perioperative respiratory complications. The STOP-Bang Questionnaire (SBQ) is a widely used screening tool; however, its utility in predicting respiratory depression during deep sedation for gastrointestinal endoscopy warrants further exploration. This study aimed to evaluate the predictive performance of the SBQ for respiratory depression in this patient population.

Cancer-associated fibroblast derived CXCL14 drives cisplatin chemoresistance by enhancing nucleotide excision repair in bladder cancer.

Background: A significant challenge in bladder cancer treatment is primary chemoresistance, in which cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) play a pivotal role. While the contributions of CAFs to tumor progression and drug resistance are well established, the precise molecular mechanisms by which they induce chemoresistance remain unclear. A comprehensive understanding of the effect of TME modulation-particularly through CAFs-on the chemotherapeutic response is crucial for developing effective strategies to overcome chemoresistance and improve patient survival.

Pan-cancer analysis of tumor suppressor ZNF132 reveals its diagnostic and prognostic significance with immunomodulatory implications in colorectal cancer.

Background: Zinc finger protein 132 (ZNF132) has emerged as a potential tumor suppressor, with its dysregulation closely associated with the initiation and progression of various malignancies. However, a comprehensive assessment of ZNF132's expression patterns across diverse cancer types, its clinical prognostic implications, and its immunoregulatory role in colorectal cancer remains insufficiently characterized. This study aims to elucidate the biological functions of ZNF132 within the context of colorectal cancer.