An evaluation of the effectiveness of 3D virtual imaging combined with intraoperative ultrasonography to guide liver staining in anatomic segmental hepatectomy.

Identification of a tumor-bearing portal territory using indocyanine green (ICG) fluorescence imaging (IGFI) facilitates precise laparoscopic anatomic hepatectomy (LAH). However, it is technically challenging to perform a transhepatic portal injection of ICG or to clamp the target portal pedicle and inject ICG during LAH. Herein, we aimed to investigate the feasibility and efficacy of portal territory identification using IGFI under the combined guidance of three-dimensional (3D) virtual imaging and intraoperative ultrasound (IOUS) in LAH.

Application of Evidence into Practice in Trauma: The Purpose to Practice (P2P) Approach to Consensus Generation.

Introduction: In trauma care, there is a need to increase communication to ensure evidence-informed, best practice care guidelines are easily accessible to all providers to yield continuity of care. Clinical guidance use is one way to address this need while employing a patient-centered team approach.

Methods: During year two of the conference series, participants gathered in person and virtually to further develop the Minimum Viable Product (MVP) created during year one.

Clinically validated graphical approaches identify hepatosplenic multimorbidity in individuals at risk of schistosomiasis.

The global burden of multimorbidity is increasing yet poorly understood, owing to insufficient methods for modelling complex systems of conditions. In particular, hepatosplenic multimorbidity has been inadequately investigated. From 17 January to 16 February 2023, we examined 3186 individuals aged 5-92 years from 52 villages across Uganda within the SchistoTrack Cohort.

Key regulatory genes in sugar beet's defense against curly top virus identified by network analysis and qRT-PCR.

Curly top disease, caused by Beet Curly Top Virus (BCTV), is a major threat to sugar beet (), resulting in significant yield losses. This study integrates RNA sequencing, gene network analysis, and experimental validation to uncover key regulatory genes involved in plant responses to viral infection. Network analysis identified nine central hub genes associated with fatty acid metabolism, stress adaptation, and transcriptional regulation.

Investigating Macular Tissue Integrity Index as a Novel Biomarker in Geographic Atrophy.

Purpose: The rate of geographic atrophy (GA) enlargement is commonly used as an outcome in clinical trials. However, this metric typically lacks specificity for central macular involvement and structure-function relationships. We propose a targeted approach in monitoring GA progression within the central macula, highlighting the limited benefit of including GA expansion beyond the 3-mm perifoveal zone when analyzing visual function.

and secondary metabolites exhibit neuroprotective potential: insights from in vitro, ex vivo and computational models.

Cinnamon and coriander plants are sources of popular spice products in different cuisines prepared by many people worldwide. The inhibitory effect of cinnamon bark and coriander seeds aqueous extracts on butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) activities, and their antioxidant properties were investigated using in vitro, molecular docking and molecular dynamics (MD) computational models. Standard experimental methods were employed to determine the plant extracts' antioxidant and enzyme-inhibitory capacities.

Feasibility of fully automatic assessment of cervical canal stenosis using MRI via deep learning.

Background: Currently, there is no fully automated tool available for evaluating the degree of cervical spinal stenosis. The aim of this study was to develop and validate the use of artificial intelligence (AI) algorithms for the assessment of cervical spinal stenosis.

Methods: In this retrospective multi-center study, cervical spine magnetic resonance imaging (MRI) scans obtained from July 2020 to June 2023 were included.

The Influence of Rolling Reduction on the Mechanical, Corrosion, Osteogenic, and Antibacterial Properties of Zn-Mg Alloys.

Biodegradable zinc (Zn) alloys are promising biodegradable metals owing to their appropriate in vivo degradation rate. To address the problem of low mechanical properties of pure Zn, magnesium (Mg) is added into Zn to develop Zn-0.5Mg alloys which are rolled subsequently.

Novel transferrin receptor-mediated enzyme replacement therapy efficiently treats myogenic and neurogenic aspects of Pompe disease in mice.

Pompe disease (PD) is a multisystemic progressive disease caused by acid-alpha glucosidase (GAA) deficiency. Patients display a spectrum of phenotypes ranging from the severe, rapidly progressive infantile-onset PD (IOPD) form to the slower progressing late-onset PD (LOPD). Enzyme replacement therapies (ERTs) are the only approved treatments; they decrease mortality in IOPD while maintaining or improving motor and respiratory function in LOPD.

Mortality After Cerebral Venous Thrombosis.

Objectives: Cerebral venous thrombosis (CVT) has historically had a poor prognosis, but advances in diagnosis and treatment may have improved outcomes. This study evaluated mortality rates, causes of death, and predictors of early and late mortality in CVT using international data.

Methods: In this multicenter cohort study, we analyzed data from adults with CVT enrolled between 1995 and 2021.

Deciphering the role of the lncRNA TRIBAL in hepatocyte models.

We recently reported that the long non-coding RNA TRIBAL/TRIB1AL was required to sustain key hepatocyte functions. Here, we identify HepaRG cells as a model for studying TRIBAL and provide additional validation and functional insights. In contrast to HepG2 and HuH-7 cells, differentiated HepaRG cells showed similarities to primary hepatocytes in response to TRIBAL suppression.

Evaluating photoplethysmography-based pulsewave parameters and composite scores for assessment of cardiac function: A comparison with echocardiography.

Introduction: This study assesses the utility of photoplethysmography (PPG) as a non-invasive method to evaluate cardiac function, addressing the critical need for accessible biomarkers in various cardiovascular conditions, including heart failure management.

Methods: By conducting simultaneous echocardiography and PPG measurements on 37 healthy volunteers, we analyzed both traditional and novel composite pulse wave scores to correlate peripheral PPG data with central echocardiographic outcomes.

Results: Our results show a good correlation between PPG-based and echocardiography-derived ejection times (r = 0.

Impact of transcatheter aortic valve implantation on retinal hemodynamics: a Doppler imaging study.

Objectives: After transcatheter aortic valve implantation (TAVI), various hemodynamic alterations occur due to increased cardiac output, which may influence retinal blood flow. This study aimed to evaluate the impact of TAVI on retinal artery dynamics by measuring Doppler parameters before and after the procedure.

Methods: In this prospective, single-centre study, patients scheduled for TAVI were evaluated using retinal Doppler within one week before TAVI, on the first postoperative day, and at one month post-procedure.

The transcriptional regulation of NUPR1 expression by MYC is implicated in the regulation of ferroptosis in human spermatogonial stem cells.

Non-obstructive azoospermia (NOA) is a leading cause of male infertility, characterized by impaired spermatogenesis. Recent studies suggest that ferroptosis, an iron-dependent form of cell death, may contribute to testicular dysfunction, however, its role in NOA remains underexplored. In this study, we investigated the roles of NUPR1 and MYC in regulating ferroptosis in human spermatogonial stem cells (SSCs) and evaluated their potential as therapeutic targets for NOA.

Defining the analytical characteristics of a novel high-sensitivity point-of-care troponin I assay in its intended clinical environment.

Objectives: To assess the imprecision and stability of the point-of-care troponin I assay in the Emergency Department and its correlation and bias to two central laboratory troponin I assays (Siemens Atellica and Abbott Alinity).

Methods: Imprecision and stability testing was performed on opportunistically selected samples using whole blood in the emergency department by non-laboratory trained personnel. Assay comparisons were undertaken on samples taken from participants of the Mersey Acute Coronary syndrome Rule Out Study.

Electrochemical Conversion of Methane to C Hydrocarbons and Hydrogen.

Catalytic methane (CH) upgrading to C products has attracted widespread interest. However, non-oxidative coupling and oxidative coupling of CH are limited by coking and over-oxidation, respectively. In this work, we propose an efficient and stable CH conversion system in a solid oxide steam electrolyzer, enabling the simultaneous production of C hydrocarbons and H.

Modelling silica using MACE-MP machine learnt interatomic potentials.

Silica polymorphs and zeolites are fundamental to a wide range of mineralogical and industrial applications owing to their diverse structural characteristics and thermodynamic and mechanical stability under varying conditions. Computational modelling has played a crucial role in understanding the relationship between the structure and functionality of silicas and silicates, including zeolites. In this study, we apply the MACE machine learnt interatomic potentials (MACE MP) to model the framework energies of siliceous zeolites and examine the phase transitions of silica and silicalite polymorphs under high-pressure conditions.

TASK2-Inspired pH-Gating Polymeric Nanochannels with Multiple Interconvertible Permeability States by Synergistic Regulation of Conformation and Charge.

Biological ion channels can regulate finely the ion transmembrane permeation, with superhigh ion selectivity and on-off ion flux in response to external stimuli, for signal transduction and energy conversion. However, fabricating smart artificial nanochannels with analogous functions remain challenging by single design of structure or charge property. In vivo, function basis of pH-gated TWIK-related acid-sensitive K channel 2 (TASK2) channels is attributed to synergy control of geometrical conformation and surface potential for filter gates.

Associations between genetic predisposition to mental health problems and academic achievement: a developmental perspective using two population-based cohorts.

Background: Children's cognitive abilities play an important role throughout their academic career, but recent studies highlight the negative impacts of aggression, inattention, and impulsivity on academic success. These behaviors and traits are central to most externalizing (EXT) and neurodevelopmental (NDD) problems, which are substantially genetically influenced. We examined the mechanisms by which high levels of genetic predispositions to EXT and NDD problems associate with elevated mental health symptoms and subsequently lead to lower levels of academic achievement in two developmental periods (i.

Quasi-Homogeneous Photocatalytic C─H Functionalization Enabled by Donor-Acceptor Microporous Polymer Aerogels Featuring Ultralong-Lived and Long-Range Excitons.

Simultaneous promotion of charge and mass transportation between catalytic centers and reactants is crucial for photocatalysis but remains a substantial challenge on account of the widespread use of homogeneous or heterogeneous photocatalysts that suffer from sluggish reactant-diffusion kinetics or interfacial electron-transport resistance, respectively. Herein, we demonstrate the construction of conjugated microporous polymer aerogels as available quasi-homogeneous photocatalysts by integrating structural designability, which allows for the incorporation of electron-acceptor building blocks featuring ultralong-lived excitons as high-concentration local catalytic centers, and hierarchically porous gel networks that wrap solvent and reactants to provide a "single" reaction phase without interfacial resistance. A total of 18 samples of C─H functionalization reactions underpinned by four different mechanisms were screened to showcase the general applicability of the obtained aerogel photocatalysts, which achieved remarkable conversion efficiencies, gram-scale productivities, and recyclability.

Sex Differences in the Association Between Physical Functioning and Cognition in Two Central European Populations.

Background: Evidence on the relationship between physical and cognitive functions remains inconsistent, and the role of sex differences is underexplored. This study examines the predictive value of a composite Physical Functioning Score (PFS) for cognitive function and assesses sex-specific associations in an Eastern European population.

Methods: Data from 7309 participants (mean age 59 ± 7.

Descriptions of Spirituality among the American Public: The Relationship between Spiritual Salience and Specific Spiritual Understandings.

Social work's ethical and professional standards underscore the importance of engaging spirituality in practice settings, but relatively little research has appeared in the profession's literature equipping practitioners to address client spirituality. To alleviate this gap, this nationally representative study determined (a) the prevalence of 14 different understandings or descriptions of spirituality among American adults and (b) the relationship between the self-ascribed salience or importance of spirituality (and religion) and specific understandings of spirituality. The most widely endorsed description of what spirituality offered respondents was peace (65.

Apixaban and Recurrent Stroke Risk With Left Ventricular Dysfunction: A Secondary Analysis of the ARCADIA Trial.

Background: Major uncertainty remains about the relationship between left ventricular (LV) systolic dysfunction, recurrent stroke, and the optimal antithrombotic therapy for secondary stroke prevention in patients with recent stroke and LV systolic dysfunction.

Methods: We performed a post hoc analysis of data from the ARCADIA trial (Atrial Cardiopathy and Antithrombotic Drugs in Prevention After Cryptogenic Stroke), a randomized trial comparing apixaban versus aspirin for secondary stroke prevention in patients with cryptogenic stroke and atrial cardiopathy. Echocardiograms were sent from 185 enrolling sites in the United States and Canada for central review at the trial echocardiography laboratory.

The Kick Inside: time-resolved mechanistic insights into the DUV-driven interconversion of pyrazole to imidazole.

The interconversion of aromatic heterocyclic molecules photochemical scaffold-hopping provides a clean and efficient formation route to otherwise synthetically challenging targets. The interconversion between pyrazole and imidazole is a widely used example in materials science and biochemical applications with arrow-pushing mechanisms used to define the reaction path. To study the photochemically driven isomerisation of pyrazole to imidazole, we combine femtosecond time-resolved photoelectron spectroscopy experiments with electronic structure calculations.

Origin and Suppression of Intragranular Cracks for Long-Cycling High-Ni Co-Free Cathodes.

Intragranular cracks have been identified as a direct reflection of failure in high-energy-density cathodes, especially for high-Ni Co-free cathodes with severe electrochemical-mechanical degradation. Here we show that antiphase boundaries (APBs) are prone to form in high-Ni Co-free cathodes and demonstrate their crucial role in determining the formation of intragranular cracks. The results show that the APBs grain boundaries are continuously expand during the electrochemical process, and their presence promotes the formation and accumulation of heterogeneous internal stresses within the layered structure, which in turn facilitates the nucleation and expansion of intragranular cracks.