Effect-based and (non-)target chemical analyses reveal concerning levels of emerging contaminants in urban streams in Sub-Saharan Africa.

Water contamination by micropollutants is a global issue, yet there is limited information from low-income regions. To address this, we evaluated surface water quality in rapidly growing Sub-Saharan area of Malawi lacking wastewater treatment. Integrated assessment of passive sample extracts representing wet and dry seasons combined effect-based approach with in vitro bioassays, target and non-target chemical analyses (NTS).

[Scrotal myiasis imported from Ecuador: case report and summary of current knowledge].

Myiasis is a parasitic infestation caused by the larvae of dipteran flies, affecting living or necrotic tissues in humans and animals. It is classified into obligatory and facultative forms, depending on the relationship between the parasite and the host. Clinically, myiasis may present as cutaneous, wound, cavity, intestinal, urogenital, or blood-feeding larval infestations.

[Conditions mimicking acute bacterial skin and soft tissue infections].

Acute bacterial skin and soft tissue infections represent a common clinical problem, and accurate diagnosis is crucial for initiating appropriate therapy. However, conditions such as cellulitis and erysipelas can be clinically mimicked by a variety of non-infectious conditions, including eczematous, venous, lymphatic, and autoimmune diseases. This review summarizes the key differences in clinical presentation, patient history, and laboratory findings that help distinguish true infections from their non-infectious mimickers.

Many plants naturalized as aliens abroad have also become more common within their native regions.

Due to anthropogenic pressure some species have declined whereas others have increased within their native ranges. Simultaneously, many species introduced by humans have established self-sustaining populations elsewhere (i.e.

In-cell NMR spectroscopy of nucleic acids: Basic concepts, practical aspects, and applications.

In-cell NMR spectroscopy has recently emerged as a unique source of atomically resolved information on the structure, dynamics, and interactions of nucleic acids (NAs) within the intracellular space of living cells. Its recent applications have helped reveal fundamental differences in the behaviour of NAs in cells compared to the in vitro conditions commonly used for their study, as well as in physiologically distinct cellular states. This review covers the fundamental principles and practical aspects of acquiring in-cell NMR data in currently established eukaryotic cellular models, Xenopus laevis oocytes, and human cells.

Symmetry and Asymmetry of Heart Rate Changes.

Heart rate belongs to the most essential clinical indices assessed in virtually every patient. It is also well known, although certainly not so widely utilized, that in addition to the mean frequency of cardiac periods, their variability provides further clinical indicators. The predictive value of low heart rate variability (HRV) is nothing new.

Haemodynamic-energetic mechanism of sudden cardiac death in severe aortic stenosis: A modelling study.

Severe aortic stenosis (AS) is a recognized risk factor for sudden cardiac death (SCD). Although ventricular tachyarrhythmias are the most common immediate cause of SCD, the majority of cases of SCD in patients with severe AS exhibited bradyarrhythmia as the primary rhythm. Enhanced activation of left ventricular baroreceptors (Bezold-Jarisch reflex) has been implicated in the pathogenesis of syncope in patients with AS.

Same parasite, diverging fates: distinct responses of tenrecs to Angiostrongylus cantonensis infection.

Tenrecs (Afrosoricida: Tenrecidae) are insectivorous mammals endemic to Madagascar, currently facing population declines due to habitat loss and subsistence hunting. Emerging infectious diseases, including parasitic infections, may pose additional threats. A comparable situation has been observed in Algerian hedgehogs (Atelerix algirus) in Mallorca, where the invasive nematode Angiostrongylus cantonensis has been associated with severe neuropathology.

The influence of altered lower-limb muscle strength on dynamic plantar pressure distribution in participants who underwent anterior cruciate ligament reconstruction.

Introduction: Deficits in lower-limb muscle strength and altered gait mechanics are common after anterior cruciate ligament reconstruction (ACL). While isokinetic strength testing is widely accepted in return-to-sport assessment, the role of plantar pressure analysis in detecting compensatory gait strategies remains underexplored.

Methods: This study included 10 male patients (30.

Contrasting pattern of subtelomeric satellites in the Cannabaceae family.

Introduction: Satellite DNA (satDNA) is a rapidly evolving component of plant genomes, typically found in (peri)centromeric, (sub)telomeric, and other heterochromatic regions. Due to their variability and species- or population-specific distribution, satDNA serves as valuable cytogenetic markers for studying chromosomal rearrangements and karyotype evolution among closely related species. Previous studies have identified species-specific subtelomeric repeats CS-1 in , HSR1 in , and HJSR in .

Integrative taxonomy reveals Parakaliella harimensis (Pilsbry, 1901) as a distinct East Asian Euconulus species with deep genetic structure.

The remarkable phenotypic plasticity of land snail shells often results in convergent evolution, leading to frequent taxonomic misidentifications and non-monophyletic classifications. The taxonomy of the Holarctic micro land snails related to Euconulus fulvus has been particularly challenging to resolve. This study integrates mitochondrial and nuclear DNA phylogenetics, geometric morphometrics, and climate suitability modeling to clarify the phylogenetic and taxonomic status of an East Asian lineage within this group.

Development of EPUAP pressure ulcer e-Learning to improve knowledge in pressure ulcer/injury management.

Education for health professionals has changed significantly over the last decade due to technological advancements, the increased demand for remote education and computerisation, as well as due to the potential likelihood of remote teaching in the event of future major emergencies (e.g. a pandemic).

Blood and cerebrospinal fluid metallomics uncover mercury, chromium, and iron alterations in Parkinson's disease.

BackgroundGiven the increasing global prevalence of Parkinson's disease (PD) and its complex etiopathogenesis, understanding the role of environmental factors is crucial. Prior investigations suggested a potential link between metal exposure and PD, yet conflicting results emerged.ObjectiveTo identify differences in metal concentrations in whole blood and cerebrospinal fluid (CSF) in PD patients compared to controls.

Hypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies.

Retroelements in the human genome are silenced via multiple mechanisms, including DNA methylation, to prevent their potential mutagenic effect. Retroelement activity, demonstrated by their expression and somatic retrotransposition events, was shown to be deregulated in multiple tumors but not yet in leukemia. We hypothesized that treatment with hypomethylating agents, commonly used in myelodysplastic syndromes and acute myeloid leukemia, could lead to increased retroelement activity and somatic retrotranspositions, thus contributing to disease progression.

Serum vitamin D levels in patients with lung metastases.

Background And Aim: Vitamin D deficiency is linked to increased cancer risk and death but the effect of vitamin D substitution on the prognosis of patients with malignant disease is debatable. We aimed to investigate the value of serum vitamin D3 levels in patients with a history of malignancy and confirmed lung metastases.

Materials And Method: Serum Vitamin D2 (25-hydroxyergokalciferol) and D3 (25‑hydroxycholekalciferol) levels were measured in 38 patients (28 with and 10 without lung metastases) using high performance liquid chromatography (HPLC).

The lab-field continuum in conservation physiology research: leveraging multiple approaches to inform policy and practice.

In the field of conservation physiology, there is often a trade off between conducting research in controlled laboratory settings or in inherently variable field environments. However, this belief sets up a false dichotomy where laboratory experiments are perceived as providing precise, mechanistic understanding with low variability at the cost of environmental realism while field studies are ecologically relevant but criticized for generating inconsistent evidence that is difficult to interpret and replicate. Despite the perceived binary view, these approaches are not in opposition to one another, but rather form a continuum along increasing ecological complexity.

Ancient genomes provide evidence of demographic shift to Slavic-associated groups in Moravia.

Background: The Slavs are a major ethnolinguistic group of Europe, yet the process that led to their formation remains disputed. As of the sixth century CE, people supposedly belonging to the Slavs populated the space between the Avar Khaganate in the Carpathian Basin, the Merovingian Frankish Empire to the West and the Balkan Peninsula to the South. Proposed theories to explain those events are, however, conceptually incompatible, as some invoke major population movements while others stress the continuity of local populations.

Ancient DNA connects large-scale migration with the spread of Slavs.

The second half of the first millennium CE in Central and Eastern Europe was accompanied by fundamental cultural and political transformations. This period of change is commonly associated with the appearance of the Slavs, which is supported by textual evidence and coincides with the emergence of similar archaeological horizons. However, so far there has been no consensus on whether this archaeological horizon spread by migration, Slavicisation or a combination of both.

MOLEonline: a web-based tool for analysing channels, tunnels and pores (2025 update).

Summary: MOLEonline is an interactive, web-based tool designed to detect and analyse channels (pores and tunnels) within protein structures. The latest version of MOLEonline addresses the limitations of its predecessor by integrating the Mol* viewer for visualisation and offering a streamlined, fully interactive user experience. The new features include colouring tunnels in the 3D viewer based on their physicochemical properties.

Differential MRI atrophy profiles and incident dementia: A cross-national comparison.

BackgroundAlzheimer's disease (AD) is a progressive neurodegenerative disorder with extensive neuropathological and clinical heterogeneity.ObjectiveWe assessed empirically derived brain atrophy profiles in relation to incident AD dementia.MethodsA secondary data analysis of two prospective cohort studies was conducted, including participants without dementia from the Alzheimer's Disease Neuroimaging Initiative (ADNI;  = 1703) and the Czech Brain Aging Study (CBAS;  = 385).

Impact of myotomy length on per-oral endoscopic myotomy (POEM) outcomes for achalasia: a meta-analysis of randomized trials.

Introduction: Peroral endoscopic myotomy (POEM) has been established as a safe and effective intervention for Type I and II achalasia. Studies have shown that short POEM is non-inferior to long POEM, with some evidence of decreased incidence of gastroesophageal reflux disease (GERD). This meta-analysis aims to systematically review and analyze randomized controlled trials (RCTs) data comparing clinical and safety outcomes for long and short POEM procedures while further investigating differences in GERD and other long-term clinical outcomes.

The Indo-European Cognate Relationships dataset.

The Indo-European Cognate Relationships (IE-CoR) dataset is an open-access relational dataset showing how related, inherited words ('cognates') pattern across 160 languages of the Indo-European family. IE-CoR is intended as a benchmark dataset for computational research into the evolution of the Indo-European languages. It is structured around 170 reference meanings in core lexicon, and contains 25731 lexeme entries, analysed into 4981 cognate sets.

Carfilzomib-specific proteasome β5/β2 inhibition drives cardiotoxicity via remodeling of protein homeostasis and the renin-angiotensin-system.

Compared to bortezomib treatment, multiple myeloma (MM) treatment with the proteasome inhibitor carfilzomib is associated with a higher incidence of cardiovascular adverse events. However, the mechanism underlying such cardiopathogenic side effects in MM patients remains elusive. Here, we show that carfilzomib-specific proteasome inhibition profoundly impairs cardiomyocyte contractility.

Conditional Protein Structure Generation with Protpardelle-1c.

We present Protpardelle-1c, a collection of protein structure generative models with robust motif scaffolding and support for multi-chain complex generation under hotspot-conditioning. Enabling sidechain-conditioning to a backbone-only model increased Protpardelle-1c's MotifBench score from 4.97 to 28.