Impact of myotomy length on per-oral endoscopic myotomy (POEM) outcomes for achalasia: a meta-analysis of randomized trials.

Introduction: Peroral endoscopic myotomy (POEM) has been established as a safe and effective intervention for Type I and II achalasia. Studies have shown that short POEM is non-inferior to long POEM, with some evidence of decreased incidence of gastroesophageal reflux disease (GERD). This meta-analysis aims to systematically review and analyze randomized controlled trials (RCTs) data comparing clinical and safety outcomes for long and short POEM procedures while further investigating differences in GERD and other long-term clinical outcomes.

Proficiency in Esophageal Peroral Endoscopic Myotomy: A Meta-Analysis of Learning Curves.

Introduction: Our analysis examines the learning curve of peroral endoscopic myotomy (POEM) training using procedure duration as a key indicator of proficiency.

Methods: We searched PubMed, Embase, Cochrane, and Web of Science from inception until November 2024 for studies evaluating the learning curve of POEM. We divided the data into 0-20, 20-40, and 40-60 cumulative procedure phases of learning.

Performance, Efficacy, and Safety of Lubiprostone in Bowel Preparation Regimens: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Introduction: Bowel preparation is an essential part of the colonoscopy process, with inadequate or poor bowel preparation associated with decreased polyp detection. We performed a systematic review and meta-analysis to investigate the effects of adjunct lubiprostone bowel prep on colonoscopies performance.

Methods: We conducted a comprehensive search in PubMed, Embase, Cochrane, and Web of Science from inception until February 2025 for RCTs comparing lubiprostone adjunct therapy, bowel prep and control.