Development of EPUAP pressure ulcer e-Learning to improve knowledge in pressure ulcer/injury management.

Education for health professionals has changed significantly over the last decade due to technological advancements, the increased demand for remote education and computerisation, as well as due to the potential likelihood of remote teaching in the event of future major emergencies (e.g. a pandemic).

The use of parenteral application of ferric carboxymaltose in the prevention of iron deficiency anaemia in suckling piglets.

This study aimed to evaluate the effectiveness of ferric carboxymaltose injection in the prevention of anaemia in suckling piglets. In group A ( = 8), piglets were administered iron in the form of iron carboxymaltose complex (Ferinject) at a dose of 200 mg i.m.

Impact of concomitant use of proton pump inhibitors or cardiovascular medication on survival outcomes of patients with metastatic renal cell carcinoma treated with nivolumab.

Renal cell cancer (RCC) is typically a disease of older adults, who often have comorbidities requiring the use of multiple concomitant medications. Even though the patients with metastatic RCC (mRCC) are often exposed to concomitant medications in parallel with anticancer agents, the impact of such co-medications remains insufficiently explored. The aim of this study was to investigate the impact of the use of proton pump inhibitors (PPIs) and/or cardiovascular medication on the outcomes of patients with mRCC receiving nivolumab.

Quantitative magnetic resonance imaging parameters of lumbar paraspinal muscles and their relationship to function and ageing in healthy subjects.

Muscle ageing involves structural and functional changes of muscles, mainly their replacement by fatty and fibrous tissue accompanied by the loss of muscle function. Quantitative magnetic resonance imaging (qMRI) methods have potential to provide biomarkers of degenerative changes in muscles with ageing. To assess the relationship between qMRI parameters of lumbar paraspinal muscles (LPMs) and their function and evolution with ageing in healthy subjects, 90 volunteers underwent MRI of lumbar spine and LPM utilising a 6-point Dixon gradient echo sequence.

Sentinel lymph node biopsy without systematic pelvic lymphadenectomy in females with early-stage cervical cancer: final outcome of the SENTIX prospective, single-arm, noninferiority, international trial.

Sentinel lymph node (SLN) biopsy with ultrastaging is standard in endometrial and vulvar cancers, whereas systematic pelvic lymphadenectomy (PLND) remains recommended in cervical cancer. The SENTIX trial prospectively evaluated the safety of SLN biopsy without PLND in early-stage cervical cancer. Female patients, International Federation of Gynaecology and Obstetrics 2018 stage IA1/LVSI+ to IB2 disease, were enrolled between 2016 and 2020 across 47 sites in 18 countries.

Catheter Ablation vs Lifestyle Modification With Antiarrhythmic Drugs to Treat Atrial Fibrillation: PRAGUE-25 Trial.

Background: Obesity is an important risk factor for atrial fibrillation (AF). Nonrandomized studies have shown that weight loss and increased physical activity are associated with AF reduction.

Objectives: The goal of this study was to assess whether treatment based on lifestyle modification (LFM; directed weight loss and physical exercise) in combination with antiarrhythmic drugs (AADs) is noninferior to catheter ablation (CA) in patients with AF and obesity.

Perioperative temperature management and coagulation: effects of mild hypothermia in a prospective study.

Background: Perioperative hypothermia is a common complication of general and regional anesthesia in children and is a known risk factor for the development of coagulation disorders. The primary aim of the study was to assess the occurrence of coagulopathy in hypothermic pediatric patients (0-18 years) undergoing arthroscopic surgery and open abdominal surgery. The secondary objective was to identify potential risk factors for the development of both hypothermia and coagulopathy.

Cabozantinib in the First-Line Treatment of Patients With Metastatic Renal Cell Carcinoma, Real-World Data From the Czech Republic and Poland: ICARO-RC Project.

Introduction: The treatment of metastatic renal cell carcinoma (RCC) has changed dramatically in the last few years, with different options being available, and with no data comparing these new systemic therapies. Therefore, the value of real-world outcomes (RWO) becomes of great interest to understand the effectiveness of these treatments. Here we analyze the outcome of metastatic RCC patients treated with first-line cabozantinib in a retrospective cohort from the Czech Republic and Poland METHODS: Patients with metastatic RCC treated with first-line cabozantinib in the Czech Republic and Poland were included in a retrospective fashion.

Cost-Effectiveness Analysis of Universal Screening for Subclinical Hypothyroidism in Pregnancy Based on the Czech Nation-Wide Pilot Screening Program in Light of Current Evidence.

Objectives: In 2023, the Czech Guideline by Endocrinology society introduced universal screening of thyrotropin (TSH) in the first trimester of pregnancy. We modeled the incremental cost-effectiveness ratio (ICER), budget impact (BI), and new endocrinology referrals (ER) for universal screening of (1) TSH for subclinical hypothyroidism compared with the current testing and (2) extension to anti-thyroid peroxidase antibodies (anti-TPO).

Methods: A decision tree was built assuming that levothyroxine reduces the risks of gestational hypertension, miscarriage, and preterm birth and anti-TPO test improves diagnosis of postpartum thyroiditis.

The impact of cardiogenic shock and out-of-hospital cardiac arrest on the outcome of acute myocardial infarction: a national-level analysis.

Cardiogenic shock (CS) and out-of-hospital cardiac arrest (OHCA) are events with profound implications for patient outcomes. We aim to analyze the predictors of CS and OHCA in patients with acute myocardial infarction and their effects on mortality. The analysis is based on data from a national registry between 2016 and 2020.

Informing prostate cancer screening policy makers in the European Union: lessons from cancer screening governance and policymaking.

Prostate cancer (PCa) poses a significant global health threat, with high incidence and mortality rates. In 2022, the Council of the European Union (EU) updated its screening recommendations, prioritizing PCa screening. This signals a crucial step towards establishing new early detection programmes in EU member states.

Association of the IL-6R rs2228145 polymorphism with diabetic nephropathy: A case-control study.

Introduction: The pathogenesis of diabetes mellitus (DM) and its complications has been previously linked to elevated levels of interleukin-6 (IL-6); IL-6 triggers intracellular pathways through interaction with the IL-6 receptor (IL-6R). This study aimed to determine the association of single nucleotide polymorphisms (SNPs) IL-6 -597G/A (rs1800797), -572G/C (rs1800796), -174G/C (rs1800795), its receptor (IL-6R) Asp358Ala (+48892A/C, rs2228145) and DM or its complications in the Czech population.

Materials And Methods: In total, 669 subjects participated in this case-control study, including 167 controls, 119 patients with type 1 DM (T1DM), and 383 patients with type 2 DM (T2DM).

Economic evaluations of interventions for the prevention and treatment of pressure ulcers: an umbrella review.

Objective: The objective of this review was to summarize the systematic review findings of economic evaluations to prevent or treat pressure ulcers.

Introduction: Pressure ulcers/injuries are one of the most common preventive complications characterized by local tissue injury. Pressure ulcers increase the mortality rate, impair quality of life, prolong the length of hospital stay, increase the cost of treatments, and alter general health outcomes.

Epidemiology and healthcare utilization in motor neuron disease in Czechia.

The demographic and epidemiological profile of motor neuron disease (MND) in Czechia remains unknown, highlighting a critical gap; this study aims to examine the epidemiology of MND using population-based data. We conducted a 10-year retrospective study (2012-2022) to analyze prevalence, incidence, mortality, and healthcare utilization, including Riluzole treatment and multidisciplinary care. Our epidemiological findings were compared with the Global Burden of Disease estimates to highlight the importance of real-world data.

The impact of pre-existing aortic stenosis and mitral regurgitation on patients with acute myocardial infarction.

The prevalence of left-sided valvular heart disease (VHD) increases with age, but data on the impact of pre-existing VHD in patients with acute myocardial infarction (AMI) are limited. We aimed to define the clinical characteristics and outcomes of AMI patients with pre-existing left VHD. The analysis is based on data from three merged national registries.

Multimodal prehabilitation before lung resection surgery: a multicentre randomised controlled trial.

Background: Respiratory muscle training may improve ventilatory efficiency (V/VCO slope), a strong predictor of postoperative pulmonary complications. We hypothesised that multimodal prehabilitation, incorporating high-intensity respiratory muscle training, before lung resection would reduce postoperative complications and length of hospital stay.

Methods: We conducted a prospective multicentre, randomised controlled trial (NCT04826575) to examine the effect of prehabilitation in individuals undergoing lung resection.

Serum Creatine Kinase and Transaminase Levels in Duchenne and Becker Muscular Dystrophies.

Introduction/aims: The distinction between hepatic and muscular origin of transaminases in Duchenne (DMD) and Becker (BMD) muscular dystrophy is challenging. We aimed to describe the relations between creatine kinase (CK), lactate dehydrogenase (LDH), myoglobin, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyltransferase (GGT), and their evolution with age, the severity of the disease, and its complications (corticosteroid therapy, cardiac ejection fraction, body mass index [BMI]).

Methods: Multiple regression analysis of the studied markers was performed in three cohorts: 1.

Effect of Treatment with Mucoactive Drugs on COPD Exacerbations During 5 years of Follow-up in the Czech Republic: A Real-World Study.

Introduction: Studies indicate that chronic treatment with mucoactive drugs may reduce COPD exacerbation rates. This real-world, multicenter, prospective, observational study aimed to determine the effect of long-term mucoactive treatment on exacerbations in patients with COPD in the Czech Republic.

Methods: 452 adult patients on the Czech Multicenter Research Database of COPD with post-bronchodilator FEV ≤ 60% of predicted value received standard of care and were followed up for 5 years.

ProstaPilot: A Comparative Study of Biparametric Magnetic Resonance Imaging Versus Prostate-specific Antigen as a Screening Test for Prostate Cancer.

Background And Objective: Our aim was to compare detection rates for clinically significant prostate cancer (csPC) between biparametric magnetic resonance imaging (bpMRI) and prostate-specific antigen (PSA) screening pathways in the Czech population, which has a high prevalence of opportunistic PSA testing (45% in the target age group).

Methods: Between May 2022 and May 2023, 423 men aged 50-69 yr who were enrolled via volunteer-based recruitment, underwent both PSA testing and bpMRI of the prostate. Positive results were defined as PSA ≥3 μg/l or a Prostate Imaging-Reporting and Data System score of 4-5.

Ultrasound examiners' ability to describe ovarian cancer spread using preacquired ultrasound videoclips from a selected patient sample with high prevalence of cancer spread.

Objectives: To assess the ability, as well as factors affecting the ability, of ultrasound examiners with different levels of ultrasound experience to detect correctly infiltration of ovarian cancer in predefined anatomical locations, and to evaluate the inter-rater agreement regarding the presence or absence of cancer infiltration, using preacquired ultrasound videoclips obtained in a selected patient sample with a high prevalence of cancer spread.

Methods: This study forms part of the Imaging Study in Advanced ovArian Cancer multicenter observational study (NCT03808792). Ultrasound videoclips showing assessment of infiltration of ovarian cancer were obtained by the principal investigator (an ultrasound expert, who did not participate in rating) at 19 predefined anatomical sites in the abdomen and pelvis, including five sites that, if infiltrated, would indicate tumor non-resectability.

Increasing the rates of pre-operative stoma site marking in patients with intestinal ostomy (INSTOSI): a best practice implementation project.

Introduction: Pre-operative stoma site marking is a strongly recommended practice for preventing complications and improving the health-related quality of life of intestinal stoma patients. Despite its benefits, this practice is not routinely implemented in clinical practice.

Objectives: This study aimed to increase the rate of pre-operative stoma site marking.

Predictors for sentinel lymph node mapping failure using indocyanine green injection in apparent early stages of endometrial cancer: A single-center prospective study.

Objective: The current study aimed to analyze predictive factors of sentinel lymph node mapping failure in apparently early stages of endometrial cancer using intracervical indocyanine green injection.

Methods: A single-center prospective study was conducted between June 2019 and August 2023 at the Department of Gynecology and Obstetrics, University Hospital Brno, Czech Republic. All patients with apparently early stage (I or II according to FIGO [International Federation of Gynecology & Obstetrics] 2009) endometrial cancer, who were indicated for sentinel node biopsy were consecutively included.

Pelvic floor muscle training during the childbirth period: a best practice implementation project.

Introduction: In the UK, the Royal College of Midwives and the Chartered Society for Physiotherapy advocate that women undertake early and effective pelvic floor muscle training (PFMT) during the childbirth period to reduce the incidence of urinary incontinence (UI).

Objectives: This project sought to assess and improve midwives' compliance with best practice recommendations for PFMT in a UK NHS maternity service, with the goal of improving PFMT for women.

Methods: This project used the JBI Evidence Implementation Framework and JBI's best practice recommendations for PFMT.

Magnetic resonance imaging and ultrasound examination in preoperative pelvic staging of early-stage cervical cancer: post-hoc analysis of SENTIX study.

Objectives: SENTIX was a prospective, single-arm, international multicenter study that evaluated sentinel lymph node biopsy without pelvic lymph node dissection in patients with early-stage cervical cancer. We aimed to evaluate the concordance between preoperative imaging modalities (magnetic resonance imaging (MRI) and ultrasound) and final pathology in the clinical staging of early-stage cervical cancer by post-hoc analysis of the SENTIX study data.

Methods: In total, 47 sites across 18 countries participated in the SENTIX study.