Pan-cancer analysis of tumor suppressor ZNF132 reveals its diagnostic and prognostic significance with immunomodulatory implications in colorectal cancer.

Background: Zinc finger protein 132 (ZNF132) has emerged as a potential tumor suppressor, with its dysregulation closely associated with the initiation and progression of various malignancies. However, a comprehensive assessment of ZNF132's expression patterns across diverse cancer types, its clinical prognostic implications, and its immunoregulatory role in colorectal cancer remains insufficiently characterized. This study aims to elucidate the biological functions of ZNF132 within the context of colorectal cancer.

Research on concept generation design of automobile seats based on human-machine co-creation.

This study aims to develop a human-machine co-creation framework for automobile seat conceptual design, leveraging an improved Deep Convolutional Generative Adversarial Network (ResNet-DCGAN) to lower design barriers for non-professionals and enhance cross-disciplinary innovation. By constructing a dataset of automobile seat images and implementing generative design strategies across three key stages, this research seeks to demonstrate the feasibility of AI-driven creativity augmentation in product design. The cooperation of human-machine co-creation can stimulate the innovative thinking of participants from different industries, reduce the design difficulty, arouse participants' enthusiasm, and provide abundant creativity in designing automobile seats.

Spatial disparities of population aging in Shenzhen: from China's Hukou perspective.

Objective: As China's youngest city with immigrants constituting 66% of its population, Shenzhen is paradoxically facing accelerated and compressed demographic aging. Although its overall aging rate remains below the international aging society threshold, the city confronts unique challenges as a migrant receiving metropolis without domestic precedents. Through a novel perspective of the Hukou system (i.

Haplotype-resolved, gap-free genome assemblies provide insights into the divergence between Asian and European pears.

Pears (Pyrus spp.) are self-incompatible crops with broad genetic diversity. High heterozygosity and technical limitations result in gaps within reference genomes.

Construction of a co-reaction system for ethanol-promoted gamma-aminobutyric acid synthesis by Pediococcus pentosaceus.

The biotransformation of L-glutamic acid (L-Glu) to γ-aminobutyric acid (GABA) using glutamate decarboxylase (GAD) in microbial whole cells represents an ideal approach for biosynthesis of food-grade and pharmaceutical-grade GABA. To overcome the cell membrane barrier, enhance mass transfer efficiency in the whole-cell reaction system, and improve GABA biosynthesis efficiency, we established a novel ethanol-enhanced whole-cell biocatalytic co-reaction system through systematic investigations on the enzymatic characteristics of GAD in Pediococcus pentosaceus whole cells and the regulatory effects mediated by ethanol. The results showed that the optimal reaction pH and temperature for GAD in P.

Advancing Myopia Management: The Therapeutic Potential of Microbiota-Targeted Interventions.

Objective: Myopia is a growing global health concern, particularly in East Asia. Recent studies suggest that ocular surface microbiota may play a key role in regulating local immune homeostasis in the eye. This study aims to investigate the relationship between ocular surface microbiota and high myopia (HM), with the goal of identifying potential microbiota targets for controlling myopia progression.

Advancements in cobalt-based oxide catalysts for soot oxidation: Enhancing catalytic performance through modification and morphology control.

The widespread use of diesel engines results in significant environmental contamination due to emitted pollutants, particularly soot particles. These pollutants are detrimental to public health. At present, one of the most effective ways to remove soot particles is the catalytic diesel particulate filter after-treatment technology, which requires the catalyst to have superior low temperature activity.

The role of PSMC4 in non-small cell lung cancer: implications for prognosis, diagnosis, and immune microenvironment modulation.

Introduction: Non-small cell lung cancer (NSCLC) remains a principal cause of cancer-related mortality. The discovery of novel biomarkers is pivotal for enhancing early diagnosis, refining prognostic evaluations, and optimizing targeted therapeutic strategies. Proteasome 26S subunit ATPase 4 (PSMC4), a proteasome subunit essential for protein degradation, influences tumor progression regulatory mechanisms.

Development of a deep-learning algorithm for etiological classification of subarachnoid hemorrhage using non-contrast CT scans.

Objectives: This study aims to develop a deep learning algorithm for differentiating aneurysmal subarachnoid hemorrhage (aSAH) from non-aneurysmal subarachnoid hemorrhage (naSAH) using non-contrast computed tomography (NCCT) scans.

Methods: This retrospective study included 618 patients diagnosed with SAH. The dataset was divided into a training and internal validation cohort (533 cases: aSAH = 305, naSAH = 228) and an external test cohort (85 cases: aSAH = 55, naSAH = 30).

Enhancement of carbon monoxide catalytic oxidation performance by co-doping silver and cerium in three-dimensionally ordered macroporous Co-based catalyst.

Carbon monoxide (CO) catalytic oxidation offers an effective solution for environmental pollutant; however, its progress is limited by sluggish kinetics, and efficient catalysts remain scarce. Herein, we prepared Ag-Ce co-doped three-dimensionally ordered macroporous (3DOM) Co-based catalysts through the synergistic approach of co-doping and morphology control, systematically investigating their CO catalytic oxidation mechanisms. The appropriate amount of Ag-Ce co-doping maintained the original 3DOM structure, promote the mass transfer and diffusion of CO, promoted the redox capacity by increasing the ratio of Co to surface reactive oxygen species (O/ O), achieving low temperature conversion of CO.

[Curcumin prevents the arsenic-induced neuroimmune injury through JAK2/STAT3 pathway].

Objective To investigate the protective effect of curcumin (Cur) against arsenic-induced neuroimmune toxicity and the underlying molecular mechanisms in vivo. Methods Eighty SPF female C57BL/6 mice were randomly assigned to four groups: a control group, an arsenic-treated group, a Cur-treated group and an arsenic+Cur group, with 20 mice in each group. The control group received distilled water; the arsenic-treated group was given 50 mg/L NaAsO in the drinking water; the Cur-treated group was gavaged with 200 mg/kg of curcumin for 45 days; and the arsenic+Cur group received distilled water and was gavaged with 200 mg/kg of curcumin.

A hemicyanine-modified upconversion nanoprobe for NIR-excited evaluating superoxide signaling in drug-induced liver injury.

Background: Drug-induced liver injury (DILI) is the most important standard for the entrance of clinical drugs into the pharmaceutical market. The elevation of superoxide anion (O) during drug metabolism can mediate apoptosis of hepatocytes and further generation of liver damage. Therefore, developing an effective imaging method for evaluating O levels during DILI is of great importance.

Dermatoscopic features of vulvar lichen sclerosus in children: A retrospective study.

Objectives: To explore the dermoscopic features of lichen sclerosus in different parts of the external genitalia in children.

Methods: A retrospective analysis of the dermoscopic features of 42 female children with vulvar lichen sclerosus treated in the Department of Dermatology of Shanxi Children's Hospital from January 2020 to May 2023.

Results: Among the 42 female children, aged 3-14 years (mean: 7.

NIR-excited imaging of drug-induced liver injury using a superoxide-activated ratiometric upconversion luminescence nanoprobe.

Drug-induced liver injury (DILI) poses a significant risk to human health. Increasing evidence indicates that the superoxide anion (O), as the precursor of the other reactive oxygen species, is key in the pathological processes associated with DILI. Nonetheless, understanding of the mechanisms of DILI is difficult due to the lack of an imaging tool for monitoring the fluctuation of O levels during the progression of DILI.

A chromosome-level genome assembly and annotation of the medicinal plant Lepidium apetalum.

Objectives: As a traditional Chinese medicine, Lepidium apetalum is commonly used for purging the lung, relieving dyspnea, alleviating edema, and has the significant pharmacological effects on cardiovascular disease, hyperlipidemia, etc. In addition, the seeds of L. apetalum are rich in unsaturated fatty acids, sterols, glucosinolates and have a variety of biological activity compounds.

Transcriptome Analysis Provides Insights into Catalpol Biosynthesis in the Medicinal Plant and the Functional Characterization of Genes.

, a member of the Scrophulariaceae family, has been widely used in traditional Chinese medicine since ancient times. The main bioactive component of is catalpol. However, the biogenesis of catalpol, especially its downstream pathway, remains unclear.

RBMS3, a downstream target of AMPK, Exerts Inhibitory Effects on Invasion and Metastasis of Lung Cancer.

Lung cancer is a highly malignant disease, primarily due to its propensity for metastasis. AMP-activated protein kinase (AMPK), the principal downstream effector of Liver Kinase B1 (LKB1), orchestrates a broad spectrum of molecular targets, thereby constraining tumor invasion and metastasis. In parallel, the RNA-binding protein RBMS3 (RNA-binding motif, single-stranded-interacting protein 3) plays a pivotal role in the epithelial-mesenchymal transition (EMT), a pivotal process in tumorigenesis.

SCG10 is required for peripheral axon maintenance and regeneration in mice.

Proper microtubule dynamics are critical for neuronal morphogenesis and functions, and their dysregulation results in neurological disorders and regeneration failure. Superior cervical ganglion-10 (SCG10, also known as stathmin-2 or STMN2) is a well-known regulator of microtubule dynamics in neurons, but its functions in the peripheral nervous system remain largely unknown. Here, we show that Scg10 knockout mice exhibit severely progressive motor and sensory dysfunctions with significant sciatic nerve myelination deficits and neuromuscular degeneration.

RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits.

RNA polymerase II (RNA Pol II) has been recognized as a passively regulated multi-subunit holoenzyme. However, the extent to which RNA Pol II subunits might be important beyond the RNA Pol II complex remains unclear. Here, fractions containing disassociated RPB3 (dRPB3) were identified by size exclusion chromatography in various cells.

Comprehensive management of post-LASIK ectasia: From prevention to treatment.

Post-laser in situ keratomileusis (post-LASIK) ectasia (PLE) is one of the most serious complications after refractive surgery, mainly manifested as progressive thinning and trembling thinning of the cornea, accompanied by increased myopia and astigmatism. The mechanisms behind mainly include genetic risk factors and external environmental factors such as eye rubbing and cornea surgery. In order to achieve the goal of reducing the incidence of ectasia, preoperative screening strategies need to be continuously improved, through the collection and assessment of genetic and environmental risk factors.

Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis Nrf2 pathway activation.

Acetaminophen (APAP)-induced liver injury (AILI) has become a growing public health problem. Ferroptosis, an iron-dependent form of cell death associated with lipid peroxide accumulation, has been recently implicated in AILI. The activation of the Nrf2 signaling pathway is a potential therapy for AILI.