Molecular Editing of Ketones Derived by Pro-aromatic of Dihydroquinazolinones.

Ketones represent a vital class of feedstock chemicals in organic synthesis. Researchers have explored a versatile deacylation strategy utilizing ketones as radical precursors, involving activation through condensation with 2-aminobenzamide to form dihydroquinazolinones (DHQZ). This aromatization-driven deconstructive reaction of ketones offers an efficient approach for the selective construction of diverse bonds, including C-H/D, C-C (sp, sp, sp), C-F, C-S/Se, C-N, and C-Si under mild conditions.

Optimizing Nitrogen Fertilizer Rate and Investigating Mechanism Driving Grain Yield Increase for Rice in the Middle Reaches of the Yangtze River.

Investigating the factors influencing rice grain yield (GY) is critical for optimizing nitrogen (N) management and enhancing resource use efficiency in rice cultivation. However, few studies have comprehensively investigated the factors affecting rice GY, considering an entire influence chain encompassing rice N uptake, growth indicators, and GY components. In this study, field experiment with six different N fertilizer rates (0, 60, 120, 180, 225, and 300 kg N ha, i.

Improvements in depression symptomatology in a sample of undergraduate students: a pre-post Balint group intervention study.

Background/objective: Previous studies have explored the effects of Balint group interventions on reducing depressive symptoms among medical workers; however, its effects on other populations have not been analyzed. This study addressed this gap by investigating whether this intervention can reduce depressive tendencies in college students and its potential mechanism.

Methods: The effects of the 6-week Balint group intervention were assessed using an experimental/control group and pre-/post-test design.

Asperustins K-P, Chlorinated Austocystins from NRRL 5856.

Asperustins K-P (-), six unreported chlorinated austocystins, were isolated from NRRL 5856. Their structures, including absolute configurations, were elucidated by extensive spectroscopic analyses, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction. Asperustin K () features an unprecedented carbon skeleton with a 6/6/6/5/5/6/6/6 fused octacyclic ring system, while asperustin L () represents a distinctive carbon skeleton with a 6/6/6/5/5/5 hexacyclic ring system.

Boundaries in the eyes: Measure event segmentation during naturalistic video watching using eye tracking.

During naturalistic information processing, individuals spontaneously segment their continuous experiences into discrete events, a phenomenon known as event segmentation. Traditional methods for assessing this process, which include subjective reports and neuroimaging techniques, often disrupt real-time segmentation or are costly and time-intensive. Our study investigated the potential of measuring event segmentation by recording and analyzing eye movements while participants viewed naturalistic videos.

Fragmentation Functions of Charged Hadrons at Next-to-Next-to-Leading Order and Constraints on the Proton Parton Distribution Functions.

We present the first global analysis of fragmentation functions for light charged hadrons (π^{±}, K^{±}) at full next-to-next-to-leading order in quantum chromodynamics, incorporating world data from both single-inclusive electron-positron annihilation and semi-inclusive deep-inelastic scattering. The collinear factorization has been tested with low-momentum-transfer data and has demonstrated success at high hadron momenta. Additionally, we study the impact of current global data on hadron production to the parton distribution functions (PDFs), and find they favor a reduced asymmetry in the strange (anti)quark PDFs, as compared to the asymmetry predicted by state-of-the-art PDFs derived from inclusive data.

Parent-Child Discrepancies in Perceived Parental Coparenting During the COVID-19 Lockdown: Associations With Chinese Adolescents' Emotional Well-Being.

Parent-child discrepancies in reports of perceived parenting behaviors are common and have been linked to adolescent mental health. However, little is known about these discrepancies for parenting behaviors involving the father-mother-child triad, such as coparenting, and their impact on adolescents' emotional well-being, especially during extraordinary circumstances such as lockdowns during the COVID-19 pandemic. This study tested a mediating model to examine whether and how discrepancy patterns are associated with depression and anxiety in adolescents through emotion regulation strategies (e.

Unveiling the impact of human activities on the coupling coordination of ecosystem functions in major grain-producing areas: A production-living-ecology perspective.

The sustainable development of major grain-producing areas necessitates a coupling coordination between ecosystem functions, while carefully considering their responses to human activities. However, our understanding of how human activities influence this coupling coordination in ecosystem functions remains limited. This study establishes an assessment framework for the coupling coordination of ecosystem functions from the production-living-ecology perspective in the Jianghan Plain (JHP), particularly by utilizing multi-source data and relevant geographic spatial models.

Detection of lumbar disc herniation and degeneration using photon-counting detector CT with virtual non-calcium imaging.

Objectives: This study aimed to compare the diagnostic performance of virtual non-calcium (VNCa) imaging using photon-counting detector CT (PCD-CT) with MRI in assessing lumbar disc herniation (LDH) and intervertebral disc degeneration (IDD).

Materials And Methods: Patients with low back pain underwent PCD-CT and MRI within 2 h. Quantitative analysis included VNCa-derived CT values and T2 relaxation times in manually placed regions of interest.

Comparative effectiveness of different exercise modality on glycaemic control and lipid profile for prediabetes: systematic review and network meta-analysis.

Background: Prediabetes is the precursor to type 2 diabetes and represents a critical, reversible window for intervention. This study aims to systematically review and conduct a network meta-analysis to evaluate the efficacy of aerobic training (AT), resistance training (RT), combined training (AT+RT), high-intensity interval training (HIIT), and traditional Chinese exercises (TCEs) on glycemic control, lipid profile, and weight management in prediabetic individuals. This marks the first time HIIT and TCEs have been included in such an assessment.

Dual-active site engineering of Co/Cu single atoms and nanoclusters on M-N-CNTs (M = Co, Cu, CoCu): Synergistic catalysis for ultrafast hydrogen production from Ammonia borane.

Progress towards a hydrogen economy depends on green and efficient ways to produce hydrogen. A promising route is the catalytic hydrolysis of ammonia borane (AB). To address challenges in catalyst performance and cost for AB hydrolysis, we developed a structurally tuned heterogeneous non-precious metal catalyst based on cobalt (Co) and copper (Cu).

Design, Synthesis, and Metabolism Studies of Triketone-Type Proherbicides for Weed Control in Rice Fields.

4-Hydroxyphenylpyruvate dioxygenase (HPPD, EC 1.13.11.

The mediating effect of quality of life between family support and advance care planning readiness of older adult patients with chronic diseases.

Objective: To investigate the mediating effect of quality of life (QoL) between family support and advance care planning (ACP) readiness among older adult patients with chronic diseases, thereby providing evidence for nursing administrators to strengthen family support and promote ACP preparedness.

Methods: From November 2024 to February 2025, a total of 262 older adult patients with chronic diseases were recruited via convenience sampling from seven tertiary hospitals located in Guangdong, Hainan, Sichuan, Heilongjiang, and Hubei provinces. Data were collected using a general information questionnaire, the EuroQoL-5 Dimension (EQ-5D-5L) scale, the Family Support Scale, and the Advance Care Planning Readiness Scale.

How parental mediation affects adolescents' problematic smartphone use: the chain mediating role of basic psychological needs and positive outcome expectations.

Purpose: Problematic smartphone use can significantly jeopardize adolescents' academic development as well as their physical and mental health. Although previous studies have explored the role of parental mediation strategies in adolescents' problematic smartphone use, the underlying mechanisms remain unclear. This study aims to investigate the relationship between parental mediation and adolescents' problematic smartphone use, with a specific focus on the chain mediation effects of basic psychological needs and positive outcome expectations.

The impact of achievement emotions on learning performance in online learning context: a meta-analysis.

Introduction: In online learning context, achievement emotions are of great significance and exert an influence on students' learning performance. However, the research conclusions about the impact of achievement emotions on learning performance are not uniform.

Methods: Following PRISMA guidelines, we searched Web of Science, Scopus, EBSCO and Google Scholar (2012-2024).

Label-Free Selective Detection of Nitrobenzene Explosives at Picomolar Sensitivity in Single-Molecule Junctions.

Developing single-molecule detection methods enables ultrasensitive identification of nitrobenzene explosives, offering groundbreaking significance in counterterrorism screening, environmental monitoring, and public safety. In this study, we demonstrate the selective and label-free detection of nitroaromatic explosives─2,4,6-trinitrotoluene (TNT), 2,4-dinitrotoluene (DNT), and 2,4,6-trinitrophenol (TNP), in single-molecule junctions using scanning tunneling microscopy break junction technique. Our findings reveal that the conductance peak areas of 4,4'-bipyridine-3-amine (Py-NH) exhibit pronounced concentration-dependent responses to nitroaromatic analytes.

Correspondence between Color Glass Condensate and High-Twist Formalism.

The color glass condensate (CGC) effective theory and the collinear factorization at high twist (HT) are two well-known frameworks describing perturbative QCD multiple scatterings in nuclear media. It has long been recognized that these two formalisms have their own domain of validity in different kinematic regions. Taking direct photon production in proton-nucleus collisions as an example, we clarify for the first time the relation between CGC and HT at the level of a physical observable.

Search for Quasiparticle Scattering in the Quark-Gluon Plasma with Jet Splittings in pp and Pb-Pb Collisions at sqrt[s_{NN}]=5.02 TeV.

The ALICE Collaboration reports measurements of the large relative transverse momentum (k_{T}) component of jet substructure in pp and Pb-Pb collisions at center-of-mass energy per nucleon pair sqrt[s_{NN}]=5.02  TeV. Enhancement in the yield of such large-k_{T} emissions in head-on Pb-Pb collisions is predicted to arise from partonic scattering with quasiparticles of the quark-gluon plasma.

Copper-Catalyzed Enantioselective ε-Site Yne-Allylic Amination.

The development of highly selective and sustainable catalytic methods for the synthesis of enantiomerically chiral amines is of great interest and importance in both the pharmaceutical and fine chemical industries. Here, we have developed a remote asymmetric copper-catalyzed ε-site yne-allylic amination of yne-allylic esters. With earth-abundant metal copper catalysts, a wide range of yne-allylic esters and aliphatic amines can be efficiently converted into highly enantioenriched chiral amines products.

Construction of the Veterinary DrugBank and Drug Repurposing.

AI-driven drug discovery relies on multiscale data integration. However, the veterinary drug development field currently lacks systematic integration of drug-disease-target information. To address this gap, we constructed the Veterinary DrugBank (https://ys.

Utilizing artificial intelligence to enhance social connections - the alleviating effect of emotionally intelligent chatbots on loneliness.

Objective: To enhance social connections using artificial intelligence and explore the alleviating effect of emotionally intelligent chatbots on loneliness.

Method: A stratified sampling method was used to distribute the Emotional Social Loneliness Inventory (ESLI) to full-time college students. Based on the ESLI assessment results, 120 young people with severe loneliness were selected as the research subjects.

Relaxation behavior near the first-order phase transition line.

Using the Metropolis algorithm, we simulate the relaxation process of the three-dimensional kinetic Ising model. Starting from a random initial configuration, we first present the average equilibration time across the entire phase boundary. It is observed that the average equilibration time increases significantly as the temperature decreases far from the critical temperature T_{c}.

Evidence for B^{-}→D^{**0}τ^{-}ν_{τ}[over ¯] Decays.

The first evidence for the decay B^{-}→D^{**0}τ^{-}ν[over ¯]_{τ} is obtained using proton-proton collision data collected by the LHCb experiment, corresponding to an integrated luminosity of 9  fb^{-1}, at centre-of-mass energies of 7, 8, and 13 TeV. Here, the D^{**0} meson represents any of the three excited charm mesons D_{1}(2420)^{0}, D_{2}^{*}(2460)^{0}, and D_{1}^{'}(2400)^{0}. The B^{-}→D^{**0}τ^{-}ν[over ¯]_{τ} signal is measured with a significance of 3.

Observation of Charmonium h_{c} Radiative Decays to Multiple Light Hadrons and the Tensor State f_{2}(1270).

Using ψ(3686)→π^{0}h_{c} decays from a data sample of (27.12±0.14)×10^{8}  ψ(3686) events collected by the BESIII detector at the BEPCII collider, h_{c} radiative decays to multiple light hadrons below 2.

Strategic Design and Synthesis of N, S, P Tridoped Carbon: A Highly Efficient Metal-Free Catalyst for Oxygen Reduction Reaction.

Doping multiple nonmetal heteroatoms into carbon materials is a promising avenue for boosting the catalytic performance of carbon-based metal-free catalysts (CMFCs) for the oxygen reduction reaction (ORR). Nevertheless, selecting appropriate precursors and doping processes to synthesize high-performance CMFCs for the ORR remains challenging. Herein, N-doped carbon (N-C) and N,S-codoped carbon (NS-C) catalysts were first prepared via in situ doping.