CRISPR screening reveals that RNA helicase DDX41 triggers ribosome biogenesis and cancer progression through R-loop-mediated RPL/RPS transcription.

The RNA helicase DDX41 is a DEAD-box helicase that is well known as a virus sensor in dendritic cells and a tumor suppressor that is frequently mutated in myeloid neoplasms. However, the functions and relevance of DDX41 in solid tumors remain largely unexplored. In this study, through in vivo CRISPR screening, we demonstrate that DDX41 is highly expressed in various solid tumor types and promotes tumorigenicity in liver cancer.

Layered Ordered Multianion Semiconductor BiOSeCl with Low -Axial Thermal Conductivity.

Layered ordered multianion materials exhibit remarkable structural flexibility and unique chemical and physical properties, which arise from the interplay of intralayer and interlayer interactions, as well as distinct local chemical environments originating from different anionic sublattices. Here, we report a novel layered quaternary compound, BiOSeCl, which features three different anionic sublattices. BiOSeCl consists of [BiOCl] and [BiOSeCl] slabs that stack along the axis alternatively.

Comprehensive Quality Evaluation of Viticis Fructus Based on Simultaneous Quantification of Nine Flavones and One Iridoid Glycoside by Ultra-High Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry and Chemometric Analysis.

Viticis fructus is the dry fruit of Vitex trifolia L. var. simplicifolia Cham.

Biomimetic Superwetting Phenomena for Antifogging Surfaces.

Fog formation on transparent windows compromises the visual clarity of these surfaces and brings hidden safety dangers, which underscores the importance of research into antifogging coatings. In recent years, biomimetic superwetting coatings have garnered significant attention as a key technology for addressing fogging issues. This review outlines the latest advancements in the design and fabrication of superwetting antifogging materials.

Tuning Surface Functions by Hydrophilic/Hydrophobic Polymer Brushes.

Polymer brushes, an optimal method for surface modification, have garnered significant interest due to their potential in surface wettability and functions regulation. This review summarizes the recent advancements in functional polymer brush surfaces based on surface wettability regulation. First, the fundamental structure and fabrication methods of polymer brushes, emphasizing the two primary strategies, "grafting-to" and "grafting-from", were introduced, and special attention was accorded to the method of subsurface-initiated atom transfer radical polymerization (SSI-ATRP) for the construction of mechanically robust polymer brushes.

Pressure-Induced Assembly of Organic Phase-Change Materials Hybridized with Expanded Graphite and Carbon Nanotubes for Direct Solar Thermal Harvesting and Thermoelectric Conversion.

Direct harvesting of abundant solar thermal energy within organic phase-change materials (PCMs) has emerged as a promising way to overcome the intermittency of renewable solar energy and pursue high-efficiency heating-related applications. Organic PCMs, however, generally suffer from several common shortcomings including melting-induced leakage, poor solar absorption, and low thermal conductivity. Compounding organic PCMs with single-component carbon materials faces the difficulty in achieving optimized comprehensive performance enhancement.

Fish-inspired dynamic charging for ultrafast self-protective solar-thermal energy storage.

Solar-thermal energy storage (STES) within solid-liquid phase change materials (PCMs) has emerged as an attractive solution to overcome intermittency of renewable energy. However, current storage systems usually suffer from slow charging rates, sacrificed storage capacity, and overheating tendency. Inspired by the thermoregulation behavior of fish, here, we present a quick-responsive, ultrafast, large-capacity, overheating-protective STES strategy.

Glucose-induced LINC01419 reprograms the glycolytic pathway by recruiting YBX1 to enhance PDK1 mRNA stability in hepatocellular carcinoma.

Metabolic reprogramming provides the necessary energy for the development of malignant tumours and is emerging as a novel tumour treatment strategy. However, the widespread expression of metabolic enzymes in diverse cell types makes the development of specific drugs that target cancer cells without affecting normal cellular functions challenging. Accumulating evidence has demonstrated the essential roles of long non-coding RNAs (lncRNAs) in the regulatory network associated with glucose metabolism in tumour cells.

Electrically Controlled Smart Window for Seasonally Adaptive Thermal Management in Buildings.

Smart windows offer a sustainable solution for energy-efficient buildings by adapting to various weather conditions. However, the challenge lies in achieving precise control over specific sunlight bands to effectively respond to complex weather changes and individual needs. Herein, a novel electrochromic smart window fabricated by integrating a self-assembled cellulose nanocrystals (CNCs) layer with an electrochromic poly(3,4-ethylenedioxythiophene):poly(styrene sulfonic acid) (PEDOT:PSS) layer is reported, which exhibits high near-infrared transmittance, low solar reflectivity (26%), and infrared emissivity (20%) in winter, and low near-infrared transmittance, high solar reflectivity (91%), and infrared emissivity (≈94%) in summer.

Elevated choline drives KLF5-dominated transcriptional reprogramming to facilitate liver cancer progression.

An increase in the total choline-containing compound content is a common characteristic of cancer cells, and aberrant choline metabolism in cancer is closely associated with malignant progression. However, the potential role of choline-induced global transcriptional changes in cancer cells remains unclear. In this study, we reveal that an elevated choline content facilitates hepatocellular carcinoma (HCC) cell proliferation by reprogramming Krüppel-like factor 5 (KLF5)-dominated core transcriptional regulatory circuitry (CRC).

Heat shock transcription factor 1 facilitates liver cancer progression by driving super-enhancer-mediated transcription of MYCN.

Background: Heat shock transcription factors (HSFs) play crucial roles in the development of malignancies. However, the specific roles of HSFs in hepatocellular carcinoma (HCC) have yet to be fully elucidated.

Aims: To explore the involvement of the HSF family, particularly HSF1, in the progression and prognosis of HCC.

Fibrillarin reprograms glucose metabolism by driving the enhancer-mediated transcription of PFKFB4 in liver cancer.

DNA- and RNA-binding proteins (DRBPs) are versatile proteins capable of binding to both DNA and RNA molecules. In this study, we identified fibrillarin (FBL) as a key DRBP that is upregulated in liver cancer tissues vs. normal tissues and is correlated with patient prognosis.

Selective Synthesis of Organonitrogen Compounds via Electrochemical C-N Coupling on Atomically Dispersed Catalysts.

The C-N coupling reaction demonstrates broad application in the fabrication of a wide range of high value-added organonitrogen molecules including fertilizers (e.g., urea), chemical feedstocks (e.

Advancing Energy Sustainability Through Solar-to-Fuel Technologies: From Materials to Devices and Systems.

To achieve carbon neutrality and sustainable development, innovative solar-to-fuel systems have been designed through the integration of solar energy harvesting and electrochemical devices. Over the last decade, there have been notable advancements in enhancing the efficiency and durability of these solar-to-fuel systems. Despite the advancements, there remains significant potential for further improvements in the performance of systems.

Carbon-Enhanced Hydrated Salt Phase Change Materials for Thermal Management Applications.

Inorganic hydrated salt phase change materials (PCMs) hold promise for improving the energy conversion efficiency of thermal systems and facilitating the exploration of renewable thermal energy. Hydrated salts, however, often suffer from low thermal conductivity, supercooling, phase separation, leakage and poor solar absorptance. In recent years, compounding hydrated salts with functional carbon materials has emerged as a promising way to overcome these shortcomings and meet the application demands.

Robust Transparent Photothermal Omniphobic Coating for Efficient Anti/Deicing and Antifogging.

Icing and fogging on optical material surfaces bring various problems in daily life. Recently, some photothermal coatings have been reported to prevent the condensation or freeze of water droplets by increasing the surface temperature. However, it is a great challenge to apply them in practical conditions due to their opaqueness and poor mechanical wear-resistant property.

Development of Multimodal Fusion Technology for Tomato Maturity Assessment.

The maturity of fruits and vegetables such as tomatoes significantly impacts indicators of their quality, such as taste, nutritional value, and shelf life, making maturity determination vital in agricultural production and the food processing industry. Tomatoes mature from the inside out, leading to an uneven ripening process inside and outside, and these situations make it very challenging to judge their maturity with the help of a single modality. In this paper, we propose a deep learning-assisted multimodal data fusion technique combining color imaging, spectroscopy, and haptic sensing for the maturity assessment of tomatoes.

Distribution, sources, partition behavior and risk assessment of polycyclic aromatic hydrocarbons (PAHs) in the waters and sediments of Lake Ulansuhai, China.

This study represents the first comprehensive investigation of 16 polycyclic aromatic hydrocarbons (PAHs) in the waters and sediments of Lake Ulansuhai. It explores their occurrence, sources, transport behavior, and associated risks to human health and ecosystems. The results revealed that concentrations of ∑PAHs in dissolved phase and sediment with no significant seasonal differences.

Long-read transcriptome landscapes of primary and metastatic liver cancers at transcript resolution.

Background: The liver ranks as the sixth most prevalent site of primary cancer in humans, and it frequently experiences metastases from cancers originating in other organs. To facilitate the development of effective treatments and improve survival rates, it is crucial to comprehend the intricate and diverse transcriptome landscape of primary and metastatic liver cancers.

Methods: We conducted long-read isoform sequencing and short-read RNA sequencing using a cohort of 95 patients with primary and secondary liver cancer who underwent hepatic resection.

Revamping Triboelectric Output by Deep Trap Construction.

High output performance is critical for building triboelectric nanogenerators (TENGs) for future multifunctional applications. Unfortunately, the high triboelectric charge dissipation rate has a significant negative impact on its electrical output performance. Herein, a new tribolayer is designed through introducing self-assembled molecules with large energy gaps on commercial PET fibric to form carrier deep traps, which improve charge retention while decreasing dissipation rates.

Efficient Solar-Driven Water Splitting Enabled by Perovskite Photovoltaics and a Halogen-Modulated Metal-Organic Framework Electrocatalyst.

Solar-driven water splitting powered by photovoltaics enables efficient storage of solar energy in the form of hydrogen fuel. In this work, we demonstrate efficient solar-to-hydrogen conversion using perovskite (PVK) tandem photovoltaics and a halogen-modulated metal-organic framework (MOF) electrocatalyst. By substituting tetrafluoroterephthalate (TFBDC) for terephthalic (BDC) ligands in a nickel-based MOF, we achieve a 152 mV improvement in oxygen evolution reaction (OER) overpotential at 10 mA·cm.

FLIBase: a comprehensive repository of full-length isoforms across human cancers and tissues.

Regulatory processes at the RNA transcript level play a crucial role in generating transcriptome diversity and proteome composition in human cells, impacting both physiological and pathological states. This study introduces FLIBase (www.FLIBase.

Inflammatory bowel disease and risk of Parkinson's disease: evidence from a meta-analysis of 14 studies involving more than 13.4 million individuals.

Background: The relationship between inflammatory bowel disease (IBD) and the risk of Parkinson's Disease (PD) has been investigated in several epidemiological studies. However, the results of these studies were inconclusive and inconsistent. We evaluated the potential relationship between IBD and PD risk by a meta-analysis.

Molecular Engineering of Metal-Organic Frameworks as Efficient Electrochemical Catalysts for Water Oxidation.

Metal-organic framework (MOF) solids with their variable functionalities are relevant for energy conversion technologies. However, the development of electroactive and stable MOFs for electrocatalysis still faces challenges. Here, a molecularly engineered MOF system featuring a 2D coordination network based on mercaptan-metal links (e.