Case Report: preoperative prediction of aneurysm rupture site using aortic morphological and biomechanical analysis validated by intraoperative imaging.

Prediction of aneurysm rupture has been a great challenge for decades. We report a successful rupture site prediction on a 97 mm abdominal aortic aneurysm (AAA). A 73-year-old man with an 11-year history of AAA presented to our outpatient clinic with a one-week history of hemoptysis.

Affinity Maturation and Light-Chain-Mediated Paratope Diversification Anticipate Viral Evolution.

A key goal of vaccinology is to train the immune system to combat current pathogens while simultaneously preparing it for future evolved variants. Understanding factors contributing to anticipatory breadth, wherein affinity maturation against an ancestral strain yields neutralization capacity against evolved variants, is therefore of great importance. Here, we investigated the mechanism of anticipatory breadth development in a public antibody family targeting the functionally restricted ACE2 binding site on SARS-CoV-2.

Intrinsic relationship between structural changes of different types of oyster proteins and flavor release after sous-vide treatment.

Proteins, as typical macromolecules in aquatic products, have been demonstrated to play a crucial role in flavor release. The structural modifications of water-soluble proteins (WSP), salt-soluble proteins (SSP), and alkali-soluble proteins (ALSP) in oysters after Sous Vide (SV) heating, along with their interactions with flavor compounds, were systematically investigated. More significant alterations in secondary and tertiary structures in SSP were observed compared to WSP and ALSP following SV heating, accompanied by the highest degree of hydrophobicity and aggregation.

Association between low-grade inflammation and distal sensorimotor polyneuropathy in type 2 diabetes: a cross-sectional study.

Background: As inflammatory processes may be involved in the pathogenesis of diabetic distal sensorimotor polyneuropathy (DSPN), the first aim of the present study was to determine the clinical characteristics of type 2 diabetes mellitus (T2DM) with distal sensorimotor polyneuorpathy (DSPN). Next goal was to investigate inflammatory biomarkers, insulin-like growth factor- 1 and lipid profile in these patients. Finally, we aimed to compare the renal function in these patients.

Erratum: Preclinical evaluation of the efficacy and safety of AAV1-hOTOF in mice and nonhuman primates.

[This corrects the article DOI: 10.1016/j.omtm.

Spinal segment-specific properties of neural stem cells contribute to the outcomes of spinal cord injury repair.

Neurons in distinct spinal cord segments serve specific functions, raising questions about whether human spinal cord-derived neural stem cells (hscNSCs) retain segment-specific properties crucial for spinal cord injury (SCI) repair. We established a culture system amplifying hscNSCs from cervical, thoracic, and lumbar segments, revealing segment-specific transcriptional profiles and differentiation potentials. Notably, thoracic hscNSCs exhibited elevated hepatocyte growth factor (HGF) expression inherited from the pre-ganglionic column, enhancing their differentiation into motor neurons.

Intraoperative UBM-guided direct cyclopexy for traumatic cyclodialysis cleft: a four-case series.

Purpose: To evaluate the feasibility and effectiveness of intraoperative ultrasonic biomicroscopy (UBM)-guided direct cyclopexy for treating traumatic cyclodialysis clefts.

Methods: Intraoperative UBM-guided direct cyclopexy was performed on a total of four eyes. Prior to the conjunctival incision, UBM evaluation was facilitated with a self-designed eye cup.

TRIM34-Mediated Ubiquitination and Degradation of HIF-1A Regulates Glycolysis in Endothelial Cells, Inhibits Angiogenesis, and Relieves the Progression of Lung Fibrosis.

Idiopathic interstitial pulmonary fibrosis (IPF) is a chronic and progressive disease characterized by interstitial fibrosis, with poor prognosis and high mortality. TRIM34 is involved in the intracellular ubiquitination process, but its mechanism of action in IPF is currently unknown. The purpose of this study was to investigate the effect of TRIM34 on the IPF process and its mechanism.

Regulatory role of E3 ubiquitin ligases in multiple myeloma: from molecular mechanisms to therapeutic strategies.

Multiple myeloma (MM) is a hematological tumor characterized by the malignant proliferation of plasma cells in bone marrow (BM). Despite the prolonged survival of MM patients, a significant amount of patients relapse or become drug resistant. This underlines the importance of the development and investigation of novel targets to improve MM therapy.

Interfacial Roughness-Reinforced Magnetic Nanosheet Colloidal Gels for Stable Embolization and Magnetothermal Therapy of Hepatic Tumor.

Injectable hydrogels have been developed for transcatheter arterial embolization (TAE) of hepatic tumor owing to their flexibility in injection and embolization. However, the dual requirement for high mechanical robustness and good injectability poses a fundamental challenge, as improvements in one often compromise the other. Colloidal gels offer tunable mechanical properties and feasible injectability through the bottom-up assembly of building blocks.

Epigenetic Plasticity Is Likely to Exacerbate Climate Change Vulnerability.

Climate change imposes a significant threat to global biodiversity. Evolutionary processes, including adaptation and migration, have been integrated to study vulnerability to changing environments. However, the role of plasticity as a source of variation in fitness-related traits remains less explored when assessing climate change vulnerability.

From Formability to Bandgap: Machine Learning Accelerates the Discovery and Application of Perovskite Materials.

Perovskite materials are considered promising candidates for applications in solar cells, photodetectors, catalysts, and light-emitting diodes, owing to their exceptional physicochemical and structural properties. Recently, the integration of machine learning into perovskite research has revolutionized the discovery and optimization process by overcoming the limitations of traditional trial-and-error methods and computationally intensive first-principles calculations. This review examines the role of machine learning in predicting perovskite properties and advancing their practical applications.

Zero-Dimensional Cuprous Iodide Clusters with Near-Unity PLQYs for White Lighting.

Low-dimensional cuprous halides have garnered significant attention as promising candidates for high-quality phosphors owing to their intrinsic broadband emissions and direct band transitions enabled by polyhedron-level exciton confinement. Herein, we report the facile synthesis and optical study of two zero-dimensional cuprous iodides, (CHNO)CuI and (CHNO)CuI clusters, with specific [CuI] rhomboid dimer and [CuI] cubane tetramer configurations, respectively. Comprehensive photophysical analysis reveals that facilitated by efficient ligand-to-core charge transfer, spatially isolated zero-dimensional [CuI] and [CuI] can function as independent blue and yellow emission centers with large Stokes shifts (>100 nm), large full widths at half-maximum (>100 nm), and near-unity photoluminescence quantum yields.

A CSDG photoelectronic transistor based on simulation model mimicking dopamine-facilitated synaptic plasticity for high energy-efficient neuromorphic system.

Charge-trap transistors are widely used for the simulation of biological synaptic functions. However, the unique structure of silicon-oxide-nitride-oxide-silicon (SONOS) makes it difficult to simulate short-term memory (STM). Based on simulation modeling, this work proposes a cylindrical surrounding double-gate (CSDG) nanowire synaptic transistor with a Si N charge trap layer in direct contact with the channel.

Tunable Emission in Bi/Te-Doped RbZrCl Crystals for White Lighting.

Wide-spectrum tunability is of great importance for the design of white light-emitting materials. The vacancy-ordered double perovskite hosts are suitable for incorporating emissive dopant ions to produce white emissions due to their high impurity tolerance and electronically "zero-dimensional" nature. This study presents a Bi/Te-doped RbZrCl phosphor with a double perovskite structure, displaying a wide-band light emission covering 400-700 nm.

Transcriptome combined single-cell sequencing explores molecular mechanisms of ANGPTL4 in sepsis-induced acute lung injury.

Objective: Sepsis-induced acute lung injury (ALI) constitutes a critical clinical syndrome associated with high mortality rates, yet its molecular mechanisms remain inadequately elucidated. Recent evidence indicates that ANGPTL4 may influence inflammatory responses and endothelial barrier integrity; however, its cell-specific regulatory mechanisms in sepsis-associated ALI are not well understood. This study utilizes transcriptome profiling combined with single-cell sequencing to systematically analyze the spatiotemporal expression patterns and functional networks of ANGPTL4 during the progression of ALI.

EDEM1 Inhibits Endoplasmic Reticulum Stress to Induce Doxorubicin Resistance through Accelerating ERAD and Activating Keap1/Nrf2 Antioxidant Pathway in Triple-Negative Breast Cancer.

Doxorubicin (DOX)-based chemotherapy is the basic treatment for triple-negative breast cancer (TNBC). However, chemoresistance is still one of the major causes of metastasis, recurrence, and poor outcomes. Recently, a close relationship between chemoresistance and endoplasmic reticulum (ER) stress has been found.

Guideline-directed medical strategies for the co-management of heart failure and metabolic dysfunction-associated steatotic liver disease.

There is a high and rising global prevalence of people with both metabolic dysfunction-associated steatotic liver disease (MASLD) and heart failure, which has a severe impact, highlighting the need to address these conditions. However, the relationship between MASLD and heart failure remains underexplored. This comprehensive narrative review explores the shared pathophysiological mechanisms, diagnostic evaluations, and current medical and surgical recommendations for heart failure therapy in the context of co-existing MASLD.

Revealing Cell-Free Mitochondrial DNA Breakage Patterns as Novel Biomarkers for Sepsis.

Accurate early diagnosis and prognosis of sepsis remain major clinical challenges. This study explores specific plasma cell-free mitochondrial DNA (cfmtDNA) breakage patterns as potential biomarkers for sepsis. Plasma samples from ten non-sepsis control patients and 63 sepsis patients are analyzed using mitochondrial DNA fragmentomics, revealing distinct breakage sites in the RNR2 (positions 2474-2478) and COX2 (positions 7761, 7775, 7776, 7777, and 7783) regions, which are intact in healthy individuals but exhibited high-frequency breakage in sepsis patients.

The miR156u/v-MhDIV3 Module Modulates Cadmium Uptake and Damage via Enhancing MhNRAMP1 Expression in Malus hupehensis.

Cadmium (Cd), a toxic heavy metal, threatens crop production and human health, and its uptake by Malus hupehensis is regulated by MhNRAMP1. The role of the DIVARICATA (DIV) transcription factor (TF) in Cd stress remains largely unclear. Here, nine DIVs were isolated from M.

The USP1-WDR48 deubiquitinase complex functions as a molecular switch regulating tumor-associated macrophage activation and anti-tumor response.

M2-like tumor-associated macrophages (TAMs) are the main immunosuppressive cells infiltrating the tumor microenvironment (TME), the activation of which is essential for cancer progression and resistance promotion to immunotherapy. However, the regulatory mechanisms underlying TAM activation have not been fully elucidated. Utilizing a CRISPR-Cas9-based genetically engineered mouse model, we discovered that USP1Lyz2 and WDR48Lyz2 mice exhibited decreased tumor formation and lung metastasis.

Blueberry Bioactives in Metabolic Syndrome.

Metabolic syndrome (MetS) is a special disorder with abnormal lipid levels, excessive body fat, high blood pressure, and insulin resistance. It is commonly associated with chronic diseases like diabetes, obesity, and cardiovascular diseases (CVDs). Blueberries are rich in bioactive substances, including flavonoids and phenolic acids.

Genetic evidence for the causal influence of inflammatory factors on intrahepatic cholangiocarcinoma risk.

Background: Intrahepatic cholangiocarcinoma (ICC) is a highly malignant liver cancer subtype with limited effective treatment options. Emerging evidence suggests that inflammatory factors play a critical role in ICC progression within the tumor microenvironment (TME). However, causal relationships between specific inflammatory factors and ICC risk remain unclear.

Benzothiadiazole-Centered Donor-Acceptor-Donor Systems: Synthesis, Characterization, and PFAS-Induced Fluorochromism.

The development of π-conjugated donor-acceptor (D-A) systems has shown significant potential in optoelectronics, sensing, and biomedical applications. Benzothiadiazole (BTD), a key electron-accepting unit, has been widely utilized in designing luminescent materials due to its tunable electronic and photophysical properties. In this work, we present a new class of BTD-centered D-A-D organic fluorophores, where the central BTD core is symmetrically flanked by π-fused phenanthroimidazolyl or pyrenoimidazolyl donor/fluorogenic groups.

Gene Therapy vs Cochlear Implantation in Restoring Hearing Function and Speech Perception for Individuals With Congenital Deafness.

Importance: OTOF gene therapy (GT) has been shown to improve hearing and speech. The efficacy of GT remains to be compared against cochlear implantation (CI), the current gold standard for congenital deafness.

Objective: To evaluate treatment outcomes in auditory and speech perception between patients with congenital deafness treated with GT, CI, or both.