Characterizing the Biochemical Role of an Unusual Fatty Acyl-AMP Ligase from a Hybrid PKS-NRPS Pathway in Nematodes.

PKAL-1 is a fatty acyl-AMP ligase that plays an essential role in the biosynthesis of the nemamides, hybrid polyketide-nonribosomal peptides from nematodes that promote recovery from starvation-induced larval arrest. This enzyme traffics biosynthetic intermediates between two enzymatic assembly lines: the hybrid polyketide synthase-nonribosomal peptide synthetase PKS-1 and the nonribosomal peptide synthetase NRPS-1. Specifically, a mutant worm strain does not produce the nemamides but accumulates a β-amino-containing polyketide, named nematide A, which is made by PKS-1 and is potentially loaded by PKAL-1 onto NRPS-1.

Tunable Emission in Bi/Te-Doped RbZrCl Crystals for White Lighting.

Wide-spectrum tunability is of great importance for the design of white light-emitting materials. The vacancy-ordered double perovskite hosts are suitable for incorporating emissive dopant ions to produce white emissions due to their high impurity tolerance and electronically "zero-dimensional" nature. This study presents a Bi/Te-doped RbZrCl phosphor with a double perovskite structure, displaying a wide-band light emission covering 400-700 nm.

Tenebrio molitor powder enhances gelation properties of Penaeus vannamei myofibrillar protein: Mechanistic insights into structural optimization and digestibility.

The study aimed to investigate how Tenebrio molitor powder (TMP) influences the gelation properties of Penaeus vannamei myofibrillar protein, specifically seeking to identify optimal TMP-to-protein ratios. TMP: myofibrillar protein ratios (1:40, 1:20, 1:10) were evaluated through texture analysis, rheological testing, water-holding capacity (WHC), and microstructure observation. Texture analysis revealed a 27.

The combined effect of cold plasma and radio frequency on the preservation of cooked crayfish during refrigerated storage.

To improve the shelf life of crayfish, the preservation effects of cold plasma (CP) and radio frequency (RF) treatments were investigated in this study. The crayfish samples were treated by CP (130 kV, 3 min), RF (3.5 kW, 15 min) or their combinations and stored at 4 °C.

Corrigendum to "Ultra-high pressure improved gelation and digestive properties of tai Lake whitebait myofibrillar protein" [Food Chemistry: X (2024) 101061].

[This corrects the article DOI: 10.1016/j.fochx.

Servo robust control of cyber-physical systems with physical uncertainty and cyber interference.

Cyber-physical system (CPS) is a complex system that integrates cyber, computer system, and physical system. Due to the large amount of information transmitted by CPS in real time, there are physical uncertainty and serious security risks, so how to accurately and effectively realize the accurate control of the CPS becomes a challenging task. In this paper, we comprehensively consider the physical uncertainty and cyber interference that the CPS may face, and then design a Servo Robust Control (SRC).

Study on the regulation of tea polyphenols on the structure and gel properties of myofibrillar protein from .

is an important freshwater fish species, rich in nutrients and proteins. However, myofibrillar proteins (MPs), as the major component of muscle, are prone to oxidative denaturation. Tea polyphenols (TPs), as natural antioxidants, have broad applications in the area of aquatic product manufacturing.

The Antibacterial Activity and Mechanisms of a Mixed Bio-Preservative on the Stains in Crab Roe Sauce.

Crab roe sauce (CRS) is prone to spoilage due to microbial contamination. Therefore, this study aimed to investigate the inhibitory effects and mechanisms of a mixed bio-preservative (0.025% ε-polylysine hydrochloride (ε-PL) + 0.

The Effect of Ultrasound Treatment on the Structural and Functional Properties of Myofibrillar Protein.

The objective of this study was to explore the impacts of various ultrasonic powers (0, 300, 500, 700, and 900 W) on the structure and functional attributes of the myofibrillar protein (MP) of . As the ultrasonic intensity escalated, the extraction efficiency and yield of the MP rose, while the particle size and turbidity decreased correspondingly. The reduction in sulfhydryl group content and the increase in carbonyl group content both suggested that ultrasonic treatment promoted the oxidation of the MP to a certain extent, which was conducive to the formation of a denser and more stable gel network structure.

The complex interplay between autism spectrum disorder and gut microbiota in children: A comprehensive review.

Autism spectrum disorder (ASD) is characterized by defects in social communication and interaction along with restricted interests and/or repetitive behavior. Children with ASD often also experience gastrointestinal (GI) problems in fact incidence of GI problems in ASD is estimated up to 80 percent. Intestinal microbiota, which is a collection of trillions of microorganisms both beneficial and potentially harmful bacteria living inside the gut, has been considered one of the key elements of gut disorders.

Knickkopf (LmKnk) is required for chitin organization in the foregut of Locusta migratoria.

The foregut, located at the front of the digestive tract, serves a vital role in insects by storing and grinding food into small particles. The innermost layer of the foregut known as the chitinous intima, comes into direct contact with the food and acts as a protective barrier against abrasive particles. Knickkopf (Knk) is required for chitin organization in the chitinous exoskeleton, tracheae and wings.

Ultra-high pressure improved gelation and digestive properties of Tai Lake whitebait myofibrillar protein.

This study investigated the effects of ultra-high pressure (UHP) at different levels on the physicochemical properties, gelling properties, and digestion characteristics of myofibrillar protein (MP) in Tai Lake whitebait. The α-helix gradually unfolded and transformed into β-sheet as the pressure increased from 0 to 400 MPa. In addition, the elastic modulus (G') and viscous modulus (G'') of the 400 MPa-treated MP samples increased by 4.

Nickel-Catalyzed Enantioselective Hydrothiocarbonylation of Cyclopropenes.

Hydrothiocarbonylation of olefins using carbon monoxide and thiols is a powerful method to synthesize thioesters from simple building blocks. Owing to the intrinsic challenges of catalyst poisoning, transition-metal-catalyzed asymmetric thiocarbonylation, particularly when utilizing earth abundant metals, remains rare in the literature. Herein, we report a nickel-catalyzed enantioselective hydrothiocarbonylation of cyclopropenes for the synthesis of a diverse collection of functionalized thioesters in good to excellent yields with high stereoselectivity.

Regioselective Hydrodeoxygenation of α-Diketones with Phosphites under Visible-Light Catalysis.

Novel regioselective hydrodeoxygenation of α-diketones with phosphites as the deoxygenation reagent was realized via visible-light photoredox catalysis. Broad substrate scope and high functional group compatibility were obtained. Unsymmetric α-diketones were selectively reduced at the carbonyls of higher electrophilicity.

Highly Diastereoselective Synthesis of Polysubstituted Cyclopropanecarbonitriles via Palladium-Catalyzed Cyanoesterification of Cyclopropenes.

We herein develop a highly diastereoselective synthesis of cyano-substituted cyclopropanes via palladium-catalyzed direct cyanoesterification of cyclopropenes, which features mild reaction conditions, good functional group compatibility, and simple operation. This transformation represents a stepwise, highly atom economic, and scalable protocol for obtaining synthetically useful cyclopropanecarbonitriles.

Metabolic and Proteomic Profiles Reveal the Response of the ASD-Associated Resistant Strain 6-1 of to Propionic Acid.

Autism spectrum disorder (ASD) seriously affects children's health. In our previous study, we isolated and identified a bacterium ( strain 6-1) that is resistant to propionic acid (PA), which has been reported to play a significant role in the formation of ASD. In order to elucidate the mechanism of the resistance to PA, this study investigated the change in the metabolic and proteomic profile of strain 6-1 in the presence and absence of PA.

Nickel-Catalyzed Asymmetric Hydroaryloxy- and Hydroalkoxycarbonylation of Cyclopropenes.

The asymmetric Reppe carbonylation reactions provide a straightforward access to α-chiral carbonyl compounds. The reported paradigms predominantly adopted precious palladium as the catalyst. Here we report a nickel-catalyzed asymmetric carbonylation of cyclopropenes with phenyl formate and CO/ROH, respectively.

The impact of COVID-19 on higher education building energy use and implications for future education building energy studies.

Although COVID-19 has significantly changed the higher educational sector, there are few studies revealing how this pandemic has changed the energy use of higher education buildings. This study was conducted not only to disclose the energy use change under COVID-19 but also to identify the corresponding facilities management strategies for future learning and teaching delivery modes under virtual campuses. This study collected the energy use data of 122 buildings across five campuses in Griffith University, located in Southeast Queensland, Australia, during the COVID-19 academic year (February 17, 2020, to February 21, 2021) and during a typical normal academic year (February 18, 2019, to February 16, 2020) by PI Vision Platform, and compared the data using the -test and multiple linear regression.

Biosynthesis and Characterization of Zinc Oxide Nanoparticles and Their Impact on the Composition of Gut Microbiota in Healthy and Attention-Deficit Hyperactivity Disorder Children.

Attention-deficit hyperactivity disorder (ADHD) seriously affects children's health, and the gut microbiome has been widely hypothesized to play a role in the regulation of ADHD behavior. The present study aims to the biosynthesize of zinc oxide nanoparticles (ZnONPs) by using strain RTN1, followed by their characterization through state-of-the-art material characterization techniques, viz., UV-vis spectroscopy, Fourier transform infrared spectroscopy, and transmission and scanning electron microscopic analyses with energy dispersive spectrometry.