Common network related to hyperkinetic seizures revealed by functional lesion network mapping.

Objective: This study aims to determine whether the anatomically heterogeneous lesions that cause hyperkinetic seizures (HKS) are connected to a common functional network.

Methods: We identified patients from the Beijing Tiantan-Fengtai Epilepsy Center with HKs as the primary ictal semiology. These included patients had focal seizure-onset zone, here referred to as a "lesion.

[Occurrence characteristics of traditional Chinese medicine (TCM) root rot and prevention and control strategies against it under new situations].

Medicinal plant underground diseases, typified by root rot, directly result in a significant reduction in both the yield and quality of traditional Chinese medicine(TCM) because of its hidden occurrence and difficulty in prevention and control. Prevention and control measures depending on chemical pesticides bring potential risks to the safety of TCM and easily cause environmental pollution. The introduction of the new version of Good Agricultural Practice for Chinese Crude Drugs(GAP) and the enhancement of pesticide residue limit standards for TCM and decoction pieces in Chinese Pharmacopoeia(2025 edition) have elevated the requirements for green and efficient disease prevention and control technologies of TCM.

Integrative metabolomic and transcriptomic analysis provides insight into the mechanism of pigmentation in potato tuber eyes.

Background: The pigmentation of tuber eyes serves as a critical morphological marker for distinguishing potato varieties, yet the molecular mechanisms underlying localized pigmentation in tuber eyes remain largely unexplored. In this study, localized pigmentation around the tuber eyes of a potato variety named M4, which produces tubers with yellow and red eyes, was studied via targeted and untargeted metabolomics and transcriptome profiling.

Results: A comparison of the yellow and red tuber eyes revealed that the main differentially accumulated metabolites (DAMs) were pelargonidin, cyanidin, and peonidin, leading to the red pigmentation surrounding the tuber eyes.

Aberrant DNA methylation and overexpression of NR0B1 are prognostic biomarkers in KEAP1-mutant lung adenocarcinomas.

The KEAP1-NRF2 pathway regulates cytoprotective responses to endogenous and exogenous stresses induced by reactive oxygen species (ROS) and electrophiles. To maintain oxidative homeostasis, cancer cells increase the transcription of antioxidant genes by acquiring either stabilizing mutations in NRF2 or inactivating mutations in its negative regulator, KEAP1. NR0B1 is a recently identified NRF2 target that supports anchorage-independent growth in KEAP1-mutant non-small cell lung cancer (NSCLC) cells.

Effective Connectivity Predicts Surgical Outcomes in Temporal Lobe Epilepsy: A SEEG Study.

Introduction: Temporal lobe epilepsy (TLE), the most common type of drug-resistant epilepsy (DRE), has a postoperative seizure-free rate of ~70%. Furthermore, precisely localizing the epileptogenic zone and determining the surgical resection area have been established as the key factors influencing surgical outcomes. Herein, we innovatively coupled the surgical resection area with characteristics of effective connectivity via intracranial electroencephalography (iEEG) to predict patients' surgical prognosis.

Identification and characterization of two putative novel genera of arteriviruses in shrews and rats.

Introduction: Certain arteriviruses causing severe diseases in domestic animals, such as porcine respiratory and reproductive syndrome viruses, could originate through viral spillover, and simian arteriviruses pose threats to public health through viral spillover. To prepare for the spillover risks, it is desirable to delve into the diversity, evolution, and potential pathogenicity of arteriviruses in non-human primates, shrews, and rats, which are close in phylogenetics to humans or share the same habitats with humans and domestic animals.

Methods: In this study, a variety of viruses in Asian house shrews () and brown rats () were detected using high-throughput sequencing and virome analysis.

The role of apoptosis and its potential as a therapeutic target in inflammatory bowel disease associated with colorectal cancer.

Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's disease (CD), is a significant global health issue characterized by a complex etiology and high rates of recurrence. IBD increases the risk of acquiring colorectal cancer (CRC). CRC, the third leading cause of cancer worldwide, is becoming increasingly prevalent each year.

The development suitability analysis for the Qinghai-Xizang-Plateau: Condition, quality, and risk.

The Qinghai-Xizang Plateau (QXP) is a globally unique ecological barrier and a vast repository of natural resources. However, its harsh ecological environment presents a critical challenge in balancing environmental protection with sustainable resource development and economic growth. To fill this gap, this study develops a development suitability index system and evaluation model that includes three key dimensions of development condition, quality, and risk.

Current status and future perspectives of research on intra-articular drug delivery systems for osteoarthritis therapy.

Osteoarthritis (OA) is a degenerative joint disease and the leading cause of joint-related disability worldwide. In current clinical treatment approaches, drug therapy remains widely used, primarily through systemic administration of anti-inflammatory drugs and intra-articular injections. However, effective OA treatment remains challenging due to several barriers: the continuous flow of synovial fluid, the dense and negatively charged cartilage matrix, and the resulting poor drug accumulation at target sites.

Mapping electrophysiological connectivity of pulvinar in seizure propagation and neuromodulation.

Objective: The pulvinar is increasingly recognized as a promising target for neuromodulation in drug-resistant epilepsy (DRE). Despite growing interest, empirical evidence substantiating the efficacy and mechanism of its deep brain stimulation (DBS) in patients with epilepsy remains scarce. This study endeavors to address this knowledge gap by investigating the electrophysiological properties of pulvinar.

Differentiating Temporal Plus "Insula" Epilepsy From Temporal Lobe Epilepsy by Brain Networks Based on Noninvasive Examinations.

Aims: To differentiate patients with temporal plus epilepsy (TPE) with insular involvement from those with temporal lobe epilepsy (TLE) using brain network analysis based on noninvasive assessments.

Method: TLE and TPE patients were retrospectively selected and matched using propensity score matching (PSM) analysis. Metabolic networks for each patient were constructed utilizing F-fluorodeoxyglucose-positron emission tomography, and graphic theory was applied for network analysis.

Hydroxychloroquine improves manifestation of PE rats under oxidative stress by regulating the PI3K/AKT/mTOR signaling pathway to inhibit autophagy.

Preeclampsia is currently thought to be characterized by placental oxidative stress damage. Hydroxychloroquine is known to have antioxidant effects, but there are fewer studies on hydroxychloroquine in oxidative stress in preeclampsia. The main objective of this study was to investigate the effects of hydroxychloroquine on oxidative stress injury in preeclampsia and its related mechanisms by establishing cellular and animal models.

Predicting postoperative motor outcomes in the surgical management of Rolandic focal cortical dysplasia: the role of glucose metabolism.

Background: This study aimed to explore the predictive value of F-fluorodeoxyglucose positron emission tomography ([F]FDG PET) metabolic activity in determining postoperative motor function outcomes in patients with Rolandic focal cortical dysplasia (FCD).

Methods: We conducted a retrospective analysis of 62 patients with FCD who underwent resective surgery in the Rolandic area. Of these, 15 patients underwent task-based functional magnetic resonance imaging (fMRI).

Copper ion-chelated supramolecular polymer/hyaluronic acid hydrogel promotes wound healing in diabetes.

Hydrogel wound dressings have shown promising potential for treating diabetic wounds, but their efficacy is limited by the complex wound microenvironment and the lack of integrated treatment strategies. In this study, a series of multifunctional hydrogel adhesives with anti-inflammatory, antibacterial, and angiogenesis-promoting properties was synthesized using free radical polymerization. The raw materials included methacrylated hyaluronic acid (HAMA), 3-(bis(pyridin-2-ylmethyl)amino)propyl methacrylate (DPAMA), and N-[tris(hydroxymethyl)methyl]acrylamide (THMA).

Corrigendum to "Decision tree distinguish affective disorder diagnosis from psychotic disorder diagnosis with clinical and lab factors" [Heliyon Volume 8, Issue 11, November 2022, Article e11514].

[This corrects the article DOI: 10.1016/j.heliyon.

Mechanism of cell death and its application in the repair of inflammatory bowel disease by mesenchymal stem cells.

The onset and progression of inflammatory bowel disease (IBD), which encompasses ulcerative colitis and Crohn's disease, are influenced by the immune system, environmental factors, genetics, and intestinal flora. Cell death is a biological phenomenon that occurs in all living organisms; nevertheless, excessive cell death has been linked to IBD, including increased immune and intestinal epithelial cell death and intestinal barrier abnormalities. Anti-tumor necrosis factor medication, which has made significant progress in treating IBD cell death, may fail in some individuals or lose effectiveness over time, necessitating the search for a safe and effective treatment.

The role of plant-based dietary compounds in gut microbiota modulation in inflammatory bowel disease.

IBD, which includes Crohn's and ulcerative colitis, is associated with gut microbiota dysbiosis. The dysbiotic environment results in an elevation of harmful microbiota and a diminution of advantageous microbiota, leading to IBD. Interestingly, plant-based dietary compounds consisting of dietary fibers and polyphenols have demonstrated promise to be safe and successful in IBD treatment, with studies revealing that they can improve dysbiosis, increase anti-inflammatory cytokines, decrease pro-inflammatory cytokines, lower oxidative stress, and improve barrier function.

Concordant interictal stereoelectroencephalographic high-frequency oscillations and magnetoencephalography predict better surgical outcomes in focal epilepsy.

Objective: This study was undertaken to investigate the concordance between magnetoencephalographic (MEG) and interictal stereoelectroencephalographic (SEEG) high-frequency oscillations (HFOs) and their impact on surgical outcomes.

Methods: Thirty focal epilepsy patients who underwent SEEG and resection surgery were selected for HFO time-lag analysis. HFOs were automatically extracted from SEEG recordings to determine their time stamps.

Tenebrio molitor powder enhances gelation properties of Penaeus vannamei myofibrillar protein: Mechanistic insights into structural optimization and digestibility.

The study aimed to investigate how Tenebrio molitor powder (TMP) influences the gelation properties of Penaeus vannamei myofibrillar protein, specifically seeking to identify optimal TMP-to-protein ratios. TMP: myofibrillar protein ratios (1:40, 1:20, 1:10) were evaluated through texture analysis, rheological testing, water-holding capacity (WHC), and microstructure observation. Texture analysis revealed a 27.

A portable soil surface roughness instrument for automatic two-dimensional profile roughness measurement in the field.

Soil surface roughness, characterized by the unevenness of the soil surface, is a critical parameter influencing radar backscatter coefficients and microwave emissivity, and is essential for applications in agriculture, soil science, climate modeling, and geology. Current roughness measurement methods, such as manual pin meters and photogrammetry, face limitations in field portability, automation, and cost efficiency. To overcome these challenges, this study introduces a novel, portable instrument utilizing automated two-dimensional rotary laser scanning to quantify surface roughness.

Ecological functional zoning for mineral resource development in Xizang, China.

Xizang is an important base of mineral resources, hosting abundant deposits. However, its unique and fragile ecological environment has long constrained resource development and utilization. Achieving a balance between ecological protection and mineral resource exploitation has become a pressing issue.

Titanium dioxide nanoparticles disturb glucose homeostasis in association with impaired enteroendocrine cell differentiation.

Gut hormones secreted by enteroendocrine cells play a critical role in maintaining glucose homeostasis. However, the adverse endocrine effects related to glucose homeostasis caused by food additives are not well understood. This work aims to investigate the effects of titanium dioxide nanoparticles (TiO NPs) in comparison to titanium dioxide microparticles (TiO MPs) on glucose homeostasis, with a specific focus on the enteroendocrine cells and gut hormones.

LPM electrode loaded with RAPA-PLGA drug sustained-release system can reduce local fibrous tissue hyperplasia and local bioelectrical impedance.

Objective: This study aims to design and fabricate a leadless pacemaker (LPM) electrode loaded with rapamycin (RAPA)-poly(lactic-co-glycolic acid) (PLGA) drug sustained-release system to reduce the local fibrous tissue proliferation after LPM implantation, reduce local bioelectrical impedance, and facilitate the safe extraction of LPM after use.

Methods: We fabricated an LPM electrode loaded with the RAPA-PLGA drug-sustained-release system and carried out in vitro and in vivo experiments to verify its effect.

Results: A scanning electron microscope showed that the LPM electrode cavity was loaded with the RAPA-PLGA drug's sustained-release system.

Synthesis of 1-isothiochromenes by regioselective C-C and C-S bond formation of enaminothiones with alkynes under rhodium catalysis.

The rhodium-catalyzed sulfur-directed C-H bond activation and tandem cyclization of enaminothiones with alkynes proceed efficiently. Most products of 1-isothiochromenes with various substituents are achieved in good yields by regioselective C-C and C-S bond formation. This protocol has some advantages over the traditional methods in synthesizing 1-isothiochromenes in terms of stable and easily available coupling substrates, simple and one-pot operation, step and atom economy, and highly unique sulfur-containing heterocyclic products.