Unraveling the Complexity of Plant Trichomes: Models, Mechanisms, and Bioengineering Strategies.

Trichomes-microscopic appendages on the plant epidermis-play vital roles as both protective barriers and specialized biosynthetic factories. Acting as the first line of defense against environmental stressors, they also produce a wide range of pharmaceutically valuable secondary metabolites. This mini-review highlights recent advances in understanding the development, structure, and function of trichomes, with a focus on glandular secretory trichomes (GSTs) in key species such as and .

A Hard yet Flexible Coating with Antiwear and Crack-Blunting Properties on Rubber Substrates.

Lubricating coatings with excellent fatigue resistance on inert rubber surfaces significantly reduce friction and wear, thereby extending the material durability and lifetime. Conventional coating strategies often face challenges in simultaneously achieving robust interfacial adhesion and low viscosity hysteresis during dynamic sliding. Herein, we propose a solvent-mediated semi-interpenetrating polymer network approach to construct subsurface-embedded lubricating structures.

The effectiveness of mindfulness-based interventions for children with autism and their parents: a systematic review and meta-analysis.

Objective: This study aims to systematically evaluate the efficacy of mindfulness-based interventions (MBIs) for children diagnosed with autism spectrum disorder (ASD) and their parents.

Methods: A comprehensive search of PubMed, Embase, Cochrane Library, Web of Science, PsycINFO and ERIC was conducted to identify randomized controlled trials (RCTs) published up to December 31, 2024, that assessed the effects of MBIs on children with ASD and their parents. Two independent reviewers screened studies, extracted relevant data, and assessed the quality of the included literature.

Gelsolin (GSN) as a key regulator in estrogen receptor-positive breast cancer: implications for prognosis, chemotherapy sensitivity, and immune infiltration.

Background: Gelsolin (GSN), a cytoskeletal regulatory protein implicated in cancer progression, remains understudied in estrogen receptor-positive breast cancer (ER + BC), particularly regarding its links to immune infiltration and drug resistance.

Methods: Transcriptomic data from TCGA (616 ER + tumors, 113 normal) and Metabric (1,497 ER + cases) were analyzed. Immunohistochemistry images were sourced from the Human Protein Atlas database (HPA).

Targeting Catenibacterium mitsuokai with icariin modulates gut microbiota and improves hepatic lipid metabolism in intrauterine growth restriction.

Male offspring with intrauterine growth restriction (IUGR) exhibit more pronounced hepatic lipid metabolism abnormalities than females, necessitating earlier intervention. Icariin (ICA) has been shown to effectively modulate hepatic lipid metabolism in male piglets with IUGR. However, the role of gut microbiota in this process remains to be elucidated.

Validity and reliability of the Chinese translation of the attitude scale towards the use of artificial intelligence technologies in nursing (ASUAITIN)- a cross-sectional study.

Aim: This study aimed to test the psychometric properties of the Attitudes Toward Artificial Intelligence in Nursing Scale (ASUAITIN) in Chinese culture.

Methods: A convenience sampling method was employed to recruit 499 clinical nurses from Sichuan Province, China. Following the Brislin model, the ASUAITIN scale underwent forward translation, synthesis, and back-translation.

Effect of Kangaroo-mother care combined with infant touch on premature infants.

Objective: To explore the effect of Kangaroo-mother care combined with infant touch on premature infants.

Methods: This was a retrospective study. Ninety two premature infants in Maternity & Child Care Center of Qinhuangdao from July 2022 to July 2023 were included.

Bioinspired Tough and Antiswelling Hydrogel via in Situ Self-Assembly of Amphiphilic Copolymers within a Hydrophilic Network.

Inspired by tropoelastin coacervation, a process in elastic fiber formation driven by hydrophobic interactions, we developed a tough, antiswelling hydrogel, PHEA-(PVA--PE), by incorporating amphiphilic poly(vinyl alcohol--ethylene) (PVA--PE) into a hydrophilic poly(2-hydroxyethyl acrylate) (PHEA) network. The PHEA-(PVA--PE) hydrogel was prepared by UV-induced polymerization of a PHEA precursor dimethyl sulfoxide (DMSO) solution containing PVA--PE, followed by immersion in water. During solvent exchange, PVA--PE self-assembled into micellar structures within the PHEA matrix, mimicking the coacervation of tropoelastin.

Intracellular Delivery Enabled by Squeezing Mechanoporation.

Squeeze mechanoporation, as an emerging method, plays an important role in intracellular delivery. It brings new opportunities to cutting-edge fields such as cell therapy, gene editing, and vaccine production, and it promises to revolutionize traditional drug delivery and treatment paradigms. By leveraging the viscoelastic properties of cells, this technique induces cell deformation under external force, creating transient micropores in cell membranes for the efficient and high-throughput delivery of diverse exogenous substances, such as nucleic acids, antibodies, nanomaterials, and drugs.

Light-Controlled Adhesive Hydrogels for On-Demand Adhesion.

The rapid and reversible adhesion between solids is of great significance, particularly in fields such as biomedicine, intelligent machines, and bioelectronic sensors. Hydrogels, as soft materials, play a vital role in reversible adhesion. To achieve a wider range of applications, it is essential to enhance the intelligence of hydrogels.

Status and analysis of Free Hospital-Based Internet + Nursing Health Consultation Services: a retrospective study.

Background: With the increasing demand for healthcare services, Free Hospital-Based Internet + Nursing Health Consultation Services have emerged as an innovative model to provide patients with timely and convenient nursing guidance.

Objective: To comprehensively evaluate the implementation and effectiveness of Free Hospital-Based Internet + Nursing Health Consultation Services, identify existing challenges, and propose evidence-based optimization strategies to enhance the precision and efficiency of future services.

Methods: A retrospective analysis was conducted based on the hospital information system, retrieving orders for Free Hospital-Based Internet + Nursing Health Consultation Services from Mianyang Central Hospital between 2021 and 2023.

Tribology in Nature: Inspirations for Advanced Lubrication Materials.

Friction-induced energy consumption is a significant global concern, driving researchers to explore advanced lubrication materials. In nature, lubrication is vital for the life cycle of animals, plants, and humans, playing key roles in movement, predation, and decomposition. After billions of years of evolution, natural lubrication exhibits remarkable professionalism, high efficiency, durability, and intelligence, offering valuable insights for designing advanced lubrication materials.

Identification and characterization of cuproptosis related gene subtypes through multi-omics bioinformatics analysis in breast cancer.

Cuproptosis, a newly suggested mechanism of controlled cellular demise, which has been extensively associated with aspects of occurrence and development in breast cancer. The aim of this study was to conduct a comprehensive multi-group bioinformatics analysis based on the expression of cuproptosis-related genes (CRGs) to identify novel breast cancer subtypes to guide clinical practice. We collected TCGA-BRCA and GSE42568 datasets to investigate the expression patterns of CRGs in breast cancer.

Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine.

Metabolic syndrome (MetS) is a difficult-to-manage disease that poses a significant risk to human health. Here, we show that the supplementation of Lactobacillus reuteri ZJ617 ameliorates symptoms of MetS in mice induced by the high-fat diet. L.

Analysis of Outcomes and Factors Influencing Community-Acquired Pressure Injury: A Retrospective Review of 413 Patients.

Purpose: The purpose of this study was to analyze the outcomes and influencing factors of patients with community-acquired pressure injuries (CAPIs) and provide insights for clinical practice.

Design: Retrospective cohort study.

Subjects And Setting: We reviewed medical records of 413 patients with a total of 522 CAPIs.

Influence and Mechanism of Solid-Phase Particle Factors on Oil-Solid Separation of Oily Sludge Treated by Flotation Method.

The solid phase composition in oily sludge (OS) is a key factor affecting the oil-solid separation of OS. In this paper, the effects and mechanisms of solid-phase particle factors on the oil content of residue phase were investigated in order to improve the oil-solid separation efficiency. Flotation experiments were carried out on single-size sand and mixed-size sand OS consisting of three particle sizes at room temperature without adding flotation reagents.

The effect of baby touch on premature infants.

Objective: Premature infants require special attention during nursing. This study aimed to explore the effects of baby touch on the growth, immunity, sleep and communication in premature infants.

Methods: This was a retrospective study.

Electrically Controlled Smart Window for Seasonally Adaptive Thermal Management in Buildings.

Smart windows offer a sustainable solution for energy-efficient buildings by adapting to various weather conditions. However, the challenge lies in achieving precise control over specific sunlight bands to effectively respond to complex weather changes and individual needs. Herein, a novel electrochromic smart window fabricated by integrating a self-assembled cellulose nanocrystals (CNCs) layer with an electrochromic poly(3,4-ethylenedioxythiophene):poly(styrene sulfonic acid) (PEDOT:PSS) layer is reported, which exhibits high near-infrared transmittance, low solar reflectivity (26%), and infrared emissivity (20%) in winter, and low near-infrared transmittance, high solar reflectivity (91%), and infrared emissivity (≈94%) in summer.

Comparative efficacy of non-pharmacological interventions for anxiety in adult intensive care unit patients: A systematic review and network meta-analysis.

Background: The primary goal of the intensive care unit is to the anxiety of conscious patients is often ignored in the care unit.

Aim: The purpose of this study was to assess the efficacy of various non-pharmacological therapies for anxiety disorders in adult patients in the intensive care unit, in order to enhance humanistic care in the intensive care unit and to promote the patients' physical and mental recovery together.

Study Design: We conducted a systematic and comprehensive search of the literature in five databases (including the Cochrane Library, PubMed, EBSCO, Web of Science, and Embase) covering nearly a decade for randomized controlled trials of non-pharmacological therapies to reduce anxiety in adult intensive care unit patients.

Branched Oligomer-Based Reversible Adhesives Enabled by Controllable Self-Aggregation.

Supramolecular adhesion material systems based on small molecules have shown great potential to unite the great contradiction between strong adhesion and reversibility. However, these material systems suffer from low adhesion strength/narrow adhesion span, limited designability, and single interaction due to fewer covalent bond content and action sites in small molecules. Herein, an ultrahigh-strength and large-span reversible adhesive enabled by a branched oligomer controllable self-aggregation strategy is developed.

The skin tears knowledge among geriatric ward nurses and associated factors: A cross-sectional study.

Aim: To determine the level of knowledge about skin tears among geriatric ward nurses and identify associated factors.

Methods: In this cross-sectional study in Southwest China, 1172 geriatric ward nurses from 10 hospitals participated. Data were collected using Sojump, a Chinese web-based platform, and the Skin Tear Knowledge Assessment Instrument was used to assess their knowledge.

Robust and Lubricating Interface Semi-Interpenetrating Network on Inert Polymer Substrates Enabled by Subsurface-Initiated Polymerization.

Lubricating hydrogel coatings on inert rubber and plastic surfaces significantly reduce friction and wear, thus enhancing material durability and lifespan. However, achieving optimal hydration lubrication typically requires a porous polymer network, which unfortunately reduces their mechanical strength and limits their applicability where robust durability and wear-resistance are essential. In the research, a hydrogel coating with remarkable wear resistance and surface stability is developed by forming a semi-interpenetrating polymer network with polymer substrate at the interface.

Effects of non-pharmacological interventions on pain in wound patients during dressing change: A systematic review.

Background: Changes to the wound dressing frequently cause pain. Some adverse side effects of pharmacologic pain management may cause problems or even impede wound healing. There is no systematic study of non-pharmacologic therapies for pain during wound dressing changes, despite the gradual promotion of non-pharmacologic pain reduction methods.