Polycyclic aromatic hydrocarbons weaken the protective effects of serum fatty acids on fasting blood glucose.

Fatty acid homeostasis plays a potential role in blood glucose regulation, while environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) can disrupt lipid metabolism through oxidative stress and inflammation. However, the combined effects of fatty acids and PAHs on fasting blood glucose (FBG) and insulin resistance remain unclear. This study included 1403 adult participants based on NHANES (2011-2014).

A study on the spatial distribution and driving factors of traditional villages-a case study of the Beijing-Tianjin-Hebei region in China.

Traditional villages encompass abundant cultural resources, possessing significant humanistic and socio-economic value. This study used ArcGIS 10.8 and GeoDa software, took "Chinese Traditional Villages" as the research object, and analyzed their spatial autocorrelation and spatial heterogeneity through methods such as nearest neighbor analysis, Moran's Index, and kernel density estimation.

Evolutionary Dynamics of Glycoside Hydrolase Family 1 Provide Insights into Insect-Plant Interactions in Lepidoptera.

Glycoside hydrolase family 1 (GH1) enzymes are essential for plant cell wall digestion and the detoxification of plant metabolites in insects, yet their evolutionary history in Lepidoptera remains unresolved. This study systematically identified genes across 61 Lepidopteran genomes and analyzed their evolutionary dynamics. In addition, the expression profiles of genes in the silkworm () across various developmental stages and tissues were related to their evolutionary histories.

Planar Patterning Design and Energy Storage Performance Comparison of Laser-Induced Graphene Flexible Supercapacitors.

Laser-induced graphene (LIG) has gained significant attention due to its efficient and rapid production, and ability to create patterned electrodes. However, the operating voltage of LIG supercapacitor (LIG SC) unit devices is relatively low, and the different patterning LIG SC devices show different performances. Additionally, the size of the laser power also has a significant impact on the performance of the device.

Ultraviolet Photothermal Radiation Customized Nitrogen Terminals of TiCT MXene for High-Performance Supercapacitors.

Two-dimensional MXenes have emerged as exceptional electrode materials for supercapacitors (SCs), making them highly attractive for energy storage and conversion applications. However, their electrochemical performance is strongly influenced by surface terminal groups and interlayer spacing. In this study, we introduce an ultraviolet(UV)-induced nitrogen-doping method that employs UV radiation to promote the thermal decomposition of ammonium oxalate while inducing nitrogen-doping.

Fragile X messenger ribonucleoprotein 1 (FMRP) regulates glycolytic gene expression under chronic hypoxia in HCT116 cells.

Oxygen shortage, known as hypoxia, occurs commonly in both physiological and pathological conditions. Transcriptional regulation by hypoxia-inducible factors is a dominant regulatory mechanism controlling hypoxia-responsive genes during acute hypoxia; however, recent studies suggest that post-transcriptional regulation, including RNA degradation, also involves hypoxia-induced gene expression during the chronic hypoxia. In this study, we developed a method to quantify the contributions of RNA synthesis and degradation to differential gene expression, and identified 102 genes mainly regulated via RNA degradation under chronic hypoxia in HCT116 cells.

Plasma club cell secretory protein reflects early lung injury: comprehensive epidemiological evidence.

Background: It is inaccurate to reflect the level of dust exposure through working years. Furthermore, identifying a predictive indicator for lung function decline is significant for coal miners. The study aimed to explored whether club cell secretory protein (CC16) levels can reflect early lung function changes.

Emergent Ferromagnetic Ladder Excitations in Heavy Fermion Superconductor CeSb_{2}.

Low-dimensional spin fluctuations play a crucial role in unconventional superconductors, with quasi-one-dimensional spin excitations potentially linked with spin-triplet superconductivity. The heavy fermion superconductor CeSb_{2} exhibits an unusual large inverted S-shaped upper critical field that suggests a possible triplet pairing state within its pressure-induced superconducting dome. Using inelastic neutron scattering, we discover quasi-one-dimensional magnetic excitations in CeSb_{2} emerging from nearly square Ce layers with minor orthorhombic deformation.

The competitive mediating role of basal metabolic rate in the association between polycyclic aromatic hydrocarbon exposure and depression risk.

Background: The effect of basal metabolic rate (BMR) on depression was unclear. This study investigated the potential role of BMR in the association of polycyclic aromatic hydrocarbons (PAHs) exposure and depression.

Methods: The study based on the National Health and Nutrition Examination Survey (NHANES).

Research hotspots and development trends of spondylitis in the past 30 years: a bibliometric analysis.

Objective: With the growing emphasis on global health issues, spondylitis, a serious complication of brucellosis, has received increasing attention from researchers. This study employed bibliometric analysis to visually illustrate the scientific advancements and research trends in the field of spondylitis research, providing a scientific basis for public health prevention and control strategies.

Method: The data were sourced from the Web of Science Core Collection database, covering the period from January 1, 1984, to December 31, 2023.

Nanozyme-based aptasensors for the detection of tumor biomarkers.

A nanozyme-based aptasensor combines the unique properties of nanozymes with the specificity of aptamers for the detection of various biomolecules. Nanozymes are nanomaterials that possess enzyme-like properties, demonstrating substantial potential for enhancing the sensing capabilities of biosensors. In recent years, the incorporation of nanozymes into biosensors has opened new avenues for the detection of tumor biomarkers.

Mechanism of - for treatment of primary liver cancer: analysis with network pharmacology, molecular docking and validation.

Objectives: To investigate the active ingredients in Hedyotis diffusa-Scutellaria barbata D. Don and the main biological processes and signaling pathways mediating their inhibitory effect on primary hepatocellular carcinoma (HCC).

Methods: The core intersecting genes of HCC and the two drugs were screened from TCMSP, Uniport, Genecards, and String databases using Cytoscape software, and GO and KEGG enrichment analyses of the intersecting genes were conducted.

LAMP3-mediated epithelial-mesenchymal transition promotes the invasion and excessive proliferation of fibroblast-like synoviocytes in rheumatoid arthritis.

Objective: The aim of this study was to explore the functional role of LAMP3-mediated epithelial-mesenchymal transition (EMT) in fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis (RA) patients and to evaluate its potential as a therapeutic target.

Methodology: Changes in EMT and LAMP3 were investigated in the synovial tissue and FLSs of RA patients. In vitro experiments were performed using the EMT inhibitor C19, siRNA, and lentivirus to examine the impact of EMT and LAMP3 on RA-FLSs and the underlying mechanisms involved.