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http://dx.doi.org/10.1093/ibd/izaf055 | DOI Listing |
CNS Neurosci Ther
September 2025
Department of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Dhaka, Bangladesh.
Introduction: The microbiota-gut-brain axis (MGBA), a complex two-way connection between the gut microbiota and the brain, has become a key regulator of neurological and neuropsychiatric disorders. Neurological disorders and gut microbiota dysbiosis are linked to these diseases. Changes in gut microbiota can lead to neurotransmitter imbalances, oxidative stress, and neuroinflammation.
View Article and Find Full Text PDFNeurogastroenterol Motil
September 2025
The Rome Foundation, Chapel Hill, North Carolina, USA.
Background And Aims: Health systems struggle to deliver guideline-recommended multidisciplinary care to patients with irritable bowel syndrome (IBS). Digital collaborative care models (DCCMs) that integrate technology with experienced providers offer a promising solution for improving IBS management. We aimed to evaluate whether a novel DCCM improved clinical outcomes in IBS.
View Article and Find Full Text PDFCytokine
September 2025
Department of Child and Adolescent Health, School of Public Health, Bengbu Medical University, No. 2600 Donghai Avenue Bengbu, Anhui, People's Republic of China; Department of Naval Nutrition and Food Hygiene, Faculty of Naval Medicine, Naval Medical University, Shanghai, PR China; Shanghai Key Labo
Purpose: This study aimed to elucidate the role of lateral hypothalamic area (LHA) Vglut2 neurons in stress-induced intestinal inflammation and to investigate the underlying mechanisms involving neuro-immune interactions. Specifically, we hypothesized that LHA Vglut2 neuron activation exacerbates intestinal inflammation via sympathetic-driven IL-1β and Cxcl1 signaling.
Methods: Transgenic mice (Vglut2-cre) and wild-type controls were subjected to chronic restraint stress (CRS).
Gastroenterol Hepatol (N Y)
July 2025
Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, United Kingdom.
One in 4 patients with endoscopically confirmed quiescent inflammatory bowel disease (IBD) reports persistent gastrointestinal symptoms, which are often compatible with irritable bowel syndrome (IBS). The reporting of these IBS-type symptoms is associated with psychological comorbidity, impaired quality of life, and increased health care utilization. The brain-gut axis, which provides the link between the central nervous system and gastrointestinal tract, may facilitate these relationships.
View Article and Find Full Text PDFNeurogastroenterol Motil
August 2025
Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Background: Cognitive and psychological inflexibility are two mental processes that influence how a person interprets and responds to esophageal symptoms. Patients with greater mental inflexibility are at risk for poorer outcomes. Brain-gut behavioral therapies (BGBT) are effective adjunctive treatments in many digestive diseases, with potential to improve mental flexibility.
View Article and Find Full Text PDF