Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Inspired by tropoelastin coacervation, a process in elastic fiber formation driven by hydrophobic interactions, we developed a tough, antiswelling hydrogel, PHEA-(PVA--PE), by incorporating amphiphilic poly(vinyl alcohol--ethylene) (PVA--PE) into a hydrophilic poly(2-hydroxyethyl acrylate) (PHEA) network. The PHEA-(PVA--PE) hydrogel was prepared by UV-induced polymerization of a PHEA precursor dimethyl sulfoxide (DMSO) solution containing PVA--PE, followed by immersion in water. During solvent exchange, PVA--PE self-assembled into micellar structures within the PHEA matrix, mimicking the coacervation of tropoelastin. Compared with PHEA and PVA--PE hydrogels, the strength of PHEA-(PVA--PE) increased by 83 and 7 times, while the toughness increased by 145 and 97 times. This strategy can be further extended to a variety of amphiphilic copolymers, demonstrating the universality. In vitro and in vivo tests demonstrated that the hydrogel possesses excellent biocompatibility and antiswelling capability. This study provides a simple method for developing a tough, biocompatible, and antiswelling hydrogel.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acsmacrolett.5c00188 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Slide-Ring Based Hydrogel Sensors with Extreme Wide Temperature Adaptability Toward Winter Swimming Sensing Application.
Small
September 2025
Shaanxi Key Laboratory of Chemical Additives for Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China.
Conductive hydrogels have significant application prospects in the field of flexible wearable sensors. However, there are still challenges to stably apply conductive hydrogels in extreme environments and various aqueous conditions. To enable the application of conductive hydrogels across a wide temperature range and in multiple environments, it is necessary to consider comprehensive properties such as anti-swelling ability, flexibility, self-adhesiveness, stable linear sensing, and certain durability.
View Article and Find Full Text PDFBreaking through Hydration Layer Barrier: a Novel Ultra-Strong Underwater Hydrogel Adhesive Toward Full-Thickness Cartilage Repair.
Adv Healthc Mater
September 2025
Laboratory of Advance Technologies of Materials, Ministry of Education, College of Medicine and School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China.
The absence of blood vessels and nerves in cartilage severely restricts its self-healing capacity. Meanwhile, the inherent anti-adhesive nature of articular cartilage matrix further complicates the integration of implanted scaffolds, leading to common issues such as scaffold displacement, reduced mechanical stability, impaired cell migration, and insufficient tissue regeneration. These challenges collectively render articular cartilage repair a formidable global issue.
View Article and Find Full Text PDFAn endoscopy deliverable hydrogel dry powder for sealing and repairing gastric perforation.
Acta Biomater
August 2025
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.
Gastric perforation (GP) is characterized by full-thickness injury of the stomach wall, a severe and potentially life-threatening gastrointestinal disease. However, current treatment, including surgical sutures and endoscopic closure, faces limitations, achieving complete sealing of the perforation and favorable healing remains a great challenge and an acute clinical demand. Here, we report a hydrogel dry powder (PPCL@Mg) for the minimally invasive treatment of GP, which can be delivered to target perforation wounds by spraying via an endoscope, and rapidly absorbing interfacial water and spontaneously forming a hydrogel.
View Article and Find Full Text PDFBiodegradable and anti-swelling peptide-based supermolecule hydrogel for eliminating ROS and inhibiting inflammation in acute spinal cord injury repair.
Acta Biomater
August 2025
The Affiliated Xiangshan Hospital of Wenzhou Medical University, Ningbo 315700, China; Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.
The treatment of spinal cord injury (SCI) presents a significant global medical challenge, as the difficulties associated with neuronal regeneration are compounded by elevated levels of reactive oxygen species (ROS) and an inflammatory microenvironment that ensues following SCI. Peptide-based supramolecular hydrogels exhibit robust advantages in repairing SCI due to their natural amino acid composition and biomimetic extracellular matrix characteristics following self-assembly. However, the potential for sequence designability remains underexplored, presenting an opportunity to develop highly bioactive peptide-based biomaterials.
View Article and Find Full Text PDFAnti-Swelling Dual-Network Zwitterionic Conductive Hydrogels for Flexible Human Activity Sensing.
Polymers (Basel)
August 2025
State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.
Conventional conductive hydrogels are susceptible to swelling in aquatic environments; which compromises their mechanical integrity; a limitation that poses a potential challenge to their long-term stability and application. In this study, a zwitterionic ion-conductive hydrogel was fabricated from polyvinyl alcohol (PVA), acrylic acid (AA), and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SMBA), forming a dual-network structure. A copolymer of zwitterionic SBMA and AA formed the first network, and PVA formed the second network by repeated freeze-thawing.
View Article and Find Full Text PDF