Restoring the enteric neuroimmune crosstalk via hollow mesoporous polydopamine nanoparticles in inflammatory bowel disease treatment.

The enteric neuro-immune crosstalk is considered crucial for maintaining intestinal mucosal immune homeostasis, offering a promising way to achieve clinical cure of inflammatory bowel disease (IBD). However, neuron loss, disruption of the enteric nervous system, and impaired acetylcholine (ACh) biosynthesis in the intestine are prevalent in IBD patients, which severely disrupts enteric neuroimmune function. Exploring effective treatments for the disease has become the research hotspot and the goal of current IBD research.

Fourier-based multiple-slice reconstruction in cryo-electron tomography.

A tomogram is reconstructed from the micrographs of the tilt series using cryo-electron tomography (cryoET). Reconstruction frequently integrates image processing steps, such as filtering and contrast transfer function (CTF) correction, to support the downstream analysis of cellular and viral structures. Most image processing steps are based on Fourier space analysis, which is theoretically more efficient to be implemented in Fourier space than in real space.

Neuronal intranuclear inclusion disease complicated by acute middle cerebral artery infarction: A case report.

Background: Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disorder with no prior reports linking it to acute large-vessel cerebral infarction.

Methods: A 65-year-old man with progressive limb numbness and acute neuropsychiatric symptoms underwent MRI, skin biopsy, and genetic testing.

Results: MRI revealed corticomedullary "ribbon signs" and right middle cerebral artery (MCA) stenosis.

[Association of angiotensin Ⅱ type 1 receptor autoantibody and sperm motility in human semen].

Objective: To investigate the relationship between angiotensin Ⅱ type 1 receptor autoantibody (AT1-AA) and semen parameters. Methods： The semen samples of 820 male patients who were treated in the Reproductive Medicine Center of Taiyuan Central Hospital from August 2022 to August 2023 were retrospectively analyzed. The levels of AT1-AA and Ang Ⅱ of semen were detected by ELISA, and the function of AT1-AA was detected by cardiomyocyte beating assay in suckling rats.

Tryptamine-Functionalized Lipid Nanocarriers Co-delivering SMO/BRD4 Inhibitors for Synergistic Medulloblastoma Therapy.

The management of medulloblastoma (MB) remains a significant challenge, primarily attributed to the presence of cancer stem cells and the inadequate delivery of therapeutic agents across the blood-brain barrier. GLI, as a regulator of the hedgehog signaling pathway in normal cerebellum development, also exerts pivotal functions in MB initiation, progression, and metastasis and maintains the stemness of MB stem cells. In this study, we devised a combined therapeutic approach by integrating the BRD4 inhibitor JQ1 with the SMO inhibitor saikosaponin B1 (SSB1) to inhibit MB via regulation of GLI activation.

Epicardial adipose tissue volume is associated with impaired left ventricular strain in patients with metabolic syndrome: the mediating role of myocardial energetic efficiency.

Background: Epicardial adipose tissue volume (EATV) has been linked to cardiac dysfunction in metabolic syndrome (MetS), but the underlying mechanisms remain unclear. The aim of this study was to investigate whether myocardial energetic efficiency partially explains the relationship between EATV and impaired left ventricular (LV) myocardial strain in MetS patients using cardiac magnetic resonance (CMR).

Methods: A total of 225 patients with MetS and 68 age - and sex - matched controls underwent CMR.

Engineered cyclodextrin-protein domain interface modulation and application in nanoscale delivery systems development for therapeutic proteins.

With the development of molecular biology and pharmacology, proteins have been considered essential therapeutic agents that directly or indirectly participate in disease treatment. However, protein-based formulations face significant drawbacks, including low storage stability, rapid metabolism in vivo, and limited organ-selective delivery. Moreover, the internal protein also participated in drug transportation and cellular endocytosis.

Controllable growth of MoO dielectrics with sub-1 nm equivalent oxide thickness for 2D electronics.

The integration of two-dimensional (2D) semiconductors with high-κ dielectrics is critical for the development of post-silicon electronics. The key challenge lies in developing an ultra-thin high-κ dielectric with damage-free interface and sub-1 nm equivalent oxide thickness (EOT) for further continuation of Moore's law. Here we report the thickness-controlled free-standing growth of layered MoO dielectrics with EOT down to 0.

Accurate helical parameter estimation based on cylindrical unrolling.

Helical structure is fundamental for filamentous and tubular macromolecular assemblies that play crucial roles in structural scaffolding and signaling processes. Structure determination of these assemblies relies on the precise estimation of their helical parameters. Although layer-line-based methods are widely used, their application is often challenging due to structural flexibility and heterogeneity.

Genetically engineered sericin hydrogels for the delivery of human adiponectin in treating ulcerative colitis in mice.

Ulcerative colitis (UC) is one type of inflammatory bowel diseases, and adiponectin (APN) is a potential therapeutic protein drug for treating UC. However, source and targeted delivery of APN to improve its effectiveness and bioavailability remain challenges. Here, we report a strategy to develop a sericin hydrogel (rhAPN-sh) through genetically engineering silkworm to spin silks mixed with recombinant human adiponectin (rhAPN), which efficiently overcome APN source and delivery.

Large artery atherosclerotic versus cardioembolism subtypes of large hemispheric infarction in the middle cerebral artery.

Background: Large hemispheric infarction (LHI) of the middle cerebral artery (MCA) is linked to high mortality and morbidity. This study aims to investigate the characteristics of large artery atherosclerosis (LAA) and cardioembolism subtypes of LHI in MCA.

Methods: This retrospective cohort study included 70 patients with LHI hospitalized at the Second Affiliated Hospital of Anhui Medical University from May 2019 to May 2021.

The adverse effects of metabolic disorder on left ventricular myocardial mechano-energetic efficiency and dysfunction in ischemic cardiomyopathy: insight from a cardiac MRI study.

Purpose: Metabolic risk factors (MetF) have emerged as the leading drivers of ischemic cardiomyopathy (ICM) worldwide. However, in patients who have already experienced myocardial ischemia/infarction, whether and in what pattern the MetF act on the heart needs to be further elucidated. This study aims to determine the adverse effects of MetF on left ventricular (LV) indexed myocardial mechano-energetic efficiency (MEEi) and dysfunction in patients with ICM, and further clarify which MetF classification is more clinically significant.

Biosynthesis of a dual growth factors (GFs) functionalized silk sericin hydrogel to promote chronic wound healing in diabetic mice.

Chronic non-healing wounds, such as diabetic foot, pressure sores and bedsores have seriously affected the life quality of patients worldwide. GFs provide a potential solution to promote chronic wound healing by promoting cell proliferation and differentiation. However, limited resource, high cost, and instability greatly hindered their clinical applications.

Efficacy and safety of Xiao'er Fengre Qing oral liquid Oseltamivir in treating pediatric influenza (wind-heat invading the defense syndrome): a multicenter, randomized, non-inferiority trial.

Background: Xiao'er Fengre Qing Oral Liquid (XFQOL) is developed based on the classical traditional Chinese medicinal formula . Compared to the original formulation, XFQOL exhibits enhanced heat-clearing, detoxification, and fever reduction, which can effectively address the common complications associated with influenza in children and is well-suited for pediatric use. However, there is currently a lack of high-quality evidence from clinical trials to support its efficacy and safety in clinical applications.

Regulation of DNA translocation of chromatin remodeler enzyme Chd1 by exit DNA unwrapping.

Nucleosomes are the fundamental unit of chromatin. Chromatin remodeler plays a crucial role in the regulation of gene expression in eukaryotes. It is involved in important physiological processes, such as development, immune response, and metabolic regulation.

Comparison of right ventricular function and clinical outcomes in type 2 diabetes patients with and without obstructive coronary artery disease: insights from a CMR study.

Background: Obstructive coronary artery disease (OCAD) marks a high-risk group within patients with type 2 diabetes mellitus (T2DM), underscoring the need for tailored prevention and management strategies. However, limited data exist on right ventricular (RV) function and clinical outcomes in T2DM patients with versus without OCAD. This study aimed to investigate the differences in RV function and clinical outcomes between these two groups.

Effect of glycemic status on myocardial deformation and microvascular function in uncomplicated pediatric type 1 diabetes mellitus: cardiac magnetic resonance imaging.

Background: Cardiovascular disease remains the leading cause of morbidity and mortality among individuals with type 1 diabetes mellitus (T1DM). Individuals with hyperglycemia are at great risk of cardiovascular complications. This study investigated the impact of glycemic control on left ventricular (LV) microvascular perfusion and myocardial deformation in uncomplicated pediatric T1DM using cardiac magnetic resonance (CMR) imaging.

Improved Dispersion of Micron-Sized Platinum Powder through Heat Treatment.

The agglomeration of micrometer-sized platinum particles prepared by chemical liquid-phase reduction results in inadequate dispersion, a wide particle size distribution, and low tap density, thereby impacting the application of the platinum powder. In this study, CaO and platinum powder were homogeneously mixed through ball milling and subsequently subjected to heat treatment at temperatures ranging from 700 to 1300 °C. Following treatment at 1100 °C, the particle size distribution of platinum became narrower with SD ( - ) decreasing from 14.

The dynamic evolution and obstacle identification of pseudo and reality human settlements in the central plains urban agglomeration of China.

Exploring the development of human settlements is crucial in creating a "Beautiful China" accelerating central China region growth, improving human settlements geography research, and advancing the human-land system theory. This study constructs a theoretical framework for the coupling and coordination of pseudo and reality human settlements and takes the Central Plains Urban Agglomeration as the study area. It investigated the dynamic evolution and driving mechanisms of pseudo and reality human settlements in the Central Plains urban agglomeration using multi-source big data from online shopping, social communication, information search, and remote sensing images during 2011-2021 and conducted comprehensive, kernel density, coupling coordination degree, and obstacle degree analyses.

Neuromorphic Transistors Integrating Photo-Sensor, Optical Memory and Visual Synapses for Artificial Vision Application.

In commercial artificial vision system (AVS), the sensing, storage, and computing units are usually physically separated due to their architecture and performance gaps, which thus increases the volume, complexity, and energy loss. This work develops a neuromorphic transistor integrating these different modules within one single device. Leveraging the gate-tunable out-of-plane electric field, the device achieves the multi-mode integration of photo-sensor, optical memory, and visual synapse.

Self-luminous nanoengineered bacteria with the sustained release of interleukin 2 as an in situ vaccine for enhanced cancer immunotherapy.

Bacteria-based in situ vaccination (ISV) has emerged as an effective therapeutic approach by activating anti-tumor immunity. However, inducing immunogenic cell death (ICD) and promoting effector T cell activation remain critical challenges in clinical applications of bacteria-based ISV. Here, we have developed a tumor microenvironment-activated nano-hybrid engineered bacterium as ISV.

Promote Sepsis Recovery through the Inhibition of Immunothrombosis via a Combination of Probenecid Nanocrystals and Cefotaxime Sodium.

Sepsis is a life-threatening organ dysfunction syndrome caused by a dysregulated host immune response to pathogenic infection. Due to its high mortality rate, it has been a major global public health problem. Recent studies have shown that the formation of immunothrombosis plays as a "double-edged sword" in the pathogenesis of sepsis, and how to properly regulate immunothrombosis to avoid organ damage and end the high-inflammation state as early as possible are the key steps for sepsis therapy.

Serum creatine kinase dynamics in amyotrophic lateral sclerosis: Predictive role of male sex, limb onset, and intermediate disease duration for stratified monitoring.

Objective: To investigate serum creatine kinase (CK) levels in amyotrophic lateral sclerosis (ALS) patients and their associations with disease characteristics, exploring its utility as a biomarker for disease progression.

Methods: This retrospective study included 81 definitive ALS patients and 99 matched controls. Serum CK levels were analyzed against sex, age, onset site, disease duration, and ALSFRS-R scores using Mann-Whitney U tests, Kruskal-Wallis tests, and multivariate regression.

The adverse effect of metabolic syndrome on left ventricular global strains and myocardial energetic efficiency in non-ischemic dilated cardiomyopathy patients: a cardiac magnetic resonance study.

Background: Metabolic syndrome (MetS) is a known risk factor for cardiovascular dysfunction; however, its impact on left ventricular (LV) global strains and myocardial energetic efficiency in non-ischemic dilated cardiomyopathy (NIDCM) remains inadequately understood. This study aimed to investigate the effect of MetS on LV dysfunction in NIDCM patients using cardiovascular magnetic resonance (CMR) imaging.

Methods: A total of 557 NIDCM patients (378 without MetS and 179 with MetS) who underwent CMR examination were included.

Efficient energy phosphorescence transfer and reversible phosphorescence in aromatic heterocyclic doped systems for advanced information storage.

Organic room-temperature phosphorescent (RTP) materials have garnered significant attention in recent years due to their unique advantages, including diverse molecular structures, excellent biocompatibility, and favorable processability. Aromatic heterocyclic groups are known to effectively promote intersystem crossing (ISC), leading to a wide range of applications in this field. In this study, dibenzo[a,c]phenazin-11-yl(phenyl)methanone (DPM) was used as an energy acceptor, doped with the host material benzophenone (BP) and its derivatives (BP-R) as energy donors.