[Association of angiotensin Ⅱ type 1 receptor autoantibody and sperm motility in human semen].

Objective: To investigate the relationship between angiotensin Ⅱ type 1 receptor autoantibody (AT1-AA) and semen parameters. Methods： The semen samples of 820 male patients who were treated in the Reproductive Medicine Center of Taiyuan Central Hospital from August 2022 to August 2023 were retrospectively analyzed. The levels of AT1-AA and Ang Ⅱ of semen were detected by ELISA, and the function of AT1-AA was detected by cardiomyocyte beating assay in suckling rats.

Arachidonic Acid Metabolism Down-Regulation-Mediated Tumor Necrosis Factor Signaling Contributes to Cutaneous Fibrosis and Skull Hyperplasia in Goldfish Hoods.

Goldfish () are renowned as a premier ornamental fish in the world. Especially, the hood, a distinctive cephalic skin protrusion, is a highly sought-after feature for its endearing aesthetics. Despite a longstanding hypothesis that the hood is a type of tumor, the details of their composition, structure, and the mechanism of its formation have remained enigmatic.

Modeling of neuronal hyperexcitability modulated by Aβ-mediated astrocyte dysfunction.

Neuronal hyperexcitability is a key feature in the early stages of Alzheimer's disease (AD). However, the underlying mechanisms have not been fully elucidated, particularly the impact of amyloid β-peptide (Aβ)-mediated astrocyte dysfunction on neuronal hyperexcitability. Building upon recent experiments demonstrating that Aβ induces neuronal hyperexcitability by reducing glutamate uptake and increasing glutamate release in astrocytes, we have developed here a neurocomputational model of the Aβ-mediated astrocyte-neuron tripartite synapse.

Association between bullous pemphigoid and hypertension: a systematic review and meta-analysis of observational studies.

Studies have indicated a relationship between bullous pemphigoid (BP) and hypertension, but the findings remain controversial. To examine this association, we conducted a systematic review using studies from PubMed, EMBASE, Web of Science, and the Cochrane Library, applying a random-effects model while performing subgroup and sensitivity analyses to explore potential sources of heterogeneity. Subgroup analyses were performed by country, data source, and sample size.

Aβ-mediated multiscale study of spontaneous calcium dynamics in astrocytes.

Some physiological experiments in Alzheimer's disease (AD) conditions have evidenced that amyloid β-peptide (Aβ) can induce spontaneous calcium oscillations in astrocytes and spontaneous calcium hyperactivity in astrocyte networks, which disrupt neuronal transmission and brain activity. However, the dynamical mechanism and potential process behind Aβ-induced spontaneous calcium dynamics have not been elucidated. Inspired by this, we develop a mathematical model of the Aβ-mediated astrocyte network to explore the multi-scale spontaneous calcium dynamics, where the network has a 3D multi-topology structure, including link radius, Erdős-Rényi, and scale-free networks.

Expression pattern changes of three homeologs in chemokine activity enhance antiviral response to herpesvirus infection in a newly synthesized alloheptaploid.

Allopolyploids often exhibit enhanced resistance to pathogen stresses. However, our understanding about the patterns that allopolyploids modify homeolog expression upon pathogen invasion remains limited. Since 2012, a disease caused by herpesvirus (CaHV) has posed a severe threat to Carassius auratus aquaculture.

Mg inhibits infection of spring viraemia of carp virus (SVCV) by enhancing IRF3 expression.

Magnesium ions (Mg), essential divalent cations, play a pivotal role in orchestrating a myriad of physiological and biochemical processes. However, the intricate relationship between Mg homeostasis and antiviral immunity in fish remains largely unexplored. In this study, we found that Mg enhances the interferon (IFN) response by increasing the expression of IFN regulatory factor 3 (IRF3) to inhibit spring viraemia of carp virus (SVCV) infection.

Enhancing anode intrinsic capacitance improves the performance of microbial fuel cells in wastewater treatment.

Capacitive anodes hold promise for enhancing microbial fuel cells (MFCs) in wastewater treatment, yet the impact of capacitive anodes with different capacitance type and mass specific capacitance on the performance remains unclear. This study compared electric double layer (EDL) and pseudo-capacitance anodes, evaluating their power generation and pollutant removal in MFCs. Results showed that EDL anode with 2 mg mass loading achieved 5.

Ghrelin alleviates high glucose-induced retinal microvascular endothelial cell injury by activating Nrf2/HO-1 pathway to inhibit ferroptosis.

Aim: To investigate the protective role of ghrelin against diabetic retinopathy (DR), focusing on its anti-ferroptotic mechanism in high glucose-induced retinal endothelial injury.

Methods: First, small interfering RNA (siRNA)-mediated interference was conducted to knockdown nuclear factor erythroid 2-related factor 2 (Nrf2). Using reverse transcription-polymerase chain reaction (RT-PCR), the expression level of Nrf2 was determined from human retinal microvascular endothelial cells (HRMECs) transfected with either si-NC or si-Nrf2.

Dynamic modeling of astrocyte-neuron interactions under the influence of Aβ deposition.

β-amyloid (Aβ) protein accumulation is recognized as a key factor in Alzheimer's disease (AD) pathogenesis. Its effects on astrocyte function appear primarily as disturbances to intracellular calcium signaling, which, in turn, affects neuronal excitability. We propose an innovative neuron-astrocyte interaction model to examine how Aβ accumulation influences astrocyte calcium oscillation and neuronal excitability, emphasizing its significance in AD pathogenesis.

Grass carp reovirus VP4 manipulates TOLLIP to degrade STING for inhibition of IFN production.

Unlabelled: Although fish possess an effective interferon (IFN) system to defend against viral infection, grass carp reovirus (GCRV) still causes epidemic hemorrhagic disease and tremendous economic loss in grass carp. Therefore, it is necessary to investigate the immune escape strategies employed by GCRV. In this study, we show that the structural protein VP4 of GCRV (encoded by the S6 segment) significantly restricts IFN expression by degrading stimulator of IFN genes (STING) through the autophagy-lysosome-dependent pathway.

A-mediated synaptic glutamate dynamics and calcium dynamics in astrocytes associated with Alzheimer's disease.

The accumulation of amyloid peptide is assumed to be one of the main causes of Alzheimer's disease . There is increasing evidence that astrocytes are the primary targets of A. A can cause abnormal synaptic glutamate, aberrant extrasynaptic glutamate, and astrocytic calcium dysregulation through astrocyte glutamate transporters facing the synaptic cleft (GLT-syn), astrocyte glutamate transporters facing the extrasynaptic space (GLT-ess), metabotropic glutamate receptors in astrocytes (mGluR), N-methyl-D-aspartate receptors in astrocytes (NMDAR), and glutamatergic gliotransmitter release (Glio-Rel).

A nomogram model for predicting advanced liver fibrosis in patients with hepatitis B: A multicenter study.

Background: Biopsy is the gold standard method for diagnosing liver fibrosis. FibroScan is a non-invasive method of diagnosing liver fibrosis, but it still faces some limitations. This study aimed to establish a nomogram model and identify patients at high risk of advanced liver fibrosis associated with hepatitis B infection.

Selection and optimization of biofilm carriers as high-effective microbial separator in microbial fuel cells.

Four biofilm carriers including pyrite, manganese ore, ceramsite, and polyurethane sponge were used to construct microbial separators (MSs), while their performance in dual-chamber microbial fuel cells (MFCs) was evaluated. Polyurethane sponge and pyrite were superior biofilm carriers for MSs. The dense biofilm on the polyurethane sponge provides MS with optimal barrier capacity against dissolved oxygen and chemical oxygen demand.

Controlling Alzheimer's disease by deep brain stimulation based on a data-driven cortical network model.

This work aims to explore the control effect of DBS on Alzheimer's disease (AD) from a neurocomputational perspective. Firstly, a data-driven cortical network model is constructed using the Diffusion Tensor Imaging data. Then, a typical electrophysiological feature of EEG slowing in AD is reproduced by reducing the synaptic connectivity parameters.

Alantolactone improves cognitive impairment in rats with Porphyromonas gingivalis infection by inhibiting neuroinflammation, oxidative stress, and reducing Aβ levels.

Neuroinflammation caused by the chronic periodontal pathogen Porphyromonas gingivalis is growing regarded as as a key factor in the pathogenesis of Alzheimer's disease (AD). Alantolactone (AL), a sesquiterpene lactone isolated from the root of Inula racemosa Hook. f, has been proven to provide various neuroprotective effects.

External circuit loading mode regulates anode biofilm electrochemistry and pollutants removal in microbial fuel cells.

This study investigated the effects of different external circuit loading mode on pollutants removal and power generation in microbial fuel cells (MFC). The results indicated that MFC exhibited distinct characteristics of higher maximum power density (P) (named MFC-HP) and lower P (named MFC-LP). And the capacitive properties of bioanodes may affect anodic electrochemistry.

A rat model of cerebral small vascular disease induced by ultrasound and protoporphyrin.

Cerebral small vascular disease (CSVD) has a high incidence worldwide, but its pathological mechanisms remain poorly understood due to the lack of proper animal models. The current animal models of CSVD have several limitations such as high mortality rates and large-sized lesions, and thus it is urgent to develop new animal models of CSVD. Ultrasound can activate protoporphyrin to produce reactive oxygen species in a liquid environment.

Insights to the cooperation of double-working potential electroactive biofilm for performance of sulfamethoxazole removal: ARG fate and microorganism communities.

Bioelectrochemical systems (BESs) have shown great potential in enhancing sulfamethoxazole (SMX) removal. However, electroactive biofilms (EBs) constructed with single potentials struggle due to limited biocatalytic activity, hindering deep SMX degradation. Here, we constructed a double-working potential BES (BES-D) to investigate its ability to eliminate SMX and reduce the levels of corresponding antibiotic resistance genes (ARGs).

Role of membrane fouling layer in microbial fuel cell-membrane bioreactor (MFC-MBR) for controlling sulfamethoxazole and corresponding resistance genes.

Integrated MFC-MBR systems effectively remove antibiotics and control the release of antibiotic resistance genes (ARGs). However, the fouling layers on membranes can potentially act as reservoirs for ARGs. This study aims to elucidate the roles of membrane fouling layers and levels in influencing sulfamethoxazole (SMX) removal and ARGs control within an MFC-MBR system.

Development of a nomogram for predicting liver transplantation prognosis in hepatocellular carcinoma.

Background: At present, liver transplantation (LT) is one of the best treatments for hepatocellular carcinoma (HCC). Accurately predicting the survival status after LT can significantly improve the survival rate after LT, and ensure the best way to make rational use of liver organs.

Aim: To develop a model for predicting prognosis after LT in patients with HCC.