ARR1/12-ETP1/2 model negatively regulates submergence-induced hypoxia response in A. thaliana.

Submergence-induced hypoxia stress hampers plant growth and yield, yet its molecular mechanisms remain elusive. Here, we found that ETP1/2 are repressed by submergence stress and negatively regulate plant tolerance to submergence. Further analysis showed that the repression of ETP1/2 during the submergence response is at least partly caused by the decreased expression of ARR1/12, as ARR1/12 can directly bind to the promoters via the AGATTTG motifs to activate ETP1/2 expression.

Association of sleep patterns with the trajectory of multimorbidity: A large community-based longitudinal study.

Objective: This study aimed to investigate whether sleep patterns are associated with the accumulation of multiple chronic diseases and multimorbidity-free survival, and to explore the role of C-reactive protein in these associations.

Methods: The study included 247,751 chronic disease--free participants from the UK Biobank (mean age: 55.20 ± 8.

Conversion therapy followed by surgery and adjuvant therapy improves survival in Barcelona C stage hepatocellular carcinoma - A propensity score-matched analysis.

Conversion therapy with a combination of tyrosine kinase inhibitor and anti-programmed death-1 antibody sequential surgery and postoperative adjuvant therapy has shown improved survival benefits in patients with Barcelona C stage (BCLC-C) hepatocellular carcinoma (HCC). We aimed to compare the survival benefits in a retrospective cohort of patients with BCLC-C HCC who underwent surgery after conversion therapy with adjuvant therapy and surgery alone. The conversion therapy group was derived from a prospective clinical study, and from January 2015 to September 2023, we selected patients diagnosed with BCLC-C HCC who underwent liver resection at Chinese PLA General Hospital as the surgical group.

Yeast cell-wall polysaccharides regulate ruminal microbial metabolism to enrich lamb with health-promoting fatty acids.

This study investigated the effects of yeast cell-wall polysaccharides (YCWPs) on lamb meat quality and the mechanisms underlying these effects. Twenty-four lambs were randomly assigned to four groups and were fed a basal diet supplemented with 0 (Control), 0.5 (YCWP 0.

Frenemy: adaptive temperate phage_SAP_1432 supports survival in changing temperatures.

Unlabelled: It is important to understand how the presence of pathogens could benefit the survival of their hosts during climate change. In this study, we investigated the influence of the heat-resistant temperate phage phage_SAP_1432 on its bacterial host Q1432 at different temperatures. Thermal host performance curves at a multiplicity of infection of 0.

Multi-Omics Joint Analysis of Molecular Mechanisms of Compound Essential Oils Inhibiting Spoilage Yeast in Paocai.

is the main spoilage fungus that causes the deterioration of paocai. Our previous study found that the compound essential oils (CEOs) of lemon, lemongrass, and nutmeg had a good inhibitory effect; however, the antimicrobial mechanism was unknown. In order to elucidate the mechanism of action of the CEO in inhibiting , transcriptomics and metabolomics were used for joint analysis.

Genome mining, synthesis, antibacterial mechanism, and application of the gut commensal-derived antibacterial peptide CR24.

The growing occurrence of antimicrobial resistance has called for an urgent need to develop new sources of antimicrobial agents against multidrug-resistant strains. The trillions of microbes living in the gut become gradually a promising source of novel antimicrobial agents. In this study, we isolated a candidate strain with good antibacterial activity identified as Bacillus haynesii strain B1 from the sheep intestine and obtained a novel antimicrobial peptide through B.

Combined effect of fasting blood glucose and serum uric acid on nonalcoholic fatty liver disease.

Background: This study sought to investigate the independent and synergistic impacts of fasting blood glucose (FBG) and serum uric acid (SUA) levels on non-alcoholic fatty liver disease (NAFLD) in participants with and without type 2 diabetes mellitus (T2DM).

Method: A total of 12,430 participants (mean age: 54.34 ± 15.

Dietary supplementation of yeast polysaccharides enhance lamb growth performance by improving immune and intestinal barrier function and the abundance of cecal microbiota.

Weaning stress can affect the growth performance and intestinal health of lambs. Yeast polysaccharides are green and safe feed additives that have been shown to improve growth performance and intestinal health in other animals. The aim of this study was to explore the effects of dietary yeast polysaccharides on the growth performance and intestinal health of weaned lambs.

In Situ Gene Engineering Approach to Overcome Tumor Resistance and Enhance T Cell-Mediated Cancer Immunotherapy.

T cell-mediated cancer immunotherapy harnesses the power of cytotoxic T lymphocytes (CTLs) to target and eradicate tumor cells. However, tumor cells often evade immune attack through membrane repair mechanisms involving endosomal sorting complexes required for transport (ESCRT) and immune suppression within the tumor microenvironment. Here, we developed a robust TMV@PpCHIL nanomedicine to address these issues by reprogramming tumor cells via in situ gene editing.

Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux.

Ruminal dysbiosis-induced liver injury is prevalent in dairy cows, yet its underlying mechanisms remain incompletely understood. Ferroptosis, a newly identified form of programmed cell death distinct from apoptosis and necrosis, has been implicated in various liver diseases by emerging studies. In the present study, lipopolysaccharide (LPS) and γ-D-glutamyl-meso-diaminopimelic acid (iE-DAP) were employed to establish in vitro and in vivo models of liver injury using bovine hepatocytes and mice, respectively.

Interactive effect of phenylalanine with duration of diabetes on the risk of small vessel disease in Chinese patients with T2DM.

Aims: Few prior studies have explored the relationship between phenylalanine and diabetic small vessel disease (SVD) in patients with different durations of type 2 diabetes mellitus(T2DM). Our study aimed to explore whether phenylalanine is associated with the risk of SVD and to further explore whether phenylalanine interacted with the duration of T2DM to alter the risk of SVD.

Materials And Methods: A total of 1,032 T2DM patients were enrolled using the Liaoning Medical University First Affiliated Hospital (LMUFAH) system.

Allelic variation in the promoter of WRKY22 enhances humid adaptation of Arabidopsis thaliana.

Submergence stress tolerance is a complex trait governed by multiple loci. Because of its wide distribution across arid and humid regions, Arabidopsis thaliana offers an opportunity to explore the genetic components and their action mechanisms underlying plant adaptation to submergence stress. In this study, using map-based cloning we identified WRKY22 that activates RAP2.

Molecular mechanisms of tetrabromobisphenol A (TBBPA) toxicity: Insights from various biological systems.

Tetrabromobisphenol A (TBBPA) is a ubiquitous brominated flame retardant extensively incorporated into a wide range of products. As its utilization has escalated, its environmental exposure risks have concomitantly increased. The molecular properties of TBBPA allow it to persist in the environment and within organisms.

β-Carotene Ameliorates LPS-Induced Endoplasmic Reticulum Stress and Mitochondrial Disorder by Targeting ORAI1 in Bovine Mammary Epithelial Cells.

Ca is an important regulator of endoplasmic reticulum (ER) and mitochondrial function. Store-operated calcium entry (SOCE) serves as the predominant pathway for the influx of extracellular Ca into the cell. ORAI1, ORAI2, and ORAI3 are the main proteins of SOCE.

Mesomycoplasma (Mycoplasma) ovipneumoniae dihydrolipoamide dehydrogenase is an immunogenic plasminogen binding protein and a putative adhesin.

The interaction of Mesomycoplasma (Mycoplasma) ovipneumoniae (M. ovipneumoniae) with host cells is a pivotal step in the infection process, underlining the necessity to develop vaccines and therapeutic approaches targeting the pathogen's key invasion mechanisms. The bacterium's capacity for adherence, invasion, and subsequent evasion of the host immune response underpins its pathogenicity, rendering adherence genes feasible vaccine targets.

Landscape of the Peripheral Immune Response Induced by Intraoperative Radiotherapy Combined with Surgery in Early Breast Cancer Patients.

A comprehensive analysis of the immune response triggered by intraoperative radiation therapy (IORT) remains incomplete. In this study, single-cell RNA sequencing and single-cell T cell receptor sequencing are conducted on peripheral blood mononuclear cells (PBMCs) from patient with early-stage breast cancer before and after IORT. Following IORT combined with surgery (defined as IORT+Surgery), PBMC counts remained stable, with increased proportions of T cells, mononuclear phagocytes, and plasma cells, and a reduction in neutrophil proportions.

Construction of a new emergency management system for potentially viral/viral municipal solid waste in China: Based on the "Beam-Column Structure" framework model.

Emergency management of municipal solid waste during public health emergencies is crucial for curbing the spread of viruses and controlling environmental pollution. Most existing solid waste management systems, are designed with a top-down approach, covering multiple industries and sectors. However, these systems often fail to effectively manage potentially viral solid waste in household waste, which impedes effective solid waste management during public health emergencies and increases the risk of viral outbreaks.

Single-cell RNA sequencing reveals intratumoral heterogeneity and multicellular community in primary hepatocellular carcinoma underlying microvascular invasion.

Background: Microvascular invasion (MVI) is associated with an unfavorable prognosis and early recurrence of hepatocellular carcinoma (HCC), which is the crucial pathological hallmark of immunotherapy. While microvascular invasion (MVI) in hepatocellular carcinoma (HCC) currently lacks a detailed single-cell analysis of the tumor microenvironment (TME), it holds significant promise for immunotherapy using immune checkpoint inhibitors (ICI).

Methods: We performed single-cell RNA sequencing (scRNA-seq) on 3 MVI positive (MVIP) and 14 MVI-negative (MVIN) tumor tissues, as well as their paired adjacent non-tumoral tissues.

Relation of Cognitive Reserve Indicator to Heart Disease and Cardiac Structure and Function: A Large Community-Based Longitudinal Study.

Background: High cognitive reserve (CR) has been related to lower dementia risk, but its association with heart disease (HD) is unknown. We aimed to explore the relation of CR to HD and cardiac structure and function.

Methods And Results: Within the UK Biobank, 349 907 HD-free participants were followed up.

CCL5/CCR5/CYP1A1 pathway prompts liver cancer cells to survive in the combination of targeted and immunological therapies.

Combination therapy of anti-programmed cell death protein-1 (PD-1) antibodies and tyrosine kinase inhibitors (TKIs) has significantly improved the prognosis for hepatocellular carcinoma (HCC), but many patients still have unsatisfactory outcomes. CD8 T cells are known to exert a pivotal function in the immune response against tumors. Nevertheless, most CD8 T cells in HCC tissues are in a state of exhaustion, losing the cytotoxic activity against malignant cells.

Association of peak expiratory flow with motoric cognitive risk syndrome among older adults.

Background: The association between lung function and motoric cognitive risk syndrome (MCR) is unclear. We aimed to explore the association of peak expiratory flow (PEF) with MCR using cross-sectional and longitudinal analyses.

Methods: Within the CHARLS, 5095 participants were included in the cross-sectional analysis, and 4340 MCR-free participants were included in the longitudinal analysis.

The GE296_RS03820 and GE296_RS03830 genes are involved in capsular polysaccharide biosynthesis in Riemerella anatipestifer.

Riemerella anatipestifer is a pathogenic bacterium that causes duck serositis and meningitis, leading to significant harm to the duck industry. To escape from the host immune system, the meningitis-causing bacteria must survive and multiply in the bloodstream, relying on specific virulence factors such as capsules. Therefore, it is essential to study the genes involved in capsule biosynthesis in R.