Longitudinal liquid biopsy identifies an early predictive biomarker of immune checkpoint blockade response in head and neck squamous cell carcinoma.

Immune checkpoint blockade (ICB) has improved outcomes for patients with head and neck squamous cell carcinoma (HNSCC), but predictive biomarkers remain limited. Here, we use a time-resolved, multi-omic approach in a murine HNSCC model to characterize peripheral immune responses to ICB. Single-cell transcriptomics and T/B cell receptor analyses  reveal early on-treatment expansion of effector memory T and B cell repertoires in responders, preceding tumor regression.

Maternal exposure to advanced oxidation protein products induces neurodevelopmental abnormalities in the offspring of mice.

Preeclampsia (PE) not only causes multi-organ damage to the mother but also exerts long-term effects on the development of the offspring. Prenatal exposure to PE has been demonstrated to result in deleterious neurodevelopment and behavioral abnormalities in the offspring. Our prior research has evidenced that advanced oxidation protein products (AOPPs), both the biomarker and promoter of oxidative stress, contribute to the pathogenesis of preeclampsia by inducing trophoblast dysfunction and systemic inflammation.

gene mutation associated with pediatric diabetes mellitus and congenital deafness: A case report.

Background: Wolfram syndrome is a rare autosomal recessive genetic disorder characterized by early-onset diabetes and progressive neurodegeneration, most notably sensorineural hearing loss and optic atrophy. Because its initial manifestations are usually similar to those of type 1 diabetes, the diagnosis may be delayed until other manifestations appear. Pathogenic variations of the gene can disrupt endoplasmic reticulum function and cellular homeostasis, but the complete mutation spectrum of has not been fully determined.

Comparing the Effects of Fentanyl, Sufentanil, and Butorphanol Combined With Flurbiprofen Axetil on Postoperative Intravenous Patient-controlled Analgesia Post Cesarean Delivery.

Background: The analgesic effects between fentanyl, sufentanil, and butorphanol combined with flurbiprofen axetil on postoperative patient-controlled intravenous analgesia (PCIA) after cesarean delivery has never been evaluated.

Objectives: To evaluate the postoperative analgesic efficacy of selected PCIA formulae.

Study Design: This is a retrospective study.

Estimated pulse wave velocity and the risk of acute kidney injury in patients undergoing coronary revascularization: a retrospective cohort study from MIMIC-IV.

Acute kidney injury (AKI) commonly complicates coronary revascularization, worsening outcomes. Estimated pulse wave velocity (ePWV), a simple arterial stiffness marker, independently predicts cardiovascular risk. This study aimed to evaluate the association between ePWV and AKI in patients undergoing coronary revascularization.

Evaluation of real-world CO and NO emissions of various in-use heavy-duty vehicles.

As a major emission source in road transportation, carbon dioxide (CO) emissions from heavy-duty vehicles (HDVs) exacerbate climate change, while nitrogen oxide (NO) emissions pose serious health risks to human health. Therefore, it is critical to investigate in-depth their emission characteristics and evaluate the real-world emission levels of in-use HDVs, as they are an important source of mobile source emission. In this study, eleven in-use HDVs were tested using a Portable Emission Measurement System (PEMS).

A review on renewable energy: Conversion and utilization of biomass.

The significant increase in demand for fuels and chemicals driven by global economic expansion has exacerbated concerns over fossil fuel consumption and environmental pollution. To achieve sustainable production of fuels and chemicals, biomass resources provide a rich repository for carbon-neutral, green renewable energy, and organic carbon. This paper reviews the transformation and utilization of lignocellulosic biomass and its derivatives, emphasizing their valorization into high-quality chemicals and biofuels.

doc2a and doc2b contribute to locomotor and social behaviors by down-regulating npas4b in zebrafish.

Background: Copy number variations (CNVs) occurring on chromosome 16p11.2 are associated with various neurodevelopmental disorders, including autism spectrum disorder (ASD), schizophrenia, and intellectual disability. Among the genes situated within the critical CNV region, DOC2A is noteworthy.

Exploring the growth and impact of artificial intelligence in anesthesiology: a bibliometric study from 2004 to 2024.

Background: The integration of artificial intelligence (AI) in anesthesiology is revolutionizing clinical practice by enhancing patient monitoring, improving risk assessment, and enabling personalized anesthetic care. This bibliometric analysis aims to evaluate publication trends, key contributors, and emerging translational pathways in AI research in anesthesiology, with special emphasis on clinical relevance, thematic clustering, and future application prospects.

Materials And Methods: Publications related to AI in anesthesiology from 2004 to 2024 were retrieved from the Web of Science Core Collection database, resulting in 658 articles.

Mechanistic insights into Schisandrin C as the active anti-renal fibrosis ingredient of Schisandra chinensis: a network pharmacology analysis and transcriptomics integrated experimental verification.

Schisandra chinensis (Turcz.) Baill (Sch) is a Traditional Chinese Medicinal (TCM) plant. It is divided into southern and northern.

Reducing ultra-high particulate number (PN) emissions from high-mileage vehicles: The effective role of compressed natural gas (CNG).

Vehicle particle number (PN) emissions pose a serious threat to human health and the environment, making it crucial to investigate their emission characteristics and control strategies in depth. In this study, high- and low-mileage bi-fuel (gasoline/CNG) taxis that use conventional gasoline, ethanol-containing gasoline, and CNG were tested via a chassis dynamometer. The results indicate that the PN emission factor is significantly affected by the fuel type and driving conditions.

Multi-omics analysis reveals Angelica sinensis-Carthamus tinctorius herb pair ameliorates diabetic retinopathy comorbid with depressive symptoms via the gut-eye-brain axis.

Background: Diabetic retinopathy (DR) comorbid with depressive symptoms represents a significant public health challenge. The limitations of monotherapeutic approaches and the complex interplay between DR and depression highlight the need for comprehensive, integrated treatment strategies.

Purpose: This study aimed to explore the therapeutic efficacy and underlying mechanisms of the Angelica sinensis-Carthamus tinctorius herb pair (ACHP) in addressing DR comorbid with depressive symptoms, utilizing an integrative multi-omics approach.

Investigation of the Cyclohexene Oxidation Mechanism Through the Direct Measurement of Organic Peroxy Radicals.

Monoterpenes, the second most abundant biogenic volatile organic compounds globally, are crucial in forming secondary organic aerosols, making their oxidation mechanisms vital for addressing climate change and air pollution. This study utilized cyclohexene as a surrogate to explore first-generation products from its ozonolysis through laboratory experiments and mechanistic modeling. We employed proton transfer reaction mass spectrometry with NH ion sources (NH-CIMS) and a custom-built OH calibration source to quantify organic peroxy radicals (RO) and closed-shell species.

Maternal immune activation upregulates the AU020206-IRFs-STAT1 axis in modulating cytokine production in the brain.

Maternal immune activation (MIA) is reported to increase the risk of psychiatric disorders in the offspring. However, the underlying mechanism remains unclear. : We constructed a MIA mouse model by intraperitoneal injection of LPS into pregnant mice and evaluated the behaviors and gene expression profiles in the brains of the female and male offspring, respectively.

Emissions of gaseous nitrous acid (HONO) from diesel trucks: Insights from real-driving emission experiments.

Nitrous acid (HONO) serves as a substantial contributor in the atmospheric chemistry of hydroxyl radicals (·OH). Despite its significance, the primary sources of atmospheric HONO, particularly diesel truck emissions, have not been thoroughly examined. This study investigated the factors influencing HONO emissions via on-road exhaust emission tests using a self-developed portable measurement system.

Revisiting the estimation indicator for HONO emissions from light-duty vehicles.

Gaseous nitrous acid (HONO), playing a crucial role in the generation of hydroxyl (OH) radicals and thus secondary pollution, lacks a source. Vehicular emission is a significant HONO source and is usually estimated by a traditional estimation indicator (R = 0.8 %).

Failure of the three-way catalyst (TWC) introduces "super emitters".

Vehicle exhaust is one of the major organic sources in urban areas. Old taxis equipped with failed three-way catalysts (TWCs) have been regarded as "super emitters". Compressed natural gas (CNG) is a regular substitution fuel for gasoline in taxis.

TGF-β neutralization attenuates tumor residency of activated T cells to enhance systemic immunity in mice.

A tissue resident-like phenotype in tumor infiltrating T cells can limit systemic anti-tumor immunity. Enhanced systemic anti-tumor immunity is observed in head and neck cancer patients after neoadjuvant PD-L1 immune checkpoint blockade (ICB) and transforming growth factor β (TGF-β) neutralization. Using T cell receptor (TCR) sequencing and functional immunity assays in a syngeneic model of oral cancer, we dissect the relative contribution of these treatments to enhanced systemic immunity.

Hierarchical lncRNA regulatory network in early-onset severe preeclampsia.

Background: Recent studies have shown that several long non-coding RNAs (lncRNAs) in the placenta are associated with preeclampsia (PE). However, the extent to which lncRNAs may contribute to the pathological progression of PE is unclear.

Results: Here, we report a hierarchical regulatory network involved in early-onset severe PE (EOSPE).

Association between triglyceride-glucose index and sarcopenia in patients with chronic inflammatory airway disease.

Objective: This research sought to explore the association between the triglyceride-glucose (TyG) index and the risk of sarcopenia in patients with chronic inflammatory airway disease (CIAD).

Methods: Data were obtained from the National Health and Nutrition Examination Survey 2011-2018. Grouping was performed using TyG index tertiles and multiple logistic regression was employed to assess the correlation between TyG levels and the risk of sarcopenia.

Exploring the impact of gut microbiota on liver health in mice and patients with Wilson disease.

Background And Aims: Distinctive gut microbial profiles have been observed between patients with Wilson disease (WD) and healthy individuals. Despite this, the exact relationship and influence of gut microbiota on the advancement of WD-related liver damage remain ambiguous. This research seeks to clarify the gut microbiota characteristics in both human patients and mouse models of WD, as well as their impact on liver injury.