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Functional RNAi Screening Identifies G2/M and Kinetochore Components as Modulators of TNFα/NF-κB Prosurvival Signaling in Head and Neck Squamous Cell Carcinoma. | LitMetric
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Functional RNAi Screening Identifies G2/M and Kinetochore Components as Modulators of TNFα/NF-κB Prosurvival Signaling in Head and Neck Squamous Cell Carcinoma.

Ethan L Morgan , Anthony D Saleh , Shaleeka Cornelius , Sophie G Carlson , Tiffany Toni , Hui Cheng , Jun Jeon , Ramya Viswanathan , Xinping Yang , Christopher Silvin , Paul E Clavijo , Anastasia L Sowers , James B Mitchell , Pinar Ormanoglu , Madhu Lal Nag , Scott E Martin , Zhong Chen , Carter Van Waes

Cancer Res Commun

Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, Maryland.

Published: November 2024

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Article Abstract

Here, RNAi library screening reveals that multiple G2/M and kinetochore components, including TTK/monopolar spindle 1, modulate TNFα-induced NF-κB activation, cell survival, and genotoxicity, underscoring their potential importance as therapeutic targets in HNSCC.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541648PMC
http://dx.doi.org/10.1158/2767-9764.CRC-24-0274DOI Listing

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