Berberine Alleviates Chronic Restraint Stress-Induced Depression-Like Behavior by Modulating Gut Microbiota and SCFA Production in Mice.

The exact mechanism by which berberine alleviates depression remains unclear. In this study, we explored the relationship between the antidepressant effect of berberine and the microbiota-brain-gut axis. The levels of IL-1β, TNF-α, IL-6, corticosterone, serotonin, and brain-derived neurotrophic factor (BDNF) were quantified using enzyme-linked immunosorbent assays (ELISA) and Western blotting.

Estimation of Genetic Parameters for Body Weight and Its Stability in Huaxi Cows from Xinjiang Region.

In this study, we analyzed data from 2992 cows to comprehensively evaluate the adult weight (WEI), a key growth and body-size indicator, in West China cattle, aiming to estimate the related phenotypic and genetic parameters. The analysis focused on four weight traits while considering non-genetic factors such as parity, season, year, and birth weight. Data were processed and corrected using a MIXED procedure and a multi-trait animal model.

A selenium-enriched glycosaminoglycan from sturgeon cartilage: characterization and anti-metabolic syndrome potential.

This study develops a novel selenium-enriched chondroitin sulfate (CSSE) from selenium-rich sturgeon cartilage that has potent multitarget activity against high-carbohydrate/high-fat diet-induced metabolic syndrome. Structural analyses (NMR/MALDI-TOF MS) confirmed Se-O-SO₃ covalent bonds (δ 78.5 ppm in C NMR) and a molecular weight of 16.

[Characteristics and Analysis of Typical Ozone Pollution Processes in Hebi].

In recent years， the central plains urban agglomeration has been facing air pollution problems， of which the ozone （O） pollution in Hebi City has been particularly prominent， for up to five months， with the most serious pollution situation occurring in June. In this study， the period from June 20-27， 2023， which had the longest O duration （8d） and high O hourly average concentration of 256 μg·m， was selected as a typical O pollution process for characterization and analysis. Various methods， such as the positive definite matrix factor decomposition （PMF） model， air pollutant source emission inventory， and ozone formation potential （OFP）， were used to resolve ozone sources.

Structural adaptations of curved-stem moso bamboo: tissue specialization for resilience under mechanical stress.

Reaction tissues in plants develop in response to external stresses. In bamboo, the absence of secondary thickening has been the cause of an ongoing debate over the role of reaction tissues in stress responses. Herein, we evaluated the structural and mechanical basis underlying the curved-stem moso bamboo (Phyllostachys edulis) to determine whether reaction tissues are involved.

The potential of wastewater monitoring as a novel surveillance tool for early warning of outbreaks.

The prolonged latency period and delayed reporting of clinical surveillance data have led to a sluggish response to outbreaks in China. Wastewater-based surveillance (WBS) provides real-time, cost-effective monitoring of various viruses. To confirm whether this approach can be applied to , 271 patients infected with were enrolled to evaluate the fecal shedding patterns of the bacterium.

Multi-omics analysis reveals Angelica sinensis-Carthamus tinctorius herb pair ameliorates diabetic retinopathy comorbid with depressive symptoms via the gut-eye-brain axis.

Background: Diabetic retinopathy (DR) comorbid with depressive symptoms represents a significant public health challenge. The limitations of monotherapeutic approaches and the complex interplay between DR and depression highlight the need for comprehensive, integrated treatment strategies.

Purpose: This study aimed to explore the therapeutic efficacy and underlying mechanisms of the Angelica sinensis-Carthamus tinctorius herb pair (ACHP) in addressing DR comorbid with depressive symptoms, utilizing an integrative multi-omics approach.

Synthesis and electronic structure of atomically thin 2H-MoTe.

An in-depth understanding of the electronic structure of 2H-MoTe at the atomic layer limit is a crucial step towards its exploitation in nanoscale devices. Here, we show that millimeter-sized monolayer (ML) MoTe samples, as well as smaller sized bilayer (BL) samples, can be obtained using the mechanical exfoliation technique. The electronic structure of these materials is investigated by angle-resolved photoemission spectroscopy (ARPES) for the first time and by density functional theory (DFT) calculations.

Microbiological and clinical predictors of sepsis-associated encephalopathy in bloodstream infections: a retrospective cohort study.

Background: Sepsis-associated encephalopathy (SAE) is a common and severe complication of sepsis, significantly contributing to morbidity and mortality. The impact of specific blood-borne pathogens on SAE risk and prognosis remains unclear. This study investigates the microbiological and clinical factors associated with bloodstream infection-induced SAE.

Isolation and identification of Streptomyces sp. D-6 and its protective effect on Crucian auratus.

Fish bacterial diseases seriously endanger the development of aquaculture. As a new type of microecological feed additive, probiotics can effectively improve the growth performance, immunity, and disease resistance of the host.In this study, an actinomycete strain with significant antibacterial activity against fish pathogenic bacteria was screened from Jiemuxi, Yuanling County, Hunan Province.

Emission and risk of atmospheric hexachlorobutadiene might be underestimated globally.

Ambiguous emission of new pollutants is a fundamental obstacle of risk prevention, such as hexachlorobutadiene (HCBD). To quantify the HCBD emission in China, we probed the emission factors for main sources based on analysis of 847 gas samples from field experiments. Considering treatment efficiency, emissions of 362 kinds of sources were measured.

The impact of Internet-based healthcare derived from the COVID-19 pandemic on outpatients in a cardiology department.

Objective: This study examines the impact of a COVID-19 pandemic-derived online medical service on cardiovascular patient visits and assesses whether these services can ease the strain on medical resources.

Method: This study investigated the impact of the COVID-19 pandemic on cardiology services and hospital operations. We analyzed key primary medical indicators in cardiology, including outpatient visits, inpatient improvement rates, cure rates, and mortality rates, over three years from 2019 to 2021.

Correlation of TgAb With Clinicopathological Features and Unfavorable Efficacy of 131I Ablation in PTC.

Context: Papillary thyroid carcinoma (PTC) is the most common malignant thyroid cancer. Several clinicopathological features may affect therapeutic efficacy.

Objective: To analyze the relationship between thyroglobulin antibodies (TgAb) with clinicopathological features and efficacy of 131I ablation in PTC patients.

The Gene Enhances the Cold Resistance of .

Plants have large amounts of the late embryogenesis abundant protein (LEA) family of proteins, which is involved in osmotic regulation. The Korla Pear () is an uncommon pear species that thrives in Xinjiang and can survive below-freezing conditions. We found that the gene was more expressed after cold treatment by looking at the transcriptome data of the Korla Pear.

Recent advances of lysine lactylation in prokaryotes and eukaryotes.

Lysine lactylation is a newly discovered protein post-translational modification that plays regulatory roles in cell metabolism, growth, reprogramming, and tumor progression. It utilizes lactate as the modification precursor, which is an end product of glycolysis while functioning as a signaling molecule in cells. Unlike previous reviews focused primarily on eukaryotes, this review aims to provide a comprehensive summary of recent knowledge about lysine lactylation in prokaryotes and eukaryotes.

Engineered probiotic E.coli Nissle 1917 for release PTEN to improve the tumor microenvironment and suppress tumor growth.

The cancer is one of the diseases of serious threat to people's health and life nowadays. But heterogeneity, drug resistance and treatment side effects of cancer, traditional treatments still have limitations. Tumor-targeting probiotics with a well-established Biosafety and efficient targeting as a delivery vectors to deliver anticancer genes or antitumor drugs to tumor microenvironment has attracted much attention in cancer therapies.

Activity-based metaproteomics driven discovery and enzymological characterization of potential α-galactosidases in the mouse gut microbiome.

The gut microbiota offers an extensive resource of enzymes, but many remain uncharacterized. To distinguish the activities of similar annotated proteins and mine the potentially applicable ones in the microbiome, we applied an effective Activity-Based Metaproteomics (ABMP) strategy using a specific activity-based probe (ABP) to screen the entire gut microbiome for directly discovering active enzymes and their potential applications, not for exploring host-microbiome interactions. By using an activity-based cyclophellitol aziridine probe specific to α-galactosidases (AGAL), we successfully identified and characterized several gut microbiota enzymes possessing AGAL activities.

Clinicopathological features affecting the efficacy in I ablation therapy of papillary thyroid carcinoma with lymph node metastasis.

Background: Lymph node metastasis is the major cause of increased recurrence and death in patients with papillary thyroid carcinoma (PTC). We evaluate the clinicopathologic factors affecting excellent response (ER) in patients with PTC with lymph node metastasis following operation and I ablation therapy.

Methods: A total of 423 patients with PTC with lymph node metastasis who underwent thyroidectomy and postoperative I ablation therapy were enrolled.

Transcriptomic Analysis Reveals the Effects of miR-122 Overexpression in the Liver of Qingyuan Partridge Chickens.

The liver of chickens is essential for maintaining physiological activities and homeostasis. This study aims to investigate the specific function and molecular regulatory mechanism of microRNA-122 (miR-122), which is highly expressed in chicken liver. A lentivirus-mediated overexpression vector of miR-122 was constructed and used to infect 12-day-old female Qingyuan Partridge chickens.

Cyclo(L-Pro-L-Trp) from Chilobrachys jingzhao alleviates formalin-induced inflammatory pain by suppressing the inflammatory response and inhibiting TRAF6-mediated MAPK and NF-κB signaling pathways.

Chronic pain has emerged as a significant public health issue, seriously affecting patients' quality of life and psychological well-being, with a lack of effective pharmacological treatments. Numerous studies have indicated that macrophages play a crucial role in inflammatory pain, and targeting neuro-immune interactions for drug development may represent a promising direction for pain management. Chilobrachys jingzhao (C.

[Advances in research on organ-at-risk protection in pelvic tumor external beam radiotherapy].

The simultaneous objectives of destroying tumor cells while protecting normal pelvic organs present a dual clinical and technical challenge within the realm of pelvic tumor radiotherapy. This article reviews the latest literatures, focusing on technological innovations in key aspects of radiotherapy such as positioning, planning, and delivery. These include positioning fixation techniques, organ-at-risk avoidance irradiation, non-coplanar irradiation techniques, as well as organ displacement protection and image-guided adaptive techniques.

Lipid safety of tenofovir alafenamide during 96-week treatment in treatment-naive chronic hepatitis B patients.

Background: This study was aimed at investigating the dynamics of lipids and the effect of TAF on the lipid profile of patients including fatty liver disease in CHB patients.

Methods: The data of TC, LDL-c, HDL-c, TG, and TC/HDL ratio were collected at baseline, 24 weeks, 48 weeks, 72 weeks, and 96 weeks. CHB patients with fatty liver at baseline were further analyzed in a subgroup.