Transcriptome Analysis of Developmental Gene Expression in Turcz.

Turcz. (), a perennial herb in the Santalaceae family, exhibits potent antibacterial and anti-inflammatory properties. Transcriptome sequencing was performed on one- and two-year-old plants across seedling, flowering, and fruiting stages (all sampled from the same location) using the illumina NovaSeq 6000 platform.

Expanding the Spectrum of -Mutated Myeloid Neoplasm Beyond Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia: A Comprehensive Analysis of 13 Cases.

Genetic alterations in , typically associated with chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML), rarely occur in other myeloid neoplasms. This study characterized the clinical, morphologic, cytogenetic, and molecular features of 13 patients with non-CNL non-aCML myeloid neoplasms with alterations. Patients (median age, 77 years) were categorized into groups with a myelodysplastic/myeloproliferative neoplasm (MDS/MPN) (n = 5), acute leukemia (n = 4), and other myeloid neoplasms (n = 4) based on the WHO 2022 and ICC criteria.

Development mechanism and parameter control of jet impingement based on chaotic modulation.

Based on the theory of chaotic modulation, the influence of the control parameters of impingement jets on the stability of the system has been studied. The range of the simulation control parameters is determined through trial calculation. The influence of the main control parameters of the nonlinear system on the stability of pressure and pressure gradient trajectories has been studied numerically.

[Characteristics and Analysis of Typical Ozone Pollution Processes in Hebi].

In recent years， the central plains urban agglomeration has been facing air pollution problems， of which the ozone （O） pollution in Hebi City has been particularly prominent， for up to five months， with the most serious pollution situation occurring in June. In this study， the period from June 20-27， 2023， which had the longest O duration （8d） and high O hourly average concentration of 256 μg·m， was selected as a typical O pollution process for characterization and analysis. Various methods， such as the positive definite matrix factor decomposition （PMF） model， air pollutant source emission inventory， and ozone formation potential （OFP）， were used to resolve ozone sources.

Human adipose-derived mesenchymal stem cell-derived exosomes induce epithelial remodeling and anti-scar healing revealed by single-cell RNA sequencing.

The scar-free healing remains a clinical challenge, and requires the concerted efforts of multiple cell types, such as keratinocytes and fibroblasts. Exosomes derived from human adipose-derived mesenchymal stem cells (hADSC-Exos) have emerged as a promising therapeutic option. Nonetheless, a thorough understanding of the mechanisms underlying regenerative healing in response to hADSC-Exos treatment is still lacking.

Tris (1,3-dichloro-2-propyl) phosphate (TDCPP) aggravates Parkinson's disease neurotoxicity through ferroptosis-related oxidative stress and neuroinflammation.

Organophosphorus flame retardant TDCPP, a substitute for brominated flame retardants, is widely used in consumer products but readily leaches into the environment, posing human exposure risks. This study investigated the neurotoxic mechanisms of TDCPP in Parkinson's disease (PD). Using an MPTP-induced PD mouse model, TDCPP exposure exacerbated behavioral deficits, reduced tyrosine hydroxylase (TH)-positive neurons in the substantia nigra, and amplified neuroinflammation characterized by enhanced microglial reactivity, elevated pro-inflammatory IFN-γ, and diminished anti-inflammatory IL-4 and regulatory T cells (Tregs).

Optimal utilization of paucicellular vitreous sample for diagnosis of primary vitreoretinal lymphoma.

Introduction: Primary vitreoretinal lymphoma (PVRL) is a rare, aggressive, and intraocular non-Hodgkin lymphoma, typically manifesting as diffuse large B-cell lymphoma (95%). Vitreous fluid cytology is the gold standard for diagnosis; however, its utility is limited by poor preservation and low cellularity. Recent studies indicate that myeloid differentation primary response protein 88 (MYD88) mutation analysis is more sensitive and accurate on low-cellularity or poorly preserved samples.

Ambulatory Blood Pressure Characteristics are Modulated by Age and Body Weight in Hypertensives: A Cohort Study of 35,367 Patients.

Ambulatory blood pressure monitoring (ABPM) is increasingly recommended in clinical practice, but few large-scale studies were conducted on the characteristics of ABPM in obese hypertensive patients. The purpose of the present study was to assess the roles of age and body weight in modulating blood pressure (BP). In this cohort, 35,367 hypertensive patients were recruited and the were used classify weight groups.

Transdifferentiation of Multiple Myeloma into Histiocytic Sarcoma: Case Report of a Highly Unusual Phenomenon.

Introduction: Transdifferentiation of multiple myeloma (MM) into histiocytic sarcoma (HS) is exceptionally rare. We report a unique case, confirming this phenomenon through cytogenetics and molecular analyses.

Case Presentation: A 46-year-old woman with high-risk light chain MM developed extramedullary disease despite multiple lines of therapy.

xOmicsShiny: an R Shiny application for cross-omics data analysis and pathway mapping.

Summary: We developed xOmicsShiny, a feature-rich R Shiny-powered application that enables biologists to fully explore omics datasets across experiments and data types, with an emphasis on uncovering biological insights at the pathway level. The data merging feature ensures flexible exploration of cross-omics data, such as transcriptomics, proteomics, metabolomics, and lipidomics. The pathway mapping function covers a broad range of databases, including WikiPathways, Reactome, and KEGG pathways.

A Mathematical Analysis of a Biomechanical Model for an Innovative Spinal Decompression and Correction System for the Conservative Treatment of Scoliosis.

Scoliosis is a three-dimensional deformity of the spine that can lead to a series of physical and psychological problems. Appropriate controlling forces should be applied to prevent the curve's progression and even correct the deformity. The aims of this study were to develop a biomechanical model that can quickly estimate the optimal positions and magnitudes of the controlling forces for treating scoliosis and to analyze the interaction between longitudinal traction and lateral forces.

Employment Intention and Associated Factors of Nursing Graduates: A Structural Equation Model.

To assess the associated factors of employment intention among contemporary nursing graduates. In the postepidemic era, the shortage of nurses and the decline in the employment rate have garnered significant attention globally. It is crucial to evaluate the factors associated with the employment intentions of nursing graduates to address the issue of nurse shortage.

NAMPT Modulates Gemcitabine Resistance in Pancreatic Cancer via the p53 Signaling Pathway.

Objective: Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed at an advanced stage. Although gemcitabine (GEM) is commonly used as the first-line chemotherapy, many patients eventually develop resistance. This study aims to investigate the role of nicotinamide phosphoribosyltransferase (NAMPT) in mediating gemcitabine resistance in PDAC, with a focus on identifying potential therapeutic targets within the nicotinate and nicotinamide metabolic pathways.

Spatio-temporal assessment of landscape ecological risk and its influencing factors in Jiangxi Province, China.

Landscape ecological risk (LER) can be assessed according to the combined effect of natural disturbances and anthropogenic activities on ecosystem, which can provide an important basis for promoting ecological civilization. On the basis of landscape patterns, an LER assessment system was developed, and the spatiotemporal change in the LER in Jiangxi Province between 2000 and 2020 was analyzed. The findings revealed that rapid urbanization in Jiangxi Province has altered land use patterns, characterized by notable decreases in forestland and cultivated land, accompanied by a substantial increase in built-up land.

Emission and risk of atmospheric hexachlorobutadiene might be underestimated globally.

Ambiguous emission of new pollutants is a fundamental obstacle of risk prevention, such as hexachlorobutadiene (HCBD). To quantify the HCBD emission in China, we probed the emission factors for main sources based on analysis of 847 gas samples from field experiments. Considering treatment efficiency, emissions of 362 kinds of sources were measured.

Investigating the cooling effect of urban lakes from the perspective of their characteristics and surrounding landscapes: A case study of 82 urban lakes in China.

In the context of global climate change, the increasing frequency of extreme heat events has exacerbated urban thermal issues, affecting the quality of life and posing a serious challenge to the sustainable development of cities. Urban lakes are regarded as effective nature-based solutions for alleviating outdoor thermal environments. In this study, the cooling intensity and extent of 82 urban lakes with their surrounding cooling landscapes across China were quantified based on land surface temperature (LST).

Highly salt-resistant and efficient dynamic Janus absorber based on thermo-responsive hydroxypropyl cellulose.

Recent advances in interfacial solar steam generation have made direct solar desalination a promising approach for providing cost-effective and environmentally friendly clean water solutions. However, developing highly effective, salt-resistant solar absorbers for long-term desalination at high efficiencies and evaporation rates remains a significant challenge. We present a Janus hydrogel-based absorber featuring a surface modified with thermo-responsive hydroxypropyl cellulose (HPC) and a hydrogel matrix containing photothermal conversion units, MXene, specifically designed for long-term seawater desalination.

Digitalized 3D Spinal Decompression and Correction Device Improved Initial Brace Corrections and Patients' Comfort Among Adolescents with Idiopathic Scoliosis: A Single-Centre, Single-Blinded Randomized Controlled Trial.

This study aimed to evaluate the efficacy of a novel three-dimensional (3D) spinal decompression and correction device in improving the in-brace correction and patient comfort level for adolescents with idiopathic scoliosis (AIS), and to assess the impact of the number of vertebrae involved in the scoliotic curve on the correction's effectiveness. A single-centre, single-blinded randomized controlled trial (RCT) was conducted in 110 AIS patients aged 10-18 years who were randomly allocated into four groups receiving 0-3 days of device intervention. Each session lasted for 30 min and was conducted twice daily.

Testing the existence of waste Kuznets curve hypothesis in 45 emerging economies: Evidence from an e-waste panel data survey.

This study examines the Waste Kuznets Curve (WKC) hypothesis by integrating it with the Tapio decoupling model to explore the relationship between economic development and e-waste imports in 45 emerging economies from 2002 to 2022. The empirical results show that (1) the relationship between economic growth and e-waste imports exhibits an inverted U-shaped curve, with decoupling achieved when GDP per capita exceeds the WKC turning point of $10,755.23; (2) Emerging economies are categorized into six quadrants based on their e-waste decoupling status: high-income non-decoupling, low-income non-decoupling, low-income relative decoupling, high-income relative decoupling, low-income absolute decoupling, and high-income absolute decoupling; (3) Most emerging economies remain in low-income non-decoupling state, with only a few countries like China and Poland achieving high-income absolute decoupling.

Automated and quantitative assessment of aortic root based on cardiac computed tomography angiography using a new deep-learning tool: a comparison study.

Background: Accurate assessment of aortic root is crucial for the preprocedural planning of transcatheter aortic valve replacement (TAVR). A variety software is emerging for the semiautomated or automated measurements during TAVR planning. This study evaluated a new deep-learning (DL) tool based on cardiac computed tomography angiography (CCTA) for fully automatic assessment of aortic root.

Effects of thermal pretreatment on the anaerobic digestion characteristics of fruit waste liquids.

Fruit waste is one of the main components of municipal waste. To study its potential and characteristics in anaerobic digestion, this study took fruit waste and its waste liquid as raw materials, investigate the influence of thermal pretreatment on the anaerobic digestion characteristics under 35 ± 17 °C. The anaerobic digestion materials were fruit waste liquid (group A1), fruit waste liquid after thermal pretreatment (group A2), fruit slurry (group A3), and the material of A2 and A3 mixed with municipal sludge (groups A4 and A5) has also been involved.

Aerobic exercise training attenuates ischemia-reperfusion injury in mice by decreasing the methylation level of METTL3-associated m6A RNA in cardiomyocytes.

Background And Aims: Ischemic heart disease (IHD) presents a significant global health challenge, with myocardial ischemia-reperfusion injury (MIRI) being a major pathophysiological contributor and lacking effective interventions. While aerobic exercise training (AET) enhances cardiovascular health, its protective mechanism in MIRI remains elusive. This study aims to elucidate the protective effect of AET in MIRI and its underlying mechanism.

Bovine serum albumin framed activatable NIR AIE photosensitizer for targeted tumor therapy.

Organic near-infrared (NIR) photosensitizers (PS) largely facilitate photodynamic therapy (PDT). To overcome aggregation induced quenching and diminishment of reactive oxygen species (ROS) generation capability of NIR-PS, aggregation-induced emission (AIE) effect groups have been introduced to generate NIR AIE photosensitizers. However, currently reported NIR AIE photosensitizers all take "always-on" activity that may cause systemic phototoxic side effects.