Application of 32P Radioactive Patch in Keloid Treatment.

Keloid, as a benign fibroblastic disease of the skin, is the result of excessive proliferation of fibroblasts and abnormal deposition of collagen during the process of skin trauma repair. Clinically, this disorder presents as a fibrous proliferation that protrudes beyond the surface of the skin beyond the margins of the original injury, affecting both function and aesthetics. In clinical treatment, the P radioactive patch is a well-established and effective treatment based on the biological effect of β-rays, which can penetrate keloid tissue, induce apoptosis of fibroblasts in the keloid, impede cell proliferation, and inhibit excessive collagen synthesis and deposition, and eventually achieve the desired therapeutic effect after a period of treatment.

Comprehensive analysis of [F]MFBG biodistribution normal patterns and variability in pediatric patients with neuroblastoma.

Purpose: [F]-meta-fluorobenzylguanidine ([F]MFBG) PET/CT is a promising imaging modality for neural crest-derived tumors, particularly neuroblastoma. Accurate interpretation necessitates an understanding of normal biodistribution and variations in physiological uptake. This study aimed to systematically characterize the physiological distribution and variability of [F]MFBG uptake in pediatric patients to enhance clinical interpretation and differentiate normal from pathological uptake.

Auxiliary Value of [F]F-Fluorocholine PET/CT in Evaluating Post-Stereotactic Radiosurgery Recurrence of Lung Cancer Brain Metastases: A Comparative Analysis with Contrast-Enhanced MRI.

Background/objectives: This study aims to evaluate the additional value of [F]F-fluorocholine ([F]F-FCH) PET/CT over contrast-enhanced magnetic resonance imaging (CE-MRI) in detecting the recurrence of brain metastases (BMs) after stereotactic radiosurgery (SRS) in patients with lung cancer brain metastases (LCBMs).

Methods: Thirty-one patients with suspected recurrence of BM in LCBM after SRS were enrolled in this retrospective study. They underwent both [F]F-FCH PET/CT and CE-MRI within 2 weeks.

Development and Validation of An Interpretable Machine Learning-Based Prediction Model of Postpartum Hemorrhage in Placenta Previa Following Cesarean Section: A Multicenter Study.

The objective of this study is to predict the occurrence of postpartum hemorrhage in women with placenta previa based on machine learning. This retrospective study enrolled 845 singleton pregnant patients with placenta previa from two hospitals. They were allocated into a training cohort (n = 403), a testing cohort (n = 174), and the external validation cohort (n = 268).

Different inhibitory effect of a neuropilin-1 monoclonal antibody on different types of hepatocellular carcinoma.

As a co-receptor for vascular endothelial growth factor, neuropilin receptor type-1 (NRP-1) plays a crucial role in tumor angiogenesis, growth, and metastasis, and is regarded as a promising target for cancer molecular imaging and therapy. However, few data on inhibitory effect of an anti-NRP-1 monoclonal antibody on HCC with different NRP-1 expression levels have been reported. This study aimed to investigate inhibitory effect of an anti-NRP-1 monoclonal antibody (A6-11-26) on different types of HCC, with a view to further understanding the role of A6-11-26 in HCC.

[F]MFBG PET/CT is an effective and preferable imaging modality for neuroblastoma in a prospective comparison with SSTR PET.

Purpose: [F]-meta-fluorobenzylguanidine ([F]MFBG) and somatostatin receptor (SSTR)-targeted PET tracers have both been proposed for imaging neuroblastoma, however, their respective clinical roles remain unclear. This prospective study compared [F]MFBG PET with SSTR-targeted PET, using either [Ga]Ga-DOTATATE or [F]AlF-NOTA-octreotide([F]-OC), to evaluate diagnostic performance and potential clinical impact in neuroblastoma.

Methods: Sixteen patients (median age 5.

Theranostic Potential of [Ga]Ga/[Lu]Lu-LNC1013: A Dual-Purpose Ligand for Cancer Imaging and Radionuclide Therapy.

Fibroblast activation protein (FAP) is highly expressed in cancer-associated fibroblasts within the tumor stroma of many epithelial malignancies. It has emerged as a promising target for both imaging and radionuclide therapy. In this study, we investigated the clinical performance and theranostic potential of [Ga]Ga/[Lu]Lu-LNC1013, a dimeric FAPI radiotracer.

Comparison of four-dimensional CT and Sestamibi SPECTCT in the localization management of primary hyperparathyroidism.

Objective: Accurate preoperative imaging localization is paramount to the success of targeted parathyroidectomy for primary hyperparathyroidism (PHPT). Four-dimensional (4D) CT is a promising method for preoperative localization of the parathyroid, but studies on the performance of 4D CT and technetium 99 m-sestamibi SPECT/CT for the diagnosis of diseases of the parathyroid are limited.

Materials And Methods: To compare the diagnostic performance of sestamibi SPECT/CT and 4D-CT for preoperative localization in patients with PHPT in a single-institution from August 2017 to May 2024.

The clinical benefits of [F]AlF-NOTA-octreotide PET/CT in staging and restaging patients with gastroenteropancreatic neuroendocrine neoplasms: comparison of [F]FDG PET/CT.

Background: Accurate clinical TNM staging is crucial for managing GEP-NENs according to the latest NCCN guidelines. [Ga] labeled somatostatin receptor (SSTR) PET/CT outperforms [F]FDG PET/CT in evaluating well and moderately differentiated NENs. However, few studies have investigated the performance of [F] labeled SSTRs in the exploration of GEP-NENs.

Organocatalytic kinetic resolution of sulfinamides by N/O exchange.

Kinetic resolution is a promising strategy for accessing enantioenriched molecules from racemic mixtures. However, this method has not previously been realized in the synthesis of chiral sulfinyl scaffolds via S(IV)-X bond exchange. We disclose a kinetic resolution reaction of sulfinamides with alcohols in this report.

Complete remission of peritoneal strumosis from struma ovarii after radioiodine therapy: a case report.

Background: Struma ovarii (SO) is a specialized monodermal teratoma composed predominantly of thyroid tissue (≥ 50%) and accounts for approximately 5% of all ovarian teratomas. In rare cases, the benign SO may spread to the peritoneal cavity and exhibit the histological features of struma ovarii in a condition termed peritoneal strumosis. Here, we present a rare case of complete remission of peritoneal strumosis from SO after radioiodine therapy.

PET/CT With [68Ga]-NOTA-FAP-2286 for Imaging of Tendon Injuries in Rat Achilles Tendon Injury Models.

Tendon injuries, particularly those affecting the Achilles tendon, are common sports-related conditions that significantly impact patients' quality of life. Although existing diagnostic methods such as MRI and ultrasound are widely used, they may occasionally fail to provide accurate pathological information. This study aimed to investigate the feasibility of using [Ga]-NOTA-FAP-2286 positron emission tomography/computed tomography (PET/CT) imaging for assessing an experimental rat model of Achilles tendon injury.

Radiolabeling and Preclinical Evaluation of 2-[F]Fluorohexanoic Acid: A Novel Medium-Chain Fatty Acid Metabolism Tracer for PET Imaging of Tumors.

Fatty acid metabolism plays a critical role in cancer development. In this study, a novel medium-chain fatty acid (MCFA) PET tracer, 2-[F]fluorohexanoic acid (F-FHA), was successfully synthesized with high radiochemical yield (65 ± 5.4%) and purity (>99%).

A lymph node metastasis of papillary thyroid carcinoma as a giant cervical cyst without a primary tumor in the thyroid gland: a case report.

Background: Papillary thyroid carcinoma (PTC) comprises the vast majority of all thyroid cancers. Lymph node metastases may be present even when the primary tumor is small and intrathyroidal. Metastatic lymph nodes of PTC presenting as giant solitary cervical cysts with no evidence of primary tumors in the thyroid gland even by postoperative pathological examination are rare.

The trans T-tube cholangial drainage versus percutaneous transhepatic cholangial drainage for the treatment of bile leakage at the biliary-enteric anastomosis: a retrospective study.

Background: The trans T-tube cholangial drainage (TTCD) is a novel approach that is first reported in this study for the treatment of bile leakage at the biliary-enteric anastomosis. However, no researchers have compared it with percutaneous transhepatic cholangial drainage (PTCD) as yet.

Methods: The clinical and imaging data of patients with bile leakage at the biliary-enteric anastomosis treated with TTCD (TTCD group) or PTCD (PTCD group) at three centers were retrospectively evaluated.

Characteristics of F-FAPI-04 PET/CT in patients with peritoneal metastasis and to predict treatment efficacy, a head-to-head comparison with F-FDG PET/CT.

Background: F-FAPI-04 PET/CT shows promise in detecting peritoneal metastases (PM), but its superiority over F-FDG PET/CT for lesion detection and predicting chemotherapy benefit remains unclear.

Purpose: To compare F-FAPI-04 and F-FDG PET/CT imaging features in PM and assess predictive value of F-FAPI-04 for chemotherapy efficacy.

Methods: 39 pathologically confirmed PM patients with digestive malignancies underwent concurrent F-FAPI-04 and F-FDG PET/CT.

Comparative Imaging Analysis of Kimura's Disease Using F-FDG PET/CT and [F]AlF-NOTA-FAPI-04 PET/CT.

Kimura's disease is a rare, chronic inflammatory disorder characterized by subcutaneous nodules, eosinophilia, and elevated serum IgE levels. It commonly affects young Asian males and typically presents in the head and neck region. Diagnosis is confirmed via histopathological examination, while treatment options include corticosteroids, surgery, and radiotherapy.

Noninvasive diagnosis and classification of kidney transplantation rejection by F-FAPI-04 PET/CT.

Purpose: Rejection, especially chronic rejection is a key factor influencing the prognosis of kidney transplantation patients. While F-fibroblast activation protein inhibitor (FAPI)-04 PET/CT has been widely utilized for diagnosing various diseases, its diagnostic efficacy in kidney transplant rejection remains unexplored.

Methods: In this study, 24 kidney transplant recipients were prospectively enrolled and divided into a control cohort and a rejection cohort (KTR), which were further classified into acute rejection (AR), mixed rejection (MR), and chronic rejection (CR) subgroups.

The predictive value of multiparametric MRI combined with [F]PSMA-1007 PET/CT for the pathological upgrade in prostate cancer: a multicenter study.

Purpose: This study aimed to develop a predictive model that integrates parameters derived from preoperative multiparametric magnetic resonance imaging (mpMRI) and [F]PSMA-1007 PET/CT for reliably predicting pathological upgrading from systematic biopsy (SB) to radical prostatectomy (RP) specimens.

Methods: We ultimately retrospectively analyzed 163 patients with biopsy-confirmed localized prostate cancer (PCa) who underwent preoperative mpMRI and [F]PSMA-1007 PET/CT scans between January 2019 and June 2022. Clinical and imaging characteristics were compared between patients with and without pathological upgrading.

[F]FAPI- 04 PET/CT for pathologic response assessment in pancreatic cancer patients with systemic treatment.

Purpose: To study the association between [F]FAPI- 04 uptake on positron emission tomography/computed tomography (PET/CT) and pathologic treatment response (PTR) in patients with pancreatic cancer (PC).

Methods: We enrolled 59 patients from August 2021, of whom 28 underwent surgical treatment after systemic therapy. The patients were investigated for a correlation between baseline fibroblast activation protein inhibitor (FAPI) uptake and PTR using College of American Pathologists (CAP) scores.

Molecular pathways and diagnosis in spatially resolved Alzheimer's hippocampal atlas.

We employed Stereo-seq combined with single-nucleus RNA sequencing (snRNA-seq) to investigate the gene expression and cell composition changes in human hippocampus with or without Alzheimer's disease (AD). The transcriptomic map, with single-cell precision, unveiled AD-associated alterations with spatial specificity, which include the following: (1) elevated synapse pruning gene expression in the fimbria of AD, with disrupted microglia-astrocyte communication likely leading to disorganized synaptic structure; (2) a globally increased energy generation in the cornu ammonis (CA) region, with varying degrees across its subregions; (3) a significant reduction in the number of CA1 neurons in AD, while CA4 neurons remained largely unaffected, potentially due to gene alterations in CA4 conferring resilience to AD; and (4) aggravated amyloid-beta (Aβ) plaques in CA1 and stratum lucidum, radiatum, and moleculare (SLRM), and integration of Stereo-seq map with Aβ staining revealed a sequential enrichment of microglia and astrocytes around Aβ plaques. Finally, reduced brain-derived extracellular vesicles carrying cholecystokinin (CCK) and peripheral myelin protein 2 (PMP2) in AD plasma highlighted their diagnostic potential for clinical applications.

Clinical Utility of Fluorine-Fibroblast Activation Protein Inhibitor-04 Positron Emission Tomography/Computed Tomography in the Evaluation of Pancreatic Ductal Adenocarcinoma: Comparison With Fluorine-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.

Pancreatic ductal adenocarcinoma (PDAC) is highly susceptible to metastasis, making early detection of metastases and associated risk factors crucial for effective management. This study aimed to assess the performance of fluorine (F)- fibroblast activation protein inhibitor-04 (F-FAPI-04) positron emission tomography/computed tomography (PET/CT) in detecting metastasis and predicting pathological characteristics and risk factors in 67 PDAC patients. Comparisons were made with F-fluorodeoxyglucose (F-FDG) PET/CT.

Prediction of pathological response to neoadjuvant immunochemotherapy with baseline and post-treatment F-FDG PET imaging biomarkers in patients with locally advanced gastric cancer.

Background: Neoadjuvant immunochemotherapy (NICT) has shown promising therapeutic benefits in patients with locally advanced gastric cancer (LAGC). Our study aimed to predict the pathological response to NICT in LAGC before surgery by correlating the metabolic parameters of baseline and post-treatment F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) of the primary lesion with the pathological response following radical surgery.

Methods: Thirty-six LAGC patients who received three cycles of NICT (combination of sintilimab and CapeOx), followed by radical surgery, were included in this study.

Synchronously Delivering Melittin and Evoking Ferroptosis via Tumor Microenvironment-Triggered Self-Destructive Metal-Organic Frameworks to Boost Cancer Immunotherapy.

The primary goal of treating malignant tumors is to efficiently eliminate the primary tumor and prevent metastasis and recurrence. Unfortunately, the immunosuppressive tumor microenvironment (TME) is a significant obstacle to effective oncotherapy. Herein, a therapeutic strategy based on melittin (MLT) encapsulated in hyaluronic acid-modified metal-organic frameworks (MOFs) is pioneered, focusing on the safe delivery and TME-responsive release of MLT to reshaping the immunosuppressive TME and simultaneously activating the immune system to eradicate cancerous cells.