Effects of different leaf colors on the quality of hawk black tea: sensory evaluation and metabolomics.

Leaf color, a vital phenotypic trait, influences the flavor quality of tea. This study investigated the flavor and metabolite profiles of hawk black tea (HBT) processed from leaves of different colors. Sensory evaluation revealed that purple-leaf HBT (PHBT) exhibited prominent floral-fruity notes, green-leaf HBT (GHBT) showed fresh camphoraceous characteristics, while mixed-leaf HBT (MHBT) demonstrated optimal flavor with the highest overall acceptability.

Metabolome analysis and functional characterization reveals that d-gluconic acid contributes to pine defence against Bursaphelenchus xylophilus infection.

Background: Pines (Pinus L.) are widely cultivated for their rich resin content and ease of wood processing. However, pines are constantly threatened by pine wood nematode (PWN; Bursaphelenchus xylophilus), causing a large number of pine forests to wilt and die.

Changes of hormone levels for postmenopausal women after bilateral oophorectomy: A meta-analysis.

Background: Bilateral oophorectomy has a significant effect on changes in hormone levels in postmenopausal women. This meta-analysis aimed to evaluate the effects of bilateral oophorectomy on estradiol, testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), sex hormone-binding globulin (SHBG), and estrone levels.

Method: We conducted a search for studies on focused ultrasound for cervical high-grade squamous intraepithelial lesions in PubMed, EMBASE, Web of Science, and Cochrane Library databases.

Hypoxia combined with a high-fat diet aggravates pulmonary vascular endothelial dysfunction in rats.

Objectives: Hypoxia and high-fat diet are independent risk factors for pulmonary vascular endothelial dysfunction (VED); however, their interactive effects are poorly understood. This study aimed to elucidate the effect and mechanism of hypoxia combined with a high-fat diet on the pulmonary arterial endothelial structure and function in rats.

Methods: Forty rats were randomly assigned to a normal diet and normoxia, a normal diet and hypoxia, a high-fat diet and normoxia, and a high-fat diet and hypoxia.

Systematic Investigation of Phosphate Decomposition and Soil Fertility Modulation by the Filamentous Fungus .

Phosphate-solubilizing microbes (PSMs) in soil play a crucial role in converting insoluble phosphates into plant-available soluble phosphorus. This paper systematically presents a comprehensive array of qualitative and quantitative techniques to assess the phosphate-decomposing capabilities of microbes. Additionally, it introduces two optimized media, namely improved Monkina medium No.

ORP2 regulates free cholesterol accumulation in hepatocytes during MASH.

Background: Cholesterol crystals in hepatocytes are known to strongly associate with human metabolic dysfunction-associated steatohepatitis. However, it remains unclear which molecular pathway(s) regulates free cholesterol accumulation and the formation of cholesterol crystals in hepatocytes. In cultured cell lines, oxysterol-binding protein-related protein 2 (ORP2) functions to deliver cholesterol to the plasma membrane from endosomal compartments.

PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis.

Lipid droplets (LDs) are evolutionarily conserved organelles that play important roles in metabolism. Each LD is enclosed by a monolayer of phospholipids, distinct from bilayer membranes. The composition of LD surface phospholipids and their impact on LD growth and function remain to be defined.

Advanced workflow for time-lapse seismic monitoring of [Formula: see text] storage in saline aquifers with its application in a field basin.

Accurately characterizing [Formula: see text] sequestration and migration post-injection is crucial to the success of carbon capture and storage (CCS) projects. Time-lapse seismic monitoring technique is an effective tool; however, it can only reveal changes in elastic properties such as compressional wave velocity ([Formula: see text]) and quality factor ([Formula: see text]). In contrast, reservoir simulation enables detailed tracking of fluid movement within the reservoir, allowing for precise simulation of [Formula: see text] saturation.

Expression and Antagonistic Activity Against Plant Pathogens of the Phage Tail-like Protein from WS-FJ9.

Microorganisms exert antagonistic effects on pathogens through different mechanisms, thereby achieving biological control of plant diseases. Many strains can produce complex secondary metabolites and substances that have toxic effects on host cells. The phage tail-like bacteriocins (tailocins) is a compound with antibacterial activity.

Melatonin application inhibits anthocyanin biosynthesis in postharvest peach fruit as revealed by transcriptional and liquid chromatographic-tandem mass spectrometric analysis.

Background: Anthocyanins are essential secondary metabolites in plants, significantly contributing to fruit coloration and offering a wide range of health benefits to consumers. This study investigated the effect of melatonin treatment on anthocyanin biosynthesis in 'Baifeng' peaches during storage. The peaches were treated with 100 μmol L melatonin and stored at room temperature (25 ± 1°C) for 9 days.

Comparison of the clinical and laboratory characteristics of neuromyelitis optica spectrum disorder with or without cerebrospinal fluid oligoclonal bands: a cohort with 36-month follow-up.

Purpose: This study aimed to explore the significance of cerebrospinal fluid (CSF) oligoclonal bands (OCBs) in the clinical diagnosis and evaluation of neuromyelitis optica spectrum disorder (NMOSD).

Methods: The demographic and clinical data of 143 aquaporin-4 immunoglobulin G (AQP4-IgG)-positive NMOSD patients were collected and analyzed, including the gender, age, clinical symptoms and signs, status of CSF OCBs, location and length of the affected spinal cord vertebral segments, Expanded Disability Status Scale (EDSS) at the first attack and at 36-month follow-up, relapse times within 36 months, concomitant connective tissue disease (CTD), and status of other autoimmune antibodies (oAIA).

Results: There were 15 patients (10.

Blue light induced transient localized acne post photodynamic therapy: A case report.

Phototherapies including LED light therapy and photodynamic therapy (PDT) are commonly used and considered safe treatment for inflammatory acne. However, there are few reports about the combination of the two methods on the same patient. We report a rare case of blue light induced transient localized acne post PDT.

Neutrophil serine proteases NE and PR3 controlled by the miR-223/STAT3 axis potentiate MASH and liver fibrosis.

Background And Aims: Metabolic dysfunction-associated steatohepatitis (MASH) and its related liver fibrosis represent a substantial public health burden with limited treatment options. Although MASH is associated with enhanced neutrophil infiltration in the liver, the mediators and mechanisms underlying neutrophil-driven progression of MASH and fibrosis remain largely unknown. This study aimed to investigate the role of neutrophil serine proteases neutrophil elastase (NE) and proteinase 3 (PR3) in the development of MASH and fibrosis.

Imaging Findings of Primary Squamous Cell Carcinoma of the Liver: Case Presentation and Literature Review.

Introduction: Primary Squamous Cell Carcinoma of the Liver (PSCCL) is an exceptionally rare clinical entity characterized by diagnostic challenges, aggressive behavior, and poor prognosis. Globally, few studies have investigated PSCCL.

Case Presentation: We report the case of a 76-year-old male patient with PSCCL, detailing his clinical presentation and imaging findings, to offer insights into the preoperative diagnosis of this disease.

Poncirin ameliorates alcoholic liver injury by regulating lipid metabolism and inflammatory response in a PPARα dependent manner.

Background: Poncirin (PO) is a citrus flavonoid with various of functional effect including cardiac ischemia-reperfusion injury, colitis, cancer, et al. Considering the role of PO in improving inflammation and lipid metabolism, it may have potential therapeutic effects on alcoholic liver injury (ALI), but there are currently no relevant reports.

Purpose: Current study aimed to explore the protective effect of PO on preventing ALI.

Adipose tissue deficiency impairs transient lipid accumulation and delays liver regeneration following partial hepatectomy in male Seipin knockout mice.

Background: Liver diseases pose significant health challenges, underscoring the importance of understanding liver regeneration mechanisms. Systemic adipose tissue is thought to be a primary source of lipids and energy during this process; however, empirical data on the effects of adipose tissue deficiency are limited. This study investigates the role of adipose tissue in liver regeneration, focusing on transient regeneration-associated steatosis (TRAS) and hepatocyte proliferation using a Seipin knockout mouse model that mimics severe human lipodystrophy.

Risk Estimation of Carcinogenic and Noncarcinogenic Diseases from Radiation for Medical X-ray Workers.

The objective of this paper is to construct a follow-up cohort of medical x-ray workers and analyze the risk estimates of radiation-induced carcinogenic and noncarcinogenic diseases induced by chronic low-dose ionizing radiation exposure in the follow-up cohort. A fixed cohort study was used. A total of 159 medical x-ray workers working in radiology departments of hospitals in Gansu Province from 1950 to 1980 were selected as the radiology group, and 149 medical workers in internal medicine, surgery, and other departments who had not engaged in radiology work at the same hospital were selected as the control group.

Establishment of embryogenic Pinus thunbergii Parl. suspension cultures: growth parameters, dynamic analysis, and plant regenerative capacities.

Background: Pinus thunbergii is an economically important conifer species that plays a fundamental role in forest ecosystems. However, the population has declined dramatically in recent years as a result of the pine wilt disease outbreak. Thus, developing pine wilt-resistant P.

Biocontrol activity and action mechanism of Pseudomonas aurantiaca ST-TJ4 against Verticillium dahliae, the causal agent of Acer truncatum wilt.

Acer truncatum wilt caused by Verticillium dahliae is a severe soilborne disease that poses a threat to the cultivation of this plant in China. The present study explored the biocontrol efficiency and underlying antagonistic mechanism of Pseudomonas aurantiaca ST-TJ4 against V. dahliae.

Tailoring Infrared Light-Molecule Coupling for Highly Sensitive Cortisol Detection Employing Aptamer-Conjugated Gold Nanonails.

Chemically synthesized gold nanoantennas possess easy processability, low cost, and suitability for large-area fabrication, making them advantageous for surface-enhanced infrared (SEIRA) biosensing. Nevertheless, current gold nanoantennas face challenges with limited enhancement of biomolecular signals that hinder their practical applications. Here, we demonstrate that the coupling rate between antennas and molecules critically impacts the enhancement of molecular signals based on temporal coupled mode theory.

Extraction mechanism of phenolic compounds by a choline chloride/glycerol solvent: DFT and molecular dynamics studies.

The mechanism of a solvent consisting of choline chloride and glycerol (ChCl/GLY) for extracting phenolic compounds from coal tar was theoretically studied using density functional theory calculations and molecular dynamics simulations. The thermodynamic properties, interaction essence, and molecular dynamics properties of the extraction system were investigated, as well as the influence of ChCl/GLY on the vibration spectra of phenolic compounds. The results show that the solvation free energy of phenolic compounds in ChCl/GLY is more negative than that in coal tar, leading to the spontaneous transfer of phenolic compounds from coal tar to ChCl/GLY.

A phosphate starvation induced small RNA promotes Bacillus biofilm formation.

Currently, almost all known regulators involved in bacterial phosphorus metabolism are proteins. In this study, we identified a conserved new small regulatory RNA (sRNA), named PhoS, encoded in the 3' untranslated region (UTR) of the phoPR genes in Bacillus velezensis and B. subtilis.

Treatment of pediatric refractory or relapsed Epstein-Barr virus-associated hemophagocytic syndrome with PD-1 inhibitors.

Purpose: Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a type of pediatric HLH that occurs frequently in Asia. Although immunochemotherapy based on etoposide and hormone has improved survival rates, there are still about 30% of HLH patients that do not respond. The objective of the article is to examine the efficacy and safety of programmed cell death protein 1 (PD-1) inhibitors for children with relapsed/refractory (r/r) EBV-HLH.

Volatiles emitted by Pseudomonas aurantiaca ST-TJ4 trigger systemic plant resistance to Verticillium dahliae.

Verticillium dahliae is among the most devastating fungal pathogens, causing significant economic harm to agriculture and forestry. To address this problem, researchers have focused on eliciting systemic resistance in host plants through utilizing volatile organic compounds (VOCs) produced by biological control agents. Herein, we meticulously measured the quantity of V.