Elinvar-Like Effect Induced by High Lattice Distortion in ZrTaO Ceramics.

Super strength and toughness, excellent deformation resistance, and high-temperature service performance are the key factors to determine the practical application of new thermal barrier coatings (TBCs). The limited mobility of dislocations and the internal inherent defects in ceramics will inevitably lead to the decline of strength-plasticity and the reduction of service performance. Introducing preexisting twin boundaries and stacking faults (SFs) or preparing ceramic materials with high configuration entropy has demonstrated to be an effective strategy for enhancing the mechanical properties of ceramics.

Sarcopenia and cardiovascular disease among adults with cardiovascular-kidney-metabolic syndrome stages 0-3: A prospective cohort study.

Background: Substantial evidence has demonstrated the correlation between sarcopenia and cardiovascular disease (CVD). However, it remains uncertain whether this correlation exists in individuals with cardiovascular-kidney-metabolic (CKM) syndrome.

Methods: This study used data from the China Health and Retirement Longitudinal Study (CHARLS).

Synergistic aptamer/molecularly imprinted polymer-driven fluorescence/colorimetric dual-mode sensor based on Au/ZIF-67 nanocomposites for ultrasensitive ochratoxin A detection.

A dual-mode fluorescent/colorimetric sensor is presented utilizing Au/ZIF-67 nanocomposites for an ultrasensitive ochratoxin A (OTA) detection. The system employs polydopamine-coated FeO nanoparticles (FeO@MIP) as magnetic recognition elements and aptamer/3,3',5,5'-tetramethylbenzidine (TMB)-functionalized Au/ZIF-67 nanocomposites (Apt/TMB/Au/ZIF-67) as dual-signal probes for both fluorescence and colorimetric detection. Through molecular imprinting-aptamer synergistic recognition, OTA binding induces the formation of sandwich-structured particles (FeO@MIP-OTA-Apt/TMB/Au/ZIF-67).

Effects of high-definition transcranial direct current stimulation for the treatment of chronic insomnia: a randomized, double-blind, controlled trial.

To evaluate effects of 10-day high-definition transcranial direct current stimulation (HD-tDCS) over the dorsal medial prefrontal cortex (DMPFC) in patients with chronic insomnia. Fifty-five chronic insomnia patients were randomized into two groups: an active tDCS group received 10 days of active anode HD-tDCS stimulation, and a sham tDCS group received sham stimulation. A anode stimulation electrode was placed in Fz (10/20 system) which intend to target the bilateral hemisphere DMPFC, and four cathodes were placed at FPz, F3, Cz, and F4 (10/20 system).

A real-world pharmacovigilance study of belzutifan in renal cell carcinoma and von Hippel-Lindau disease: insights from the FDA adverse event reporting system database.

Background: Belzutifan, a first-in-class HIF-2α inhibitor, has been approved for von Hippel-Lindau (VHL) disease-associated renal cell carcinoma (RCC) and previously treated sporadic RCC. While its safety profile has been characterized in LITESPARK clinical trials, real-world pharmacovigilance data remain limited.

Aim: This study evaluated the characteristics (including frequency, system-specific toxicities, and time-to-onset) of real-world belzutifan-associated adverse events (AEs), aiming to identify emerging safety signals, and assessing potential disease progression-related AEs using data from the FDA Adverse Event Reporting System (FAERS).

What is the current status of transplant pharmacy services in China? A nationwide cross-sectional survey.

Background: Pharmacists are vital to the multidisciplinary care for transplant patients, but the workforce of their work in China remains unclear.

Objective: To assess the current status of transplant pharmacists' work in China through a national workforce survey to evaluate service provision across transplantation stages and pharmacist capacity.

Design, Setting And Participants: Nationwide cross-sectional questionnaire-based study (25 March-1 April 2024) involving 91 transplant centres performing>90% of China's organ transplants.

Exploring the influences of myopia in primary and secondary school students in Xinjiang using propensity score matching.

Objective: Due to the high prevalence of myopia among primary and secondary school students in Shihezi City in recent years, this study was conducted to understand the prevalence and the factors influencing it and to provide a scientific basis for future interventions to improve, protect, and promote the visual health of these students.

Methods: The study population consisted of primary and secondary school students in Shihezi City. Stratified random sampling was employed for participant selection.

Role of M2 macrophage-derived exosomes in cancer drug resistance via noncoding RNAs.

This review summarizes recent findings on the role of M2 tumor-associated macrophages (TAMs) and their exosome-derived non-coding RNAs (ncRNAs) in cancer cell resistance to therapeutics. M2 TAMs promote angiogenesis, suppress immune responses, and facilitate metastasis, thereby creating a tumor-supporting microenvironment. A range of antitumor drugs, including 5-FU, cisplatin, and gemcitabine, are mediated by M2 exosomes, each with distinct mechanisms of action.

Trends in myopia prevalence among children and adolescents: a large-scale cross-sectional study in Shihezi, China.

Purpose: The aim of this study was to understand the trends of myopia prevalence among children and adolescents in Shihezi, China.

Methods: This was a cross-sectional study using data from 2018 to 2023 from the Vision Surveillance Research Program for Students in Shihezi City. Describe the prevalence of myopia with 95% CIs in 31,265 children and adolescents in urban and rural areas, by sex and age.

Effects of SGLT2 inhibitors and GLP-1 receptor agonists on glycemic variability, islet cell function, and insulin resistance in patients with type 2 diabetes mellitus and renal cell carcinoma.

This study evaluated the effects of sodium-glucose co-transporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) on glycemic control, islet cell function, and insulin resistance in type 2 diabetes mellitus (T2DM) patients with T1-stage renal cell carcinoma (RCC). A retrospective cohort of 175 patients was divided into a control group receiving SGLT2i monotherapy (n = 84) and an observation group receiving combination therapy with SGLT2i and GLP-1RA (n = 91). Propensity score matching (PSM) was employed to balance baseline characteristics, resulting in 35 patients per group.

Continuous-wave second-harmonic generation of green light in periodically poled thin-film lithium tantalate.

Thin-film lithium tantalate (TFLT) is attracting increasing attention in nonlinear generation of visible lasers due to its large second-order nonlinearity and reduced photorefractive effect. In this Letter, we design and fabricate a periodically poled TFLT waveguide for frequency doubling of a near-infrared laser operating at around 1064 nm. Continuous-wave 1.

Human immunodeficiency virus-related renal cell carcinoma: a 13.5-year experience.

Background: Few reports have focused on renal cell carcinoma (RCC) in the people with HIV(PWH).

Methods: We analyzed patients diagnosed with RCC at our center between January 2011 and June 2024, divided into groups based on their HIV status. Categorical variables were compared using the chi-square test, and continuous variables were analyzed with the t-test.

Forsythoside B activates Siglec-14 to inhibit HIV-1 replication via the JAK1/STAT1 pathway.

The HIV/AIDS epidemic poses a severe global health challenge. While antiretroviral therapy is crucial, it has limitations, including high costs and resistance, and requires long-term use. Consequently, novel antiviral agents with unique structures and innovative mechanisms are needed for better management of HIV/AIDS.

Genetic Links between Gastrointestinal Disorders and Kidney Stone Disease: Insights from a Genome-Wide Cross-Trait Analysis.

Key Points: Positive genetic links and shared genetic architecture exist between gastrointestinal disorders and kidney stone disease. Ion homeostasis and response to vitamin D bridge two types of disorders. Genetically predicted irritable bowel syndrome, gastroesophageal reflux, and Crohn's disease were associated with higher risk of kidney stone disease.

Magnetic fields improve the gel properties of myofibrillar proteins in low-salt myofibrillar protein emulsion systems.

The effect of magnetic field on the properties of emulsified gels containing myofibrillar protein (MP-emulsified gels) with different salt concentration (0, 0.2, 0.4, 0.

NUF2 is associated with cancer stem cell characteristics and a potential drug target for prostate cancer.

Background: Cancer stem cells are characterized by self-renewal, clonal tumor initiation capacity, and treatment resistance, which play essential roles in the tumor progression of prostate cancer (PCa). In this study, we aim to explore the features of cancer stemness and characterize the expression of stem cell-related genes for PCa.

Methods: We downloaded RNA-seq data and related clinical information from The Cancer Genome Atlas (TCGA) database.

Fluorescence/colorimetric sensor based on aptamers-molecular imprinted polymers synergistic recognition for ultrasensitive and interference-free detection of aflatoxin B1.

This work aimed to develop a fluorescence/colorimetric sensor for the ultrasensitive detection of AFB1 based on the aptamers and molecular imprinted polymers (MIPs). The polydopamine on FeO (FeO@MIP) was used to achieve efficient separation of AFB1. The aptamer-modified carbon dots and metal-organic frameworks (Apt-CDs@MOF) were used to form sandwich particles (FeO@MIP-AFB1-Apt-CDs@MOF).

High-efficiency nonlinear frequency conversion enabled by optimizing the ferroelectric domain structure in -cut LNOI ridge waveguide.

Photonic devices based on ferroelectric domain engineering in thin film lithium niobate are key components for both classical and quantum information processing. Periodic poling of ridge waveguide can avoid the selective etching effect of lithium niobate, however, the fabrication of high-quality ferroelectric domain is still a challenge. In this work, we optimized the applied electric field distribution, and rectangular inverted domain structure was obtained in the ridge waveguide which is beneficial for efficient nonlinear frequency conversions.

Impact of pre-transplant malignancy on outcomes in kidney transplant recipients: an updated meta-analysis with systematic review.

Purpose: Kidney transplantation is the optimal therapy for end-stage renal disease, but pre-transplant malignancy (PTM) is a concern due to the increased risk of cancer recurrence with immunosuppression. While advancements in immunosuppression and cancer treatments have improved kidney recipient and graft survival, the impact of PTM on survival remains unclear and warrants comprehensive assessment.

Methods: This systematic review and meta-analysis followed PRISMA guidelines.

Single-atom nanozyme liposome-integrated microneedles for in situ drug delivery and anti-inflammatory therapy in Parkinson's disease.

Treatment for Parkinson's disease (PD) has been impeded by inefficient treatment results and multiple membrane barriers during drug delivery. This study reports the design, synthesis, and application of microneedles (MNs) loaded with mitochondrion-targeted liposome encapsulated iron (Fe)-isolated single-atom nanozymes (Mito@Fe-ISAzyme, MFeI), called MFeI MNs, for in situ drug delivery into the brain parenchyma and efficient enrichment of drugs in lesion sites. In in vitro experiments, MFeI can scavenge reactive oxygen species (ROS) and protect the neurons via mitochondrial targeting, guaranteeing the subsequent treatment of PD.

Exploring the conformational dynamics and key amino acids in the CD26-caveolin-1 interaction and potential therapeutic interventions.

This study aimed to decipher the interaction between CD26 and caveolin-1, key proteins involved in cell signaling and linked to various diseases. Using computational methods, we predicted their binding conformations and assessed stability through 100 ns molecular dynamics (MD) simulations. We identified two distinct binding conformations (con1 and con4), with con1 exhibiting superior stability.

Comprehensive pan-cancer analysis of ZNF337 as a potential diagnostic, immunological, and prognostic biomarker.

Background: Zinc Finger Protein 337 (ZNF337) is a novel Zinc Finger (ZNF) protein family member. However, the roles of ZNF337 in human cancers have not yet been investigated.

Methods: In this study, with the aid of TCGA databases, GTEx databases, and online websites, we determined the expression levels of ZNF337 in pan-cancer and its potential value as a diagnostic and prognostic marker for pan-cancer and analyzed the relationship between ZNF337 expression and immune cell infiltration and immune checkpoint genes.

Fluorescence/visual aptasensor based on Au/MOF nanocomposite for accurate and convenient aflatoxin B1 detection.

A dual-mode fluorescence/visual aptasensor was developed for straightforward and accurate determination of aflatoxin B1 (AFB1) based on an Au/metal-organic framework (Au/MOF) composite. Aptamer-modified Au/FeO (Apt/Au/FeO) served as the recognition element, and Au/MOF modified with complementary chains and 3,3',5,5'-tetramethylbenzidine (cDNA/TMB/Au/MOF) acted as the fluorescence and visual probes. These components are integrated to form conjugates (Apt/Au/FeO-cDNA/TMB/Au/MOF).