[Ilizarov external fixation technique combined with limited osteotomy for post-traumatic equinovarus deformity].

Objective: To evaluate the effectiveness of correcting post-traumatic equinovarus deformity using Ilizarov external fixation technique combined with limited osteotomy.

Methods: A retrospective analysis was conducted on clinical data from 29 patients with post-traumatic equinovarus deformity treated between July 2018 and March 2023. The cohort included 18 males and 11 females, with ages ranging from 15 to 57 years (mean, 24.

Comprehensive Multi-omics Analysis of Regulatory Variants for Body Weight in Cattle.

Body weight is a polygenic trait with intricate inheritance patterns. Functional genomics enriched with multi-layer annotations offers essential resources for exploring the genetic architecture of complex traits. In this study, we undertook an extensive characterization of regulatory variants for body weight related traits in cattle using a multi-omics approach.

and Genes Are Involved in SlMYB15-Regulated Redox Homeostasis to Enhance Cold Tolerance in Tomato.

Cold stress is a major abiotic factor limiting plant growth and productivity. MYB transcription factors are important regulators of stress responses. Our previous study identified SlMYB15 as a positive regulator of cold tolerance in tomato.

Prediction of 3D spatial distribution, driving factors, and risk for heavy metal(loid)s in sediment of Dongdagou River based on ensemble learning.

Sediments contaminated with heavy metal(loid)s can cause harm to the environment. This study proposed the use of machine learning methods to predict, classify, and identify the three-dimensional distribution of heavy metal(loid)s in sediment. Based on the 1423 sampling data from Dongdagou, a total of 8 metal(loid)s and 18 covariates were used to train and test the model.

Can Percutaneous Kyphoplasty Be a New Solution for Vertebral Fractures in Patients With Diffuse Idiopathic Skeletal Hyperostosis? Retrospective Study.

Background: Diffuse idiopathic skeletal hyperostosis (DISH) is a metabolic disease that is prevalent in elderly patients and is characterized by spinal ankylosis. Traditional surgical treatment requires open long-segment internal fixation. Percutaneous kyphoplasty (PKP), as a minimally invasive spinal surgery technology, can accurately relieve pain and improve quality of life.

Multi-omics integration analysis reveals the regulatory impact of CNVs for slaughter traits in cattle.

Copy number variations (CNVs) represent a crucial class of genomic variations that modulate gene expression and contribute to phenotypic diversity. In this study, we systematically identified 124,790 CNVs across genome using Bovine HD SNP array. A CNV-based genome-wide association study (GWAS) identified 17 and 3 significant CNV segments associated with lean meat percentage (LMP) and dressing percentage (DP), respectively.

Confinement-induced chirality in phase-separated achiral polymer solutions.

Self-organization of polymers in constrained geometries largely determines their applications in high-strength materials, photonics, and electronics. Chiral organization under confinement is well established for polymers with intrinsic molecular chirality; however, it has not been observed for achiral polymers. Here, we report the emergence of chirality in spatially confined solutions of achiral rigid-rod polymers.

Exploratory analysis of the key role of immune function changes in BPD.

Bronchopulmonary dysplasia (BPD) is one of the most prevalent and severe chronic lung diseases in premature infants. The objective of the current study was to screen for key BPD-associated genes and pathways by transcriptomic analysis from clinical patients and animal models. In our study, the differentially expressed genes were screened from 58 children with 14-day BPD and 40 normal children in the GSE32472 dataset of the Gene Expression Omnibus database.

Advances in the study of mechanisms underlying olfactory dysfunction in obstructive sleep apnea:a narrative review.

Obstructive sleep apnea (OSA) and olfactory dysfunction have a reciprocal relationship, where each condition exacerbates the other. This review aims to systematically explore the key mechanisms underlying the association between OSA and olfactory impairment, offering a detailed analysis of these interrelated phenomena. A comprehensive literature search was conducted on PubMed/MEDLINE in October 2024, focusing on studies published in the last decade that investigate the link between OSA and olfactory dysfunction.

Modified transforaminal epidural steroid injection combined with pulsed radiofrequency: an effective treatment measure for lumbar radiculopathy.

Background: Lumbar disc herniation (LDH) is a prevalent condition encountered in the clinical diagnosis and management of spinal surgery. Certain people may experience excruciating radicular pain in the lower extremities. If these symptoms are not promptly alleviated, they may progressively deteriorate, ultimately resulting in radiating pain in the lower extremities, advancing neurological impairments, and potential trouble in standing, significantly impairing the patient's quality of life.

The effcet of annulus fibrosus suture combined with percutaneous transforaminal endoscopic discectomy on obese patients with lumbar disc herniation.

Background: Lumbar disc herniation (LDH) is a prevalent degenerative disc disorder frequently resulting in lumbar and leg pain. Obese patients with LDH often encounter the scenario where the disc herniation is not completely resolved in the short term following percutaneous transforaminal endoscopic discectomy (PTED), necessitating subsequent surgical intervention, or where long-term reherniation occurs post-procedure. Currently, the literature provides little information regarding the application of annulus fibrosus suture (AFS) as a supplementary measure to PTED for diminishing the recurrence of disc herniation.

Effects and functional mechanisms of digital fitness platforms on online fitness payment behavior under the perspective of "She-economy".

Women have become an important force for economic development. Online fitness payment behavior is an important part of women's pursuit of "beautiful skin and healthy body", and is also an important embodiment of the integration of the digital industry and the fitness industry. Based on Stimuli-Organism-Response and Technology Acceptance Model theories, this study systematically explored the relationship and mechanism of action between digital fitness platforms and online fitness payment behavior through a survey of 259 women using Structural Equation Modeling and Fuzzy Set Qualitative Comparative Analysis.

Self-driving lab for the photochemical synthesis of plasmonic nanoparticles with targeted structural and optical properties.

Many applications of plasmonic nanoparticles require precise control of their optical properties that are governed by nanoparticle dimensions, shape, morphology and composition. Finding reaction conditions for the synthesis of nanoparticles with targeted characteristics is a time-consuming and resource-intensive trial-and-error process, however closed-loop nanoparticle synthesis enables the accelerated exploration of large chemical spaces without human intervention. Here, we introduce the Autonomous Fluidic Identification and Optimization Nanochemistry (AFION) self-driving lab that integrates a microfluidic reactor, in-flow spectroscopic nanoparticle characterization, and machine learning for the exploration and optimization of the multidimensional chemical space for the photochemical synthesis of plasmonic nanoparticles.

Harnessing Anti-Inflammatory and Regenerative Potential: GelMA Hydrogel Loaded with IL-10 and Kartogenin for Intervertebral Disc Degeneration Therapy.

Intervertebral disc degeneration (IVDD) is a major contributor to chronic back pain and disability, with limited effective therapeutic options. Current treatment options, including conservative management and surgical interventions, often fail to effectively halt disease progression and come with notable side effects. IVDD is characterized by the breakdown of the extracellular matrix (ECM) and the infiltration of inflammatory cells, which exacerbate disc degeneration.

Surgical treatment of congenital pseudarthrosis of the tibia in children: CPAM-LRC consensus and guidelines.

Purpose: Congenital pseudarthrosis of the tibia (CPT) is a rare condition typically manifesting within the first decade of life. The primary objectives of surgical intervention for CPT include achieving long-term bony union of the tibia, preventing or minimizing limb length discrepancies (LLD), avoiding mechanical axis deviations of the tibia and adjacent joints, and preventing refracture. This study aims to conduct a systematic review of current treatment methods for CPT to determine the most effective non-surgical and surgical management strategies for pediatric patients with this condition.

Integrating multi-layered biological priors to improve genomic prediction accuracy in beef cattle.

Background: Integrating multi-layered information can enhance the accuracy of genomic prediction for complex traits. However, the improvement and application of effective strategies for genomic prediction (GP) using multi-omics data remains challenging.

Methods: We generated 11 feature sets for sequencing variants from genomics, transcriptomics, metabolomics, and epigenetics data in beef cattle, then we assessed the contribution of functional variants using genomic restricted maximum likelihood (GREML).

Non-image-forming photoreceptors improve visual orientation selectivity and image perception.

It has long been a decades-old dogma that image perception is mediated solely by rods and cones, while intrinsically photosensitive retinal ganglion cells (ipRGCs) are responsible only for non-image-forming vision, such as circadian photoentrainment and pupillary light reflexes. Surprisingly, we discovered that ipRGC activation enhances the orientation selectivity of layer 2/3 neurons in the primary visual cortex (V1) of mice by both increasing preferred-orientation responses and narrowing tuning bandwidth. Mechanistically, we found that the tuning properties of V1 excitatory and inhibitory neurons are differentially influenced by ipRGC activation, leading to a reshaping of the excitatory/inhibitory balance that enhances visual cortical orientation selectivity.

E2F1 and E2F7 regulate gastric cancer cell proliferation, respectively, through transcriptional activation and transcriptional repression of MYBL2.

Gastric cancer (GC) is the most common malignant tumor of the digestive tract. However, the molecular pathogenesis is not well understood. Through bioinformatic analysis and analyzing clinical tissue samples, we found that E2F1 and E2F7 as well as their potential downstream target MYBL2 were all upregulated in GC tissues and that their expressions correlated with patient prognosis.

Room-temperature non-volatile optical manipulation of polar order in a charge density wave.

Utilizing ultrafast light-matter interaction to manipulate electronic states of quantum materials is an emerging area of research in condensed matter physics. It has significant implications for the development of future ultrafast electronic devices. However, the ability to induce long-lasting metastable electronic states in a fully reversible manner is a long-standing challenge.

The evaluation of cytokines in predicting the organ injury of critically pediatric patients: a retrospective study.

Background: The current early warning model for organ damage in critically ill patients has certain limitations. Based on the pathological mechanism, the establishment of an early warning system for organ damage in critically ill children using cytokines profile has not been explored. The aim of this study is to explore the predicting value of cytokines in critically ill patients.

Posttranslational modifications of E2F family members in the physiological state and in cancer: Roles, mechanisms and therapeutic targets.

The E2F transcription factor family, whose members are encoded by the E2F1-E2F8 genes, plays pivotal roles in the cell cycle, apoptosis, metabolism, stemness, metastasis, aging, angiogenesis, tumor promotion or suppression, and other biological processes. The activity of E2Fs is regulated at multiple levels, with posttranslational modifications being an important regulatory mechanism. There are numerous types of posttranslational modifications, among which phosphorylation, acetylation, methylation, ubiquitination, SUMOylation, neddylation, and poly(ADP-ribosyl)ation are the most commonly studied in the context of the E2F family.

Deep Learning-Based Microscopic Cell Detection Using Inverse Distance Transform and Auxiliary Counting.

Microscopic cell detection is a challenging task due to significant inter-cell occlusions in dense clusters and diverse cell morphologies. This paper introduces a novel framework designed to enhance automated cell detection. The proposed approach integrates a deep learning model that produces an inverse distance transform-based detection map from the given image, accompanied by a secondary network designed to regress a cell density map from the same input.

Quality of cementing in hemiarthroplasty for elderly neck of femur fractures does not affect short term functional outcomes.

Introduction: Cemented hip hemiarthroplasty is a routine surgical option for elderly neck of femur (NOF) fractures. It is uncertain if quality of cementing has any effect on functional outcomes. The aim of this study was to determine if the quality of cementing would affect short term functional outcomes in elderly neck of femur fractures.