Serum GPR37 as a novel biomarker for disease activity, disability, and differential diagnosis in NMOSD.

Background: G protein-coupled receptor 37 (GPR37) has recently been earmarked as a rising candidate for use as a marker for central nervous system (CNS) demyelinating illness. In this study, we explored the ability of serum GPR37 to assess disease activity, functional impairment, and the efficacy of therapeutic interventions in patient cases of neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS).

Methods: We prospectively enrolled 144 cases of NMOSD and 132 cases of MS, as well as 160 controls (healthy individuals and cases of other neural disorders).

Effect of cavitation erosion distance on the damage of hydraulic turbine materials.

Cavitation erosion could lead to material loss and structural damage in the flow components of hydraulic machinery, affecting the stable operation and efficiency of the equipment. This study established a cavitation erosion distance model for the gap in the cavitation field. High-speed cameras were used to capture the bubble distribution under different cavitation erosion distances.

Design and Evaluation of a Capacitive Micromachined Ultrasonic Transducer(CMUT) Linear Array System for Thickness Measurement of Marine Structures Under Varying Environmental Conditions.

This paper presents the design, fabrication, and experimental evaluation of a capacitive micromachined ultrasonic transducer (CMUT) linear array for non-contact thickness measurement of marine engineering structures. A 16-element CMUT array was fabricated using a silicon-silicon wafer bonding process, and encapsulated in polyurethane to ensure acoustic impedance matching and environmental protection in underwater conditions. The acoustic performance of the encapsulated CMUT was characterized using standard piezoelectric transducers as reference.

[Study on the spinal cord and peripheral mechanisms of electroacupuncture in anti-inflammation and analgesia in rats with fibromyalgia syndrome].

Objectives: To observe the effect of electroacupuncture (EA) on mast cell (MC) activity, substance P (SP) and glial fibrillary acidic protein (GFAP) expression in the lumbar spinal dorsal horns (SDHs) and related inflammatory factors in the anterior tibial muscle, lumbar spinal cord and serum of fibromyalgia syndrome (FMS) model rats, so as to explore its mechanisms underlying improvement of FMS.

Methods: Thirty-six male SD rats were randomly divided into blank control, model and EA groups, with 12 rats in each group. The FMS model was established by injecting 2-morphine phenol ethanol sulfate into the left anterior tibial muscle.

Aptamer-based NIR II imaging for breast cancer surgical resection.

The accuracy of intraoperative tumor margin assessment is the main challenge in breast conserving surgery (BCS). NIR-II fluorescence-guided surgery enables surgeons to visualize the tumor margins dynamically in real time and facilitate the precision of tumor resection. We develop an aptamer-conjugated NIR-II probe for intraoperative fluorescence imaging.

Spherical nucleic acids-based nanomachines enable in situ tracing of exosomal lncRNA at the single-vesicle level.

Exosomal long non-coding RNAs (lncRNAs) serve as promising, non-invasive biomarkers for further cancer therapy. Conventional techniques for detecting exosomal lncRNAs often rely on exosome lysis and total RNA extraction. Direct, non-destructive tracking of exosomal molecular cargoes is thus crucial for the precise and high-fidelity detection of exosomal lncRNAs.

Catalyst-free partial oxidation of methane under ambient conditions boosted by mechanical stirring-enhanced ultrasonic cavitation.

The partial oxidation of methane (POM) into value-added C chemicals (e.g., CHOH, HCHO, and CO) offers a promising approach for natural gas utilization under mild conditions.

Salicylic acid influences the resistance of colored calla lily to soft rot (Pectobacterium carotovorum) via the TGA2-LNC88940-miR528-SOD module.

Soft rot is a major disease affecting the production of colored calla lily, significantly compromising its ornamental, commercial, and market value. In this study, we identified potential long non-coding RNAs (lncRNAs) in colored calla lily (Zantedeschia elliottiana) leaves infected with soft rot via transcriptome sequencing. Among them, long non-coding RNA 88490 (LNC88940) was identified as a differentially expressed lncRNA that was significantly upregulated following soft rot infection.

Synergizing Nanosensor-Enhanced Wearable Devices with Machine Learning for Precision Health Management Benefiting Older Adult Populations.

Population aging presents significant health challenges and socioeconomic burdens globally, driving an increased demand for precision health management. In the era of big data, the exponential growth of health information is accelerating advances in precision health strategies for older adults. For this population, effective strategies can be achieved by the integration of wearable devices, nanosensors, and machine learning.

Rolling circle amplification and CRISPR/Cas14a with nanozyme for electrochemical detecting miRNA-205 in NPC-derived exosomes.

Nasopharyngeal carcinoma (NPC) is a highly malignant tumor, and early detection of biomarkers like miRNA-205 (miR-205) is critical for improving prognosis. However, accurate detection of miR-205 remains challenging due to its low abundance and matrix interference. Herein, an ultrasensitive electrochemical biosensor integrating Pt nanowires/MXene (PtNWs/MXene), rolling circle amplification (RCA), and CRISPR/Cas14a was developed for detecting exosomal miR-205.

Environmental moderators of tic severity and quality of life in children with tic disorders.

Unlabelled: Tic disorders (TD) are common neurodevelopmental disorders that can significantly impact on patients' quality of life. Growing evidence suggests that environmental factors play an important role in the development of children with TD. This study aims to investigate the effect of physical activity, academic achievement, peer relationships, and parent-child reading on the severity of tics and quality of life in children with TD.

Predictive modeling of postoperative hyponatremia after pituitary adenoma surgery.

Objective: To improve the prediction of postoperative hyponatremia after pituitary surgery by comparing six machine learning (ML) models.

Methods: We analyzed 777 patients post-pituitary surgery, with 118 developing hyponatremia, and validated our findings in an external cohort of 183 patients (28 hyponatremia cases). Six ML models were developed using pre- and postoperative clinical and laboratory data, with predictive accuracy assessed via the area under the ROC curve (AUC).

IL-17A as a Key Mediator of Pulmonary-Intestinal Immune Interactions in a Mouse Model of Asthma and Colitis.

Background: The immunological interaction between the lung and gut remains underexplored, particularly in the context of coexisting mucosal inflammation. While IL-17A has been implicated in both asthma and colitis independently, its role in coordinating systemic immune responses across tissue compartments is not well defined.

Methods: In this study, we developed a combined house dust mite-induced asthma model and dextran sulfate sodium-induced colitis model to investigate the role of IL-17A in driving inflammation in both the lungs and the intestines.

Flexible Field-Effect Transistor Sensors for Next-Generation Health Monitoring: Materials to Advanced Applications.

Flexible field-effect transistor (FET) sensors have emerged as a promising technology for human health monitoring, driven by breakthroughs in materials, device design, and fabrication processes. Their unique advantages, including multi-parametric detection, intrinsic signal amplification, low power consumption, and scalable production, position them at the forefront of wearable and implantable biosensing systems. This review outlines the structural design and operational principles of flexible FET sensors, systematically summarizing material innovations for critical components (substrates, dielectrics, semiconductor channels, and electrodes) and strategies to harmonize electrical performance with mechanical robustness.

Prognostic value of a lncRNA signature in early-stage invasive breast cancer patients.

Background: Existing staging approaches fall short in precisely forecasting the likelihood of recurrence and survival outcomes among patients undergoing surgery for early-stage breast cancer (EBC). Our study hypothesized that multivariate long non-coding RNA (lncRNA) expression profiles, when systematically integrated into a composite model, may synergistically refine postoperative risk categorization and enhance prognostic forecasting precision in this patient cohort.

Methods: For the discovery set, lncRNA expression profiling associated with breast cancer progression was discovered by analyzing the differential expression profiles in three paired primary breast cancer tumor tissues and liver metastases.

Efficacy and safety of limertinib versus gefitinib as first-line treatment for locally advanced or metastatic non-small-cell lung cancer with EGFR-sensitising mutation: a randomised, double-blind, double-dummy, phase 3 trial.

Background: Limertinib is a new third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. This study aimed to prospectively assess the efficacy and safety of limertinib versus gefitinib as a first-line treatment for locally advanced or metastatic non-small-cell lung cancer (NSCLC) with EGFR-sensitising mutation.

Methods: This multicentre, randomised, double-blind, double-dummy, phase 3 trial was done at 56 hospitals in China.

Enhanced Adsorption-Photocatalytic Activity of Bismuth-Based Materials via Interfacial Charge Driving Force and Highly Active Crystal Plane.

Large interfacial charge transfer driving force and the incorporation of highly active specific crystalline surfaces have the potential to address the issue of inadequate adsorption-photocatalytic degradation efficiency of photocatalytic materials for organic pollutants. In this study, we synthesized BiWO-BiOCl-BiSiO (BSWC) photocatalysts with excellent adsorption and photocatalytic properties by introducing BiOCl via a double anionic layer in situ induction strategy. The photocatalytic activities of the optimized BSWC-3 were 27.

[Mechanism of electroacupuncture-induced macrophage polarization in promoting acute skeletal muscle injury repair in rats].

Objective: To investigate the potential mechanism by which electroacupuncture (EA) induces macrophage polarization to promote muscle satellite cell proliferation and differentiation, accelerating the repair of acute skeletal muscle injury.

Methods: Forty-two SPF-grade SD rats were randomly divided into three groups: a blank group (=6), a model group (=18), and an EA group (=18). The model and EA groups established acute blunt contusion model of the right gastrocnemius muscle using a self-made striking device.

Is performing the Kasai portoenterostomy in the neonatal period associated with a better prognosis? A single-center, retrospective cohort study from China.

Background/purpose: This study aimed to evaluate discrepancies in prognosis after the Kasai portoenterostomy (KPE) procedure between neonatal and non-neonatal periods among patients undergoing the KPE procedure less than 60 days after birth (≤ 60 days).

Methods: All type III BA patients who performed KPE less than 60 days from June 2020 to May 2024 in the Department of Neonatal Surgery of Beijing Children's Hospital were retrospectively reviewed. They were divided into two groups according to the age at Kasai: the early KPE group (EK group, or neonatal group ≤ 30 days after birth) and the late KPE group (LK group, or non-neonatal group 31-60 days after birth), to evaluate the effect of surgical age on the postoperative efficacy following Kasai.

Nanozymes enhancing field-effect transistor nanosensor for in-situ monitoring intracellular hydrogen peroxide release.

Field-effect transistor (FET) nanodevices are widely recognized as highly sensitive sensors for continuous detection of bioactive molecules like hydrogen peroxide (HO). However, accurate and real-time monitoring of HO poses challenges due to its instability and low concentration in organisms. To address these challenges, we construct an enhanced FET by one-step interfacing with nanozymes that possess natural enzyme-like catalytic properties and exceptional stability.

[Analysis of Risk Factors for Meningeal Metastasis in Patients with Lung Adenocarcinoma Following Non-surgical Interventions].

Background: Meningeal metastasis (MM) is a form of malignant metastasis where tumor cells spread from the primary site to the pia mater, dura mater, arachnoid, subarachnoid space, and other cerebrospinal fluid compartments. Lung cancer is one of the most common malignant tumor types with MM. MM not only signifies that the lung cancer has progressed to an advanced stage but also leads to a range of severe clinical symptoms due to meningeal involvement.

Unraveling the Dyslipidemic Landscape in Moyamoya Disease: OxLDL as a Key Biomarker.

Aims: The pathogenic mechanisms of moyamoya disease (MMD) remain unrecognized. Although genetic predisposition and hemodynamic changes have been focused on, emerging evidence suggests dyslipidemia may also contribute to MMD. Here, we performed a comprehensive analysis of lipid profiles, aiming to elucidate potential mechanisms in MMD.

Precise synthesis of targeted noble metal-based high-entropy alloy nanomaterials.

Noble metal-based high-entropy alloys (NM-HEAs) are promising catalysts because of their diverse compositions and complex surface structures, although understanding their formation and achieving precise atomic control remain challenging. Our team introduces a cost-effective synthesis method combining spray drying and thermal decomposition-reduction to produce HEA three-dimensional nanoframeworks (HEA-3DNFs) from quinary to octonary compositions, including Pt-, Ir-, Ru-, and PtRu-based HEAs. Mild heating in H2 facilitates simultaneous reduction of multiple elements, forming single-phase solid solution alloys.

Microneedle biosensor for real-time monitoring of hydrogen sulfide release from paraventricular nucleus of hypertension rats stimulated by electroacupuncture.

Acupuncture therapy reduces blood pressure in hypertensive patients by stimulating acupoints located at specific anatomical positions with needles. Hydrogen sulfide (HS) release and accumulation in the paraventricular nucleus (PVN) might be a pivotal step for triggering blood pressure reduction. But to date, the dynamics of HS in the PVN during acupuncture treatment remain unclear.