Effect of cavitation erosion distance on the damage of hydraulic turbine materials.

Cavitation erosion could lead to material loss and structural damage in the flow components of hydraulic machinery, affecting the stable operation and efficiency of the equipment. This study established a cavitation erosion distance model for the gap in the cavitation field. High-speed cameras were used to capture the bubble distribution under different cavitation erosion distances.

Chromatin dynamics and regulatory drivers of hypoplastic hepatic progenitor cells in partial hepatectomy model.

The remarkable plasticity of hepatocytes underlies diverse roles in distinct patterns of liver injury. Specifically, hepatocyte-derived progenitor cells play dominant roles in driving the regenerative response during chronic liver injury. However, the potential for hepatocytes to transdifferentiate into progenitor-like cells following partial hepatectomy (PHx) remains debated.

Stereo-cell: Spatial enhanced-resolution single-cell sequencing with high-density DNA nanoball-patterned arrays.

Single-cell sequencing technologies have advanced our understanding of cellular heterogeneity and biological complexity. However, existing methods face limitations in throughput, capture uniformity, cell size flexibility, and technical extensibility. We present Stereo-cell, a spatial enhanced-resolution single-cell sequencing platform based on high-density DNA nanoball (DNB)-patterned arrays, which enables scalable and unbiased cell capture at a wide input range and supports high-fidelity transcriptome profiling.

Process-Structure Co-Optimization of Glass Fiber-Reinforced Polymer Automotive Front-End Module.

For automotive GFRP structural components, beyond structural design, the warpage, residual stress/strain, and fiber orientation inevitably induced during the injection molding process significantly compromise their service performance. These factors also diminish the reliability of performance assessments. Thus, it is imperative to develop a process-structure co-optimization approach for GFRP components.

Adsorption and Separation Mechanism of Methanol-Toluene Azeotropes on Porous Carbon Materials: Insights from Theoretical and Experimental Studies.

Currently, research on the adsorption of methanol and toluene by carbon-based materials has mainly focused on the adsorption performance of a single compound. However, there has been minimal investigation into the adsorption and separation of toluene and methanol azeotropes, and their potential mechanisms are still unclear. In this work, theoretical calculations were employed to investigate the effect of oxygen-containing functional groups and the pore size distribution of porous carbon on the adsorption and separation of methanol and toluene.

Prognostic analysis and mechanistic exploration of the autophagy-related exosome genes ITGA3, ITGB4, and PTK6 in pancreatic ductal adenocarcinoma.

Pancreatic cancer (PC) is a highly malignant tumor with an extremely poor prognosis, but early diagnosis and treatment can significantly improve prognosis. This study aimed to screen autophagy-related exosome genes associated with poor prognosis in PC and to explore the underlying mechanisms in malignant progression via bioinformatics analysis to provide a reference for the diagnosis, treatment and prognosis evaluation of PC, especially pancreatic ductal adenocarcinoma (PDAC). Matrix files of 178 PC tissues (including 143 PDAC) and 167 healthy human pancreatic tissues and clinical data were downloaded from the UCSC Xena database, exosome database (exoRbase) and autophagy database (HADb), and the relevant mechanisms were explored by bioinformatics methods, including differential analysis, LASSO regression analysis, survival analysis, functional analysis, immune infiltration analysis and drug sensitivity analysis.

Hot Compression Behavior and Processing Maps of 6063 Aluminum Alloy Under Medium Strain Rate.

A hot compression test was conducted across a range of temperatures (350, 400, 450, and 500 °C) and varying strain rates (0.001-10 s) to explore the hot compression behavior of the 6063 alloy. Hot processing maps were obtained based on the stress-strain curves.

Treatment performance and microbial community dynamics in vertical flow constructed wetlands integrated with gradient magnetic fields.

Low and inconsistent pollutant removal remains a key challenge in constructed wetlands (CWs). We developed CWs integrated with gradient magnetic fields (MF-CWs) to enhance domestic wastewater treatment. Results demonstrated that MF-CWs significantly outperformed conventional CWs in removing NH-N, TP, and COD.

An Anti-Interrupted-Sampling Repeater Jamming Method Based on Simulated Annealing-2-Optimization Parallel Optimization of Waveforms and Fractional Domain Extraction.

Faced with increasingly complex electronic jamming environments, intra-pulse agility has become a primary method of anti-interrupted-sampling repeater jamming (ISRJ) for radar systems. However, existing intra-pulse agile signals suffer from high autocorrelation sidelobe levels and limited jamming suppression capabilities. These issues restrict the performance of intra-pulse agile signals in complex electromagnetic environments.

Salt stress activates the CDK8-AHL10-SUVH2/9 module to dynamically regulate salt tolerance in Arabidopsis.

Salt stress has devastating effects on agriculture, yet the key regulators modulating the transcriptional dynamics of salt-responsive genes remain largely elusive in plants. Here, we discover that salt stress substantially induces the kinase activity of Mediator cyclin-dependent kinase 8 (CDK8), which is essential for its positive role in regulating salt tolerance. CDK8 is identified to phosphorylate AT-hook motif nuclear-localized protein 10 (AHL10) at serine 314, leading to its degradation under salt stress.

Design and Aerodynamic Analysis of a Flapping Mechanism for Foldable Biomimetic Aircraft.

This study investigates the unsteady aerodynamic mechanisms underlying the efficient flight of birds and proposes a biomimetic flapping-wing aircraft design utilizing a double-crank double-rocker mechanism. Building upon a detailed analysis of avian flight dynamics, a two-stage foldable flapping mechanism was developed, integrating an optimized double-crank double-rocker structure with a secondary linkage system. This design enables synchronized wing flapping and spanwise folding, significantly enhancing aerodynamic efficiency and dynamic performance.

A scATAC-seq atlas of stasis zone in rat skin burn injury wound process.

Burn injuries often leave behind a "stasis zone", a region of tissue critically important for determining both the severity of the injury and the potential for recovery. To understand the intricate cellular and epigenetic changes occurring within this critical zone, we utilized single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) to profile over 31,500 cells from both healthy rat skin and the stasis zone at nine different time points after a burn injury. This comprehensive approach revealed 26 distinct cell types and the dynamic shifts in the proportions of these cell types over time.

Abnormal-Sound Diagnosis for Kaplan Hydroelectric Generating Units Based on Continuous Wavelet Transform and Transfer Learning.

To realize abnormal-sound diagnosis in hydroelectric generating units, this study proposes a method based on continuous wavelet transform (CWT) and Transfer Learning (TL). A denoising algorithm utilizing spectral noise-gate technology is proposed to enhance fault characteristics in hydroelectric units. Subsequently, Continuous Wavelet Transform is applied to obtain frequency components, and the results are converted into a series of pseudo-color images to highlight information differences.

Performance and by-product generation in sulfur-siderite/limestone autotrophic denitrification systems: Enhancing nitrogen removal efficiency and operational insights.

Sulfur autotrophic denitrification technology is a promising nitrogen removing process and is suitable for the tail water of sewage treatment plants with easy biodegradation and low C/N ratio. Nitrogen removal efficiency and along-path variation of related product concentrations in the sulfur-siderite autotrophic denitrification (SSAD) and sulfur-limestone autotrophic denitrification (SLAD) systems were comprehensively investigated in this work. The optimal denitrification conditions for SSAD and SLAD systems were pH of 7, HRT of 3 h, temperatures of 20-25 °C with NO-N removal rates of more than 99%.

TVDO: Tchebycheff Value-Decomposition Optimization for Multiagent Reinforcement Learning.

In cooperative multiagent reinforcement learning (MARL), centralized training with decentralized execution (CTDE) has recently attracted more attention due to the physical demand. However, the most dilemma therein is the inconsistency between jointly-trained policies and individually executed actions. In this article, we propose a factorized Tchebycheff value-decomposition optimization (TVDO) method to overcome the trouble of inconsistency.

Effect of Extrusion Ratio on Mechanical Behavior and Microstructure Evolution of 7003 Aluminum Alloy at High-Speed Impact.

The extrusion ratio (ER) is one of the most important factors affecting the service performance of aluminum profiles. In this study, the influence of ER on the mechanical behavior and microstructure evolution of 7003 aluminum alloy at high-speed impact with strain rates ranging from 700 s to 1100 s was investigated. The studied alloy with an ER of 56 formed coarse grain rings during the heat treatment.

Establishment of Dissolution Test Method for Multi-Components in Traditional Chinese Medicine Preparations Based on In Vitro-In Vivo Correlation.

In this study, a multi-component integrated dissolution evaluation system of Yuanhu Zhitong tablets (YZTs) was established based on in vitro and in vivo correlation (IVIVC). The dissolution tests of five quality markers (Q-markers), including tetrahydropalmatine, α-allocryptopine, protopine, corydaline, and byakangelicin, in YZTs were conducted under different dissolution conditions, and pharmacokinetic studies were performed in beagle dogs to construct a correlation model using numerical deconvolution. The data of the five ingredients were integrated in vitro and in vivo according to the biopharmaceutical classification system (BCS) to establish an IVIVC integrating multiple Q-markers.

Integrated transcriptomic and metabolomic analysis reveals the effects and potential mechanism of hydrogen peroxide on pigment metabolism in postharvest broccoli.

To understand the effects and related potential mechanism of HO on pigment metabolism in postharvest broccoli, an integrated analysis of transcriptome and metabolome was performed. Results suggested that 65 differentially expressed genes and 26 differentially accumulated metabolites involved in chlorophyll, carotenoid, and flavonoid metabolism were identified. HO treatment delayed the decrease of chlorophyll content by upregulating the expressions of chlorophyll synthetic genes, thylakoid synthetic genes, and 15 light-harvesting complex genes compared with the control and diphenylene iodonium treatments.

A single-cell chromatin accessibility dataset of human primed and naïve pluripotent stem cell-derived teratoma.

Teratoma, due to its remarkable ability to differentiate into multiple cell lineages, is a valuable model for studying human embryonic development. The similarity of the gene expression and chromatin accessibility patterns in these cells to those observed in vivo further underscores its potential as a research tool. Notably, teratomas derived from human naïve (pre-implantation epiblast-like) pluripotent stem cells (PSCs) have larger embryonic cell diversity and contain extraembryonic lineages, making them more suitable to study developmental processes.

Swing Trend Prediction of Main Guide Bearing in Hydropower Units Based on MFS-DCGNN.

Hydropower units are the core equipment of hydropower stations, and research on the fault prediction and health management of these units can help improve their safety, stability, and the level of reliable operation and can effectively reduce costs. Therefore, it is necessary to predict the swing trend of these units. Firstly, this study considers the influence of various factors, such as electrical, mechanical, and hydraulic swing factors, on the swing signal of the main guide bearing -axis.

A novel approach to alleviate acetaminophen-induced hepatotoxicity with hybrid balloon flower root-derived exosome-like nanoparticles (BDEs) with silymarin via inhibition of hepatocyte MAPK pathway and apoptosis.

Introduction: Balloon flower root-derived exosome-like nanoparticles (BDEs) have recently been proposed as physiologically active molecules with no cytotoxicity. However, the therapeutic effects of drug-induced hepatotoxicity of BDEs have not been elucidated. BDEs contain a large amount of platycodin D, which is widely known to be effective in regulating inflammation and ameliorating systemic toxicity.

Predictive value of plasma ephrinB2 levels for amputation risk following endovascular revascularization in peripheral artery disease.

Background: The aim of this study is to investigate the expression levels of ephrinB2 in patients with lower extremity peripheral arterial disease (PAD) and explore its association with the severity of the disease and the risk of amputation after endovascular revascularization.

Methods: During the period from March 2021 to March 2023, this study collected blood samples and clinical data from 133 patients diagnosed with lower extremity PAD and 51 healthy volunteer donors. The severity of lower extremity PAD patients was classified using the Rutherford categories.

Down-regulation of long noncoding RNA HOXA11-AS nullifies the impact of microRNA-506-3p on chondrocytes proliferation and apoptosis in osteoarthritis.

Objectives: This study was directed towards exploring the impacts of lncRNA HOXA11-AS-mediated microRNA (miR)-506-3p on chondrocytes proliferation and apoptosis in osteoarthritis (OA).

Methods: The articular cartilages were provided by OA patients who received total knee arthroplasty, and Human Chondrocyte (HC)-OA (HCOA) was also attained. The miR-506-3p and HOXA11-AS expressions in articular cartilages from OA patients and HCOA cells were analyzed via qPCR.

Multimodal cell atlas of the ageing human skeletal muscle.

Muscle atrophy and functional decline (sarcopenia) are common manifestations of frailty and are critical contributors to morbidity and mortality in older people. Deciphering the molecular mechanisms underlying sarcopenia has major implications for understanding human ageing. Yet, progress has been slow, partly due to the difficulties of characterizing skeletal muscle niche heterogeneity (whereby myofibres are the most abundant) and obtaining well-characterized human samples.