Defective Hoxb8 microglia are causative for both chronic anxiety and pathological overgrooming in mice.

Disruption of the Hoxb8 gene results in chronic anxiety and pathological overgrooming in mice. Using bilateral intracerebral cell transplantation, we demonstrate that mutant Hoxb8 microglia are causative for both behaviors. Mice contain two microglia lineages, Hoxb8 and non-Hoxb8 microglia.

Aggregate index of systemic inflammation as a novel prognostic biomarker in Chinese patients with acute decompensated heart failure: a population-based real-world study.

Introduction: Inflammation is hypothesized as an early trigger for decompensation in heart failure patients. This study aims to evaluate the prognostic value of a novel inflammatory biomarker, the Aggregate Index of Systemic Inflammation (AISI), for predicting 30-day mortality in patients with acute decompensated heart failure (ADHF).

Methods: This analysis included 2,765 patients from the Jiangxi-ADHF II registry (2018-2024).

Impact of remnant cholesterol on short-term mortality in acute decompensated heart failure: cohort study evidence from Jiangxi, China.

Introduction: Remnant cholesterol (RC), a highly atherogenic lipid component, has been strongly implicated in the pathogenesis and adverse clinical outcomes of numerous cardiovascular and cerebrovascular diseases. However, its impact on short-term prognosis in patients with acute decompensated heart failure (ADHF) remains to be elucidated.

Methods: This study enrolled 2,365 patients with acute decompensated heart failure (ADHF) admitted to Jiangxi Provincial People's Hospital from 2018 to 2024.

Independent and combined associations of high-density lipoprotein cholesterol-modified triglyceride-glucose index with all-cause and cardiovascular mortality in patients with acute decompensated heart failure.

Introduction: Dysregulation of glucolipid metabolism is a central pathological mechanism underlying acute decompensated heart failure (ADHF) and significantly impacts its poor prognosis. This study aims to investigate the association between the high-density lipoprotein cholesterol-modified triglyceride-glucose index (defined as TyG/HDL-C) and their interaction with 30-day mortality in patients with ADHF.

Methods: From 2018 to 2024, 2,329 ADHF patients enrolled in the Jiangxi-ADHF II cohort were included.

Impact of anatomical variations of the circle of Willis on the blood flow within unruptured intracranial aneurysm.

Background: Anatomical variations of the circle of Willis (CoW) are closely associated with the occurrence of intracranial aneurysms (IAs). However, the impact of anatomical variations on the rupture risk of IAs remains unclear. The purpose of this study was to explore the effect of artery absence on the internal flow and rupture risk of IAs.

New rhodium(III)-triphenylphosphine complexes with 5-halogenate-8-hydroxyquinoline as ligands: synthesis, characterization, cytotoxicity, and mechanism of action.

The incorporation of triphenylphosphine (PPh) can enhance the antiproliferative activity of complexes. Herein, four Rh(III) complexes GUPT1-GUPT4 were synthesized. GUPT4 exhibited stronger anticancer activity than HGU, cisplatin, and GUPT1-GUPT3 against human non-small cell lung A549 and its cisplatin-resistant A549 cell line (CR-A549), with IC values of 6.

Patterns of lifestyle and their associations with anxiety symptoms among adolescents in Liaoning Province, China: a latent class analysis.

Objective: To explore the latent categories of adolescents' lifestyles and analyze the relationship between these lifestyle categories and anxiety.

Study Design: A cross-sectional survey.

Methods: The questionnaire was designed to assess demographic characteristics, lifestyle behaviors, and anxiety.

Microbial and clinical disparities in pneumonia: insights from metagenomic next-generation sequencing in patients with community-acquired and severe pneumonia.

Background: Community-acquired pneumonia (CAP) is a major global cause of death, with its varying symptoms and severity complicating diagnosis and treatment. Severe pneumonia (SP), a more critical form of CAP, has higher mortality and often requires intensive care. The identification of clinical markers to differentiate CAP from SP has the potential to improve treatment protocols and patient outcomes.

Metallothionein TaMT1f-1B has dual functions in enhancing cadmium and salt tolerance of wheat (Triticum aestivum L.).

Wheat (Triticum aestivum L.), a cereal cultivated worldwide, is vital for global food security. Cadmium (Cd) contamination of soil and salinity are major abiotic stresses adversely affecting wheat production.

Robust Fluorine-Decorated {Yb}-Organic Framework for CH Capture and Efficient Catalytic Performance on CO-Epoxide Cycloaddition.

Fluorine-functionalized MOFs have excellent unusual properties such as gas adsorption and separation and catalysis, but the functionalization of existing ligands and the self-assembly of functionalized MOFs remain a challenge. Herein, we report a robust fluorine-functionalized nanochannel-based ytterbium(III)-organic framework of {(MeNH)[Yb(CFPDA)(μ-HCO)(μ-OH)(HO)]·4DMF·5HO} (, HCFPDA = 4,4'-(4-(4-carboxy-2-fluorophenyl)pyridine-2,6-diyl)diisophthalic acid) with [Yb(μ-OH)(μ-HCO)(HO)] clusters as secondary building units (SBUs). Compared to reported anionic skeleton of [Yb(BDCP)(μ-HCO)(μ-OH)(HO)] (), the void volume of (54.

Ready-to-Use OECT Biosensor toward Rapid and Real-Time Protein Detection in Complex Biological Environments.

Organic electrochemical transistor (OECT) sensors are a promising approach for point-of-care testing (POCT) thanks to their high sensitivity and ability to operate in an aqueous environment. However, OECTs suffer from biological fouling at the gate and channel interfaces when exposed to complex biological samples. These nonspecific interactions can often obscure the weak signal from the trace biomarker, compromising the accuracy and sensitivity of measurements and even leading to false detection outcomes.

Knowledge, attitude, and practice of cardiac rehabilitation referral among healthcare professionals in China: A mediation model.

Objective: Despite proven clinical benefits, cardiac rehabilitation referral rates remained insufficient and low globally. Healthcare professionals' knowledge and attitudes of cardiac rehabilitation may affect their referral behaviors, yet their interrelationships are rarely studied in China. This study aims to examine the cardiac rehabilitation referral rate among Chinese healthcare professionals and explore the associations among knowledge, attitude, and practice (KAP) of cardiac rehabilitation referral.

Surface-Driven Phase Segregation in Conducting Polymer Thin Films Enables High Selectivity and Storage Stability of Chemiresistive Sensors in Humid Air.

Chemiresistive sensors integrated with functionalized conductive polymers have emerged as promising candidates for wearable applications, offering adequate protection against highly toxic and widely prevalent organophosphate compounds, due to their high sensitivity, room-temperature operation, and straightforward fabrication process. However, these chemiresistive sensors exhibit poor resistance to water vapor due to the intrinsic properties of these conducting polymers, likely leading to false sensor alarms. In this study, we engineered a series of water-vapor-resistant, yet organophosphate-sensitive, conducting polymers by electro-copolymerizing hexafluoroisopropanol (HFIP)-grafted 3,4-ethylenedioxythiophene (EDOT-HFIP) with EDOT comonomers bearing hydrophobic alkyl groups of varying lengths (ethyl, butyl, and hexyl).

Limbic system abnormalities in episodic cluster headache: a 7T MRI multimodal study.

Background: Although the limbic system has long been thought to be involved in the pathophysiology of cluster headache, inconsistencies in imaging studies of episodic cluster headache (eCH) patients and limited understanding of the specific regions within the limbic system have prevented a full explanation of its involvement in the disease. Therefore, we performed multimodal imaging analysis using 7 T MRI with the aim of exploring structural-functional abnormalities in subregions of the limbic system and their relationship with clinical features.

Methods: In this cross-sectional study, we employed 7T MRI to investigate structural (volumetric) and functional (fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo)) alterations in limbic subregions (hypothalamus, thalamus, amygdala, hippocampus) among 69 in-bout but outside the attacks eCH patients and 63 healthy controls (HCs).

Hexosamine biosynthesis dysfunction-induced LIFR N-glycosylation deficiency exacerbates steatotic liver ischemia/reperfusion injury.

Background: More and more steatotic livers undergo resection or transplantation but they exhibit higher susceptibility to ischemia-reperfusion injury (IRI), which results in increased perioperative complication morbidity and mortality. IRI is driven by various cytokines and receptors, both of which are extensively modified by N-glycosylation. We aim to elucidate susceptibility of steatotic livers to IRI from the perspective of N-glycosylation.

Effects of acute sleep deprivation on the brain function of individuals with migraine: a resting-state functional magnetic resonance imaging study.

Background: Sleep deprivation can trigger acute headache attacks in individuals with migraine; however, the underlying mechanism remains poorly understood. The aim of this study was to investigate the effects of acute sleep deprivation (ASD) on brain function in individuals with migraine without aura (MWoA) via functional magnetic resonance imaging (fMRI).

Methods: Twenty three MWoA individuals and 23 healthy controls (HCs) were fairly included in this study.

A Universal and Versatile Zwitterionic Coating for Blood-Contacting Catheters with Long Lengths and Complex Geometries.

Blood-contacting catheters are highly susceptible to thrombus formation, making heparin coating essential for reducing clinical complications. However, the limitations of heparin coatings have spurred significant efforts to develop alternative strategies. This study demonstrates a cost-efficient, mechanically viable, and universal zwitterion coating approach for long and complex catheters with near-zero fouling, super anticoagulation, and selective biocapturing.

Neuroimaging differences between chronic migraine with and without medication overuse headache: a 7 Tesla multimodal MRI study.

Background: Chronic migraine (CM) patients with medication overuse headache (MOH) exhibit distinct neurobiological alterations compared to those without MOH. However, prior studies, often limited to single imaging modalities, have yielded inconsistent findings. This study employs multimodal MRI-combining structural, diffusion tensor, and functional imaging-to characterize brain abnormalities in CM patients with and without MOH, while investigating the relationship between acute analgesic use frequency and these changes.

The sentinels of coronary artery disease: heterogeneous monocytes.

Monocytes are heterogeneous immune cells that play a crucial role in the inflammatory response during atherosclerosis, influencing the progression and outcome of the disease. In the pathogenesis of atherosclerotic diseases, such as coronary artery disease (CAD), monocytes not only serve as the initial sensors of endogenous and exogenous pathogenic factors, but also function as intermediators that bridge the circulatory system and localized lesions. In the bloodstream, heterogeneous monocytes, acting as sentinels, are rapidly recruited to atherosclerotic lesions, where they exhibit a heightened capacity to respond to various pathological stimuli upon detecting signals from damaged vascular endothelial cells.

Depression and anxiety in Chinese patients hospitalized with primary headache: A cross-sectional multicenter study.

Background: Primary headache and psychiatric diseases are bidirectional correlated. The real-world data of depression and anxiety in Chinese patients hospitalized for primary headache, considering all subtypes, remain unclear.

Methods: This study enrolled patients attending eight Chinese headache centers from October 2022 to September 2023.

Fibrosis-4plus score: a novel machine learning-based tool for screening high-risk varices in compensated cirrhosis (CHESS2004): an international multicenter study.

Background/aims: A large percentage of patients undergoing esophagogastroduodenoscopy (EGD) screening do not have esophageal varices (EV) or have only small EV. We evaluated a large, international, multicenter cohort to develop a novel score, termed FIB-4plus, by combining the fibrosis-4 (FIB-4) score, liver stiffness measurement (LSM), and spleen stiffness measurement (SSM) to identify high-risk EV (HRV) in compensated cirrhosis.

Methods: This international cohort study involved patients with compensated cirrhosis from 17 Chinese hospitals and one Croatian institution (NCT04546360).

Case report: Cutaneous metastasis of squamous cervical carcinoma: complete regression after molecular diagnosis.

Common metastasis sites for cervical cancer are the lungs, bones, liver, brain, ovaries, and lymph nodes, among other sites. Skin metastasis is very uncommon, and is only observed in approximately 1% of patients. The cancer spreads typically through lymphatic or blood vessels, but a definitive example of lymphatic spread has not been documented thoroughly in the existing literature.

alleviates ischemia-reperfusion injury in steatotic donor liver by inhibiting ferroptosis via the Foxo3-Alox15 signaling pathway.

Ischemia-reperfusion injury (IRI) is a major obstacle in liver transplantation, especially with steatotic donor livers. Dysbiosis of the gut microbiota has been implicated in modulating IRI, and plays a pivotal role in regulating host inflammatory and immune responses, but its specific role in liver transplantation IRI remains unclear. This study explores whether can mitigate IRI and its underlying mechanisms.

Innate immune cells in vascular lesions: mechanism and significance of diversified immune regulation.

Angiogenesis is a complex physiological process. In recent years, the immune regulation of angiogenesis has received increasing attention, and innate immune cells, which are centred on macrophages, are thought to play important roles in vascular neogenesis and development. Various innate immune cells can act on the vasculature through a variety of mechanisms, with commonalities as well as differences and synergistic effects, which are crucial for the progression of vascular lesions.

Relationship Between the Carbonation Depth and Microstructure of Concrete Under Freeze-Thaw Conditions.

Concrete structures in cold regions are affected by freeze-thaw cycles (FTCs) and carbonation, which lead to the premature failure of concrete structures. The carbonation depth, relative dynamic elastic modulus (RDEM), compressive strength, porosity, and pore size distribution of concrete under FTC conditions were tested through an accelerated carbonation experiment to study the carbonation performance evolution. The freeze-thaw effect mechanism on concrete carbonation was further analyzed via the obtained relationship between carbonation depth and pore structure.