New rhodium(III)-triphenylphosphine complexes with 5-halogenate-8-hydroxyquinoline as ligands: synthesis, characterization, cytotoxicity, and mechanism of action.

The incorporation of triphenylphosphine (PPh) can enhance the antiproliferative activity of complexes. Herein, four Rh(III) complexes GUPT1-GUPT4 were synthesized. GUPT4 exhibited stronger anticancer activity than HGU, cisplatin, and GUPT1-GUPT3 against human non-small cell lung A549 and its cisplatin-resistant A549 cell line (CR-A549), with IC values of 6.

On Patient Quality of Life: Impacts of Knee Osteoarthritis on Pain, Anxiety, Depression, Fatigue and Sleep Disorders.

Aim: Patients repeatedly experiencing a sustained disease course, recurrent chronic pain, and serious sleep disorder will weaken their physical resistance and self-care ability. Further evidence on patients with knee osteoarthritis (KOA) and related latent classes (LCs) of symptom clusters is needed in order to clarify its significance for symptom management and quality of life (QoL) enhancement.

Design: This study aimed to generate evidence on differences in symptoms experienced by patients with knee osteoarthritis, identify related LCs, and explore the differences of each LC by demographic, disease, individual characteristics, and QoL.

Chitosan-Based Dressing Materials for Burn Wound Healing.

The treatment of burn injuries remains a significant global challenge. Although conventional cellulose-based dressings are still the dominant clinical choice, chitosan-based burn wound dressing materials have emerged as a promising alternative due to their unique physicochemical properties and biocompatibility. In this mini-review, we aim to provide a summary of recent advances in chitosan-based dressing materials and highlight their advantages in the treatment of burn wounds.

Small G Protein OsRab6a Confers Cold Tolerance by Cooperating With OsRAN2 and Suppressing ABA Signalling in Rice.

Global climate change has increased the frequency of extreme low-temperature events, severely affecting rice production worldwide. Although numerous cold-tolerance genes have been mapped and cloned over the past four decades, the molecular mechanisms governing rice's response to cold stress remain incompletely understood. In this study, we employed an integrated approach combining reverse genetics, biochemical assays, and molecular biology to elucidate the role of OsRab6a, a small GTP-binding protein, in rice cold tolerance.

The predictive value of a prognostic risk model constructed for three aging-associated genes in glioma.

BackgroundGliomas are malignant brain tumors with poor prognosis, and aging is believed to play a role in their malignant transformation. However, the relationship between aging and glioma prognosis remains unclear.ObjectiveThis study aims to construct and validate a prognostic risk model based on aging-related differential expression genes (ARDEGs) to understand their role in glioma prognosis and tumorigenesis, with a particular focus on immune responses.

Manufacture of Necator americanus as an infectious challenge agent: Accelerating human hookworm vaccine development.

Hookworms infect 450 million people globally and account for the loss of 5 million disability-adjusted life years annually. Over the last decade, the Human Hookworm Vaccine (HHV) candidate N. americanus Glutathione-S-Transferase-1 (Na-GST-1) has advanced to efficacy testing.

Tailoring Polyamide66 Mechanical Performance: A Strategy for Condensed Phase Structure Optimization Through Hydrogen Bond Reorganization.

Polymers are widely used in various industries due to their unique properties, but their mechanical strength often falls short compared to other materials. This has spurred extensive research into enhancing their mechanical performance through condensed phase structure regulation. This study investigates the enhancement of mechanical properties in polyamide 66 (PA66) through the introduction of arylamide-based materials (TMB-5) during the melt-spinning process.

Integrative Disulfidptosis-Based Risk Assessment for Prognostic Stratification and Immune Profiling in Glioma.

Disulfidptosis, a new form of programmed cell death, plays a role in multiple types of cancer. However, research on disulfidptosis in glioma is lacking. A disulfidptosis-associated risk score was constructed using Cox regression modelling, while LASSO regression was applied for feature selection.

Synthesis and Performance of Epoxy-Terminated Hyperbranched Polymers Based on Epoxidized Soybean Oil.

Epoxy-terminated hyperbranched polymers (EHBPs) are a class of macromolecular polymers with a hyperbranched structure containing epoxy groups. They possess characteristics such as low viscosity, high functionality, and thermal stability, which endow them with broad application potential in materials science and chemical engineering. This study uses epoxidized soybean oil (ESO) as the raw material, which undergoes ring-opening reactions with glycerol and is esterified with 2,2-bis(hydroxymethyl)propionic acid (DMPA) to obtain epoxy soybean oil polyol (EGD) with a high hydroxyl value.

Fabrication of Polydopamine/hemin/TiO Composites with Enhanced Visible Light Absorption for Efficient Photocatalytic Degradation of Methylene Blue.

With the rapid progression of industrialization, water pollution has emerged as an increasingly critical issue, especially due to the release of organic dyes such as methylene blue (MB), which poses serious threats to both the environment and human health. Developing efficient photocatalysts to effectively degrade these pollutants is therefore of paramount importance. In this work, titanium dioxide (TiO) was modified with the photosensitizer hemin and the hydroxyl-rich polymer polydopamine (PDA) to enhance its photocatalytic degradation performance.

Randomized, observer-blind, controlled Phase 1 study of the safety and immunogenicity of the Na-GST-1/Alhydrogel hookworm vaccine with or without a CpG ODN adjuvant in hookworm-naïve adults.

Background: Recombinant Necator americanus Glutathione-S-Transferase-1 (Na-GST-1) formulated on Alhydrogel (Na-GST-1/Alhydrogel) is being developed to prevent anemia and other complications of N. americanus infection. Antibodies induced by vaccination with recombinant Na-GST-1 are hypothesized to interfere with the blood digestion pathway of adult hookworms in the host.

Effects of Ethylene Propylene Diene Monomer (EPDM)-Based Polar Macromolecular Compatibilizers on the Low-Temperature Properties of Fluoroelastomer/EPDM Rubber Blends.

Integrating rubber with superior low-temperature capabilities, such as ethylene propylene diene monomer (EPDM), is a strategic approach to bolster the low-temperature performance of fluoroelastomer (FKM). However, FKM and EPDM are thermodynamically incompatible. This work synthetized three EPDM-based polar macromolecular compatibilizers, epoxidized EPDM (EPDM-EP), 2,2-trifluoroethylamine-grafted epoxidized EPDM (EPDM-TF), and 2,4-difluorobenzylamine-grafted epoxidized EPDM (EPDM-DF), to enhance the compatibility between FKM and EPDM.

Nanoparticle-Mediated Gene Delivery for Bone Tissue Engineering.

Critical-sized bone defects represent an urgent clinical problem, necessitating innovative treatment approaches. Gene-activated grafts for bone tissue engineering have emerged as a promising solution. However, traditional gene delivery methods are constrained by limited osteogenic efficacy and safety concerns.

Clinical and genetic analysis of macrophage activation syndrome complicating juvenile idiopathic inflammatory myopathies.

Background: Macrophage activation syndrome (MAS) is a serve complication of juvenile idiopathic inflammatory myopathies (JIIMs). This study delineates the clinical manifestations and genetic underpinnings of JIIM-MAS patients.

Methods: We retrospectively analysed clinical and UNC13D gene from JIIM patients admitted to our centre between 2011 and 2021 to identify cases of MAS.

New Species and Cytotoxicity Mechanism of Halohydroxybenzonitrile Disinfection Byproducts in Drinking Water.

Recently, seven dihalohydroxybenzonitriles (diHHBNs) have been determined as concerning nitrogenous aromatic disinfection byproducts (DBPs) in drinking water. Herein, eight new monohalohydroxybenzonitriles (monoHHBNs), including 3-chloro-2-hydroxybenzonitrile, 5-chloro-2-hydroxybenzonitrile, 3-chloro-4-hydroxybenzonitrile, 3-bromo-2-hydroxybenzonitrile, 5-bromo-2-hydroxybenzonitrile, 3-bromo-4-hydroxybenzonitrile, 5-iodo-2-hydroxybenzonitrile, and 3-iodo-4-hydroxybenzonitrile, were detected and identified in drinking water for the first time. Thereafter, the relative concentration-cytotoxicity contribution of each HHBN was calculated based on the acquired occurrence level and cytotoxicity data in this study, the genome-scale cytotoxicity mechanism was explored, and a quantitative structure-activity relationship (QSAR) model was developed.

The causal relationship between gut microbiota and constipation: a two-sample Mendelian randomization study.

Background: Constipation is one of the most common gastrointestinal disorders afflicting the population, with recent observational studies implicating dysfunction of the gut microbiota in constipation. Despite observational studies indicating a relationship, a clear causality remains unclear. This study aims to use two-sample Mendelian randomization (MR) to establish a clearer causal relationship between the two.

Low-/Negative-Pressure Hydrocephalus: To Understand the Formation Mechanism from the Perspective of Clinicians.

Low-/negative-pressure hydrocephalus (LPH/NePH) is uncommon in clinical practice, and doctors are unfamiliar with it. LPH/NePH is frequently caused by other central nervous system diseases, and patients are frequently misdiagnosed with other types of hydrocephalus, resulting in delayed treatment. LPH/NePH therapy evolved to therapeutic measures based on "external ventricular drainage below atmospheric pressure" as the number of patients with LPH/NePH described in the literature has increased.

ANKZF1 knockdown inhibits glioblastoma progression by promoting intramitochondrial protein aggregation through mitoRQC.

Protein homeostasis is fundamental to the development of tumors. Ribosome-associated quality-control (RQC) is able to add alanine and threonine to the stagnant polypeptide chain C-terminal (CAT-tail) when protein translation is hindered, while Ankyrin repeat and zinc-finger domain-containing-protein 1 (ANKZF1) can counteract the formation of the CAT-tail, preventing the aggregation of polypeptide chains. In particular, ANKZF1 plays an important role in maintaining mitochondrial protein homeostasis by mitochondrial RQC (mitoRQC) after translation stagnation of precursor proteins targeting mitochondria.

Safety and immunogenicity of the co-administered Na-APR-1 and Na-GST-1 hookworm vaccines in school-aged children in Gabon: a randomised, controlled, observer-blind, phase 1, dose-escalation trial.

Background: A human hookworm vaccine is being developed to protect children against iron deficiency and anaemia associated with chronic infection with hookworms. Necator americanus aspartic protease-1 (Na-APR-1) and N americanus glutathione S-transferase-1 (Na-GST-1) are components of the blood digestion pathway critical to hookworm survival in the host. Recombinant Na-GST-1 and catalytically inactive Na-APR-1 (Na-APR-1[M74]) adsorbed to Alhydrogel were safe and immunogenic when delivered separately or co-administered to adults in phase 1 trials in non-endemic and endemic areas.

SP140 inhibitor suppressing TRIM22 expression regulates glioma progress through PI3K/AKT signaling pathway.

Background: SP gene family, consisting of SP100, SP110, SP140, and SP140L, has been implicated in the initiation and advancement of numerous malignancies. Nevertheless, their clinical significance in glioma remains incompletely understood.

Method: Expression levels and prognostic significance of SP family members were evaluated in the TCGA and CGGA datasets.

Identification and validation of a novel 9-gene signature of non-specific classification to predict prognosis in glioma patients.

This study aimed to identify and validate a 9-gene signature for predicting overall survival (OS) in glioma patients. Analysis of multiple gene expression datasets led to the identification of 135 candidate genes associated with OS in glioma patients. Further analysis revealed that IGFBP2, PBK, NRXN3, TGIF1, DNAJA4, and LGALS3BP were identified as risk factors for OS, while ENAH, PPP2R2C, and SPHKAP were found to be protective factors.

Acetylation of mtHSP70 at Lys595/653 affecting its interaction between GrpEL1 regulates glioblastoma progression via UPRmt.

Background: The mitochondrial unfolded protein response (UPRmt) is a vital biological process that regulates mitochondrial protein homeostasis and enables glioblastoma cells to cope with mitochondrial oxidative stress in the tumor microenvironment. We previously reported that the binding of mitochondrial stress-70 protein (mtHSP70) to GrpE protein homolog 1 (GrpEL1) is involved in the regulation of the UPRmt. However, the mechanisms regulating their binding remain unclear.