Speed control, visual adaptation, and mental workload in urban short underpass tunnels: A naturalistic driving study.

Objective: Urban short underpass tunnels, characterized by steep longitudinal slopes, limited lengths, and abrupt light transitions, pose significant driving risks. This study aims to comprehensively investigate drivers' speed control behavior, visual adaptation processes, and mental workload mechanisms within such tunnels under real traffic conditions.

Methods: A real-vehicle experiment was conducted involving 35 drivers.

Impact of remnant cholesterol on short-term mortality in acute decompensated heart failure: cohort study evidence from Jiangxi, China.

Introduction: Remnant cholesterol (RC), a highly atherogenic lipid component, has been strongly implicated in the pathogenesis and adverse clinical outcomes of numerous cardiovascular and cerebrovascular diseases. However, its impact on short-term prognosis in patients with acute decompensated heart failure (ADHF) remains to be elucidated.

Methods: This study enrolled 2,365 patients with acute decompensated heart failure (ADHF) admitted to Jiangxi Provincial People's Hospital from 2018 to 2024.

Metallothionein 1X is a tumor suppressor gene and inhibits oxidative stress and metastasis in renal cell carcinoma.

Metallothioneins 1X (MT1X) is expressed at low levels in renal cell carcinoma (RCC) and correlates with tumor progression, stage, grade and prognosis, but the mechanism of MT1X's role in renal cell carcinoma is not fully understood at present, and the aim of this study was to investigate the molecular mechanism of MT1X's role in renal cell carcinoma. We used immunofluorescence and flow cytometry to detect intracellular reactive oxygen species (ROS) levels and immunoblotting to detect the expression levels of key proteins of the epithelial-mesenchymal transition (EMT) signaling pathway, transwell assay to assess the cell migration and invasion capacity. It was found that MT1X knockdown significantly upregulated HO-induced intracellular ROS, activated the EMT pathway, and ultimately promoted cell migration and invasion whereas Trolox inhibited cell migration and invasion by suppressing the elevated ROS induced by MT1X knockdown.

Independent and combined associations of high-density lipoprotein cholesterol-modified triglyceride-glucose index with all-cause and cardiovascular mortality in patients with acute decompensated heart failure.

Introduction: Dysregulation of glucolipid metabolism is a central pathological mechanism underlying acute decompensated heart failure (ADHF) and significantly impacts its poor prognosis. This study aims to investigate the association between the high-density lipoprotein cholesterol-modified triglyceride-glucose index (defined as TyG/HDL-C) and their interaction with 30-day mortality in patients with ADHF.

Methods: From 2018 to 2024, 2,329 ADHF patients enrolled in the Jiangxi-ADHF II cohort were included.

Do visual guiding facilities in freeway tunnels affect drivers' perception of longitudinal safety distance? A simulation experiment.

Objective: The safety perception of longitudinal distance by drivers in tunnels is critical for road safety. However, existing studies mainly focus on the effects of visual guiding facilities on speed perception and vehicle position, with limited research on their impact on longitudinal distance perception. This study aims to evaluate the effect of different types of visual guiding facilities on drivers' safety perception of longitudinal distance in freeway tunnels.

Impact of triglyceride glucose-weight adjusted waist index and its cumulative exposure on stroke risk: a nationwide prospective cohort study.

Background: Insulin resistance and obesity are significant factors contributing to the incidence of stroke. The present research examines the association between stroke risk and both the triglyceride glucose-weight adjusted waist index (TyG-WWI, a composite marker of insulin resistance and obesity) and its cumulative exposure (CumTyG-WWI).

Methods: A total of 4,718 participants without baseline stroke history were included in this investigation, with new-onset stroke cases identified as the main study outcome.

COL22A1 Activates the PI3K/AKT Signaling Pathway to Sustain the Malignancy of Glioblastoma.

Glioblastoma (GBM) represents an aggressive malignancy in the central nervous system, with a poor prognosis. Despite ongoing research efforts, there is still a lack of effective treatments, leading to the need for new therapeutic targets. Collagen plays a crucial role in the extracellular matrix and can impact the progression of cancer.

Single-Cell Analysis Reveals that Vitamin C Inhibits Bone Metastasis of Renal Cancer via Cell Cycle Arrest and Microenvironment Remodeling.

Bone metastasis is the second most common site of distant metastatic spread in renal cell carcinoma (RCC) patients, significantly contributing to cancer-related mortality. The metastatic process is driven by both intrinsic tumor cell properties, such as cancer stem cell-like characteristics, and the bone microenvironment. Understanding the complex interactions between cancer cells and their niche is crucial for identifying therapeutic targets to eliminate metastasis-initiating cells and prevent overt metastasis.

Longitudinal changes and patterns in cardiometabolic index and the natural course of prediabetes in the China health and retirement longitudinal study.

Background: Prediabetes is one of the most common metabolic disorders in the aging process. This study aims to investigate the longitudinal changes in the Cardiometabolic Index (CMI) and their relationship with the natural course of prediabetes in middle-aged and elderly populations.

Methods: This study used longitudinal data from the China Health and Retirement Longitudinal Study.

The fasting plasma glucose to high-density lipoprotein cholesterol ratio: a novel index for identifying NAFLD.

Background: Previous research has indicated that the fasting plasma glucose to high-density lipoprotein cholesterol ratio (FHR) is a novel biomarker for assessing cardiovascular disease prognosis. The objective of this study is to investigate the potential relationship of FHR with non-alcoholic fatty liver disease (NAFLD).

Methods: The present study employed a retrospective design and included 14,251 participants who underwent health examinations.

Association between estimated glucose disposal rate and prediabetes reversion and progression: a nationwide cohort study of middle-aged and elderly people in China.

Objective: Prediabetes is a chronic condition characterized by elevated blood glucose levels that are not yet high enough to be classified as diabetes. It is particularly prevalent among middle-aged and elderly populations. This study aims to investigate the association between a novel marker of insulin resistance-the estimated glucose disposal rate (eGDR)-and the reversion of prediabetes to normoglycaemia or progression to diabetes in a Chinese population.

BUN-to-ALB ratio as an effective predictor of 30 day mortality in ADHF patients in eastern China.

Aims: The blood urea nitrogen-to-albumin ratio (BAR) is considered a potential indicator for assessing the poor prognosis of heart failure (HF). However, its prognostic value for Chinese patients with acute decompensated HF (ADHF) remains unclear.

Methods: This study included ADHF patients who met the study criteria and were admitted to Jiangxi Provincial People's Hospital from 2019 to 2022.

Paeonol enhances a recombinant EGFR-targeted fusion protein-drug conjugate induced antitumor efficacy in esophageal cancer.

Esophageal cancer (EC) is a gastrointestinal cancer with high morbidity and mortality, along with a low 5-year survival rate, which urgently requires the discovery of new drugs for prevention and treatment. Our previous studies have found a novel EGFR-targeted fusion protein-drug conjugate, Fv-LDP-D3-AE, which exhibits significant inhibitory activity against esophageal cancer. However, the effectiveness of monotherapy still faces major challenges in clinical translation for esophageal cancer treatment.

Analyzing the impact of glycemic metabolic status on cardiovascular mortality and all-cause mortality related to the estimated glucose disposal rate: a nationwide cohort study.

Objective: The Estimated Glucose Disposal Rate (eGDR) serves as a surrogate marker for insulin resistance, with numerous studies highlighting its significant prognostic value. This paper aims to analyze the impact of eGDR on cardiovascular and all-cause mortality across different glycemic metabolic statuses, including normal fasting glucose (NFG), prediabetes, and diabetes.

Methods: This study included 46,016 American adults who underwent health examinations as part of the National Health and Nutrition Examination Survey from 1999 to 2018.

Evaluating the effectiveness of rhythmic visual guidance technology for mitigating driving risks in highway tunnel groups: A simulation study.

Driving in highway tunnel groups necessitates frequent adaptation to drastic changes in the traffic environment, thereby increasing driving difficulty and risk. This study integrates drivers' preferences for rhythmic information with the inherent rhythmic characteristics of tunnel group structures to propose a new and adaptive method to mitigate driving risks using rhythmic visual guidance (RVG) technology. Unlike traditional visual guidance systems, which often rely on static signals, RVG utilizes dynamic, rhythmically varying cues to capture drivers' attention and improve situational awareness more effectively.

A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer.

Esophageal cancer (EC) is one of the most common highly malignant tumors of the digestive system, with a poor prognosis under current treatment regimens. Nucleolin (NCL) is overexpressed in many tumors, and drugs specifically targeting NCL may offer a promising strategy for treating esophageal cancer. Here, we designed and prepared a novel aptamer-conjugated drug targeting NCL by AS1411 aptamer-human serum albumin (HSA)-the apoprotein of lidamycin (LDP)-active enediyne chromophore (AE), in order to achieve targeted treatment of esophageal cancer.

The systemic inflammation response index as a significant predictor of short-term adverse outcomes in acute decompensated heart failure patients: a cohort study from Southern China.

Objective: The deterioration of acute decompensated heart failure (ADHF) is associated with abnormal activation of inflammatory pathways. This study aims to evaluate the impact and predictive value of a novel inflammatory marker, the systemic inflammation response index (SIRI), on short-term adverse outcomes in ADHF patients.

Methods: This retrospective cohort study included 1,448 ADHF patients from Jiangxi Provincial People's Hospital between 2019-2022.

YWHAG promotes bladder cancer metastasis by regulating TMOD3 to activate ERK1/2 and JNK phosphorylation in the MAPK pathway.

Objective: This study aims to investigate the molecular mechanisms by which YWHAG (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma) promotes metastasis in bladder cancer. Specifically, it seeks to elucidate the role of YWHAG in driving cancer cell invasion and its potential as a prognostic marker for bladder cancer progression.

Methods: The expression pattern of YWHAG in both primary and metastatic bladder cancer tissues was analyzed using immunohistochemistry (IHC) to determine its correlation with clinical stage and prognosis in bladder cancer patients.

Isorhamnetin ameliorates dopaminergic neuronal damage via targeting FOSL1 to activate AKT/mTOR in 6-OHDA-induced SH-SY5Y cells.

Parkinson's disease (PD) is a chronic neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra compacta, which may result from mitochondrial dysfunction and oxidative stress. Isorhamnetin (Iso) has important antioxidative stress and antiapoptotic effects, this study investigated the effects of Iso on PD in vitro and its underlying mechanisms using a model of 6-hydroxydopamine (6-OHDA)-induced SH-SY5Y cell damage. The results showed that Iso significantly ameliorated 6-OHDA-induced SH-SY5Y cell injury, including decreased cell viability, increased apoptosis and senescence, and oxidative stress injury.

Assessing the validity of METS-IR for predicting the future onset of diabetes: an analysis using time-dependent receiver operating characteristics.

Background: The Metabolic Insulin Resistance Score (METS-IR) is a non-invasive proxy for insulin resistance (IR) that has been newly developed in recent years and has been shown to be associated with diabetes risk. Our aim was to assess the predictive value of METS-IR for the future development of diabetes and its temporal differences in people of different sex, age, and body mass index (BMI).

Methods: The current study included 15,453 baseline non-diabetic subjects in the NAGALA cohort and then grouped according to the World Health Organization's (WHO) recommended criteria for age and BMI.

Can retroreflective rings enhance drivers' safety perception of spatial right-of-way in freeway tunnels? A simulation exploration.

In order to investigate whether retroreflective rings can enhance drivers' perception of spatial right-of-way in freeway tunnels, this paper explores a simulation test. The characteristics of spatial right-of-way in tunnels are elucidated, and a comparative test is conducted using commonly used delineators and raised pavement markers against retroreflective rings to enhance the perception of spatial right-of-way. The test employs the perception of lateral deviation and longitudinal distance as indicators to reflect the lateral and longitudinal right-of-way.

The Clínica Universidad de Navarra-Body Adiposity Estimator index is a reliable tool for screening metabolic dysfunction-associated steatotic liver disease: an analysis from a gender perspective.

Background: The Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE) Index, serves as an effective tool for evaluating body fat (BF) levels. This research seeks to clarify the association between the CUN-BAE Index and metabolic dysfunction-associated steatotic liver disease (MASLD) from a gender perspective.

Methods: The study utilized data from a comprehensive health assessment initiative known as "Human Dock", involving 14,251 participants.

Urinary kallikrein reverses neuropathic pain by inhibiting ectopic neural discharges, neural inflammation and oxidative stress.

Background: Neuropathic pain is a refractory disease and badly impacts the lives of patients. Urinary kallikrein (UK) acted as a glycoprotein has been discovered to play a pivotal role in neuroprotection. However, the regulatory impacts and correlative pathways of UK in the progression of neuropathic pain remain dimness.

The newly proposed plasma-glycosylated hemoglobin A1c/High-Density lipoprotein cholesterol ratio serves as a simple and practical indicator for screening metabolic associated fatty liver disease: an observational study based on a physical examination population.

Background: Glycotoxicity and lipotoxicity are key pathophysiological mechanisms underlying the development of metabolic associated fatty liver disease (MAFLD). The primary objective of this study is to investigate the association between the newly proposed Plasma-Glycosylated Hemoglobin A1c/High-Density Lipoprotein Cholesterol Ratio (HbA1c/HDL-C ratio) and the risk of MAFLD.

Methods: A study population of 14,251 individuals undergoing health examinations was included.

Impact of sidewall information on drivers' visual load among different lanes: Traditional guiding facilities and decorated pattern.

Objectives: This research aims to: (i) compare the effects of different sidewall entrainment facilities on drivers' visual behavior; (ii) compare the effects of the same sight entrainment facilities on drivers in different lanes; (iii) give recommendations for engineering applications based on the results of the study.

Methods: The study designed four different scenes, each with symmetrically designed visual facilities on the both sidewalls of the tunnel, scene a represents a typical urban tunnel in China (horizontal stripes on sidewalls), scene b includes vertical stripes on sidewalls in addition to scene a, scene c introduces an LED-arch based on scene b, and scene d features a rhythmic pattern (Wave pattern on sidewalls). 30 participants, 21 men and 9 women, aged 21-54, drove the four scenes.